Association of 32 type 1 diabetes risk loci in Pakistani patients

Diabetes Research and Clinical Practice

Volumn 108, Issue 1, 2015, Pages 137-142

  Kiani, Aysha Karim ^a   John, Peter ^a   Bhatti, Attya ^a   Zia, Asima ^a   Shahid, Gulbin ^b   Akhtar, Parveen ^c   Wang, Xingbin ^d   Demirci, F Yesim ^d   Kamboh, M Ilyas ^d  

^a NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

^b PAKISTAN INSTITUTE OF MEDICAL SCIENCES   (Pakistan)

^c FAUJI FOUNDATION HOSPITAL   (Pakistan)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Association studies; Auto immune disease; Diabetes; Diabetes in Pakistan; Insulin dependent diabetes mellitus; Type 1 diabetes

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 3; HLA DQA1 ANTIGEN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; DNA; HLA DQ ANTIGEN; HLA-DQA1 ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; BACH2 GENE; C6ORF173 GENE; CAUCASIAN; CD226 GENE; CONTROLLED STUDY; DNA EXTRACTION; ERBB3 GENE; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLIS3 GENE; HLA DQA1 GENE; HUMAN; IKZF1 GENE; IL2 KIAA1109 GENE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PAKISTANI; PTPN2 GENE; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SIRPG GENE; ALLELE; CHILD; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION; GENETICS; PAKISTAN; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; YOUNG ADULT;

ADOLESCENT; ADULT; ALLELES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DQ ALPHA-CHAINS; HUMANS; MALE; PAKISTAN; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; RISK FACTORS; YOUNG ADULT;

EID: 84926215903     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2015.01.022     Document Type: Article

References (24)

1. Morahan G. Insights into type 1 diabetes provided by genetic analyses. Curr Opin Endocrinol Diabetes Obes 2012, 19:263-270.
2. Weets I., Van Autreve J., Van der Auwera B.J., Schuit F.C., Du Caju M.V., Decochez K., et al. Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index. Diabetologia 2001, 44:40-47.
3. Krischer J.P., Cuthbertson D.D., Greenbaum C. Male sex increases the risk of autoimmunity but not type 1 diabetes. Diabetes Care 2004, 27:1985-1990.
4. Park Y. Why is type 1 diabetes uncommon in Asia?. Ann NY Acad Sci 2006, 1079:31-40.
5. Rosinger S., Nutland S., Mickelson E., Varney M.D., Boehm B.O., Olsem G.J., et al. Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the type 1 diabetes genetics consortium. Clin Trials 2010, 7:S65-S74.
6. Polychronakos C., Li Q. Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 2011, 12:781-792.
7. Yu L., Cuthbertson D.D., Eisenbarth G.S., Krischer J.P. Diabetes prevention trial 1: prevalence of GAD and ICA512 (IA-2) autoantibodies by relationship to proband. Ann NY Acad Sci 2002, 958:254-258.
8. Barrett J.C., Clayton D.G., Concannon P., Akolkar B., Cooper J.D., Erlich H.A., et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009, 41:703-707.
9. Patterson C.C., Dahlquist G.G., Gyurus E., Green A., Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009, 373:2027-2033.
10. Coon S.C. The races of Europe 1939, The Macmillan Company, New York, NY.
11. O'Connell J.R., Weeks D.E. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998, 63:259-266.
12. Zhu X., Li S., Cooper R.S., Elston R.C. A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet 2008, 82:352-365.
13. Shera A.S., Miyan Z., Basit A., Maqsood A., Ahmadani M.Y., Fawwad A., et al. Trends of type 1 diabetes in Karachi, Pakistan. Pediatr Diabetes 2008, 9:401-406.
14. Todd J.A., Walker N.M., Cooper J.D., Smyth D.J., Downes K., Plagnol V., et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007, 39:857-864.
15. Genome-wide association Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 2007, 447:661-678.
16. Al-Jenaidi F.A., Wakim-Ghorayeb S.F., Al-Abbasi A., Arekat M.R., Irani-Hakime N., Najm P., et al. Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs. J Clin Endocrinol Metab 2005, 90:5104-5109.
17. Erlich H., Valdes A.M., Noble J., Carlson J.A., Varney M., Concannon P., et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes 2008, 57:1084-1092.
18. Awata T., Kawasaki E., Tanaka S., Ikegami H., Maruyama T., Shimada A., et al. Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. J Clin Endocrinol Metab 2009, 94:231-235.
19. Cooper J.D., Smyth D.J., Smiles A.M., Plagnol V., Walker N.M., Allen J.E., et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet 2008, 40:1399-1401.
20. Cooper J.D., Howson J.M., Smyth D., Walker N.M., Stevens H., Yang J.H., et al. Confirmation of novel type 1 diabetes risk loci in families. Diabetologia 2012, 55:996-1000.
21. Swafford A.D., Howson J.M., Davison L.J., Wallace C., Smyth D.J., Schuilenburg H., et al. An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Diabetes 2011, 60:1041-1044.
22. Bradfield J.P., Qu H.Q., Wang K., Zhang H., Sleiman P.M., Kim C.E., et al. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. PLoS Genet 2011, 7:e1002293.
23. Howson J.M., Walker N.M., Smyth D.J., Todd J.A. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Genes Immun 2009, 10(Suppl 1):S74-S84.
24. Wallace C., Smyth D.J., Maisuria-Armer M., Walker N.M., Todd J.A., Clayton D.G. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet 2010, 42:68-71.