Antiplaque and antigingivitis toothpastes

Monographs in Oral Science

Volumn 23, Issue , 2013, Pages 27-44

  Sanz, Mariano ^a   Serrano, Jorge ^a   Iniesta, Margarita ^a   Santa Cruz, Isabel ^a   Herrera, David ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TOOTHPASTE;

ARTICLE; BIOFILM; CHEMISTRY; CLINICAL TRIAL (TOPIC); DRUG EFFECT; GINGIVITIS; HUMAN; MICROBIOLOGY; TOOTH BRUSHING; TOOTH PLAQUE;

BIOFILMS; CLINICAL TRIALS AS TOPIC; DENTAL PLAQUE; DENTIFRICES; GINGIVITIS; HUMANS; TOOTHBRUSHING; TOOTHPASTES;

EID: 84925864624     PISSN: 00770892     EISSN: 16623843     Source Type: Book Series    
DOI: 10.1159/000350465     Document Type: Article

References (168)

1. Commission FDI: Mouthrinses and periodontal disease. Int Dent J 2002; 52: 346-352.
2. Lang NP, Newman HN: Consensus report of sesion II; in Lang Np, Karring T, Lindhe J (eds): Proceedings of the 2nd European Workshop on Periodontology, Chemicals in Periodontics. London, Quintessence, 1997, pp 192-195.
3. Addy M, Moran JM: Clinical indications for the use of chemical adjuncts to plaque control: chlorhexidine formulations. Periodontol 2000 1997; 15: 52-54.
4. Shapiro S, Giertsen E, Guggenheim B: An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses. Caries Res 2002; 36: 93-100.
5. Socransky SS, Haffajee AD: Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002; 28: 12-55.
6. Xu KD, McFeters GA, Stewart PS: Biofilm resistance to antimicrobial agents. Microbiology 2000; 146: 547-549.
7. Bonesvoll P: Retention and plaque-inhibiting effect in man of chlorhexidine after multiple mouth rinses and retention and release of chlorhexidine after toothbrushing with a chlorhexidine gel. Arch Oral Biol 1978; 23: 295-300.
8. Bonesvoll P, Lokken P, Rolla G: Influence of concentration, time, temperature and pH on the retention of chlorhexidine in the human oral cavity after mouth rinses. Arch Oral Biol 1974; 19: 1025-1029.
9. Bonesvoll P, Lokken P, Rolla G, Paus PN: Retention of chlorhexidine in the human oral cavity after mouth rinses. Arch Oral Biol 1974; 19: 209-212.
10. Gjermo P, Bonesvoll P, Hjeljord LG, Rolla G: Influence of variation of pH of chlorhexidine mouth rinses on oral retention and plague-inhibiting effect. Caries Res 1975; 9: 74-82.
11. Gjermo P, Bonesvoll P, Rolla G: Relationship between plaque-inhibiting effect and retention of chlorhexidine in the human oral cavity. Arch Oral Biol 1974; 19: 1031-1034.
12. Rolla G, Loe H, Schiott CR: Retention of chlorhexidine in the human oral cavity. Arch Oral Biol 1971; 16: 1109-1116.
13. Addy M, Willis L, Moran J: Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol 1983; 10: 89-99.
14. Arweiler NB, Henning G, Reich E, Netuschil L: Effect of an amine-fluoridetriclosan mouthrinse on plaque regrowth and biofilm vitality. J Clin Periodontol 2002; 29: 358-363.
15. Harrap GJ: Assessment of the effect of dentifrices on the growth of dental plaque. J Clin Periodontol 1974; 1: 166-174.
16. Moran J, Addy M, Wade WG, Maynard JH: A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. J Clin Periodontol 1992; 19: 749-753.
17. Pizzo G, La CM, Licata ME, Pizzo I, D'Angelo M: The effects of an essential oil and an amine fluoride/stannous fluoride mouthrinse on supragingival plaque regrowth. J Periodontol 2008; 79: 1177-1183.
18. Löe H: Experimental gingivitis in man. J Periodontol 1965; 36: 177-187.
19. Löe H, Schiott CR: The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res 1970; 5: 79-83.
20. Pan P, Barnett ML, Coelho J, Brogdon C, Finnegan MB: Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method. J Clin Periodontol 2000; 27: 256-261.
21. Sreenivasan PK, Mattai J, Nabi N, Xu T, Gaffar A: A simple approach to examine early oral microbial biofilm formation and the effects of treatments. Oral Microbiol Immunol 2004; 19: 297-302.
22. American Dental Association: Guidelines for acceptance of chemotherapeutic products for the control of supragingival dental plaque and gingivitis. Council of Dental Therapeutics. J Am Dent Assoc 1986; 112: 529-532.
