-
1
-
-
0023506466
-
Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer's disease
-
Goldgaber D, Lerman MI, McBride WO, Saffiotti U, Gajdusek DC. Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer's disease. J Neural Transm Suppl 1987;24:23-28.
-
(1987)
J Neural Transm Suppl
, vol.24
, pp. 23-28
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, W.O.3
Saffiotti, U.4
Gajdusek, D.C.5
-
2
-
-
0023107655
-
Chromosome 21q21 sublocalisation of gene encoding β-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome
-
Robakis N, Wisniewski HM, Jenkins EC, et al. Chromosome 21q21 sublocalisation of gene encoding β-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome. Lancet 1987;1:384-385.
-
(1987)
Lancet
, vol.1
, pp. 384-385
-
-
Robakis, N.1
Wisniewski, H.M.2
Jenkins, E.C.3
-
3
-
-
0023109592
-
Amyloid beta protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 1987;235: 880-884.
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
-
4
-
-
0024093904
-
Expression of the Alzheimer amyloid precursor gene transcripts in the human brain
-
Neve RL, Finch EA, Dawes LR. Expression of the Alzheimer amyloid precursor gene transcripts in the human brain. Neuron 1988;1:669-677.
-
(1988)
Neuron
, vol.1
, pp. 669-677
-
-
Neve, R.L.1
Finch, E.A.2
Dawes, L.R.3
-
5
-
-
0027519407
-
Regulation and expression of Alzheimer's beta/A4 amyloid protein precursor in health disease and Down's syndrome
-
Beyreuther K, Pollwein P, Multhaup G, et al. Regulation and expression of Alzheimer's beta/A4 amyloid protein precursor in health disease and Down's syndrome. Ann NY Acad Sci 1993;695:91-102.
-
(1993)
Ann NY Acad Sci
, vol.695
, pp. 91-102
-
-
Beyreuther, K.1
Pollwein, P.2
Multhaup, G.3
-
6
-
-
0036370776
-
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
-
Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med 2002;1:1-31.
-
(2002)
Neuromolecular Med
, vol.1
, pp. 1-31
-
-
Sambamurti, K.1
Greig, N.H.2
Lahiri, D.K.3
-
7
-
-
29444442794
-
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
-
Rovelet-Lecrux A, Hannequin D, Raux G, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 2006;38:24-26.
-
(2006)
Nat Genet
, vol.38
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
-
8
-
-
33750579333
-
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
-
Sleegers K, Brouwers N, Gijselinck I, et al. APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy. Brain 2006;129:2977-2983.
-
(2006)
Brain
, vol.129
, pp. 2977-2983
-
-
Sleegers, K.1
Brouwers, N.2
Gijselinck, I.3
-
9
-
-
80051726275
-
The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease
-
Zhou ZD, Chan CH, Ma QH, Xu XH, Xiao ZC, Tan EK. The roles of amyloid precursor protein (APP) in neurogenesis: implications to pathogenesis and therapy of Alzheimer disease. Cell Adh Migr 2011;5:280-292.
-
(2011)
Cell Adh Migr
, vol.5
, pp. 280-292
-
-
Zhou, Z.D.1
Chan, C.H.2
Ma, Q.H.3
Xu, X.H.4
Xiao, Z.C.5
Tan, E.K.6
-
10
-
-
0021956826
-
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
-
Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985;17:278-282.
-
(1985)
Ann Neurol
, vol.17
, pp. 278-282
-
-
Wisniewski, K.E.1
Wisniewski, H.M.2
Wen, G.Y.3
-
11
-
-
0023729624
-
Alzheimer's disease and Down's syndrome
-
Mann DM. Alzheimer's disease and Down's syndrome. Histopathology 1988;13:125-137.
-
(1988)
Histopathology
, vol.13
, pp. 125-137
-
-
Mann, D.M.1
-
12
-
-
0024343222
-
Cerebral amyloidosis, ageing and Alzheimer's disease: A contribution from studies on Down's syndrome
-
discussion 412-414
-
Mann DM. Cerebral amyloidosis, ageing and Alzheimer's disease: A contribution from studies on Down's syndrome. Neurobiol Aging 1989;10:397-399; discussion 412-414.
-
(1989)
Neurobiol Aging
, vol.10
, pp. 397-399
-
-
Mann, D.M.1
-
13
-
-
17544399111
-
Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: A regional quantitative analysis
-
Leverenz JB, Raskind MA. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: A regional quantitative analysis. Exp Neruol 1998;150:296-304.
-
(1998)
Exp Neruol
, vol.150
, pp. 296-304
-
-
Leverenz, J.B.1
Raskind, M.A.2
-
14
-
-
0031039294
-
Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome
-
Visser FE, Aldenkamp AP, van Huffelen AC, Kuilman M, Overweg J, van Wijk J. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. Am J Ment Retard 1997;101:400-412.
