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Volumn 13, Issue 1, 2015, Pages 47-59

Lipid metabolism and cancer progression: The missing target in metastatic cancer treatment

Author keywords

Adipocytes; Breast cancer; Cytokines; Fatty acid synthase; Glycolysis; Inflammation; Oxidative phosphorylation; Palmitate; Prostate cancer; Tumorigenesis

Indexed keywords

2 HYDROXYGLUTARIC ACID; ADIPOCYTOKINE; FATTY ACID; FATTY ACID SYNTHASE; FUMARATE HYDRATASE; GLUCOSE; ISOCITRATE DEHYDROGENASE; LIPID; PALMITIC ACID; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; TUMOR NECROSIS FACTOR ALPHA;

EID: 84925955033     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.1016/j.jab.2014.09.004     Document Type: Review
Times cited : (20)

References (58)
  • 1
    • 84901195692 scopus 로고    scopus 로고
    • Rare insights into cancer biology
    • Adam, J., Yang, M., Soga, T., Pollard, P.J., 2014. Rare insights into cancer biology. Oncogene 33, 2547-2556.
    • (2014) Oncogene , vol.33 , pp. 2547-2556
    • Adam, J.1    Yang, M.2    Soga, T.3    Pollard, P.J.4
  • 2
    • 84897492159 scopus 로고    scopus 로고
    • Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia
    • Aldhafiri, F.K., McColl, J.H., Reilly, J.J., 2014. Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia. J. Pediatr. Hematol. Oncol. 36, 234-236.
    • (2014) J. Pediatr. Hematol. Oncol. , vol.36 , pp. 234-236
    • Aldhafiri, F.K.1    McColl, J.H.2    Reilly, J.J.3
  • 4
    • 37149051335 scopus 로고    scopus 로고
    • Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
    • Besnard, V., Xu, Y., Whitsett, J.A., 2007. Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L1395-L1405.
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.293 , pp. L1395-L1405
    • Besnard, V.1    Xu, Y.2    Whitsett, J.A.3
  • 5
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown, M.S., Goldstein, J.L., 1986. A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 84897528102 scopus 로고    scopus 로고
    • Targeting FASN in breast cancer and the discovery of promising inhibitors from natural products derived from Traditional Chinese Medicine
    • Cheng, C.S., Wang, Z., Chen, J., 2014. Targeting FASN in breast cancer and the discovery of promising inhibitors from natural products derived from Traditional Chinese Medicine. Evid. Based Compl. Alternat. Med. 2014, 232946.
    • (2014) Evid. Based Compl. Alternat. Med. , vol.2014 , pp. 232946
    • Cheng, C.S.1    Wang, Z.2    Chen, J.3
  • 8
    • 77953981792 scopus 로고    scopus 로고
    • Effect of obesity on breast cancer development
    • Cleary, M.P., Grossmann, M.E., Ray, A., 2010. Effect of obesity on breast cancer development. Vet. Pathol. 47, 202-213.
    • (2010) Vet. Pathol. , vol.47 , pp. 202-213
    • Cleary, M.P.1    Grossmann, M.E.2    Ray, A.3
  • 9
    • 0038418257 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
    • De Schrijver, E., Brusselmans, K., Heyns, W., Verhoeven, G., Swinnen, J.V., 2003. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res. 63, 3799-3804.
    • (2003) Cancer Res. , vol.63 , pp. 3799-3804
    • De Schrijver, E.1    Brusselmans, K.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 13
    • 84892170909 scopus 로고    scopus 로고
    • Molecular pathways: Sterols and receptor signaling in cancer
    • Gabitova, L., Gorin, A., Astsaturov, I., 2014. Molecular pathways: sterols and receptor signaling in cancer. Clin. Cancer Res. 20, 28-34.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 28-34
    • Gabitova, L.1    Gorin, A.2    Astsaturov, I.3
  • 15
    • 33645066625 scopus 로고    scopus 로고
    • Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: Possible role of obesityrelated stimuli
    • PMID: 16533767
