Licochalcone A, a polyphenol present in licorice, suppresses UV-induced COX-2 expression by targeting PI3K, MEK1, and B-Raf

International Journal of Molecular Sciences

Volumn 16, Issue 3, 2015, Pages 4453-4470

  Song, Nu Ry ^a,b   Kim, Jong Eun ^a,b   Park, Jun Seong ^c   Kim, Jong Rhan ^a,b   Kang, Heerim ^a,b   Lee, Eunjung ^a,b,d   Kang, Young Gyu ^c   Son, Joe Eun ^a,b   Seo, Sang Gwon ^a,b   Heo, Yong Seok ^e   Lee, Ki Won ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Amorepacific RandD Center   (South Korea)

^d Korea Food Research Institute   (South Korea)

^e Konkuk University   (South Korea)

Author keywords

B Raf; Cyclooxygenase 2; Licochalcone A; MEK1; PI3K; Solar ultraviolet

Indexed keywords

B RAF KINASE; CYCLOOXYGENASE 2; LICOCHALCONE A; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; S6 KINASE; ADENOSINE TRIPHOSPHATE; BRAF PROTEIN, HUMAN; CHALCONE DERIVATIVE; GLYCYRRHIZIC ACID; MAP2K1 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME IMMUNOASSAY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR MODEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION; WESTERN BLOTTING; BINDING COMPETITION; BIOSYNTHESIS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GLYCYRRHIZA; KERATINOCYTE; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; RADIATION RESPONSE;

GLYCYRRHIZA; MAMMALIA;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELLS, CULTURED; CHALCONES; CYCLOOXYGENASE 2; DINOPROSTONE; GENE EXPRESSION; GLYCYRRHIZA; GLYCYRRHIZIC ACID; HUMANS; KERATINOCYTES; MAP KINASE KINASE 1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS B-RAF; ULTRAVIOLET RAYS;

EID: 84925842347     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16034453     Document Type: Article

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