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Volumn 28, Issue 3, 2015, Pages 207-215

Drug development in schizophrenia: Are glutamatergic targets still worth aiming at?

Author keywords

glutamate; mGluR5; N methyl D aspartate; schizophrenia

Indexed keywords

AMPA RECEPTOR; CYCLOSERINE; DOPAMINE; GLUTAMATE RECEPTOR; GLYCINE; LAMOTRIGINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHODIESTERASE INHIBITOR; RECEPTOR SUBTYPE; AMINO ACID RECEPTOR AFFECTING AGENT; GLUTAMIC ACID; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; TRIAZINE DERIVATIVE;

EID: 84926313738     PISSN: 09517367     EISSN: 14736578     Source Type: Journal    
DOI: 10.1097/YCO.0000000000000152     Document Type: Review
Times cited : (37)

References (118)
  • 1
    • 0015583229 scopus 로고
    • Provocation of schizophrenic symptoms by intravenous administration of methylphenidate
    • Janowsky D, El-Yousef M, Davis J, et al. Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch Gen Psychiatry 1973; 28: 185-191.
    • (1973) Arch Gen Psychiatry , vol.28 , pp. 185-191
    • Janowsky, D.1    El-Yousef, M.2    Davis, J.3
  • 2
    • 0017068246 scopus 로고
    • Antipsychotic drug doses and neuroleptic/ dopamine receptors
    • Seeman P, Lee T, Chau-Wong M. Antipsychotic drug doses and neuroleptic/ dopamine receptors. Nature 1976; 261: 717-719.
    • (1976) Nature , vol.261 , pp. 717-719
    • Seeman, P.1    Lee, T.2    Chau-Wong, M.3
  • 3
    • 0026070134 scopus 로고
    • DavidsonM. Dopamine in schizophrenia: A review and reconceptualization
    • Davis K, Kahn R, Ko G, DavidsonM. Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 1991; 148: 1474-1486.
    • (1991) Am J Psychiatry , vol.148 , pp. 1474-1486
    • Davis, K.1    Kahn, R.2    Ko, G.3
  • 4
    • 81055137500 scopus 로고    scopus 로고
    • Diverse facets of COMT: From a plausible predictive marker to a potential drug target for schizophrenia
    • Gupta M, Kaur H, Jajodia A, et al. Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia. Curr Mol Med 2011; 11: 732-743.
    • (2011) Curr Mol Med , vol.11 , pp. 732-743
    • Gupta, M.1    Kaur, H.2    Jajodia, A.3
  • 5
    • 84926393206 scopus 로고    scopus 로고
    • Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder
    • Rosell DR, Zaluda LC, McClure MM, et al. Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder. Neuropsychopharmacology 2015; 40: 446-453.
    • (2015) Neuro Psychopharmacology , vol.40 , pp. 446-453
    • Rosell, D.R.1    Zaluda, L.C.2    McClure, M.M.3
  • 7
    • 0025363344 scopus 로고
    • Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease
    • Carlsson M, Carlsson A. Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease. Trends Neurosci 1990; 13: 272-276.
    • (1990) Trends Neurosci , vol.13 , pp. 272-276
    • Carlsson, M.1    Carlsson, A.2
  • 8
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt D, Zukin S. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 1991; 148: 1301-1308.
    • (1991) Am J Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.1    Zukin, S.2
  • 9
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995; 52: 998-1007.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 10
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal JH, Karper LP, Seibyl JP, et al. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51: 199-214.
    • (1994) Arch Gen Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3
  • 11
    • 0032903301 scopus 로고    scopus 로고
    • The neuropsychopharmacology of phencyclidine: From NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia
    • Jentsch J, Roth R. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1999; 20: 201-225.
    • (1999) Neuro Psychopharmacology , vol.20 , pp. 201-225
    • Jentsch, J.1    Roth, R.2
  • 12
    • 0028921447 scopus 로고
    • Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke Results of a phase II a randomized trial
    • Grotta J, Clark W, Coull B, et al. Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial. Stroke 1995; 26: 602-605.
    • (1995) Stroke , vol.26 , pp. 602-605
    • Grotta, J.1    Clark, W.2    Coull, B.3
  • 13
    • 0028943849 scopus 로고
    • Ketamine activates psychosis and alters limibic blood flow in schizophrenia
    • Lahti AC, Holcomb HH, Medoff DR, Tamminga CA. Ketamine activates psychosis and alters limibic blood flow in schizophrenia. Neuroreport 1995; 6: 869-872.
    • (1995) Neuroreport , vol.6 , pp. 869-872
    • Lahti, A.C.1    Holcomb, H.H.2    Medoff, D.R.3    Tamminga, C.A.4
  • 14
    • 0030861444 scopus 로고    scopus 로고
    • Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: A study with ketamine
    • Malhotra A, Adler C, Kennison S, et al. Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: a study with ketamine. Biol Psychiatry 1997; 42: 664-668.
    • (1997) Biol Psychiatry , vol.42 , pp. 664-668
    • Malhotra, A.1    Adler, C.2    Kennison, S.3
  • 15
    • 43649089662 scopus 로고    scopus 로고
    • Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine
    • Gozzi A, Large CH, Schwarz A, et al. Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine. Neuropsychopharmacology 2008; 33: 1690-1703.