    • Garofalo, C., Koda, M., Cascio, S., Sulkowska, M., Kanczuga-Koda, L., Golaszewska, J., Russo, A., Sulkowski, S., Surmacz, E., 2006. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesityrelated stimuli. Clin. Cancer Res. 12, 1447-1453 PMID: 16533767.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1447-1453
    • Garofalo, C.1    Koda, M.2    Cascio, S.3    Sulkowska, M.4    Kanczuga-Koda, L.5    Golaszewska, J.6    Russo, A.7    Sulkowski, S.8    Surmacz, E.9
  • 20
    • 84890859981 scopus 로고    scopus 로고
    • Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
    • Hopperton, K.E., Duncan, R.E., Bazinet, R.P., Archer, M.C., 2014. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp. Cell Res. 320, 302-310.
    • (2014) Exp. Cell Res. , vol.320 , pp. 302-310
    • Hopperton, K.E.1    Duncan, R.E.2    Bazinet, R.P.3    Archer, M.C.4
  • 21
    • 29244467687 scopus 로고    scopus 로고
    • Adipose tissue: A regulator of inflammation, Best Practice and Research
    • Juge-Aubry, C.E., Henrichot, E., Meier, C.A., 2005. Adipose tissue: a regulator of inflammation, Best Practice and Research. Clin. Endocrinol. Metabol. 19, 547-566.
    • (2005) Clin. Endocrinol. Metabol. , vol.19 , pp. 547-566
    • Juge-Aubry, C.E.1    Henrichot, E.2    Meier, C.A.3
  • 22
    • 36048956529 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors: New directions for oncology
    • Kridel, S.J., Lowther, W.T., Pemble IV, C.W., 2007. Fatty acid synthase inhibitors: new directions for oncology. Expert Opin. Investig. Drugs 16, 1817-1829.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , pp. 1817-1829
    • Kridel, S.J.1    Lowther, W.T.2    Pemble, C.W.3
  • 23
    • 39649124202 scopus 로고    scopus 로고
    • Overweight and obesity and incidence of leukemia: A meta-analysis of cohort studies
    • Larsson, S.C., Wolk, A., 2008. Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies. Int. J. Cancer 122, 1418-1421.
    • (2008) Int. J. Cancer , vol.122 , pp. 1418-1421
    • Larsson, S.C.1    Wolk, A.2
  • 24
    • 80054917121 scopus 로고    scopus 로고
    • Body mass index and risk of non- Hodgkin's and Hodgkin's lymphoma: A meta-analysis of prospective studies
    • Larsson, S.C., Wolk, A., 2011. Body mass index and risk of non- Hodgkin's and Hodgkin's lymphoma: a meta-analysis of prospective studies. Eur. J. Cancer 47, 2422-2430.
    • (2011) Eur. J. Cancer , vol.47 , pp. 2422-2430
    • Larsson, S.C.1    Wolk, A.2
  • 25
    • 70449635843 scopus 로고    scopus 로고
    • Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast cancer cells
    • PMID: 19838920
    • Lautenbach, A., Budde, A., Wrann, C.D., Teichmann, B., Vieten, G., Karl, T., Nave, H., 2009. Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast cancer cells. Nutr. Cancer 61, 484-491 PMID: 19838920.
    • (2009) Nutr. Cancer , vol.61 , pp. 484-491
    • Lautenbach, A.1    Budde, A.2    Wrann, C.D.3    Teichmann, B.4    Vieten, G.5    Karl, T.6    Nave, H.7
  • 26
    • 69149106050 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells
    • Lee, J.S., Lee, M.S., Oh, W.K., Sul, J.Y., 2009. Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells. Biol. Pharm. Bull. 32, 1427-1432.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 1427-1432
    • Lee, J.S.1    Lee, M.S.2    Oh, W.K.3    Sul, J.Y.4
  • 27
    • 79952148424 scopus 로고    scopus 로고
    • Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker
    • Liu, H., Liu, J.Y., Wu, X., Zhang, J.T., 2010. Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int. J. Biochem. Mol. Biol. 1, 69-89.
    • (2010) Int. J. Biochem. Mol. Biol. , vol.1 , pp. 69-89
    • Liu, H.1    Liu, J.Y.2    Wu, X.3    Zhang, J.T.4
  • 28
    • 84885184663 scopus 로고    scopus 로고
    • Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids
    • Louie, S.M., Roberts, L.S., Mulvihill, M.M., Luo, K., Nomura, D.K., 2013. Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids. Biochim. Biophys. Acta 1831, 1566-1572.