-
(1997)
Am J Ment Retard
, vol.101
, pp. 400-412
-
-
Visser, F.E.1
Aldenkamp, A.P.2
Van Huffelen, A.C.3
Kuilman, M.4
Overweg, J.5
Van Wijk, J.6
-
15
-
-
0024370171
-
A prospective study of Alzheimer disease and Down syndrome
-
Lai F, Williams RS. A prospective study of Alzheimer disease and Down syndrome. Arch Neurol 1989;46:849-853.
-
(1989)
Arch Neurol
, vol.46
, pp. 849-853
-
-
Lai, F.1
Williams, R.S.2
-
16
-
-
79960193987
-
Using positron emission tomography and carbon 11-labeled Pittsburg compound B to image brain fibrillar b-amyloid in adults with Down syndrome
-
Landt J, D'Abrera C, Holland AJ, et al. Using positron emission tomography and carbon 11-labeled Pittsburg compound B to image brain fibrillar b-amyloid in adults with Down syndrome. Arch Neurol 2011;68:890-896.
-
(2011)
Arch Neurol
, vol.68
, pp. 890-896
-
-
Landt, J.1
D'Abrera, C.2
Holland, A.J.3
-
17
-
-
84867893925
-
Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B
-
Handen BL, Cohen AD, Channamalappa U, et al. Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B. Alzheimers Dement 2012;8:496-501.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 496-501
-
-
Handen, B.L.1
Cohen, A.D.2
Channamalappa, U.3
-
18
-
-
81355154155
-
Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with Down syndrome and Alzheimer disease
-
Sabbagh MN, Fleisher A, Chen K, et al. Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with Down syndrome and Alzheimer disease. Arch Neurol 2011;68:1461-1466.
-
(2011)
Arch Neurol
, vol.68
, pp. 1461-1466
-
-
Sabbagh, M.N.1
Fleisher, A.2
Chen, K.3
-
19
-
-
80055040100
-
Florbetaben to trace amyloid-b in the Alzheimer brain by means of PET
-
Barthel H, Sabri O. Florbetaben to trace amyloid-b in the Alzheimer brain by means of PET. J Alzheimers Dis 2011; 26:117-121.
-
(2011)
J Alzheimers Dis
, vol.26
, pp. 117-121
-
-
Barthel, H.1
Sabri, O.2
-
20
-
-
84869021291
-
Development of positron emission tomography b-amyloid plaque imaging agents
-
Mathis CA, Mason NS, Lopresti BJ, Klunk WE. Development of positron emission tomography b-amyloid plaque imaging agents. Semin Nucl Med 2012;42:423-432.
-
(2012)
Semin Nucl Med
, vol.42
, pp. 423-432
-
-
Mathis, C.A.1
Mason, N.S.2
Lopresti, B.J.3
Klunk, W.E.4
-
21
-
-
84862686384
-
Comparison of 11C-PiB and 18F-florbetaben for Ab imaging in ageing and Alzheimer's disease
-
Villemagne VL, Mulligan RS, Pejoska S, et al. Comparison of 11C-PiB and 18F-florbetaben for Ab imaging in ageing and Alzheimer's disease. Eur J Nucl Med Mol Imaging 2012;39:983-989.
-
(2012)
Eur J Nucl Med Mol Imaging
, vol.39
, pp. 983-989
-
-
Villemagne, V.L.1
Mulligan, R.S.2
Pejoska, S.3
-
22
-
-
38149081191
-
Imaging of amyloid b in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
-
Rowe CC, Ackerman U, Browne W, et al. Imaging of amyloid b in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008;7:129-135.
-
(2008)
Lancet Neurol
, vol.7
, pp. 129-135
-
-
Rowe, C.C.1
Ackerman, U.2
Browne, W.3
-
23
-
-
77953023001
-
Proof of mechanism study to detect cerebral beta-amyloid plaques in patients with Alzheimer's disease (AD) using BAY 94- 9172 and PET
-
Barthel H, Patt M, Hammerstein E, et al. Proof of mechanism study to detect cerebral beta-amyloid plaques in patients with Alzheimer's disease (AD) using BAY 94- 9172 and PET. J Nucl Med 2008;49:33.
-
(2008)
J Nucl Med
, vol.49
, pp. 33
-
-
Barthel, H.1
Patt, M.2
Hammerstein, E.3
-
24
-
-
80455174804
-
Individualized quantification of brain b-amyloid burden: Results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
-
Barthel H, Luthardt J, Becker G, et al. Individualized quantification of brain b-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls. Eur J Nucl Med Mol Imaging 2011;38:1702-1714.
-
(2011)
Eur J Nucl Med Mol Imaging
, vol.38
, pp. 1702-1714
-
-
Barthel, H.1
Luthardt, J.2
Becker, G.3
-
25
-
-
84863880089
-
Impact of betaamyloid specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease
-
Schipke CG, Peters O, Heuser I, et al. Impact of betaamyloid specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease. Dement Geriatr Cogn Disord 2012;33:416-422.
