The three-year incidence of fracture in chronic kidney disease

Kidney International

Volumn 86, Issue 4, 2014, Pages 810-818

  Naylor, Kyla L ^a   McArthur, Eric ^b   Leslie, William D ^c   Fraser, Lisa Ann ^a   Jamal, Sophie A ^d   Cadarette, Suzanne M ^b,e   Pouget, Jennie G ^f   Lok, Charmaine E ^g   Hodsman, Anthony B ^a   Adachi, Jonathan D ^h   Garg, Amit X ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d WOMEN S COLLEGE HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g TORONTO GENERAL HOSPITAL   (Canada)

^h MCMASTER UNIVERSITY   (Canada)

Author keywords

bone; chronic kidney disease; dialysis

Indexed keywords

ADULT; ALBUMINURIA; ARTICLE; CANADA; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; FALLING; FEMALE; FOREARM FRACTURE; FRACTURE; GLOMERULUS FILTRATION RATE; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; HYPERTENSION; INCIDENCE; INCOME; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; PELVIS FRACTURE; PREVALENCE; PRIORITY JOURNAL; PROTEINURIA; RISK FACTOR; AGE; AGED; FRACTURES, BONE; HIP FRACTURES; HOSPITALIZATION; INJURIES; MIDDLE AGED; PATHOPHYSIOLOGY; PELVIC GIRDLE; RADIUS FRACTURES; RENAL INSUFFICIENCY; SEX DIFFERENCE; SHOULDER FRACTURES; STATISTICS AND NUMERICAL DATA; ULNA FRACTURES;

ACCIDENTAL FALLS; ADULT; AGE FACTORS; AGED; COHORT STUDIES; FEMALE; FRACTURES, BONE; GLOMERULAR FILTRATION RATE; HIP FRACTURES; HOSPITALIZATION; HUMANS; INCIDENCE; MALE; MIDDLE AGED; ONTARIO; PELVIC BONES; PROTEINURIA; RADIUS FRACTURES; RENAL INSUFFICIENCY; SEX FACTORS; SHOULDER FRACTURES; ULNA FRACTURES;

EID: 84926136346     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.547     Document Type: Article

References (64)