    • (2008) Neuro Psychopharmacology , vol.33 , pp. 1690-1703
    • Gozzi, A.1    Large, C.H.2    Schwarz, A.3
  • 16
    • 0034054949 scopus 로고    scopus 로고
    • Attentuation of the neuropsychiatric effects of ketamine with lamotrigine
    • Anand A, Charney DS, Oren DA, et al. Attentuation of the neuropsychiatric effects of ketamine with lamotrigine. Arch Gen Psychiatry 2000; 57: 270-276.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 270-276
    • Anand, A.1    Charney, D.S.2    Oren, D.A.3
  • 17
    • 20944439080 scopus 로고    scopus 로고
    • Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
    • Krystal JH, Abi-Saab W, Perry E, et al. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology 2005; 179: 303-309.
    • (2005) Psychopharmacology , vol.179 , pp. 303-309
    • Krystal, J.H.1    Abi-Saab, W.2    Perry, E.3
  • 19
    • 0033558578 scopus 로고    scopus 로고
    • Reversal of the behavioral and neurochemical effects of phencylidine by glycine and glycine transport inhibitors
    • Javitt DC, Balla A, Sershen H, Lajtha A. Reversal of the behavioral and neurochemical effects of phencylidine by glycine and glycine transport inhibitors. Biol Psychiatry 1999; 45: 668-679.
    • (1999) Biol Psychiatry , vol.45 , pp. 668-679
    • Javitt, D.C.1    Balla, A.2    Sershen, H.3    Lajtha, A.4
  • 20
    • 34250615885 scopus 로고    scopus 로고
    • Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
    • Large CH. Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs? J Psychopharmacol 2007; 21: 283-301.
    • (2007) J Psychopharmacol , vol.21 , pp. 283-301
    • Large, C.H.1
  • 21
    • 79951920911 scopus 로고    scopus 로고
    • Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response
    • Hwang R, Souza RP, Tiwari AK, et al. Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response. Pharmacogenomics 2011; 12: 277-291.
    • (2011) Pharmacogenomics , vol.12 , pp. 277-291
    • Hwang, R.1    Souza, R.P.2    Tiwari, A.K.3
  • 23
    • 84924965598 scopus 로고    scopus 로고
    • Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: Potential mechanism of increased vulnerability in the immature brain
    • Jantzie LL, Talos DM, Jackson MC, et al. Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain. Cereb Cortex 2013; 25: 482-495.
    • (2013) Cereb Cortex , vol.25 , pp. 482-495
    • Jantzie, L.L.1    Talos, D.M.2    Jackson, M.C.3
  • 24
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium.. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013; 381: 1371-1379.
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 25
    • 80755153558 scopus 로고    scopus 로고
    • Glutamate receptor dynamics and protein interaction: Lessons from the NMDA receptor
    • Bard L, Groc L. Glutamate receptor dynamics and protein interaction: lessons from the NMDA receptor. Mol Cell Neurosci 2011; 48: 298-307.
    • (2011) Mol Cell Neurosci , vol.48 , pp. 298-307
    • Bard, L.1    Groc, L.2
  • 26
    • 84856102195 scopus 로고    scopus 로고
    • GABAergic interneuron origin of schizophrenia patho physiology
    • Nakazawa K, Zsiros V, Jiang Z, et al. GABAergic interneuron origin of schizophrenia pathophysiology. Neuropharmacology 2012; 62: 1574-1583.
    • (2012) Neuropharmacology , vol.62 , pp. 1574-1583
    • Nakazawa, K.1    Zsiros, V.2    Jiang, Z.3
  • 27
    • 73949136265 scopus 로고    scopus 로고
    • Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
    • Belforte JE, Zsiros V, Sklar ER, et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat Neurosci 2010; 13: 76-83.
    • (2010) Nat Neurosci , vol.13 , pp. 76-83
    • Belforte, J.E.1    Zsiros, V.2    Sklar, E.R.3
  • 28
    • 84863201711 scopus 로고    scopus 로고
    • NMDA receptor hypofunction, parvalbuminpositive neurons, and cortical gamma oscillations in schizophrenia
    • Gonzalez-Burgos G, Lewis DA. NMDA receptor hypofunction, parvalbuminpositive neurons, and cortical gamma oscillations in schizophrenia. Schizophr Bull 2012; 38: 950-957.
    • (2012) Schizophr Bull , vol.38 , pp. 950-957
    • Gonzalez-Burgos, G.1    Lewis, D.A.2
  • 29
    • 67449138840 scopus 로고    scopus 로고
    • Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex
    • Wang HX, Gao WJ. Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex. Neuropsychopharmacology 2009; 34: 2028-2040.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2028-2040
    • Wang, H.X.1    Gao, W.J.2
  • 30
    • 35548991088 scopus 로고    scopus 로고
    • NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons
    • Homayoun H, Moghaddam B. NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J Neurosci 2007; 27: 11496-11500.
    • (2007) J Neurosci , vol.27 , pp. 11496-11500
    • Homayoun, H.1    Moghaddam, B.2
  • 31
    • 78650898268 scopus 로고    scopus 로고
    • Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: Relevance for schizophrenia
    • Rotaru DC, Yoshino H, Lewis DA, et al. Glutamate receptor subtypes mediating synaptic activation of prefrontal cortex neurons: relevance for schizophrenia. J Neurosci 2011; 31: 142-156.
    • (2011) J Neurosci , vol.31 , pp. 142-156
    • Rotaru, D.C.1    Yoshino, H.2    Lewis, D.A.3
  • 32
    • 84861092297 scopus 로고    scopus 로고
    • Differential role of NR2A and NR2B subunits in N-methyl-Daspartate receptor antagonist-induced aberrant cortical gamma oscillations
    • Kocsis B. Differential role of NR2A and NR2B subunits in N-methyl-Daspartate receptor antagonist-induced aberrant cortical gamma oscillations. Biol Psychiatry 2012; 71: 987-995.