23. Overholser CD Jr: Longitudinal clinical studies with antimicrobial mouthrinses. J Clin Periodontol 1988; 15: 517-519.
24. Addy M: Chlorhexidine compared with other locally delivered antimicrobials. A short review. J Clin Periodontol 1986; 13: 957-964.
25. Hatti S, Ravindra S, Satpathy A, Kulkarni RD, Parande MV: Biofilm inhibition and antimicrobial activity of a dentifrice containing salivary substitutes. Int J Dent Hyg 2007; 5: 218-224.
26. Kirstila V, Lenander-Lumikari M, Tenovuo J: Effects of a lactoperoxidase-system-containing toothpaste on dental plaque and whole saliva in vivo. Acta Odontol Scand 1994; 52: 346-353.
27. Moran J, Addy M, Newcombe R: Comparison of the effect of toothpastes containing enzymes or antimicrobial compounds with a conventional fluoride toothpaste on the development of plaque and gingivitis. J Clin Periodontol 1989; 16: 295-299.
28. Elworthy AJ, Edgar R, Moran J, Addy M, Movert R, Kelty E, et al: A 6-month home-usage trial of 0.1 and 0.2 delmopinol mouthwashes (II). Effects on the plaque microflora. J Clin Periodontol 1995; 22: 527-532.
29. Rundegren J, Simonsson T, Petersson LG, Hansson E: Effect of delmopinol on the cohesion of glucan-containing plaque formed by Streptococcus mutans in a flow cell system. J Dent Res 1992; 71: 1792-1796.
30. Simonsson T, Hvid EB, Rundegren J, Edwardsson S: Effect of delmopinol on in vitro dental plaque formation, bacterial production and the number of microorganisms in human saliva. Oral Microbiol Immunol 1991; 6: 305-309.
31. Abbott DM, Gunsolley JC, Koertge TE, Payne EL: The relative efficacy of 0.1 and 0.2 delmopinol mouthrinses in inhibiting the development of supragingival dental plaque and gingivitis in man. J Periodontol 1994; 65: 437-441.
32. Claydon N, Hunter L, Moran J, Wade WG, Kelty E, Movert R, et al: A 6-month home-usage trial of 0.1 and 0.2 delmopinol mouthwashes (I). Effects on plaque, gingivitis, supragingival calculus and tooth staining. J Clin Periodontol 1996; 23: 220-228.
33. Collaert B, Attstrîm R, De Bruyn H, Movert R: The effect of delmopinol rinsing on dental plaque formation and gingivitis healing. J Clin Periodontol 1992; 19: 274-280.
34. Zee KY, Rundegren J, Attstrîm R: Effect of delmopinol hydrochloride mouthrinse on plaque formation and gingivitis in 'rapid' and 'slow' plaque formers. J Clin Periodontol 1997; 24: 486-491.
35. Navada R, Kumari H, Le S, Zhang J: Oral malodor reduction from a zinc-containing toothpaste. J Clin Dent 2008; 19: 69-73.
36. Newby CS, Rowland JL, Lynch RJ, Bradshaw DJ, Whitworth D, Bosma ML: Benefits of a silica-based fluoride toothpaste containing o-cymen-5-ol, zinc chloride and sodium fluoride. Int Dent J 2011; 61(suppl 3):74-80.
37. Newby EE, Hickling JM, Hughes FJ, Proskin HM, Bosma MP: Control of oral malodour by dentifrices measured by gas chromatography. Arch Oral Biol 2008; 53(suppl 1):S19-S25.
38. Young A, Jonski G: Effect of a single brushing with two Zn-containing toothpastes on VSC in morning breath: a 12 h, randomized, double-blind, crossover clinical study. J Breath Res 2011; 5: 046012.
39. Young A, Jonski G, Rolla G: Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride-effect of concentration. Eur J Oral Sci 2003; 111: 400-404.
40. Lobene RR, Soparkar PM, Newman MB, Kohut BE: Reduced formation of supragingival calculus with use of fluoridezinc chloride dentifrice. J Am Dent Assoc 1987; 114: 350-352.
41. Sowinski J, Petrone DM, Battista G, Simone AJ, Crawford R, Patel S, et al: Clinical efficacy of a dentifrice containing zinc citrate: a 12-week calculus clinical study in adults. Compend Contin Educ Dent 1998; 19(suppl 2):16-19.
42. Pories WJ, Henzel JH, Rob CG, Strain WH: Acceleration of wound healing in man with zinc sulphate given by mouth. Lancet 1967; 1: 121-124.
