Extent of lymph node dissection and recurrence-free survival after radical cystectomy: A meta-analysis

Urologic Oncology: Seminars and Original Investigations

Volumn 32, Issue 8, 2014, Pages 1184-1190

  Mandel, Philipp ^a   Tilki, Derya ^b   Eslick, Guy D ^c  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Extended LND; Lymph node dissection; Radical cystectomy; Standard LND

Indexed keywords

BLADDER CANCER; CANCER PATIENT; COMPARATIVE STUDY; CYSTECTOMY; HEALTH CARE QUALITY; HUMAN; LYMPH NODE DISSECTION; META ANALYSIS; MORTALITY; OVERALL SURVIVAL; PEROPERATIVE COMPLICATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENCE FREE SURVIVAL; REVIEW; SYSTEMATIC REVIEW; DISEASE FREE SURVIVAL; LYMPH NODE; PATHOLOGY; PROCEDURES; PROGNOSIS; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS;

CYSTECTOMY; DISEASE-FREE SURVIVAL; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; PROGNOSIS; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS;

EID: 84925956134     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2014.01.017     Document Type: Review

References (31)

1. Burkhard F.C., Roth B., Zehnder P., et al. Lymphadenectomy for bladder cancer: indications and controversies. Urol Clin North Am 2011, 38:397-405.
2. Dorin R., Daneshmand S., Eisenberg M., et al. Lymph node dissection technique is more important than lymph node count in identifying nodal metastases in radical cystectomy patients: a comparative mapping study. Eur Urol 2011, 60:946.
3. Abdel-Latif M., Abol-Enein H., El-Baz M., et al. Nodal involvement in bladder cancer cases treated with radical cystectomy: incidence and prognosis. J Urol 2004, 172:85.
4. Morgan T., Kaffenberger S., Cookson M. Surgical and chemotherapeutic management of regional lymph nodes in bladder cancer. J Urol 2012, 188:1081.
5. Leissner J., Ghoneim M.A., Abol-Enein H., et al. Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol 2004, 171:139.
6. Mills R.D., Turner W., Fleischmann A., et al. Pelvic lymph node metastases from bladder cancer: outcome in 83 patients after radical cystectomy and pelvic lymphadenectomy. J Urol 2001, 166:19-23.
7. Stenzl A., Cowan N.C., De Santis M., et al. Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines. Eur Urol 2011, 59:1009-1018.
8. Vazina A., Dugi D., Shariat S., et al. Stage specific lymphnodemetastasis mapping in radical cystectomy specimens. J Urol 2004, 171:1830.
9. Roth B., Wissmeyer M.P., Zehnder P., et al. A new multimodality technique accurately maps the primary lymphatic landing sites of the bladder. Eur Urol 2012, 57:205.
10. Weisbach L., Dahlem R., Simone G., et al. Lymph node dissection during radical cystectomy for bladder cancer treatment: considerations on relevance and extent. Int Urol Nephrol 2013, 45:1561-1567. 10.1007/s11255-013-0503-2.
11. Pohar K. The anatomic extent and completeness of pelvic lymphadenectomy is what matters. Curr Opin Urol 2013, 23:444-448. 10.1097/MOU.0b013e328363f5f8.
12. Tilki D., Brausi M., Colombo R., et al. Lymphadenectomy for bladder cancer at the time of radical cystectomy. Eur Urol 2013, 64:266-276.
13. Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009, 151:264.
14. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177.
15. Higgins J., Thompson S.G., Deeks J.J., et al. Measuring inconsistency in meta-analyses. Br Med J 2003, 327:557.
16. Egger M., Davey S., Schneider M., et al. Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997, 315:629.
17. Orwin R. A fail-safe N for effect size in meta-analysis. J Educ Stat 1983, 8:157.
18. Dhar N., Klein E., Reuther A., et al. Outcome after radical cystectomy with limited or extended pelvic lymph node dissection. J Urol 2008, 179:873.
19. Poulsen A., Horn T., Kenneth S. Radical cystectomy: extending the limits of pelvic lymph node dissection improves survival for patients with bladder cancer confined to the bladder wall. Urology 1998, 160:2015-2020.
20. Abol-Enein H., Tilki D., Mosbah A., et al. Does the extent of lymphadenectomy in radical cystectomy for bladder cancer influence disease-free survival? A prospective single-center study. Eur Urol 2011, 60:572.
21. Holmer M., Bendahl P.-O., Davidsson T., et al. Extended lymph node dissection in patients with urothelial cell carcinoma of the bladder: can it make a difference?. World J Urol 2009, 27:521.
22. Simone G., Papalia R., Ferriero M., et al. Stage-specific impact of extended versus standard pelvic lymph node dissection in radical cystectomy. Int J Urol 2013, 20:390-397.
23. Jensen J., Ulhøi B., Jensen K. Extended versus limited lymph node dissection in radical cystectomy: impact on recurrence pattern and survival. Int J Urol 2012, 19:39-47.
24. Park J., Kim S., Jeong I.G., et al. Does the greater number of lymph nodes removed during standard lymph node dissection predict better patient survival following radical cystectomy?. World J Urol 2011, 29:443-449.
25. Zehnder P., Studer U., Skinner E., et al. Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study. J Urol 2011, 186:1261-1268.
26. Leissner J., Hohenfellner R., Thueroff J.W., et al. Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int 2000, 85:817.
27. Liu X., Shen K., Yan X., et al. Clinical significance of radical cystectomy with extended lymphadenectomy. Beijing Da Xue Xue Bao 2011, 43:574-578.
28. Honma I., Masumori N., Sato E., et al. Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer-analysis of role of pelvic lymph node dissection. Urology 2006, 68:817-823.
29. Herr H. Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy. Urology 2003, 61:105-108.
30. Stein J., Penson D., Cai J., et al. Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer. Urology 2007, 177:876-882.
31. Stein J. Lymphadenectomy in bladder cancer: how high is "high enough"?. Urol Oncol 2006, 24:349-355.