    • (2013) Biochim. Biophys. Acta , vol.1831 , pp. 1566-1572
    • Louie, S.M.1    Roberts, L.S.2    Mulvihill, M.M.3    Luo, K.4    Nomura, D.K.5
  • 29
    • 57649130593 scopus 로고    scopus 로고
    • Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
    • Lu, C.W., Lin, S.C., Chen, K.F., Lai, Y.Y., Tsai, S.J., 2008. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J. Biol. Chem. 283, 28106-28114.
    • (2008) J. Biol. Chem. , vol.283 , pp. 28106-28114
    • Lu, C.W.1    Lin, S.C.2    Chen, K.F.3    Lai, Y.Y.4    Tsai, S.J.5
  • 30
    • 33845909566 scopus 로고    scopus 로고
    • Pharmacological inhibitors of Fatty Acid Synthase (FASN)-catalyzed endogenous fatty acid biogenesis: A new family of anti-cancer agents?
    • Lupu, R., Menendez, J.A., 2006. Pharmacological inhibitors of Fatty Acid Synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr. Pharm. Biotechnol. 7, 483-493.
    • (2006) Curr. Pharm. Biotechnol. , vol.7 , pp. 483-493
    • Lupu, R.1    Menendez, J.A.2
  • 31
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes, G., Thomas, A., Weinhouse, S., 1953. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res. 13, 27-29.
    • (1953) Cancer Res. , vol.13 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 32
    • 3142720785 scopus 로고    scopus 로고
    • Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB
    • Menendez, J.A., Mehmi, I., Atlas, E., Colomer, R., Lupu, R., 2004. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. Int. J. Oncol. 24, 591-608.
    • (2004) Int. J. Oncol. , vol.24 , pp. 591-608
    • Menendez, J.A.1    Mehmi, I.2    Atlas, E.3    Colomer, R.4    Lupu, R.5
  • 33
    • 17644394237 scopus 로고    scopus 로고
    • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity
    • May
    • Menendez, J.A., Vellon, L., Colomer, R., Lupu, R., 2005. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. Int. J. Cancer 115 (May), 19-35.
    • (2005) Int. J. Cancer , vol.115 , pp. 19-35
    • Menendez, J.A.1    Vellon, L.2    Colomer, R.3    Lupu, R.4
  • 34
    • 84866696143 scopus 로고    scopus 로고
    • Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma
    • October
    • Moschetta, A., 2011. Nuclear receptor LXR as a novel therapeutic antitumoral target in glioblastoma. Cancer Discov. 1 (October), 381-382.
    • (2011) Cancer Discov. , vol.1 , pp. 381-382
    • Moschetta, A.1
  • 35
    • 81555208672 scopus 로고    scopus 로고
    • Adipocytes enhance the proliferation of human leiomyoma cells via TNF-a proinflammatory cytokine
    • PMID: 22096007
    • Nair, S., Al-Hendy, A., 2011. Adipocytes enhance the proliferation of human leiomyoma cells via TNF-a proinflammatory cytokine. Reprod. Sci. 18, 1186-1192 PMID: 22096007.
    • (2011) Reprod. Sci. , vol.18 , pp. 1186-1192
    • Nair, S.1    Al-Hendy, A.2
  • 36
    • 84925942283 scopus 로고    scopus 로고
    • Obesity and the endometrium: Adipocyte-secreted proinflammatory TNF a cytokine enhances the proliferation of human endometrial glandular cells
    • PMID: 24288542
    • Nair, S., Nguyen, H., Salama, S., Al-Hendy, A., 2013. Obesity and the endometrium: adipocyte-secreted proinflammatory TNF a cytokine enhances the proliferation of human endometrial glandular cells. Obstet. Gynecol. Int. 2013, 368543 PMID: 24288542.
    • (2013) Obstet. Gynecol. Int. , vol.2013 , pp. 368543
    • Nair, S.1    Nguyen, H.2    Salama, S.3    Al-Hendy, A.4
  • 40
    • 85030389987 scopus 로고    scopus 로고
    • 2013 dissecting the biology of solid tumor: The microenvironment and cancer progression
    • Omabe, M., Odii, B.O., 2013. 2013 Dissecting The Biology of Solid Tumor: The Microenvironment and Cancer Progression. Br. J. Med. Med. Res. 3, 1786-1797.
    • (2013) Br. J. Med. Med. Res. , vol.3 , pp. 1786-1797
    • Omabe, M.1    Odii, B.O.2
  • 41
    • 85030394169 scopus 로고    scopus 로고