    • (2012) Biol Psychiatry , vol.71 , pp. 987-995
    • Kocsis, B.1
  • 33
    • 0034307054 scopus 로고    scopus 로고
    • Modulation of amphetamineinduced striatal dopamine release by ketamine in humans: Implications for schizophrenia
    • Kegeles LS, Abi-Dargham A, Zea-Ponce Y, et al. Modulation of amphetamineinduced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry 2000; 48: 627-640.
    • (2000) Biol Psychiatry , vol.48 , pp. 627-640
    • Kegeles, L.S.1    Abi-Dargham, A.2    Zea-Ponce, Y.3
  • 34
    • 0036179194 scopus 로고    scopus 로고
    • Excitotoxicity: Perspectives based on N-methyl-Daspartate receptor subtypes
    • Lynch DR, Guttmann RP. Excitotoxicity: perspectives based on N-methyl-Daspartate receptor subtypes. Journal Pharmacol Exp Ther 2002; 300: 717-723.
    • (2002) Journal Pharmacol Exp Ther , vol.300 , pp. 717-723
    • Lynch, D.R.1    Guttmann, R.P.2
  • 35
    • 0024849434 scopus 로고
    • Milacemide, a glycine pro-drug, enhances performance of learning tasks in normal and amnestic rodents
    • Handelmann G, Nevins M, Mueller L, et al. Milacemide, a glycine pro-drug, enhances performance of learning tasks in normal and amnestic rodents. Biochem Pharmacol Behav 1989; 34: 823-828.
    • (1989) Biochem Pharmacol Behav , vol.34 , pp. 823-828
    • Handelmann, G.1    Nevins, M.2    Mueller, L.3
  • 36
    • 0025913740 scopus 로고
    • An NMDA intervention strategy in schizophrenia with ''low dose'' milacemide
    • Rosse RB, Schwartz BL, Davis RE, Deutsch SI. An NMDA intervention strategy in schizophrenia with ''low dose'' milacemide. Clin Neuropharmacol 1991; 14: 268-272.
    • (1991) Clin Neuropharmacol , vol.14 , pp. 268-272
    • Rosse, R.B.1    Schwartz, B.L.2    Davis, R.E.3    Deutsch, S.I.4
  • 37
    • 0025297561 scopus 로고
    • An open-label trial of milacemide in schizophrenia: An NMDA intervention strategy
    • Rosse RB, Schwartz BL, Leighton MP, et al. An open-label trial of milacemide in schizophrenia: an NMDA intervention strategy. Clin Neuropharmacol 1990; 13: 348-354.
    • (1990) Clin Neuropharmacol , vol.13 , pp. 348-354
    • Rosse, R.B.1    Schwartz, B.L.2    Leighton, M.P.3
  • 38
    • 9244243064 scopus 로고    scopus 로고
    • Glutamatergic drugs for schizophrenia: A systematic review and meta-analysis
    • Tuominen HJ, Tiihonen J, Wahlbeck K. Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr Res 2005; 72: 225-234.
    • (2005) Schizophr Res , vol.72 , pp. 225-234
    • Tuominen, H.J.1    Tiihonen, J.2    Wahlbeck, K.3
  • 39
    • 32144442536 scopus 로고    scopus 로고
    • D-alanine added to antipsychotics for the treatment of schizophrenia
    • Tsai GE, Yang P, Chang YC, Chong MY. D-alanine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 2006; 59: 230-234.
    • (2006) Biol Psychiatry , vol.59 , pp. 230-234
    • Tsai, G.E.1    Yang, P.2    Chang, Y.C.3    Chong, M.Y.4
  • 40
    • 15444377601 scopus 로고    scopus 로고
    • D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia
    • Heresco-Levy U, Javitt DC, Ebstein R, et al. D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia. Biol Psychiatry 2005; 57: 577-585.
    • (2005) Biol Psychiatry , vol.57 , pp. 577-585
    • Heresco-Levy, U.1    Javitt, D.C.2    Ebstein, R.3
  • 41
    • 0032403626 scopus 로고    scopus 로고
    • D-serine added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Yang P, Chung L-C, et al. D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 1998; 44: 1081-1089.
    • (1998) Biol Psychiatry , vol.44 , pp. 1081-1089
    • Tsai, G.1    Yang, P.2    Chung, L.-C.3
  • 42
    • 0032902238 scopus 로고    scopus 로고
    • A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia
    • Goff D, Tsai G, Levitt J, et al. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psych 1999; 56: 21-27.
    • (1999) Arch Gen Psych , vol.56 , pp. 21-27
    • Goff, D.1    Tsai, G.2    Levitt, J.3
  • 43
    • 20944441298 scopus 로고    scopus 로고
    • A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients
    • Goff DC, Herz L, Posever T, et al. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology 2005; 179: 144-150.
    • (2005) Psychopharmacology , vol.179 , pp. 144-150
    • Goff, D.C.1    Herz, L.2    Posever, T.3
  • 44
    • 0033557737 scopus 로고    scopus 로고
    • A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia
    • Goff D, Henderson D, Evins A, Amico E. A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia. Biol Psychiatry 1999; 45: 512-514.
    • (1999) Biol Psychiatry , vol.45 , pp. 512-514
    • Goff, D.1    Henderson, D.2    Evins, A.3    Amico, E.4
  • 45
    • 35748969317 scopus 로고    scopus 로고
    • The cognitive and negative symptoms in schizophrenia trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan RW, Javitt DC, Marder SR, et al. The cognitive and negative symptoms in schizophrenia trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry 2007; 164: 1593-1602.