1. Zhang QL, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health 2008; 8: 117.
2. Ettinger B, Black DM, Nevitt MC et al. Contribution of vertebral deformities to chronic back pain and disability. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 1992; 7: 449-456.
3. Center JR, Nguyen TV, Schneider D et al. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999; 353: 878-882.
4. Wiktorowicz ME, Goeree R, Papaioannou A et al. Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int 2001; 12: 271-278.
5. Adachi JD, Ioannidis G, Pickard L et al. The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 2003; 14: 895-904.
6. Nikitovic M, Wodchis WP, Krahn MD et al. Direct health-care costs attributed to hip fractures among seniors: a matched cohort study. Osteoporos Int 2013; 24: 659-669.
7. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group, KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int 2009; 113: S1-130.
8. Mirza MA, Karlsson MK, Mellstrom D et al. Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men. J Bone Miner Res 2011; 26: 857-864.
9. Owda A, Elhwairis H, Narra S et al. Secondary hyperparathyroidism in chronic hemodialysis patients: prevalence and race. Ren Fail 2003; 25: 595-602.
10. Sherrard DJ, Hercz G, Pei Y et al. The spectrum of bone disease in endstage renal failure-an evolving disorder. Kidney Int 1993; 43: 436-442.
11. Amling M, Grote HJ, Vogel M et al. Three-dimensional analysis of the spine in autopsy cases with renal osteodystrophy. Kidney Int 1994; 46: 733-743.
12. Schober HC, Han ZH, Foldes AJ et al. Mineralized bone loss at different sites in dialysis patients: implications for prevention. J Am Soc Nephrol 1998; 9: 1225-1233.
13. Dukas L, Schacht E, Stahelin HB. In elderly men and women treated for osteoporosis a low creatinine clearance of o65 ml/min is a risk factor for falls and fractures. Osteoporos Int 2005; 16: 1683-1690.
14. Jamal SA, Leiter RE, Jassal V et al. Impaired muscle strength is associated with fractures in hemodialysis patients. Osteoporos Int 2006; 17: 1390-1397.
15. Jadoul M, Albert JM, Akiba T et al. Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int 2006; 70: 1358-1366.
16. Maravic M, Ostertag A, Torres PU et al. Incidence and risk factors for hip fractures in dialysis patients. Osteoporos Int 2013.
17. Tentori F, McCullough K, Kilpatrick RD et al. High rates of death and hospitalization follow bone fracture among hemodialysis patients. Kidney Int 2013.
18. Elliott MJ, James MT, Quinn RR et al. Estimated GFR and fracture risk: a population-based study. Clin J Am Soc Nephrol 2013; 8: 1367-1376.
19. Kinsella S, Chavrimootoo S, Molloy MG et al. Moderate chronic kidney disease in women is associated with fracture occurrence independently of osteoporosis. Nephron Clin Pract 2010; 116: c256-c262.
20. Fried LF, Biggs ML, Shlipak MG et al. Association of kidney function with incident hip fracture in older adults. J Am Soc Nephrol 2007; 18: 282-286.
21. Ensrud KE, Lui LY, Taylor BC et al. Renal function and risk of hip and vertebral fractures in older women. Arch Intern Med 2007; 167: 133-139.
22. Nickolas TL, McMahon DJ, Shane E. Relationship between moderate to severe kidney disease and hip fracture in the United States. J Am Soc Nephrol 2006; 17: 3223-3232.
23. Dooley AC, Weiss NS, Kestenbaum B. Increased risk of hip fracture among men with CKD. Am J Kidney Dis 2008; 51: 38-44.
24. Harris ST, Watts NB, Genant HK et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA 1999; 282: 1344-1352.
25. Leslie WD, O'Donnell S, Jean S et al. Trends in hip fracture rates in Canada. JAMA 2009; 302: 883-889.
26. Coco M, Rush H. Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone. Am J Kidney Dis 2000; 36: 1115-1121.
27. Centers for Disease Control and Prevention, Centers for Disease Control and Prevention: Report of the Surgeon General, US Department of Health and Human Services. CDC: Atlanta, GA, 1996.
28. Nickolas TL, Leonard MB, Shane E. Chronic kidney disease and bone fracture: a growing concern. Kidney Int 2008; 74: 721-731.
29. Jamal SA, Hayden JA, Beyene J. Low bone mineral density and fractures in long-term hemodialysis patients: a meta-analysis. Am J Kidney Dis 2007; 49: 674-681.
30. LaCroix AZ, Lee JS, Wu L et al. Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women. J Am Geriatr Soc 2008; 56: 1434-1441.
31. Ensrud KE, Parimi N, Cauley JA et al. Cystatin C and risk of hip fractures in older women. J Bone Miner Res 2013; 28: 1275-1282.
32. Ensrud KE, Parimi N, Fink HA et al. Estimated GFR and Risk of Hip Fracture in Older Men: Comparison of Associations Using Cystatin C and Creatinine. Am J Kidney Dis 2013; pii S0272-6386: 00965-00967.
33. Kidney Disease: Improving Global Outcomes Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013; 3: 1-150.
