Comparison of histopathologic analysis following renal sympathetic denervation over multiple time points

Circulation: Cardiovascular Interventions

Volumn 8, Issue 2, 2015, Pages

  Sakakura, Kenichi ^a   Tunev, Stefan ^b   Yahagi, Kazuyuki ^a   O'Brien, Amanda J ^b   Ladich, Elena ^a   Kolodgie, Frank D ^a   Melder, Robert J ^b   Joner, Michael ^a   Virmani, Renu ^a  

^a CVPATH INSTITUTE   (United States)

^b MEDTRONIC INC   (United States)

Author keywords

Pathology; Preclinical study; Radiofrequency; Renal artery; Renal denervation

Indexed keywords

COLLAGEN; TYROSINE 3 MONOOXYGENASE; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BARROW (SWINE); CELL LOSS; CELL VACUOLE; CHRONOLOGY; COMPARATIVE STUDY; CONTROLLED STUDY; FAT NECROSIS; FEMALE; GRANULATION TISSUE; HISTOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; KIDNEY DENERVATION; MALE; NEOVASCULARIZATION (PATHOLOGY); NERVE INJURY SCORE; NERVE REGENERATION; NEUROLOGIC DISEASE ASSESSMENT; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; RADIOFREQUENCY RENAL SYMPATHETIC DENERVATION; RENAL ARTERY; SCORING SYSTEM; SMOOTH MUSCLE FIBER; SOW (SWINE); TYROSINE HYDROXYLASE SCORE; ADRENERGIC SYSTEM; ANIMAL; ANIMAL MODEL; CATHETER ABLATION; INNERVATION; KIDNEY; KIDNEY ARTERY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PIG; PROCEDURES; SURGERY; SYMPATHECTOMY; TIME; VASCULAR REMODELING; VASCULARIZATION;

ANIMALS; BIOLOGICAL MARKERS; CATHETER ABLATION; FEMALE; KIDNEY; MALE; MODELS, ANIMAL; NERVE REGENERATION; RENAL ARTERY; SUS SCROFA; SYMPATHECTOMY; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; VASCULAR REMODELING;

EID: 84925882924     PISSN: 19417640     EISSN: 19417632     Source Type: Journal    
DOI: 10.1161/CIRCINTERVENTIONS.114.001813     Document Type: Article

References (24)

1. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith SC Jr, Svetkey LP, Taler SJ, Townsend RR, Wright JT Jr, Narva AS, Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507-520. doi: 10.1001/jama.2013.284427.
2. Grassi G, Mancia G. New therapeutic approaches for resistant hypertension. J Nephrol. 2012;25:276-281. doi: 10.5301/jn. 5000097.
3. Sarafidis PA. Epidemiology of resistant hypertension. J Clin Hypertens (Greenwich). 2011;13:523-528. doi: 10.1111/j.1751-7176.2011.00445.x.
4. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51:1403-1419. doi: 10.1161/HYPERTENSIONAHA.108.189141.
5. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (the SYMPLICITY HTN-2 trial): a randomised controlled trial. Lancet. 2010;376:1903-1909.
6. Prochnau D, Lucas N, Kuehnert H, Figulla HR, Surber R. Catheter-based renal denervation for drug-resistant hypertension by using a standard electrophysiology catheter. EuroIntervention. 2012;7:1077-1080. doi: 10.4244/EIJV7I9A171.
7. Worthley SG, Tsioufis C P, Worthley MI, Sinhal A, Chew D P, Meredith IT, Malaiapan Y, Papademetriou V. Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial. Eur Heart J. 2013;34:2132-2140. doi: 10.1093/eurheartj/eht197.
8. Krum H, Schlaich MP, Bohm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler MD. Percutaneous renal denervation in patients with treatmentresistant hypertension: final 3-year report of the SYMPLICITY HTN-1 study. Lancet. 2014;383:622-629.
9. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL; SYMPLICITY HTN-3 Investigators. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393-1401. doi: 10.1056/NEJMoa1402670.
10. Rippy MK, Zarins D, Barman NC, Wu A, Duncan KL, Zarins CK. Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety. Clin Res Cardiol. 2011;100:1095-1101. doi: 10.1007/s00392-011-0346-8.
11. Steigerwald K, Titova A, Malle C, Kennerknecht E, Jilek C, Hausleiter J, Nährig JM, Laugwitz KL, Joner M. Morphological assessment of renal arteries after radiofrequency catheter-based sympathetic denervation in a porcine model. J Hypertens. 2012;30:2230-2239. doi: 10.1097/HJH.0b013e32835821e5.
12. Sakakura K, Ladich E, Edelman ER, Markham P, Stanley JR, Keating J, Kolodgie FD, Virmani R, Joner M. Methodological standardization for the pre-clinical evaluation of renal sympathetic denervation. JACC Cardiovasc Interv. 2014;7:1184-1193. doi: 10.1016/j.jcin. 2014.04.024.
13. Ferreira LM, Floriddia EM, Quadrato G, Di Giovanni S. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobiol. 2012;46:227-241. doi: 10.1007/s12035-012-8290-9.
14. Mulder J, Hökfelt T, Knuepfer MM, Kopp UC. Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats. Am J Physiol Regul Integr Comp Physiol. 2013;304:R675-R682. doi: 10.1152/ajpregu.00599.2012.
15. Couch NP, McBride RA, Dammin GJ, Murray JE. Observations on the nature of the enlargement, the regeneration of the nerves, and the function of the canine renal autograft. Br J Exp Pathol. 1961;42:106-113.
16. Gazdar AF, Dammin GJ. Neural degeneration and regeneration in human renal transplants. N Engl J Med. 1970;283:222-224. doi: 10.1056/NEJM197007302830502.
17. Serrano Falcón C, Serrano Falcón Mdel M, Ruiz Villaverde R, Linares Solano J, Serrano Ortega S. Amputation neuromas after neck surgery. Dermatol Online J. 2005;11:24.
18. Kandzari DE, Bhatt DL, Sobotka PA, O'Neill WW, Esler M, Flack JM, Katzen BT, Leon MB, Massaro JM, Negoita M, Oparil S, Rocha-Singh K, Straley C, Townsend RR, Bakris G. Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 Trial. Clin Cardiol. 2012;35:528-535. doi: 10.1002/clc.22008.
19. Templin C, Jaguszewski M, Ghadri JR, Sudano I, Gaehwiler R, Hellermann JP, Schoenenberger-Berzins R, Landmesser U, Erne P, Noll G, Lüscher TF. Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity catheter system and the EnligHTN multi-electrode renal denervation catheter. Eur Heart J. 2013;34:2141-2148, 2148b. doi: 10.1093/eurheartj/eht141.
20. Sakakura K, Ladich E, Cheng Q, Otsuka F, Yahagi K, Fowler DR, Kolodgie FD, Virmani R, Joner M. Anatomic assessment of sympathetic peri-arterial renal nerves in man. J Am Coll Cardiol. 2014;64:635-643. doi: 10.1016/j.jacc.2014.03.059.
21. Tellez A, Rousselle S, Palmieri T, Rate WR, 4th, Wicks J, Degrange A, Hyon CM, Gongora CA, Hart R, Grundy W, Kaluza GL, Granada JF. Renal artery nerve distribution and density in the porcine model: biologic implications for the development of radiofrequency ablation therapies. Transl Res. 2013;162:381-389. doi: 10.1016/j.trsl.2013.07.002.
22. Pomar C, Harris DL, Savoie P, Minvielle F. Computer simulation model of swine production systems: III. A dynamic herd simulation model including reproduction. J Anim Sci. 1991;69:2822-2836.
23. Prochnau D, Figulla HR, Romeike BF, Franz M, Schubert H, Bischoff S, Lauten A, Kuehnert H, Surber R. Percutaneous catheter-based cryoablation of the renal artery is effective for sympathetic denervation in a sheep model. Int J Cardiol. 2011;152:268-270. doi: 10.1016/j.ijcard.2011.08.001.
24. Prochnau D, Romeike BF, Bischoff S, Schubert H, Figulla HR, Surber R. Reduction of neurofilaments following renal denervation with radiofrequency current in a sheep model. Int J Cardiol. 2013;168:4450-4452. doi: 10.1016/j.ijcard.2013.06.149.