43. Gunbay S, Bicakci N, Guneri T, Kirilmaz L: The effect of zinc chloride dentifrices on plaque growth and oral zinc levels. Quintessence Int 1992; 23: 619-624.
44. Kakar A, Newby EE, Ghosh S, Butler A, Bosma ML: A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1w/w o-cymen-5-ol, 0.6w/w zinc chloride. Int Dent J 2011; 61(suppl 3):21-27.
45. Williams C, McBride S, Mostler K, Petrone DM, Simone AJ, Crawford R, et al: Efficacy of a dentifrice containing zinc citrate for the control of plaque and gingivitis: a 6-month clinical study in adults. Compend Contin Educ Dent 1998; 19(suppl 2):4-15.
46. Tinanoff N: Review of the antimicrobial action of stannous fluoride. J Clin Dent 1990; 2: 22-27.
47. Miller JT, Shannon IL, Kilgore WG, Bookman JE: Use of a water-free stannous fluoride-containing gel in the control of dental hypersensitivity. J Periodontol 1969; 40: 490-491.
48. Beiswanger BB, Doyle PM, Jackson R, Mallatt ME, Mau M, Bollmer BW, et al: The clinical effect of dentifrices containing stabilised stannous fluoride on plaque formation and gingivitis-a six-month study with ad libitum brushing. J Clin Dent 1995; 6: 46-53.
49. Mankodi S, Petrone DM, Battista G, Petrone ME, Chaknis P, DeVizio W, et al: Clinical efficacy of an optimized stannous fluoride dentifrice. 2. A 6-month plaque/gingivitis clinical study, northeast USA. Compend Contin Educ Dent 1997; 18: 10-15.
50. McClanahan SF, Beiswanger BB, Bartizek RD, Lanzalaco AC, Bacca L, White DJ: A comparison of stabilized stannous fluoride dentifrice and triclosan/copolymer dentifrice for efficacy in the reduction of gingivitis and gingival bleeding: six-month clinical results. J Clin Dent 1997; 8: 39-45.
51. Perlich MA, Bacca LA, Bollmer BW, Lanzalaco AC: The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: a six-month study. J Clin Dent 1995; 6: 54-58.
52. Williams C, McBride S, Bolden TE, Mostler K, Petrone DM, Petrone ME, et al: Clinical efficacy of an optimized stannous fluoride dentifrice. 3. A 6-month plaque/gingivitis clinical study, southeast USA. Compend Contin Educ Dent 1997; 18: 16-20.
53. Boneta AE, Aguilar MM, Romeu FL, Stewart B, DeVizio W, Proskin HM: Comparative investigation of the efficacy of triclosan/copolymer/sodium fluoride and stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrices for the control of established supragingival plaque and gingivitis in a six-month clinical study. J Clin Dent 2010; 21: 117-123.
54. Mallatt M, Mankodi S, Bauroth K, Bsoul SA, Bartizek RD, He T: A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis. J Clin Periodontol 2007; 34: 762-767.
55. Mankodi S, Bartizek RD, Winston JL, Biesbrock AR, McClanahan SF, He T: Anti-gingivitis efficacy of a stabilized 0.454 stannous fluoride/sodium hexametaphosphate dentifrice. J Clin Periodontol 2005; 32: 75-80.
56. Boyd RL, Chun YS: Eighteen-month evaluation of the effects of a 0.4 stannous fluoride gel on gingivitis in orthodontic patients. Am J Orthod Dentofacial Orthop 1994; 105: 35-41.
57. Wolff LF, Pihlstrom BL, Bakdash MB, Aeppli DM, Bandt CL: Effect of toothbrushing with 0.4 stannous fluoride and 0.22 sodium fluoride gel on gingivitis for 18 months. J Am Dent Assoc 1989; 119: 283-289.
58. Gunsolley JC: A meta-analysis of sixmonth studies of antiplaque and antigingivitis agents. J Am Dent Assoc 2006; 137: 1649-1657.
59. Paraskevas S, van der Weijden GA: A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006; 33: 1-13.
60. Tinanoff N, Manwell MA, Zameck RL, Grasso JE: Clinical and microbiological effects of daily brushing with either NaF or SnF 2 gels in subjects with fixed or removable dental prostheses. J Clin Periodontol 1989; 16: 284-290.
61. Weiland B, Netuschil L, Hoffmann T, Lorenz K: Substantivity of amine fluoride/stannous fluoride following different modes of application: a randomized, investigator-blind, placebo-controlled trial. Acta Odontol Scand 2008; 66: 307-313.