    • (2007) Am J Psychiatry , vol.164 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3
  • 46
    • 0033048899 scopus 로고    scopus 로고
    • The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist-than dopamine agonist-induced hyperactivity in mice
    • Carlsson ML, Martin P, Nilsson M, et al. The 5-HT2A receptor antagonist M100907 is more effective in counteracting NMDA antagonist-than dopamine agonist-induced hyperactivity in mice. J Neural Transm 1999; 106: 123-129.
    • (1999) J Neural Transm , vol.106 , pp. 123-129
    • Carlsson, M.L.1    Martin, P.2    Nilsson, M.3
  • 47
    • 0037333394 scopus 로고    scopus 로고
    • Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex
    • Ninan I, Jardemark KE, Wang RY. Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex. Neuropharmacology 2003; 44: 462-472.
    • (2003) Neuropharmacology , vol.44 , pp. 462-472
    • Ninan, I.1    Jardemark, K.E.2    Wang, R.Y.3
  • 48
    • 0036627616 scopus 로고    scopus 로고
    • Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: Potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    • Breese GR, Knapp DJ, Moy SS. Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness. Neurosci Biobehav Rev 2002; 26: 441-455.
    • (2002) Neurosci Biobehav Rev , vol.26 , pp. 441-455
    • Breese, G.R.1    Knapp, D.J.2    Moy, S.S.3
  • 49
    • 84872486732 scopus 로고    scopus 로고
    • Feasibility, safety, and efficacy of the combination of d-serine and computerized cognitive retraining in schizophrenia: An international collaborative pilot study
    • D'Souza DC, Radhakrishnan R, Perry E, et al. Feasibility, safety, and efficacy of the combination of d-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study. Neuropsychopharmacology 2013; 38: 492-503.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 492-503
    • D'Souza, D.C.1    Radhakrishnan, R.2    Perry, E.3
  • 50
    • 84863550158 scopus 로고    scopus 로고
    • A multicenter, add-on randomized controlled trial of low-dose d-serine for negative and cognitive symptoms of schizophrenia
    • Weiser M, Heresco-Levy U, Davidson M, et al. A multicenter, add-on randomized controlled trial of low-dose d-serine for negative and cognitive symptoms of schizophrenia. J Clin Psychiatry 2012; 73: e728-e734.
    • (2012) J Clin Psychiatry , vol.73 , pp. e728-e734
    • Weiser, M.1    Heresco-Levy, U.2    Davidson, M.3
  • 51
    • 77955056793 scopus 로고    scopus 로고
    • High dose D-serine in the treatment of schizophrenia
    • Kantrowitz JT, Malhotra D, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res 2010; 121: 125-130.
    • (2010) Schizophr Res , vol.121 , pp. 125-130
    • Kantrowitz, J.T.1    Malhotra, D.2    Cornblatt, B.3
  • 52
    • 67649989298 scopus 로고    scopus 로고
    • Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification
    • Javitt DC. Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification. Curr Opin Drug Discov Devel 2009; 12: 468-478.
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 468-478
    • Javitt, D.C.1
  • 53
    • 0032441894 scopus 로고    scopus 로고
    • Modulation of N-methyl-D-aspartate receptor function by glycine transport
    • Bergeron R, Meyer T, Coyle J, Greene R.Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc Natl Acad Sci USA 1998; 95: 15730-15734.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15730-15734
    • Bergeron, R.1    Meyer, T.2    Coyle, J.3    Greene, R.4
  • 54
    • 33748751382 scopus 로고    scopus 로고
    • Glycine transporter i inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    • Lane HY, Huang CL, Wu PL, et al. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biol Psychiatry 2006; 60: 645-649.
    • (2006) Biol Psychiatry , vol.60 , pp. 645-649
    • Lane, H.Y.1    Huang, C.L.2    Wu, P.L.3
  • 55
    • 1542617755 scopus 로고    scopus 로고
    • Glycine transporter i inhibitor N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Lane HY, Yang P, et al.Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 2004; 55: 452-456.
    • (2004) Biol Psychiatry , vol.55 , pp. 452-456
    • Tsai, G.1    Lane, H.Y.2    Yang, P.3
  • 56
    • 27744529018 scopus 로고    scopus 로고
    • Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: A randomized, double-blind, placebocontrolled study
    • Lane HY, Chang YC, Liu YC, et al. Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebocontrolled study. Arch Gen Psychiatry 2005; 62: 1196-1204.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 1196-1204
    • Lane, H.Y.1    Chang, Y.C.2    Liu, Y.C.3
  • 57
    • 84872495665 scopus 로고    scopus 로고
    • Glycine transporter type 1 occupancy by bitopertin: A positron emission tomography study in healthy volunteers
    • Martin-Facklam M, Pizzagalli F, Zhou Y, et al. Glycine transporter type 1 occupancy by bitopertin: a positron emission tomography study in healthy volunteers. Neuropsychopharmacology 2013; 38: 504-512.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 504-512
    • Martin-Facklam, M.1    Pizzagalli, F.2    Zhou, Y.3
  • 58
    • 84900411478 scopus 로고    scopus 로고
    • A randomized, double-blind, proof-of-concept study of the effect of bitopertin, a glycine reuptake 2 inhibitor, on negative symptoms of schizophrenia
    • Umbricht D, Alberati D, Martin-Facklam M, et al. A randomized, double-blind, proof-of-concept study of the effect of bitopertin, a glycine reuptake 2 inhibitor, on negative symptoms of schizophrenia. JAMA Psychiatry 2014; 71: 637-646.