    • Metabolic basis of treatment failures; Autophagy and malignant cancer progression
    • Omabe, M., Ezeani, M., Donatus, U., 2013. Metabolic basis of treatment failures; autophagy and malignant cancer progression. J. Clin. Exp. Oncol. 2, 3.
    • (2013) J. Clin. Exp. Oncol. , vol.2 , pp. 3
    • Omabe, M.1    Ezeani, M.2    Donatus, U.3
  • 42
    • 84875908777 scopus 로고    scopus 로고
    • Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy
    • Pramanik, R., Sheng, X., Ichihara, B., Heisterkamp, N., Mittelman, S.D., 2013. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk. Res. 37, 503-509.
    • (2013) Leuk. Res. , vol.37 , pp. 503-509
    • Pramanik, R.1    Sheng, X.2    Ichihara, B.3    Heisterkamp, N.4    Mittelman, S.D.5
  • 44
    • 0032992528 scopus 로고    scopus 로고
    • The HER-2/neu oncogene: Prognostic factor, predictive factor and target for therapy
    • Ross, J.S., Fletcher, J.A., 1999. The HER-2/neu oncogene: prognostic factor, predictive factor and target for therapy. Semin. Cancer Biol. 9, 125-138.
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 125-138
    • Ross, J.S.1    Fletcher, J.A.2
  • 46
    • 34250843751 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride
    • Schmidt, L.J., Ballman, K.V., Tindall, D.J., 2007. Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride. Prostate 67, 1111-1120.
    • (2007) Prostate , vol.67 , pp. 1111-1120
    • Schmidt, L.J.1    Ballman, K.V.2    Tindall, D.J.3
  • 48
    • 77954672503 scopus 로고    scopus 로고
    • Adipose tissue macrophages: Their role in adipose tissue remodeling
    • Suganami, T., Ogawa, Y., 2010. Adipose tissue macrophages: their role in adipose tissue remodeling. J. Leukoc. Biol. 88, 33-39.
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 33-39
    • Suganami, T.1    Ogawa, Y.2
  • 49
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor alpha
    • PMID: 16123319
    • Suganami, T., Nishida, J., Ogawa, Y., 2005. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler. Thromb. Vasc. Biol. 25, 2062-2068 PMID: 16123319.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 50
    • 34248157798 scopus 로고    scopus 로고
    • Obesity hormone leptin: A new target in breast cancer?
    • Surmacz, E., 2007. Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res. 9, 301.
    • (2007) Breast Cancer Res. , vol.9 , pp. 301
    • Surmacz, E.1
  • 51
    • 38549147538 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
    • Vazquez-Martin, A., Colomer, R., Brunet, J., Lupu, R., Menendez, J.A., 2008. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif. 41, 59-85.
    • (2008) Cell Prolif. , vol.41 , pp. 59-85
    • Vazquez-Martin, A.1    Colomer, R.2    Brunet, J.3    Lupu, R.4    Menendez, J.A.5
  • 52
    • 35848962736 scopus 로고    scopus 로고
    • Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells
    • Vazquez-Martin, A., Colomer, R., Brunet, J., Menendez, J.A., 2007. Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. Int. J. Oncol. 31, 769-776.
    • (2007) Int. J. Oncol. , vol.31 , pp. 769-776
    • Vazquez-Martin, A.1    Colomer, R.2    Brunet, J.3    Menendez, J.A.4
  • 55
    • 84864957283 scopus 로고    scopus 로고
    • Emerging glycolysis targeting and drug discovery from Chinese medicine in cancer therapy
    • Wang, Z., Wang, N., Chen, J., Shen, J., 2012. Emerging glycolysis targeting and drug discovery from Chinese medicine in cancer therapy. Evid. Based Compl. Alternat. Med. 2012, 873175.
    • (2012) Evid. Based Compl. Alternat. Med. , vol.2012 , pp. 873175
    • Wang, Z.1    Wang, N.2    Chen, J.3    Shen, J.4
  • 56
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O., 1956. On the origin of cancer cells. Science 123, 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1


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