34. Toussaint ND, Elder GJ, Kerr PG. Bisphosphonates in chronic kidney disease; balancing potential benefits and adverse effects on bone and soft tissue. Clin J Am Soc Nephrol 2009; 4: 221-233.
35. Schwartz AV, Nevitt MC, Brown BW Jr et al. Increased falling as a risk factor for fracture among older women: the study of osteoporotic fractures. Am J Epidemiol 2005; 161: 180-185.
36. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995; 332: 767-773.
37. Cooper C, Atkinson EJ, O'Fallon WM et al. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989. J Bone Miner Res 1992; 7: 221-227.
38. O'Riordan SE, Webb MC, Stowe HJ et al. Cystatin C improves the detection of mild renal dysfunction in older patients. Ann Clin Biochem 2003; 40: 648-655.
39. Government of Canada, Statistics Canada: Visible Minority Groups, 2006 Counts, for Canada, Provinces and Territories, and Census Metropolitan Areas and Census Agglomerations-20% Sample Data. Government of Canada: Ontario, 2006.
40. Ensrud KE, Barbour K, Canales MT et al. Renal function and nonvertebral fracture risk in multiethnic women: the Women's Health Initiative (WHI). Osteoporos Int 2012; 23: 887-899.
41. Rucker D, Allan JA, Fick GH et al. Vitamin D insufficiency in a population of healthy western Canadians. CMAJ 2002; 166: 1517-1524.
42. LeBoff MS, Kohlmeier L, Hurwitz S et al. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA 1999; 281: 1505-1511.
43. Molnar AO, Coca SG, Devereaux PJ et al. Statin use associates with a lower incidence of acute kidney injury after major elective surgery. J Am Soc Nephrol 2011; 22: 939-946.
44. Siddiqui NF, Coca SG, Devereaux PJ et al. Secular trends in acute dialysis after elective major surgery-1995 to 2009. CMAJ 2012; 184: 1237-1245.
45. Shih AW, Weir MA, Clemens KK et al. Oral bisphosphonate use in the elderly is not associated with acute kidney injury. Kidney Int 2012; 82: 903-908.
46. Garg AX, Pouget J, Young A et al. Fracture risk in living kidney donors: a matched cohort study. Am J Kidney Dis 2012; 59: 770-776.
47. Ontario Ministry of Finance. Ontairo Population Projections Update 2012-2036. Government of Ontario: Toronto, Ontario, 2013.
48. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.
49. Jamal SA, Bauer DC, Ensrud KE et al. Alendronate treatment in women with normal to severely impaired renal function: an analysis of the fracture intervention trial. J Bone Miner Res 2007; 22: 503-508.
50. Miller PD, Roux C, Boonen S et al. Safety and efficacy of risedronate in patients with age-related reduced renal function as estimated by the Cockcroft and Gault method: a pooled analysis of nine clinical trials. J Bone Miner Res 2005; 20: 2105-2115.
51. Cranney A, Guyatt G, Krolicki N et al. A meta-analysis of etidronate for the treatment of postmenopausal osteoporosis. Osteoporos Int 2001; 12: 140-151.
52. Cranney A, Tugwell P, Adachi J et al. Meta-analyses of therapies for postmenopausal osteoporosis. III. Meta-analysis of risedronate for the treatment of postmenopausal osteoporosis. Endocr Rev 2002; 23: 517-523.
53. Curtis JR, Mudano AS, Solomon DH et al. Identification and validation of vertebral compression fractures using administrative claims data. Med Care 2009; 47: 69-72.
54. Joakimsen RM, Fonnebo V, Sogaard AJ et al. The Tromso study: registration of fractures, how good are self-reports, a computerized radiographic register and a discharge register? Osteoporos Int 2001; 12: 1001-1005.
55. Henderson T, Shepheard J, Sundararajan V. Quality of diagnosis and procedure coding in ICD-10 administrative data. Med Care 2006; 44: 1011-1019.
56. Juurlink DPC, Croxford R, Chong A et al. Canadian Information Discharge Abstract Database: A Validation Study 2006.
57. Ray WA, Griffin MR, Fought RL et al. Identification of fractures from computerized Medicare files. J Clin Epidemiol 1992; 45: 703-714.
58. Lippuner K, von Overbeck J, Perrelet R et al. Incidence and direct medical costs of hospitalizations due to osteoporotic fractures in Switzerland. Osteoporos Int 1997; 7: 414-425.
59. Melton LJ 3rd, Thamer M, Ray NF et al. Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation. J Bone Miner Res 1997; 12: 16-23.
60. Phillips S, Fox N, Jacobs J et al. The direct medical costs of osteoporosis for American women aged 45 and older, 1986. Bone 1988; 9: 271-279.
61. Warriner AH, Patkar NM, Curtis JR et al. Which fractures are most attributable to osteoporosis? J Clin Epidemiol 2011; 64: 46-53.
62. Tamblyn R, Reid T, Mayo N et al. Using medical services claims to assess injuries in the elderly: sensitivity of diagnostic and procedure codes for injury ascertainment. J Clin Epidemiol 2000; 53: 183-194.
63. Mackey DC, Lui LY, Cawthon PM et al. High-trauma fractures and low bone mineral density in older women and men. JAMA 2007; 298: 2381-2388.
64. Austin PC. Using the Standardized Difference to Compare the Prevalence of a Binary Variable Between Two Groups in Observational Research. Commun Stat 2009; 38: 1228. 818