-
(2012)
Dement Geriatr Cogn Disord
, vol.33
, pp. 416-422
-
-
Schipke, C.G.1
Peters, O.2
Heuser, I.3
-
26
-
-
84877106494
-
PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains
-
Becker GA, Ichise M, Barthel H, et al. PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains. J Nucl Med 2013;54:723-731.
-
(2013)
J Nucl Med
, vol.54
, pp. 723-731
-
-
Becker, G.A.1
Ichise, M.2
Barthel, H.3
-
27
-
-
34248159588
-
Dementia screening questionnaire for individuals with intellectual disabilities
-
Deb S, Hare M, Prior L, Bhaumik S. Dementia screening questionnaire for individuals with intellectual disabilities. Br J Psychiatry 2007;190:440-444.
-
(2007)
Br J Psychiatry
, vol.190
, pp. 440-444
-
-
Deb, S.1
Hare, M.2
Prior, L.3
Bhaumik, S.4
-
28
-
-
0036322886
-
Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain
-
Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002;5:273-289.
-
(2002)
Neuroimage
, vol.5
, pp. 273-289
-
-
Tzourio-Mazoyer, N.1
Landeau, B.2
Papathanassiou, D.3
-
29
-
-
79954748692
-
Cerebral amyloid-b PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multi-centre phase 2 diagnostic study
-
Barthel H, Gertz HJ, Dresel S, et al. Cerebral amyloid-b PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: A multi-centre phase 2 diagnostic study. Lancet Neurol 2011;10:424-435.
-
(2011)
Lancet Neurol
, vol.10
, pp. 424-435
-
-
Barthel, H.1
Gertz, H.J.2
Dresel, S.3
-
31
-
-
79958729432
-
Positron emission tomography of brain b-amyloid and t levels in adults with Down syndrome
-
Nelson LD, Siddarth P, Kepe V, et al. Positron emission tomography of brain b-amyloid and t levels in adults with Down syndrome. Arch Neurol 2011;68:768-774.
-
(2011)
Arch Neurol
, vol.68
, pp. 768-774
-
-
Nelson, L.D.1
Siddarth, P.2
Kepe, V.3
-
32
-
-
33645778041
-
Cell type-specific overexpression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
-
Li CM, Guo M, Salas M, et al. Cell type-specific overexpression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21. BMC Med Genet 2006;7:24.
-
(2006)
BMC Med Genet
, vol.7
, pp. 24
-
-
Li, C.M.1
Guo, M.2
Salas, M.3
-
33
-
-
0028055038
-
Down's syndrome: Up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination
-
Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, Ihara Y. Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. J Neurochem 1994;62:1062-1066.
-
(1994)
J Neurochem
, vol.62
, pp. 1062-1066
-
-
Oyama, F.1
Cairns, N.J.2
Shimada, H.3
Oyama, R.4
Titani, K.5
Ihara, Y.6
-
34
-
-
84875250937
-
Amyloid b deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
-
Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
-
Villemagne VL, Burnham S, Bourgeat P, et al; Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group. Amyloid b deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. Lancet Neurol 2013;12: 357-367.
-
(2013)
Lancet Neurol
, vol.12
, pp. 357-367
-
-
Villemagne, V.L.1
Burnham, S.2
Bourgeat, P.3
-
35
-
-
59249096066
-
Radiation dosimetry of b-amyloid tracers 11C-PiB and 18F-BAY94-9172
-
O'Keefe GJ, Saunder TH, Ng S, et al. Radiation dosimetry of b-amyloid tracers 11C-PiB and 18F-BAY94-9172. J Nucl Med 2009;50:309-315.
-
(2009)
J Nucl Med
, vol.50
, pp. 309-315
-
-
O'Keefe, G.J.1
Saunder, T.H.2
Ng, S.3
-
36
-
-
0035113305
-
Review of the next generation of Alzheimer's disease therapeutics: Challenges for drug development
-
Cutler NR, Sramek JJ. Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:27-57.
-
(2001)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.25
, pp. 27-57
-
-
Cutler, N.R.1
Sramek, J.J.2
-
37
-
-
84895734354
-
Advances in the prevention of Alzheimer's disease
-
Solomon A, Mangialasche F, Richard E, et al. Advances in the prevention of Alzheimer's disease. J Int Med 2014; 275:229-250.
-
(2014)
J Int Med
, vol.275
, pp. 229-250
-
-
Solomon, A.1
Mangialasche, F.2
Richard, E.3
-
38
-
-
84895729926
-
Amyloid-b-directed immunotherapy for Alzheimer's disease
-
Lannfelt L, Relkin NR, Siemers ER. Amyloid-b-directed immunotherapy for Alzheimer's disease. J Intern Med 2014;27:284-295.
-
(2014)
J Intern Med
, vol.27
, pp. 284-295
-
-
Lannfelt, L.1
Relkin, N.R.2
Siemers, E.R.3
|