메뉴 건너뛰기




Volumn 37, Issue 2, 2015, Pages 141-146

Improved investigations in drug safety by more in-depth individual pharmacokinetics using high-resolution mass spectrometry

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; TAMOXIFEN; DRUG;

EID: 84925843301     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0000000000000129     Document Type: Article
Times cited : (2)

References (19)
  • 1
    • 84898027570 scopus 로고    scopus 로고
    • Quantitative monitoring of tamoxifen in human plasma extended to forty metabolites using liquid-chromatography-high resolution-mass spectrometry: New investigation capabilities for clinical pharmacology
    • Dahmane E, Boccard J, Csajka C, et al. Quantitative monitoring of tamoxifen in human plasma extended to forty metabolites using liquid-chromatography-high resolution-mass spectrometry: new investigation capabilities for clinical pharmacology. Anal Bioanal Chem. 2014;406:2627-2640.
    • (2014) Anal Bioanal Chem. , vol.406 , pp. 2627-2640
    • Dahmane, E.1    Boccard, J.2    Csajka, C.3
  • 2
    • 84865018531 scopus 로고    scopus 로고
    • Quantitative/qualitative analysis using LC-HRMS: The fundamental step forward for clinical laboratories and clinical practice
    • Rochat B. Quantitative/qualitative analysis using LC-HRMS: the fundamental step forward for clinical laboratories and clinical practice. Bioanalysis. 2012;4:1709-1711.
    • (2012) Bioanalysis. , vol.4 , pp. 1709-1711
    • Rochat, B.1
  • 3
    • 77954145052 scopus 로고    scopus 로고
    • Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry) "where is the crossover point?"
    • Kaufmann A, Butcher P, Maden K, et al. Comprehensive comparison of liquid chromatography selectivity as provided by two types of liquid chromatography detectors (high resolution mass spectrometry and tandem mass spectrometry) "where is the crossover point?" Anal Chim Acta. 2010;673:60-72.
    • (2010) Anal Chim Acta. , vol.673 , pp. 60-72
    • Kaufmann, A.1    Butcher, P.2    Maden, K.3
  • 4
    • 84858377475 scopus 로고    scopus 로고
    • The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena
    • Ramanathan R, Korfmacher W. The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena. Bioanalysis. 2012;4:467-469.
    • (2012) Bioanalysis. , vol.4 , pp. 467-469
    • Ramanathan, R.1    Korfmacher, W.2
  • 5
    • 84856756316 scopus 로고    scopus 로고
    • Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs
    • Henry H, Sobhi HR, Scheibner O, et al. Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs. Rapid Commun Mass Spectrom. 2012;26:499-509.
    • (2012) Rapid Commun Mass Spectrom. , vol.26 , pp. 499-509
    • Henry, H.1    Sobhi, H.R.2    Scheibner, O.3
  • 6
    • 84871318641 scopus 로고    scopus 로고
    • The future key role of LC-high-resolution-MS analyses in clinical laboratories: A focus on quantification
    • Rochat B, Kottelat E, McMullen J. The future key role of LC-high-resolution-MS analyses in clinical laboratories: a focus on quantification. Bioanalysis. 2012;4:2939-2958.
    • (2012) Bioanalysis. , vol.4 , pp. 2939-2958
    • Rochat, B.1    Kottelat, E.2    McMullen, J.3
  • 7
    • 46749141730 scopus 로고    scopus 로고
    • Imatinib metabolite profiling in parallel to imatinib quantification in plasma of treated patients using liquid chromatography-mass spectrometry
    • Rochat B, Fayet F, Widmer N, et al. Imatinib metabolite profiling in parallel to imatinib quantification in plasma of treated patients using liquid chromatography-mass spectrometry. J Mass Spectrom. 2008;43:736-752.
    • (2008) J Mass Spectrom. , vol.43 , pp. 736-752
    • Rochat, B.1    Fayet, F.2    Widmer, N.3
  • 8
    • 84865841672 scopus 로고    scopus 로고
    • Monitoring medicines use: The role of the clinical pharmacologist
    • Williams D. Monitoring medicines use: the role of the clinical pharmacologist. Br J Clin Pharmacol. 2012;74:685-690.
    • (2012) Br J Clin Pharmacol. , vol.74 , pp. 685-690
    • Williams, D.1
  • 9
    • 84925869425 scopus 로고    scopus 로고
    • Accessed June 8, 2014
    • Food and Drug Administration. Available at: http://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm110632.htm. Accessed June 8, 2014.
  • 11
    • 79952771693 scopus 로고    scopus 로고
    • Mechanisms of drug toxicity and relevance to pharmaceutical development
    • Guengerich FP. Mechanisms of drug toxicity and relevance to pharmaceutical development. Drug Metab Pharmacokinet. 2011;26:3-14.
    • (2011) Drug Metab Pharmacokinet. , vol.26 , pp. 3-14
    • Guengerich, F.P.1
  • 12
    • 79960120779 scopus 로고    scopus 로고
    • Mechanisms of drug toxicity or intolerance
    • Egan LJ. Mechanisms of drug toxicity or intolerance. Dig Dis. 2011;29:172-176.
    • (2011) Dig Dis. , vol.29 , pp. 172-176
    • Egan, L.J.1
  • 13
    • 53549097600 scopus 로고    scopus 로고
    • Food and Drug Administration. Accessed June 8, 2014
    • Food and Drug Administration. Guidance for Industry: Safety Testing of Drug Metabolites. Available at: http://www.fda.gov/downloads/Drugs/Guidance ComplianceRegulatory Information/Guidances/ucm079266.pdf Accessed June 8, 2014.
    • Guidance for Industry: Safety Testing of Drug Metabolites
  • 15
    • 79957961908 scopus 로고    scopus 로고
    • Addressing MIST (Metabolites in Safety Testing): Bioanalytical approaches to address metabolite exposures in humans and animals
    • Gao H, Obach RS. Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals. Curr Drug Metab. 2011; 12:578-586.
    • (2011) Curr Drug Metab. , vol.12 , pp. 578-586
    • Gao, H.1    Obach, R.S.2
  • 16
    • 1642451400 scopus 로고    scopus 로고
    • Accessed June 8, 2014
    • World Health Organization. The Importance of Pharmacovigilance. Available at: http://apps.who.int/medicinedocs/pdf/s4893e/s4893e. pdf. Accessed June 8, 2014.
    • The Importance of Pharmacovigilance
  • 17
    • 84925842494 scopus 로고    scopus 로고
    • Food and Drug Administration Accessed June 8, 2014 Accessed June 8, 2014.
    • Food and Drug Administration. Available at: http://www.fda.gov/Drugs/GuidanceCompliance RegulatoryInformation/Surveillance/Adverse DrugEffects/default.htm
  • 19
    • 33344462585 scopus 로고    scopus 로고
    • Minimising the potential for metabolic activation in drug discovery
    • Kalgutkar AS, Soglia JR. Minimising the potential for metabolic activation in drug discovery. Expert Opin Drug Metab Toxicol. 2005;1:91-142.
    • (2005) Expert Opin Drug Metab Toxicol. , vol.1 , pp. 91-142
    • Kalgutkar, A.S.1    Soglia, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.