62. Sgan-Cohen HD, Gat E, Schwartz Z: The effectiveness of an amine fluoride/stannous fluoride dentifrice on the gingival health of teenagers: results after six months. Int Dent J 1996; 46: 340-345.
63. Shapira L, Shapira M, Tandlich M, Gedalia I: Effect of amine fluoride-stannous fluoride containing toothpaste (Meridol) on plaque and gingivitis in adults: a six-month clinical study. J Int Acad Periodontol 1999; 1: 117-120.
64. Mengel R, Wissing E, Schmitz-Habben A, Flores-de-Jacoby L: Comparative study of plaque and gingivitis prevention by AmF/SnF 2 and NaF. A clinical and microbiological 9-month study. J Clin Periodontol 1996; 23: 372-378.
65. Paraskevas S, Versteeg PA, Timmerman MF, Van der Velden U, van der Weijden GA: The effect of a dentifrice and mouth rinse combination containing amine fluoride/stannous fluoride on plaque and gingivitis: a 6-month field study. J Clin Periodontol 2005; 32: 757-764.
66. Moran J: A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl). J Clin Periodontol 1988; 15: 612-616.
67. Quirynen M, Marechal M, van Steenberghe D: Comparative antiplaque activity of sanguinarine and chlorhexidine in man. J Clin Periodontol 1990; 17: 223-227.
68. Scherer W, Gultz J, Lee SS, Kaim JM: The ability of an herbal mouthrinse to reduce gingival bleeding. J Clin Dent 1998; 9: 97-100.
69. Lobene RR, Soparkar PM, Newman MB: The effects of a sanguinaria dentifrice on plaque and gingivitis. Compend Contin Educ Dent 1986;(suppl 7):S185-S188.
70. Mauriello SM, Bader JD: Six-month effects of a sanguinarine dentifrice on plaque and gingivitis. J Periodontol 1988; 59: 238-243.
71. Hannah JJ, Johnson JD, Kuftinec MM: Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment. Am J Orthod Dentofacial Orthop 1989; 96: 199-207.
72. Harper DS, Mueller LJ, Fine JB, Gordon JM, Laster LL: Clinical efficacy of a dentifrice and oral rinse containing sanguinaria extract and zinc chloride during 6 months of use. J Periodontol 1990; 61: 352-358.
73. Kopczyk RA, Abrams H, Brown AT, Matheny JL, Kaplan AL: Clinical and microbiological effects of a sanguinariacontaining mouthrinse and dentifrice with and without fluoride during 6 months of use. J Periodontol 1991; 62: 617-622.
74. Ciancio SG: Antiseptics and antibiotics as chemotherapeutic agents for periodontitis management. Compendium 2000; 21: 59-78.
75. Gilbert RJ, Williams PE: The oral retention and antiplaque efficacy of triclosan in human volunteers. Br J Clin Pharmacol 1987; 23: 579-583.
76. Barkvoll P, Rolla G: Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure. J Clin Periodontol 1994; 21: 717-719.
77. Gaffar A, Scherl D, Afflitto J, Coleman EJ: The effect of triclosan on mediators of gingival inflammation. J Clin Periodontol 1995; 22: 480-484.
78. Kjaerheim V, Skaare A, Barkvoll P: Antiplaque, antibacterial and anti-inflammatory properties of triclosan mouthrinse in combination with zinc citrate or polyvinylmethylether maleic acid (PVAMA) copolymer. Eur J Oral Sci 1996; 104: 529-534.
79. Palomo F, Wantland L, Sanchez A, Volpe AR, McCool J, DeVizio W: The effect of three commercially available dentifrices containing triclosan on supragingival plaque formation and gingivitis: a six month clinical study. Int Dent J 1994; 44(suppl 1):75-81.
80. Renvert S, Birkhed D: Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora. J Clin Periodontol 1995; 22: 63-70.
81. Stephen KW, Saxton CA, Jones CL, Ritchie JA, Morrison T: Control of gingivitis and calculus by a dentifrice containing a zinc salt and triclosan. J Periodontol 1990; 61: 674-679.
82. Svatun B, Sadxton CA, Huntington E, Cummins D: The effects of three silica dentifrices containing Triclosan on supragingival plaque and calculus formation and on gingivitis. Int Dent J 1993; 43(suppl 1):441-452.
83. Svatun B, Saxton CA, Huntington E, Cummins D: The effects of a silica dentifrice containing Triclosan and zinc citrate on supragingival plaque and calculus formation and the control of gingivitis. Int Dent J 1993; 43(suppl 1):431-439.
84. Svatun B, Saxton CA, Rolla G: Sixmonth study of the effect of a dentifrice containing zinc citrate and triclosan on plaque, gingival health, and calculus. Scand J Dent Res 1990; 98: 301-304.
