Microbiological and genetic characterization of carbapenem-resistant Klebsiella pneumoniae isolated from pediatric patients

Journal of the Pediatric Infectious Diseases Society

Volumn 3, Issue 1, 2014, Pages

  Dara, Jasmeen S ^a   Chen, Liang ^b   Levi, Michael H ^c   Kreiswirth, Barry N ^b   Pellett madan, Rebecca ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^c MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Carbapenemase; Klebsiella pneumoniae; Polymyxin

Indexed keywords

AMIKACIN; BETA LACTAMASE; CARBAPENEM; CEFEPIME; CIPROFLOXACIN; DAPTOMYCIN; GENTAMICIN; LINEZOLID; MEROPENEM; METRONIDAZOLE; PIPERACILLIN PLUS TAZOBACTAM; POLYMYXIN B; PORIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TIGECYCLINE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; CARDIOPULMONARY ARREST; CHILD; CLINICAL ARTICLE; CLONAL VARIATION; DNA SEQUENCE; ENTEROCOCCUS FAECALIS; FEMALE; FEVER; GENETIC ANALYSIS; GROUP A STREPTOCOCCAL INFECTION; HUMAN; HYPOTENSION; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LUNG EDEMA; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR PHYLOGENY; MORAXELLA CATARRHALIS; MULTILOCUS SEQUENCE TYPING; NONHUMAN; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; PYURIA; SCHOOL CHILD; SEPSIS; STENOTROPHOMONAS MALTOPHILIA; TRANSPOSON; BACTERIAL COLONIZATION; BACTERIUM EXAMINATION; BACTERIUM ISOLATE; BRAIN VENTRICLE PERITONEUM SHUNT; CARBAPENEM RESISTANT KLEBSIELLA PNEUMONIAE; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; INFANT; RESPIRATORY DISTRESS; SHUNT INFECTION; STAPHYLOCOCCAL BACTEREMIA;

EID: 84926167899     PISSN: 20487193     EISSN: 20487207     Source Type: Journal    
DOI: 10.1093/jpids/pit049     Document Type: Article

References (14)

1. Kitchel B, et al. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: Clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 2009; 53:3365-70.
2. Jacob JT, et al. Vital signs: Carbapenem-resistant Enterobacteriaceae. MMWR2013; 62:165-70.
3. Nordmann P, Naas T, Poirel L. Global spread of carbapenemaseproducing Enterobacteriaceae. Emerg Infect Dis 2011; 17:1791-8.
4. Chen L, et al. Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variants. J Clin Microbiol 2011; 49:579-85.
5. Tsai YK, et al. Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother 2011; 55:1485-93.
6. CLSI document M100-S23. In: Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement. Clinical and Laboratory Standards Institute; Wayne, PA: 2013.
7. Diancourt L, et al. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 2005; 43: 4178-82.
8. Kaczmarek FM, et al. High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe. Antimicrob Agents Chemother 2006; 50:3396-406.
9. Naas T, et al. Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. Antimicrob Agents Chemother 2008; 52:1257-63.
10. Ribot EM, et al. Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis 2006; 3:59-67.
11. Patel G, et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008; 29: 1099-106.
12. Pasteran F, et al. Sensitive screening tests for suspected class A carbapenemase production in species of Enterobacteriaceae. J Clin Microbiol 2009; 47:1631-9.
13. Alba J, et al. Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase. Antimicrob Agents Chemother 2005; 49:4760-2.
14. Snitkin ES, et al. Tracking a hospital outbreak of carbapenemresistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012; 4:p148ra116.