Peritoneal lavage using chlorhexidine gluconate at the end of colon surgery reduces postoperative intra-abdominal infection in mice

Journal of Surgical Research

Volumn 195, Issue 1, 2015, Pages 121-127

  Shams, Wael E ^a   Hanley, Gregory A ^a   Orvik, Andrea ^a   Lewis, Nicole ^b   Shurbaji, M Salah ^a  

^a East Tennessee State University   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Chlorhexidine gluconate; Colon surgery; Lavage; Mice; Peritoneal

Indexed keywords

CHLORHEXIDINE GLUCONATE; CHLORHEXIDINE; TOPICAL ANTIINFECTIVE AGENT;

ABDOMINAL ABSCESS; ABDOMINAL INFECTION; ABDOMINAL WALL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; COLON RESECTION; COLON SURGERY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FOLLOW UP; MALE; MICROSCOPY; MOUSE; NONHUMAN; PERITONEAL FIBROSIS; PERITONEUM LAVAGE; PNEUMATOSIS INTESTINALIS; POSTOPERATIVE INFECTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SURGICAL MORTALITY; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAABDOMINAL INFECTIONS; POSTOPERATIVE COMPLICATIONS; RANDOMIZATION;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; COLECTOMY; INTRAABDOMINAL INFECTIONS; MALE; MICE, INBRED ICR; PERITONEAL LAVAGE; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION;

EID: 84926204721     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2015.01.030     Document Type: Article

References (25)

1. J.T. DiPiro, R.G. Martindale, A. Bakst, P.F. Vacani, P. Watson, and M.T. Miller Infection in surgical patients: effects on mortality, hospitalization, and postdischarge care Am J Health Syst Pharm 55 1998 777
2. J.B. Dimick, S.L. Chen, P.A. Taheri, W.G. Henderson, S.F. Khuri, and D.A. Campbell Jr. Hospital costs associated with surgical complications: a report from the private-sector National Surgical Quality Improvement Program J Am Coll Surg 199 2004 531
3. K.J. Eagye, and D.P. Nicolau Deep and organ/space infections in patients undergoing elective colorectal surgery: incidence and impact on hospital length of stay and costs Am J Surg 198 2009 359
4. A.J. Mangram, T.C. Horan, M.L. Pearson, L.C. Silver, and W.R. Jarvis Guideline for prevention of surgical site infection, 1999. Hospital infection control Practices Advisory Committee Infect Control Hosp Epidemiol 20 1999 250 quiz 279-80
5. R.L. Smith, J.K. Bohl, and S.T. McElearney Wound infection after elective colorectal resection Ann Surg 239 2004 599 discussion 605-7
6. K.B. Kirkland, J.P. Briggs, S.L. Trivette, W.E. Wilkinson, and D.J. Sexton The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs Infect Control Hosp Epidemiol 20 1999 725
7. B. DeBaun Evaluation of the antimicrobial properties of an alcohol-free 2% chlorhexidine gluconate solution AORN J 87 2008 925
8. J.S. Hibbard, G.K. Mulberry, and A.R. Brady A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine J Infus Nurs 25 2002 244
9. J.S. Hibbard Analyses comparing the antimicrobial activity and safety of current antiseptic agents: a review J Infus Nurs 28 2005 194
10. Food and Drug Administration (FDA). Available from: http://www.fda.gov/MedicalDevices/Produsctand%20MedicalProcedures/DeviceApprovalsandClearances/510kClearances/ucm134494.htm. Accessed on June 6, 2012.
11. Y. Ishii, T. Sawada, and A. Shimizu An experimental sclerosing encapsulating peritonitis model in mice Nephrol Dial Transplant 16 2001 1262
12. H. Arai, A. Furusu, and T. Nishino Thalidomide prevents the progression of peritoneal fibrosis in mice Acta Histochem Cytochem 44 2011 51 60
13. W.K. Lo, K.T. Chan, A.C. Leung, S.W. Pang, and C.Y. Tse Sclerosing peritonitis complicating prolonged use of chlorhexidine in alcohol in the connection procedure for continuous ambulatory peritoneal dialysis Perit Dial Int 11 1991 166
14. C.P. Jones, S. Carver, and L.V. Kendall Evaluation of common anesthetic and analgesic techniques for tail biopsy in mice J Am Assoc Lab Anim Sci 51 2012 808 814
15. J. Donovan, and P. Brown Euthanasia Curr Protoc Immunol 2006 Chapter 1:Unit 1 8
16. K. Bosscha, T.J. van Vroonhoven, and C. van der Werken Surgical management of severe secondary peritonitis Br J Surg 86 1999 1371
17. C. Platell, J.M. Papadimitriou, and J.C. Hall The influence of lavage on peritonitis J Am Coll Surg 191 2000 672
18. A. Maleckas, V. Daubaras, and V. Vaitkus Increased postoperative peritoneal adhesion formation after the treatment of experimental peritonitis with chlorhexidine Langenbecks Arch Surg 389 2004 256
19. M. Oguz, M. Bektemir, M. Dulger, and R. Yalin Treatment of experimental peritonitis with intraperitoneal povidone-iodine solution Can J Surg 31 1988 169
20. J.P. Keating, M. Neill, and G.L. Hill Sclerosing encapsulating peritonitis after intraperitoneal use of povidone iodine Aust N Z J Surg 67 1997 742
21. J. Platt, R.A. Jones, and R.A. Bucknall Intraperitoneal antiseptics in experimental bacterial peritonitis Br J Surg 71 1984 626
22. V.M. Bondar, C. Rago, F.J. Cottone, D.K. Wilkerson, and J. Riggs Chlorhexidine lavage in the treatment of experimental intra-abdominal infection Arch Surg 135 2000 309
23. P.R. Bicalho, C.A. Mayrink, and F. Fernandes Treatment with chlorhexidine modifies the healing of colon anastomosis in rats J Invest Surg 24 2011 8 12
24. P.R. Bicalho, C.A. Mayrink, and F. Fernandes Chlorhexidine as a factor that promotes peritoneal adhesions in rats with induced peritonitis Acta Cir Bras 28 2013 641 645
25. L. Walkin, S.E. Herrick, and A. Summers The role of mouse strain differences in the susceptibility to fibrosis: a systematic review Fibrogenesis Tissue Repair 6 2013 18