85. Svatun B, Saxton CA, Rolla G, van der Ouderaa FJ: One-year study of the efficacy of a dentifrice containing zinc citrate and triclosan to maintain gingival health. Scand J Dent Res 1989; 97: 242-246.
86. Hioe KP, van der Weijden GA: The effectiveness of self-performed mechanical plaque control with triclosan containing dentifrices. Int J Dent Hyg 2005; 3: 192-204.
87. Allen DR, Battista GW, Petrone DM, Petrone ME, Chaknis P, DeVizio W, et al: The clinical efficacy of Colgate Total Plus Whitening Toothpaste containing a special grade of silica and Colgate Total Fresh Stripe Toothpaste in the control of plaque and gingivitis: a six-month clinical study. J Clin Dent 2002; 13: 59-64.
88. Bolden TE, Zambon JJ, Sowinski J, Ayad F, McCool JJ, Volpe AR, et al: The clinical effect of a dentifrice containing triclosan and a copolymer in a sodium fluoride/silica base on plaque formation and gingivitis: a six-month clinical study. J Clin Dent 1992; 3: 125-131.
89. Charles CH, Sharma NC, Galustians HJ, Qaqish J, McGuire JA, Vincent JW: Comparative efficacy of an antiseptic mouthrinse and an antiplaque/ antigingivitis dentifrice. A six-month clinical trial. J Am Dent Assoc 2001; 132: 670-675.
90. Cubells AB, Dalmau LB, Petrone ME, Chaknis P, Volpe AR: The effect of a Triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a six-month clinical study. J Clin Dent 1991; 2: 63-69.
91. Deasy MJ, Singh SM, Rustogi KN, Petrone DM, Battista G, Petrone ME, et al: Effect of a dentifrice containing triclosan and a copolymer on plaque formation and gingivitis. Clin Prev Dent 1991; 13: 12-19.
92. Denepitiya JL, Fine D, Singh S, DeVizio W, Volpe AR, Person P: Effect upon plaque formation and gingivitis of a triclosan/copolymer/fluoride dentifrice: a 6-month clinical study. Am J Dent 1992; 5: 307-311.
93. Garcia-Godoy F, DeVizio W, Volpe AR, Ferlauto RJ, Miller JM: Effect of a triclosan/copolymer/fluoride dentifrice on plaque formation and gingivitis: a 7-month clinical study. Am J Dent 1990; 3: 15-26.
94. Hu D, Zhang J, Wan H, Zhang Y, Volpe AR, Petrone ME: Efficacy of a triclosan/copolymer dentifrice in the control of plaque and gingivitis: a six-month study in China. Hua XiKou QiangYiXueZa Zhi 1997; 15: 333-335.
95. Kanchanakamol U, Umpriwan R, Jotikasthira N, Srisilapanan P, Tuongratanaphan S, Sholitkul W, et al: Reduction of plaque formation and gingivitis by a dentifrice containing triclosan and copolymer. J Periodontol 1995; 66: 109-112.
96. Lindhe J, Rosling B, Socransky SS, Volpe AR: The effect of a triclosan-containing dentifrice on established plaque and gingivitis. J Clin Periodontol 1993; 20: 327-334.
97. Mankodi S, Walker C, Conforti N, DeVizio W, McCool JJ, Volpe AR: Clinical effect of a triclosan-containing dentifrice on plaque and gingivitis: a six-month study. Clin Prev Dent 1992; 14: 4-10.
98. Triratana T, Kraivaphan P, Amornchat C, Rustogi KN, Petrone MP, Volpe AR: Effect of a triclosan-copolymer prebrush mou thrinse on established plaque formation and gingivitis: a six month clinical study in Thailand. J Clin Dent 1995; 6: 142-147.
99. Winston JL, Bartizek RD, McClanahan SF, Mau MS, Beiswanger BB: A clinical methods study of the effects of triclosan dentifrices on gingivitis over six months. J Clin Dent 2002; 13: 240-248.
100. Grossman E, Hou L, Bollmer BW, Court LK, McClary JM, Bennett S, et al: Triclosan/pyrophosphate dentifrice: dental plaque and gingivitis effects in a 6-month randomized controlled clinical study. J Clin Dent 2002; 13: 149-157.
101. Wade WG, Addy M: In vitro activity of a chlorhexidine-containing mouthwash against subgingival bacteria. J Periodontol 1989; 60: 521-525.
102. Hugo WB, Longworth AR: Some aspects of the mode of action of chlorhexidine. J Pharm Pharmacol 1964; 16: 655-662.
103. Hugo WB, Longworth AR: Cytological aspects of the mode of action of chlorhexidine diacetate. J Pharm Pharmacol 1965; 17: 28-32.