    • (2014) JAMA Psychiatry , vol.71 , pp. 637-646
    • Umbricht, D.1    Alberati, D.2    Martin-Facklam, M.3
  • 59
    • 84891155212 scopus 로고    scopus 로고
    • Imaging glutamate in schizophrenia: Review of findings and implications for drug discovery
    • Poels EM, Kegeles LS, Kantrowitz JT, et al. Imaging glutamate in schizophrenia: review of findings and implications for drug discovery. Mol Psychiatry 2014; 19: 20-29.
    • (2014) Mol Psychiatry , vol.19 , pp. 20-29
    • Poels, E.M.1    Kegeles, L.S.2    Kantrowitz, J.T.3
  • 60
    • 80052554378 scopus 로고    scopus 로고
    • Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis
    • Fusar-Poli P, Stone JM, Broome MR, et al. Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis. Arch Gen Psychiatry 2011; 68: 881-890.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 881-890
    • Fusar-Poli, P.1    Stone, J.M.2    Broome, M.R.3
  • 61
    • 84890084726 scopus 로고    scopus 로고
    • Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia
    • Kraguljac NV, White DM, Reid MA, Lahti AC. Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia. JAMA Psychiatry 2013; 70: 1294-1302.
    • (2013) JAMA Psychiatry , vol.70 , pp. 1294-1302
    • Kraguljac, N.V.1    White, D.M.2    Reid, M.A.3    Lahti, A.C.4
  • 62
    • 84876084495 scopus 로고    scopus 로고
    • Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
    • Schobel SA, Chaudhury NH, Khan UA, et al. Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver. Neuron 2013; 78: 81-93.
    • (2013) Neuron , vol.78 , pp. 81-93
    • Schobel, S.A.1    Chaudhury, N.H.2    Khan, U.A.3
  • 63
    • 72449136678 scopus 로고    scopus 로고
    • The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia
    • Labrie V, Roder JC. The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. Neurosci Biobehav Rev 2010; 34: 351-372.
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 351-372
    • Labrie, V.1    Roder, J.C.2
  • 64
    • 52049087606 scopus 로고    scopus 로고
    • PLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: Effect on schizophrenia susceptibility
    • Sacchi S, Bernasconi M, Martineau M, et al. pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility. J Biol Chem 2008; 283: 22244-22256.
    • (2008) J Biol Chem , vol.283 , pp. 22244-22256
    • Sacchi, S.1    Bernasconi, M.2    Martineau, M.3
  • 65
    • 84890018607 scopus 로고    scopus 로고
    • Add-on treatment of benzoate for schizophrenia: A randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor
    • Lane HY, Lin CH, Green MF, et al. Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor. JAMA Psychiatry 2013; 70: 1267-1275.
    • (2013) JAMA Psychiatry , vol.70 , pp. 1267-1275
    • Lane, H.Y.1    Lin, C.H.2    Green, M.F.3
  • 66
    • 2942595866 scopus 로고    scopus 로고
    • Characterization and localization of a human serine racemase
    • Xia M, Liu Y, Figueroa DJ, et al. Characterization and localization of a human serine racemase. Brain Res Mol Brain Res 2004; 125: 96-104.
    • (2004) Brain Res Mol Brain Res , vol.125 , pp. 96-104
    • Xia, M.1    Liu, Y.2    Figueroa, D.J.3
  • 67
    • 34047261852 scopus 로고    scopus 로고
    • Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS
    • Rutter AR, Fradley RL, Garrett EM, et al. Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci 2007; 25: 1757-1766.
    • (2007) Eur J Neurosci , vol.25 , pp. 1757-1766
    • Rutter, A.R.1    Fradley, R.L.2    Garrett, E.M.3
  • 68
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia - A double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry 2008; 64: 361-368.
    • (2008) Biol Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 69
    • 84857482073 scopus 로고    scopus 로고
    • Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: A double-blind, randomized, placebo-controlled trial
    • Carmeli C, Knyazeva MG, Cuenod M, Do KQ. Glutathione precursor N-acetyl-cysteine modulates EEG synchronization in schizophrenia patients: a double-blind, randomized, placebo-controlled trial. PloS One 2012; 7: e29341.
    • (2012) PloS One , vol.7 , pp. e29341
    • Carmeli, C.1    Knyazeva, M.G.2    Cuenod, M.3    Do, K.Q.4
  • 70
    • 43649090465 scopus 로고    scopus 로고
    • Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine
    • Baker DA, Madayag A, Kristiansen LV, et al. Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine. Neuropsychopharmacology 2008; 33: 1760-1772.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1760-1772
    • Baker, D.A.1    Madayag, A.2    Kristiansen, L.V.3
  • 71
    • 0742323784 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan degradation as a drug target
    • Schwarcz R. The kynurenine pathway of tryptophan degradation as a drug target. Curr Opin Pharmacol 2004; 4: 12-17.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 12-17
    • Schwarcz, R.1
  • 72
    • 33646765763 scopus 로고    scopus 로고
    • Modulators of the kynurenine pathway of tryptophan metabolism: Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor
    • Pellicciari R, Rizzo RC, Costantino G, et al. Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. ChemMedChem 2006; 1: 528-531.
    • (2006) ChemMedChem , vol.1 , pp. 528-531
    • Pellicciari, R.1    Rizzo, R.C.2    Costantino, G.3
  • 73
    • 77953617514 scopus 로고    scopus 로고
    • Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior
    • Potter MC, Elmer GI, Bergeron R, et al. Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology 2010; 35: 1734-1742.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1734-1742
    • Potter, M.C.1    Elmer, G.I.2    Bergeron, R.3
  • 74
    • 33747083749 scopus 로고    scopus 로고
    • Effects of D-cycloserine on extinction: Translation from preclinical to clinical work
    • Davis M, Ressler K, Rothbaum BO, Richardson R. Effects of D-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry 2006; 60: 369-375.
