Undergraduates improve upon published crystal structure in class assignment

Biochemistry and Molecular Biology Education

Volumn 42, Issue 5, 2014, Pages 398-404

  Horowitz, Scott ^a   Koldewey, Philipp ^a   Bardwell, James C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Active learning; Assessment and the design of probes for student understanding and learning; Biophysical methods; Computational biology; Laboratory exercises; Learning and curriculum design; Problem based learning; Protein structure function and folding

Indexed keywords

AMINO ACID; PROTEIN;

AMINO ACID SEQUENCE; CHEMISTRY; CRYSTALLIZATION; CURRICULUM; HUMAN; MOTIVATION; PROBLEM BASED LEARNING; PROCEDURES; QUESTIONNAIRE; REPRODUCIBILITY; STUDENT; TEACHING; UNIVERSITY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACIDS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CURRICULUM; HUMANS; MOTIVATION; PROBLEM-BASED LEARNING; PROTEINS; QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; STUDENTS; TEACHING; UNIVERSITIES;

EID: 84925944136     PISSN: 14708175     EISSN: 15393429     Source Type: Journal    
DOI: 10.1002/bmb.20811     Document Type: Article

References (7)

1. Kleywegt, G. J., Harris, M. R., Zou, J. Y., Taylor, T. C., Wahlby, A., and Jones, T. A. (2004) The Uppsala electron-density server. Acta Crystallogr. D Biol. Crystallogr. 60, 2240-2249.
2. Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot. Acta. Crystallogr. D Biol. Crystallogr. 66, 486-501.
3. Moulaei, T., Botos, I., Ziolkowska, N. E., Bokesch, H. R., Krumpe, L. R., Mckee, T. C., O'keefe, B. R., Dauter, Z., and Wlodawer, A. (2007) Atomic-resolution crystal structure of the antiviral lectin scytovirin. Protein Sci. 16, 2756-2760.
4. Chen, V. B., Arendall, W. B., III, Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S., and Richardson, D. C. (2010) MolProbity: All-atom structure validation for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66, 12-21.
5. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., III, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) MolProbity: All-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res. 35, W375-W383.
6. Holden, H. Project CRYSTAL: Colleagues Researching with Young Scientists: Teaching and Learning. Available at: http://www.projectcrystal.org. Accessed on July 3, 2014.
7. Echols, N., Grosse-Kunstleve, R. W., Afonine, P. V., Bunkoczi, G., Chen, V. B., Headd, J. J., Mccoy, A. J., Moriarty, N. W., Read, R. J., Richardson, D. C., Richardson, J. S., Terwilliger, T. C., and Adams, P. D. (2012) Graphical tools for macromolecular crystallography in PHENIX. J. Appl. Crystallogr. 45, 581-586.