104. Fine DH: Mouthrinses as adjuncts for plaque and gingivitis management. A status report for the American Journal of Dentistry. Am J Dent 1988; 1: 259-263.
105. Hugo WB, Longworth AR: The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus . J Pharm Pharmacol 1966; 18: 569-578.
106. Arweiler NB, Netuschil L, Reich E: Alcohol-free mouthrinse solutions to reduce supragingival plaque regrowth and vitality. A controlled clinical study. J Clin Periodontol 2001; 28: 168-174.
107. Jenkins S, Addy M, Newcombe RG: Comparison of two commercially available chlorhexidine mouthrinses. II. Effects on plaque reformation, gingivitis and tooth staining. Clin Prev Dent 1989; 11: 12-16.
108. Jenkins S, Addy M, Wade WG: The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol 1988; 15: 415-424.
109. Rolla G, Melsen B: On the mechanism of the plaque inhibition by chlorhexidine. J Dent Res 1975; 54: 57-62.
110. Wolff LF: Chemotherapeutic agents in the prevention and treatment of periodontal disease. Northwest Dent 1985; 64: 15-24.
111. Vacca-Smith AM, Bowen WH: Effects of some antiplaque agents on the activity of glycosyltransferases of Streptococcus mutans adsorbed onto salivacoated hydroxyapatite and in solution. Biofilms 1996; 1: 1360-1365.
112. Schiott CR, Loe H, Jensen SB, Kilian M, Davies RM, Glavind K: The effect of chlorhexidine mouthrinses on the human oral flora. J Periodontal Res 1970; 5: 84-89.
113. Yates R, Jenkins S, Newcombe RG, Wade WG, Moran J, Addy M: A 6-month home usage trial of a 1 chlorhexidine toothpaste (1). Effects on plaque, gingivitis, calculus and toothstaining. J Clin Periodontol 1993; 20: 130-138.
114. Sanz M, Vallcorba N, Fabregues S, Muller I, Herkstroter F: The effect of a dentifrice containing chlorhexidine and zinc on plaque, gingivitis, calculus and tooth staining. J Clin Periodontol 1994; 21: 431-437.
115. Saxen L, Niemi ML, Ainamo J: Intraoral spread of the antimicrobial effect of a chlorhexidine gel. Scand J Dent Res 1976; 84: 304-307.
116. Francis JR, Hunter B, Addy M: A comparison of three delivery methods of chlorhexidine in handicapped children. I. Effects on plaque, gingivitis, and toothstaining. J Periodontol 1987; 58: 451-455.
117. Pannuti CM, Saraiva MC, Ferraro A, Falsi D, Cai S, Lotufo RF: Efficacy of a 0.5 chlorhexidine gel on the control of gingivitis in Brazilian mentally handicapped patients. J Clin Periodontol 2003; 30: 573-576.
118. Slot DE, Rosema NA, Hennequin-Hoenderdos NL, Versteeg PA, Van DV, van der Weijden GA: The effect of 1 chlorhexidine gel and 0.12 dentifrice gel on plaque accumulation: a 3-day non-brushing model. Int J Dent Hyg 2010; 8: 294-300.
119. Francis JR, Addy M, Hunter B: A comparison of three delivery methods of chlorhexidine in handicapped children. II. Parent and house-parent preferences. J Periodontol 1987; 58: 456-459.
120. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL: Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. J Oral Maxillofac Surg 2008; 66: 441-445.
121. Minguez-Serra MP, Salort-Llorca C, Silvestre-Donat FJ: Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens. Med Oral Patol Oral Cir Bucal 2009; 14:e445-e449.
122. Bollen CM, Mongardini C, Papaioannou W, van SD, Quirynen M: The effect of a one-stage full-mouth disinfection on different intra-oral niches. Clinical and microbiological observations. J Clin Periodontol 1998; 25: 56-66.
123. Bollen CM, Vandekerckhove BN, Papaioannou W, Van EJ, Quirynen M: Full-versus partial-mouth disinfection in the treatment of periodontal infections. A pilot study: long-term microbiological observations. J Clin Periodontol 1996; 23: 960-970.
124. Heitz-Mayfield LJ, Salvi GE, Botticelli D, Mombelli A, Faddy M, Lang NP: Anti-infective treatment of peri-implant mucositis: a randomised controlled clinical trial. Clin Oral Implants Res 2011; 22: 237-241.
125. Merianos JJ: Quaternary ammonium antimicrobial compounds; in Block SS (ed): Disinfection, Sterilization and Preservation. Philadelphia, Lea & Febiger, 1991, pp 225-255.