    • (2006) Biol Psychiatry , vol.60 , pp. 369-375
    • Davis, M.1    Ressler, K.2    Rothbaum, B.O.3    Richardson, R.4
  • 75
    • 16844387460 scopus 로고    scopus 로고
    • Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats
    • Parnas AS, Weber M, Richardson R. Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats. Neurobiol Learn Mem 2005; 83: 224-231.
    • (2005) Neurobiol Learn Mem , vol.83 , pp. 224-231
    • Parnas, A.S.1    Weber, M.2    Richardson, R.3
  • 76
    • 0028246912 scopus 로고
    • Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention
    • Quartermain D, Mower J, Rafferty MF, et al. Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention. Eur J Pharm 1994; 257: 7-12.
    • (1994) Eur J Pharm , vol.257 , pp. 7-12
    • Quartermain, D.1    Mower, J.2    Rafferty, M.F.3
  • 77
    • 0037456846 scopus 로고    scopus 로고
    • Glycine binding primes NMDA receptor internalization
    • Nong Y, Huang YQ, Ju W, et al. Glycine binding primes NMDA receptor internalization. Nature 2003; 422: 302-307.
    • (2003) Nature , vol.422 , pp. 302-307
    • Nong, Y.1    Huang, Y.Q.2    Ju, W.3
  • 78
    • 77249087107 scopus 로고    scopus 로고
    • Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors
    • Dravid SM, Burger PB, Prakash A, et al. Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. J Neurosci 2010; 30: 2741-2754.
    • (2010) J Neurosci , vol.30 , pp. 2741-2754
    • Dravid, S.M.1    Burger, P.B.2    Prakash, A.3
  • 79
    • 47249164327 scopus 로고    scopus 로고
    • Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder
    • Beneyto M, Meador-Woodruff JH. Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 2008; 33: 2175-2186.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2175-2186
    • Beneyto, M.1    Meador-Woodruff, J.H.2
  • 80
    • 57349128912 scopus 로고    scopus 로고
    • D-cycloserine facilitates extinction the first time but not the second time: An examination of the role of NMDA across the course of repeated extinction sessions
    • Langton JM, Richardson R. D-cycloserine facilitates extinction the first time but not the second time: an examination of the role of NMDA across the course of repeated extinction sessions. Neuropsychopharmacology 2008; 33: 3096-3102.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 3096-3102
    • Langton, J.M.1    Richardson, R.2
  • 81
    • 56049099989 scopus 로고    scopus 로고
    • Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: An exploratory study
    • Goff DC, Cather C, Gottlieb JD, et al. Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: an exploratory study. Schizophr Res 2008; 106: 320-327.
    • (2008) Schizophr Res , vol.106 , pp. 320-327
    • Goff, D.C.1    Cather, C.2    Gottlieb, J.D.3
  • 82
    • 84895782150 scopus 로고    scopus 로고
    • D-Cycloserine augmentation of cognitive remediation in schizophrenia
    • Cain CK, McCue M, Bello I, et al. D-Cycloserine augmentation of cognitive remediation in schizophrenia. Schizophr Res 2014; 153: 177-183.
    • (2014) Schizophr Res , vol.153 , pp. 177-183
    • Cain, C.K.1    McCue, M.2    Bello, I.3
  • 83
    • 84866703056 scopus 로고    scopus 로고
    • D-cycloserine: An evolving role in learning and neuroplasticity in schizophrenia
    • Goff DC. D-cycloserine: an evolving role in learning and neuroplasticity in schizophrenia. Schizophr Bull 2012; 38: 936-941.
    • (2012) Schizophr Bull , vol.38 , pp. 936-941
    • Goff, D.C.1
  • 84
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • Maeng S, Zarate CA Jr, Du J, et al. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 2008; 63: 349-352.
    • (2008) Biol Psychiatry , vol.63 , pp. 349-352
    • Maeng, S.1    Zarate, C.A.2    Du, J.3
  • 85
    • 84892403784 scopus 로고    scopus 로고
    • GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
    • Moskal JR, Burch R, Burgdorf JS, et al. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists. Expert Opin Investig Drugs 2014; 23: 243-254.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 243-254
    • Moskal, J.R.1    Burch, R.2    Burgdorf, J.S.3
  • 86
    • 84880252318 scopus 로고    scopus 로고
    • A subunit-selective potentiator of NR2C-and NR2D-containing NMDA receptors
    • Mullasseril P, Hansen KB, Vance KM, et al. A subunit-selective potentiator of NR2C-and NR2D-containing NMDA receptors. Nat Commun 2010; 1: 90.
    • (2010) Nat Commun , vol.1 , pp. 90
    • Mullasseril, P.1    Hansen, K.B.2    Vance, K.M.3
  • 87
    • 84892415121 scopus 로고    scopus 로고
    • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice
    • Suryavanshi PS, Ugale RR, Yilmazer-Hanke D, et al. GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. Br J Pharmacol 2014; 171: 799-809.
    • (2014) Br J Pharmacol , vol.171 , pp. 799-809
    • Suryavanshi, P.S.1    Ugale, R.R.2    Yilmazer-Hanke, D.3
  • 88
    • 84869021995 scopus 로고    scopus 로고
    • Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: Implications for schizophrenia
    • Curley AA, Eggan SM, Lazarus MS, et al. Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia. Neurobiol Dis 2013; 50: 179-186.
