Identification and determination of the major constituents in traditional Chinese medicine Longdan Xiegan Pill by HPLC-DAD-ESI-MS

Journal of Pharmaceutical Analysis

Volumn 1, Issue 1, 2011, Pages 1-7

  Liu, Hui ^a   Su, Juan ^a   Liang, Xu ^a   Zhang, Xi ^a   He, Ya Jun ^b   Huang, Hai Qiang ^a   Ye, Ji ^a   Zhang, Wei Dong ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Aristolochic acid A; Hierarchical cluster analysis; High performance liquid chromatography diode array detector coupled with an electrospray tandem mass spectrometer (HPLC DAD ESI MS); Longdan Xiegan Pill; Qualitative evaluation

Indexed keywords

ARISTOLOCHIC ACID; BAICALEIN; BAICALIN; CROCIN; FORMIC ACID; GENIPOSIDE; GENIPOSIDIC ACID; GENTIOPICRIN; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; LIQUIRITIN; LONGDAN XIEGAN PILL; OROXYLIN A; UNCLASSIFIED DRUG; WOGONIN; WOGONOSIDE;

ACCURACY; ARTICLE; CHINESE MEDICINE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; PRESCRIPTION; QUALITY CONTROL;

EID: 84925835420     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-1779(11)70001-6     Document Type: Article

References (22)

1. The Pharmacopeia Commission of P. R. China. Pharmacopeia of the People's Republic of China. Version 2005, Vol. 1, Chemical Industry Press, Beijing, China, 2005:416.
2. Hu LH, Chen XG, Kong L, et al. Improved performance of comprehensive two-dimensional HPLC separation of traditional Chinese medicines by using a silica monolithic column and normalization of peak heights. J Chromatogr A, 2005, 1092(1-2):191-198. (Pubitemid 41393927)
3. Koo HJ, Lee S, Shin KH, et al. Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med, 2004, 70(5):467-469. (Pubitemid 38716483)
4. Koo HJ, Lim KH, Jung HJ, et al. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol, 2006, 103(3):496-500.
5. Kumarasamy Y, Nahar L, Sarker SD. Bioactivity of gentiopicroside from the aerial parts of Centaurium erythraea. Fitoterapia, 2003, 74(1-2):151-154. (Pubitemid 36287264)
6. Li ZM. Noticing the renal damage of the traditional medicine with arisochic acid. Drug Eval, 2005, 2(2):142-143. (in Chinese)
7. Yang FY, Wei CY. Clinical pathological study for 36 cases of aristolochic acid nephropathy. China Clin Prac Med, 2008, 2 (11):22-24. (in Chinese)
8. Sun Y, Zhao H. Clinical study for 66 cases of aristolochic acid nephropathy. Chin J Gen Pract, 2008, 7(8):568-569. (In Chinese)
9. Zhang N, Xie M. The nephrotoxicity in rats caused by Longdan Xiegan decoction. Zhongguo Thong Yao Za Zhi, 2006, 31 (10):836-839. (in Chinese)
10. Liu MC, Maruyama S, Mizuno M, et al. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Clin Exp Nephrolo, 2003, 7(3):186-194. (Pubitemid 37229250)
11. Martena MJ, van der Wielen JCA, van de Laak LFJ, et al. Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market. Anal Biolanal Chem, 2007, 389(1):263-275. (Pubitemid 47325230)
12. Xue X, Xiao Y, Gong LK, et al. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb. ) koidz., Akebia quinata (Thunb. ) Decne. and Caulis aristolochiae manshuriensis in mice. J Ethnopharmacol, 2008, 119(1):87-93.
13. Vanherweghem JL, Tielemans C, Abramowicz D, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet, 1993, 341(8842):387-391.
14. Li CR, Zhou LM, Lin G, et al. Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix Scutellariae. J Pharm Biomed Anal, 2009, 50(3):298-306.
15. Yin LH, Lu BN, Qi Y, et al. Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control. J Pharm Biomed Anal, 2009, 49(4):1101-1108.
16. Ding L, Luo XB, Tang F, et al. Quality control of medicinal herbs Fructus gardeniae, Common Andrographis Herb and their preparations for their active constituents by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. Talanta , 2008, 74(5):1344-1349.
17. Wang XJ, Sun WJ, Sun H, et al. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS. J Pharm Biomed Anal, 2008, 46(3):477-490.
18. Wang Y, Kong L, Hu LH, et al. Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. J Chromatogr B, 2007, 860(2):185-194. (Pubitemid 350181633)
19. Jong TT, Lee MR, Chiang YC, et al. Using LC/MS/MS to determine matrine, oxymatrine, ferulic acid, mangiferin, and glycyrrhizin in the Chinese medicinal preparations Shiau-feng-saan and Dang-guei-nian-tong-tang. J Pharm Biomed Anal, 2006, 40(2):472-477.
20. n. J Pharm Biomed Anal, 2007, 44(2):430-438. (Pubitemid 46880096)
21. Wang Y, Kong L, Lei XY, et al. Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction. J Chromatogr A, 2009, 1216(11):2185-2191.
22. Chan SA, Chen MJ, Liu TY, et al. Determination of aristolochic acids in medicinal plant and herbal product by liquid chromatography-electrospmyion trap mass spectrometry. Talanta, 2003, 60(4):679-685.