126. Smith RN, Anderson RN, Kolenbrander PE: Inhibition of intergeneric coaggregation among oral bacteria by cetylpyridinium chloride, chlorhexidine digluconate and octenidine dihydrochloride. J Periodontal Res 1991; 26: 422-428.
127. Bonesvoll P, Gjermo P: A comparision between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque-inhibiting effect in the human mouth after mouth rinses. Arch Oral Biol 1978; 23: 289-294.
128. Roberts WR, Addy M: Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. J Clin Periodontol 1981; 8: 295-310.
129. Brecx MC, Macdonald LL, Legary K, Cheang M, Forgay MG: Long-term effects of Meridol and chlorhexidine mouthrinses on plaque, gingivitis, staining, and bacterial vitality. J Dent Res 1993; 72: 1194-1197.
130. Paraskevas S, Timmerman MF, Van der Velden U, van der Weijden GA: Additional effect of dentifrices on the instant efficacy of toothbrushing. J Periodontol 2006; 77: 1522-1527.
131. Mascarenhas AK, Allen CM, Moeschberger ML: The association between Viadent use and oral leukoplakia-results of a matched case-control study. J Public Health Dent 2002; 62: 158-162.
132. Rule KL, Ebbett VR, Vikesland PJ: Formation of chloroform and chlorinated organics by free-chlorinemediated oxidation of triclosan. Environ Sci Technol 2005; 39: 3176-3185.
133. Beaudouin E, Kanny G, Morisset M, Renaudin JM, Mertes M, Laxenaire MC, et al: Immediate hypersensitivity to chlorhexidine: literature review. Allerg Immunol (Paris) 2004; 36: 123-126.
134. Aursnes J: Ototoxic effect of iodine disinfectants. Acta Otolaryngol 1982; 93: 219-226.
135. Breslin PA, Tharp CD: Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses 2001; 26: 105-116.
136. Marinone MG, Savoldi E: Chlorhexidine and taste. Influence of mouthwashes concentration and of rinsing time. Minerva Stomatol 2000; 49: 221-226.
137. Flotra L, Gjermo P, Rolla G, Waerhaug J: Side effects of chlorhexidine mouth washes. Scand J Dent Res 1971; 79: 119-125.
138. van der Weijden GA, Ten Heggeler JM, Slot DE, Rosema NA, Van der Velden U: Parotid gland swelling following mouthrinse use. Int J Dent Hyg 2010; 8: 276-279.
139. Almqvist H, Luthman J: Gingival and mucosal reactions after intensive chlorhexidine gel treatment with or without oral hygiene measures. Scand J Dent Res 1988; 96: 557-560.
140. Sanz M, Newman MG, Anderson L, Matoska W, Otomo-Corgel J, Saltini C: Clinical enhancement of postperiodontal surgical therapy by a 0.12 chlorhexidine gluconate mouthrinse. J Periodontol 1989; 60: 570-576.
141. Schiott CR, Briner WW, Kirkland JJ, Loe H: Two years oral use of chlorhexidine in man. III. Changes in sensitivity of the salivary flora. J Periodontal Res 1976; 11: 153-157.
142. Schiott CR, Briner WW, Loe H: Two year oral use of chlorhexidine in man. II. The effect on the salivary bacterial flora. J Periodontal Res 1976; 11: 145-152.
143. Lobene RR, Kashket S, Soparkar PM: The effect of cetylpyridinium chloride on human plaque bacteria and gingivitis. Pharmacol Therapeut Dent 1979; 4: 33-47.
144. Ciancio SG, Mather ML, Bunnell HL: Clinical evaluation of a quaternary ammonium-containing mouthrinse. J Periodontol 1975; 46: 397-401.
145. Barkvoll P, Rolla G, Bellagamba S: Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro. Scand J Dent Res 1988; 96: 30-33.
146. Sheen S, Owens J, Addy M: The effect of toothpaste on the propensity of chlorhexidine and cetyl pyridinium chloride to produce staining in vitro: a possible predictor of inactivation. J Clin Periodontol 2001; 28: 46-51.
147. Ogaard B, Alm AA, Larsson E, Adolfsson U: A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients. Eur J Orthod 2006; 28: 8-12.
148. Bruhn G, Netuschil L, Richter S, Brecx MC, Hoffmann T: Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing-an investigation in periodontitis patients over 28 weeks. Clin Oral Investig 2002; 6: 124-127.
149. Rosling B, Dahlen G, Volpe AR, Furuichi Y, Ramberg P, Lindhe J: Effect of triclosan on the subgingival microbiota of periodontitis-susceptible subjects. J Clin Periodontol 1997; 24: 881-887.
