Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

Nucleic acids research

Volumn 42, Issue 20, 2014, Pages 12768-12778

  deLorimier, Elaine ^a   Coonrod, Leslie A ^a   Copperman, Jeremy ^a   Taber, Alex ^a   Reister, Emily E ^a   Sharma, Kush ^a   Todd, Peter K ^a   Guenza, Marina G ^a   Berglund, J Andrew ^a  

^a UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PSEUDOURIDINE; RNA; RNA BINDING PROTEIN; WATER;

ALTERNATIVE RNA SPLICING; ANIMAL; BASE MISPAIRING; CHEMISTRY; CONFORMATION; DISEASE MODEL; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; METHYLATION; MYOTONIC DYSTROPHY; NUCLEOTIDE REPEAT; ZEBRA FISH;

ALTERNATIVE SPLICING; ANIMALS; BASE PAIR MISMATCH; DISEASE MODELS, ANIMAL; HELA CELLS; HUMANS; METHYLATION; MYOTONIC DYSTROPHY; NUCLEIC ACID CONFORMATION; PSEUDOURIDINE; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA; RNA-BINDING PROTEINS; WATER; ZEBRAFISH;

EID: 84926122695     PISSN: None     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku941     Document Type: Article

References (0)