Prospects of untreatable gonorrhea and ways forward

Future Microbiology

Volumn 10, Issue 3, 2015, Pages 313-316

  Whiley, David M ^a   Lahra, Monica M ^b   Unemo, Magnus ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

^c ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antimicrobial resistance; Azithromycin; Ceftriaxone; Genetic; Gonorrhea; Neisseria gonorrhoeae; PenA; Surveillance

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; CEFTRIAXONE;

ALTERNATIVE MEDICINE; ANTIBIOTIC RESISTANCE; ARTICLE; GENETIC SUSCEPTIBILITY; GONORRHEA; HUMAN; PRIORITY JOURNAL; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MULTIDRUG RESISTANCE; NEISSERIA GONORRHOEAE;

NEISSERIA GONORRHOEAE;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GONORRHEA; HUMANS; MICROBIAL SENSITIVITY TESTS; NEISSERIA GONORRHOEAE;

EID: 84926215210     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/FMB.14.138     Document Type: Article

References (17)

1. Whiley DM, Goire N, Lahra MM et al. The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting. J. Antimicrob. Chemother. 67, 2059-2061 (2012).
2. st century: past, evolution, and future. Clin. Microbiol. Rev. 27, 587-613 (2014).
3. European Centre for Disease Prevention and Control (ECDC). Gonococcal Antimicrobial Susceptibility Surveillance in Europe 2012. ECDC, Stockholm, Sweden (2014).
4. Centers for Disease Control and Prevention (CDC). 2012 STD Surveillance Report - Gonorrhea. CDC, GA, USA (2014).
5. Ison CA, Town K, Obi C et al. Decreased susceptibility to cephalosporins among gonococci: data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales, 2007-2011. Lancet Infect. Dis. 13, 762-768 (2013).
6. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. High-level cefixime- and ceftriaxoneresistant N. gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob. Agents Chemother. 56, 1273-1280 (2012).
7. Cámara J, Serra J, Ayats J et al. Molecular characterization of two high-level ceftriaxoneresistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J. Antimicrob. Chemother. 67, 1858-1860 (2012).
8. Ohnishi M, Golparian D, Shimuta K et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea? Detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob. Agents Chemother. 55, 3538-3545 (2011).
9. Lahra MM, Ryder N, Whiley DM. A new multidrug-resistant strain of Neisseria gonorrhoeae in Australia. N. Engl. J. Med. 371, 1850-1851 (2014).
10. Unemo M, Golparian D, Stary A, Eigentler A. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria (2011). www.eurosurveillance.org
11. Chen SC, Yin YP, Dai XQ, Unemo M, Chen XS. Antimicrobial resistance, genetic resistance determinants for ceftriaxone and molecular epidemiology of Neisseria gonorrhoeae isolates in Nanjing, China. J. Antimicrob. Chemother. 69, 2959-2965 (2014).
12. Tanaka M, Nakayama H, Huruya K et al. Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype. Int. J. Antimicrob. Agents. 27, 20-26 (2006).
13. Unemo M, Nicholas RA. Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 7, 1401-1422 (2012).
14. th International Pathogenic Neisseria Conference. Asheville, NC, USA, 12-17 October 2014.
15. Bignell C, Garley J. Azithromycin in the treatment of infection with Neisseria gonorrhoeae. Sex. Transm. Infect. 86, 422-426 (2010).
16. Allen VG, Seah C, Martin I, Melano RG. Azithromycin resistance is coevolving with reduced susceptibility to cephalosporins in Neisseria gonorrhoeae in Ontario, Canada. Antimicrob. Agents Chemother. 58, 2528-2534 (2014).
17. Goire N, Lahra MM, Chen M et al. Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nat. Rev. Microbiol. 12, 223-229 (2014).