150. Rosling B, Wannfors B, Volpe AR, Furuichi Y, Ramberg P, Lindhe J: The use of a triclosan/copolymer dentifrice may retard the progression of periodontitis. J Clin Periodontol 1997; 24: 873-880.
151. Ciancio SG, Lauciello F, Shibly O, Vitello M, Mather M: The effect of an antiseptic mouthrinse on implant maintenance: plaque and peri-implant gingival tissues. J Periodontol 1995; 66: 962-965.
152. Di Carlo F, Quaranta A, Di AL, Ronconi LF, Quaranta M, Piattelli A: Influence of amine fluoride/stannous fluoride mouthwashes with and without chlorhexidine on secretion of proinflammatory molecules by peri-implant crevicular fluid cells. Minerva Stomatol 2008; 57: 215-221, 221-225.
153. Sreenivasan PK, Vered Y, Zini A, Mann J, Kolog H, Steinberg D, et al: A 6-month study of the effects of 0.3 triclosan/copolymer dentifrice on dental implants. J Clin Periodontol 2011; 38: 33-42.
154. Panagakos FS, Volpe AR, Petrone ME, DeVizio W, Davies RM, Proskin HM: Advanced oral antibacterial/anti-inflammatory technology: a comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice. J Clin Dent 2005; 16(suppl): S1-S19.
155. Mann J, Vered Y, Babayof I, Sintes J, Petrone ME, Volpe AR, et al: The comparative anticaries efficacy of a dentifrice containing 0.3 triclosan and 2.0 copolymer in a 0.243 sodium fluoride/silica base and a dentifrice containing 0.243 sodium fluoride/silica base: a two-year coronal caries clinical trial on adults in Israel. J Clin Dent 2001; 12: 71-76.
156. Paraskevas S, Danser MM, Timmerman MF, van der Velden U, Van der Weijden GA: Amine fluoride/stannous fluoride and incidence of root caries in periodontal maintenance patients. A 2 year evaluation. J Clin Periodontol 2004; 31: 965-971.
157. Tinanoff N, Hock J, Camosci D, Hellden L: Effect of stannous fluoride mouthrinse on dental plaque formation. J Clin Periodontol 1980; 7: 232-241.
158. Shaw WC, Addy M, Griffiths S, Price C: Chlorhexidine and traumatic ulcers in orthodontic patients. Eur J Orthod 1984; 6: 137-140.
159. Skaare A, Herlofson BB, Barkvoll P: Mouthrinses containing triclosan reduce the incidence of recurrent aphthous ulcers. J Clin Periodontol 1996; 23: 778-781.
160. Hu D, Zhang YP, Petrone M, Volpe AR, DeVizio W, Giniger M: Clinical effectiveness of a triclosan/copolymer/sodium fluoride dentifrice in controlling oral malodor: a 3-week clinical trial. Oral Dis 2005; 11(suppl 1):51-53.
161. Niles HP, Hunter CM, Vazquez J, Williams MI, Cummins D: Clinical comparison of Colgate Total Advanced Fresh vs a commercially available fluoride breath-freshening toothpaste in reducing breath odor overnight: a multiple-use study. Compend Contin Educ Dent 2003; 24(suppl 9):29-33.
162. Sharma NC, Galustians HJ, Qaquish J, Galustians A, Rustogi KN, Petrone ME, et al: The clinical effectiveness of a dentifrice containing triclosan and a copolymer for controlling breath odor measured organoleptically twelve hours after toothbrushing. J Clin Dent 1999; 10: 131-134.
163. van Steenberghe D: Breath malodor. Curr Opin Periodontol 1997; 4: 137-143.
164. Roldán S, Herrera D, Santacruz I, O'Connor A, Gonzalez I, Sanz M: Comparative effects of different chlorhexidine mouth-rinse formulations on
165. Roldán S, Winkel EG, Herrera D, Sanz M, van Winkelhoff AJ: The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study. J Clin Periodontol 2003; 30: 427-434.
166. Winkel EG, Roldán S, van Winkelhoff AJ, Herrera D, Sanz M: Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinclactate on oral halitosis. A dual-center, double-blind placebo-controlled study. J Clin Periodontol 2003; 30: 300-306.
167. Roldán S, Herrera D, Sanz M: Biofilms and the tongue: therapeutical approaches for the control of halitosis. Clin Oral Investig 2003; 7: 189-197.
168. Davies R, Scully C, Preston AJ: Dentifrices-an update. Med Oral Patol Oral Cir Bucal 2010; 15:e976-e982.