    • (2013) Neurobiol Dis , vol.50 , pp. 179-186
    • Curley, A.A.1    Eggan, S.M.2    Lazarus, M.S.3
  • 89
    • 0029880412 scopus 로고    scopus 로고
    • NMDA-dependent modulation of CA1 local circuit inhibition
    • Grunze HC, Rainnie DG, Hasselmo ME, et al. NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci 1996; 16: 2034-2043.
    • (1996) J Neurosci , vol.16 , pp. 2034-2043
    • Grunze, H.C.1    Rainnie, D.G.2    Hasselmo, M.E.3
  • 90
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial
    • Patil ST, Zhang L, Martenyi F, et al. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med 2007; 13: 1102-1107.
    • (2007) Nat Med , vol.13 , pp. 1102-1107
    • Patil, S.T.1    Zhang, L.2    Martenyi, F.3
  • 91
    • 0142095347 scopus 로고    scopus 로고
    • Lamotrigine in treatmentresistant schizophrenia: A randomized placebo-controlled crossover trial
    • Tiihonen J, Hallikainen T, Ryynanen OP, et al. Lamotrigine in treatmentresistant schizophrenia: a randomized placebo-controlled crossover trial. Biol Psychiatry 2003; 54: 1241-1248.
    • (2003) Biol Psychiatry , vol.54 , pp. 1241-1248
    • Tiihonen, J.1    Hallikainen, T.2    Ryynanen, O.P.3
  • 92
    • 84886304673 scopus 로고    scopus 로고
    • Pomaglumetad methionil: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
    • Stauffer VL, Millen BA, Andersen S, et al. Pomaglumetad methionil: no significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo. Schizophr Res 2013; 150: 434-441.
    • (2013) Schizophr Res , vol.150 , pp. 434-441
    • Stauffer, V.L.1    Millen, B.A.2    Andersen, S.3
  • 93
    • 39649116488 scopus 로고    scopus 로고
    • Lamotrigine as add-on therapy in schizophrenia: Results of 2 placebo-controlled trials
    • Goff DC, Keefe R, Citrome L, et al. Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials. J Clin Psychopharmacol 2007; 27: 582-589.
    • (2007) J Clin Psychopharmacol , vol.27 , pp. 582-589
    • Goff, D.C.1    Keefe, R.2    Citrome, L.3
  • 94
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapineresistant schizophrenia: A systematic review and meta-analysis
    • Tiihonen J, Wahlbeck K, Kiviniemi V. The efficacy of lamotrigine in clozapineresistant schizophrenia: a systematic review and meta-analysis. Schizophr Res 2009; 109: 10-14.
    • (2009) Schizophr Res , vol.109 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 95
    • 84887009409 scopus 로고    scopus 로고
    • AMPARs and synaptic plasticity: The last 25 years
    • Huganir RL, Nicoll RA. AMPARs and synaptic plasticity: the last 25 years. Neuron 2013; 80: 704-717.
    • (2013) Neuron , vol.80 , pp. 704-717
    • Huganir, R.L.1    Nicoll, R.A.2
  • 96
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Ann Rev Neurosci 2002; 25: 103-126.
    • (2002) Ann Rev Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 97
    • 36649004164 scopus 로고    scopus 로고
    • Activation of medial prefrontal cortex neurons by phencyclidine is mediated via AMPA/kainate glutamate receptors in anesthetized rats
    • Katayama T, Jodo E, Suzuki Y, et al. Activation of medial prefrontal cortex neurons by phencyclidine is mediated via AMPA/kainate glutamate receptors in anesthetized rats. Neuroscience 2007; 150: 442-448.
    • (2007) Neuroscience , vol.150 , pp. 442-448
    • Katayama, T.1    Jodo, E.2    Suzuki, Y.3
  • 98
    • 34249083509 scopus 로고    scopus 로고
    • Pharmacology of ampakine modulators: From AMPA receptors to synapses and behavior
    • Arai AC, Kessler M. Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior. Curr Drug Targets 2007; 8: 583-602.
    • (2007) Curr Drug Targets , vol.8 , pp. 583-602
    • Arai, A.C.1    Kessler, M.2
  • 99
    • 0034796599 scopus 로고    scopus 로고
    • A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia
    • Goff DC, Leahy L, Berman I, et al. A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. J Clin Psychopharmacol 2001; 21: 484-487.
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 484-487
    • Goff, D.C.1    Leahy, L.2    Berman, I.3
  • 100
    • 38149132338 scopus 로고    scopus 로고
    • A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia
    • Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology 2008; 33: 465-472.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 465-472
    • Goff, D.C.1    Lamberti, J.S.2    Leon, A.C.3
  • 101
    • 84858651719 scopus 로고    scopus 로고
    • Deleterious GRM1 mutations in schizophrenia
    • Ayoub MA, Angelicheva D, Vile D, et al. Deleterious GRM1 mutations in schizophrenia. PloS One 2012; 7: e32849.
    • (2012) PloS One , vol.7 , pp. e32849
    • Ayoub, M.A.1    Angelicheva, D.2    Vile, D.3
  • 102
    • 84872735105 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia
    • Matosin N, Newell KA. Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia. Neurosci Biobehav Rev 2013; 37: 256-268.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 256-268
    • Matosin, N.1    Newell, K.A.2
  • 103
    • 67650152231 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    • Loane DJ, Stoica BA, Pajoohesh-Ganji A, et al. Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem 2009; 284: 15629-15639.
    • (2009) J Biol Chem , vol.284 , pp. 15629-15639
    • Loane, D.J.1    Stoica, B.A.2    Pajoohesh-Ganji, A.3
  • 104
    • 67651087294 scopus 로고    scopus 로고
    • MGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
    • Ayala JE, Chen Y, Banko JL, et al. mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology 2009; 34: 2057-2071.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2057-2071
    • Ayala, J.E.1    Chen, Y.2    Banko, J.L.3
  • 105
    • 84892915525 scopus 로고    scopus 로고
    • Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: Implications for the future of novel therapeutics
    • Newell KA, Matosin N. Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics. BMC Psychiatry 2014; 14: 23.
    • (2014) BMC Psychiatry , vol.14 , pp. 23
    • Newell, K.A.1    Matosin, N.2
  • 106
    • 70349682718 scopus 로고    scopus 로고
    • Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects
    • Donohoe G, Walters J, Morris DW, et al. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Arch Gen Psychiatry 2009; 66: 1045-1054.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 1045-1054
    • Donohoe, G.1    Walters, J.2    Morris, D.W.3
  • 107
    • 69349098490 scopus 로고    scopus 로고
    • Warming and resource availability shift food web structure and metabolism
    • O'Connor MI, Piehler MF, Leech DM, et al. Warming and resource availability shift food web structure and metabolism. PLoS Biol 2009; 7: e1000178.
    • (2009) PLoS Biol , vol.7 , pp. e1000178
    • O'Connor, M.I.1    Piehler, M.F.2    Leech, D.M.3
  • 108
    • 64949180420 scopus 로고    scopus 로고
    • Identification of a schizophreniaassociated functional noncoding variant in NOS1AP
    • Wratten NS, Memoli H, Huang Y, et al. Identification of a schizophreniaassociated functional noncoding variant in NOS1AP. Am J Psychiatry 2009; 166: 434-441.
    • (2009) Am J Psychiatry , vol.166 , pp. 434-441
    • Wratten, N.S.1    Memoli, H.2    Huang, Y.3
  • 109
    • 84880530466 scopus 로고    scopus 로고
    • Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: A randomized, double-blind, placebo-controlled trial
    • Hallak JE, Maia-de-Oliveira JP, Abrao J, et al. Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: a randomized, double-blind, placebo-controlled trial. JAMA Psychiatry 2013; 70: 668-676.
    • (2013) JAMA Psychiatry , vol.70 , pp. 668-676
    • Hallak, J.E.1    Maia-De-Oliveira, J.P.2    Abrao, J.3
  • 110
    • 59449106602 scopus 로고    scopus 로고
    • Selective phosphodiesterase inhibitors: A promising target for cognition enhancement
    • Reneerkens OA, Rutten K, Steinbusch HW, et al. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology 2009; 202: 419-443.
    • (2009) Psychopharmacology , vol.202 , pp. 419-443
    • Reneerkens, O.A.1    Rutten, K.2    Steinbusch, H.W.3
  • 111
    • 84883529469 scopus 로고    scopus 로고
    • Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease
    • Saavedra A, Giralt A, Arumi H, et al. Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease. PloS One 2013; 8: e73664.
    • (2013) PloS One , vol.8 , pp. e73664
    • Saavedra, A.1    Giralt, A.2    Arumi, H.3
  • 112
    • 85027957693 scopus 로고    scopus 로고
    • Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice
    • Wang C, Zhang J, Lu Y, et al. Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice. Metab Brain Dis 2014; 29: 673-682.
    • (2014) Metab Brain Dis , vol.29 , pp. 673-682
    • Wang, C.1    Zhang, J.2    Lu, Y.3
  • 113
    • 34547439896 scopus 로고    scopus 로고
    • Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules
    • Agostino PV, Plano SA, Golombek DA. Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules. Proc Natl Acad Sci USA 2007; 104: 9834-9839.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9834-9839
    • Agostino, P.V.1    Plano, S.A.2    Golombek, D.A.3
  • 114
    • 84856078086 scopus 로고    scopus 로고
    • Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats
    • Rodefer JS, Saland SK, Eckrich SJ. Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats. Neuropharmacology 2012; 62: 1182-1190.
    • (2012) Neuropharmacology , vol.62 , pp. 1182-1190
    • Rodefer, J.S.1    Saland, S.K.2    Eckrich, S.J.3
  • 115
    • 79952487439 scopus 로고    scopus 로고
    • Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: A double-blind randomized placebo-controlled trial
    • Akhondzadeh S, Ghayyoumi R, Rezaei F, et al. Sildenafil adjunctive therapy to risperidone in the treatment of the negative symptoms of schizophrenia: a double-blind randomized placebo-controlled trial. Psychopharmacology 2011; 213: 809-815.
    • (2011) Psychopharmacology , vol.213 , pp. 809-815
    • Akhondzadeh, S.1    Ghayyoumi, R.2    Rezaei, F.3
  • 116
    • 59449098930 scopus 로고    scopus 로고
    • A placebo-controlled study of sildenafil effects on cognition in schizophrenia
    • Goff DC, Cather C, Freudenreich O, et al. A placebo-controlled study of sildenafil effects on cognition in schizophrenia. Psychopharmacology 2009; 202: 411-417.
    • (2009) Psychopharmacology , vol.202 , pp. 411-417
    • Goff, D.C.1    Cather, C.2    Freudenreich, O.3
  • 117
    • 55949132109 scopus 로고    scopus 로고
    • The role of phosphodiesterases in schizophrenia: Therapeutic implications
    • Siuciak JA. The role of phosphodiesterases in schizophrenia: therapeutic implications. CNS Drugs 2008; 22: 983-993.
    • (2008) CNS Drugs , vol.22 , pp. 983-993
    • Siuciak, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.