Adjunctive treatment with quetiapine for major depressive disorder: Are the benefits of treatment worth the risks?

BMJ (Online)

Volumn 350, Issue , 2015, Pages

  Pringsheim, Tamara ^a   Gardner, David ^b   Patten, Scott B ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LITHIUM; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NEUROLEPTIC AGENT; PLACEBO; QUETIAPINE; SEROTONIN UPTAKE INHIBITOR; TRIACYLGLYCEROL; DIBENZOTHIAZEPINE DERIVATIVE;

ADD ON THERAPY; ADJUVANT THERAPY; ARTICLE; BODY WEIGHT DISORDER; CHOLESTEROL BLOOD LEVEL; COGNITIVE THERAPY; DRUG EFFICACY; DRUG PREFERENCE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EXTRAPYRAMIDAL SYMPTOM; HAMILTON DEPRESSION RATING SCALE; HUMAN; HYPERGLYCEMIA; MAJOR DEPRESSION; MONOTHERAPY; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NUMBERS NEEDED TO TREAT; PREVALENCE; PRIORITY JOURNAL; PSYCHOTHERAPY; RELAPSE; REMISSION; SEDATION; THYROID DISEASE; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN; CHEMICALLY INDUCED; DEPRESSIVE DISORDER, MAJOR; DRUG COMBINATION; DYSLIPIDEMIA; RISK ASSESSMENT; TREATMENT OUTCOME;

ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; DEPRESSIVE DISORDER, MAJOR; DIBENZOTHIAZEPINES; DRUG THERAPY, COMBINATION; DYSLIPIDEMIAS; HUMANS; HYPERGLYCEMIA; RISK ASSESSMENT; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 84925763766     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.h569     Document Type: Article

References (25)

1. Spielmans GI, Berman MI, Linardatos E, Rosenlicht NZ, Perry A, Tsai AC. Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life and safety outcomes. PLoS Med 2013;10:e1001403.
2. Gerhard T, Akincigil A, Correll CU, Foglio NJ, Crystal S, Olfson M. National trends in second-generation antipsychotic augmentation for nonpsychotic depression. J Clin Psychiatry 2014;75:490-7.
3. Olfson M, Marcus SC. National patterns in antidepressant medication treatment. Arch Gen Psychiatry 2009;66:848-56.
4. Pringsheim T, Gardner D. Dispensed prescriptions for quetiapine and other second generation antipsychotics in Canada from 2005 to 2012: a descriptive study. CMAJ Open 2014;2:E225-32..
5. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJL, et al. Burden of depressive disorders by country, sex, age and year: findings from the Global Burden of Disease Study 2010. PLoS Med 2013;10:e10001547.
6. ∗D report. Am J Psychiatry 2006;163:1905-17.
7. Quante A, Regen F, Schindler F, Volkmer K, Severus E, Urbanek C, et al. Quetiapine as combination treatment with citalopram in unipolar depression with prominent somatic symptoms: a randomised, double-blind, placebo-controlled pilot study. Psychiatr Danub 2013;25:214-20.
8. Komossa K, Depping AM, Gaudchau A, Kissling W, Leucht S. Second-generation antipsychotics for major depressive disorder and dysthymia. Cochrane Database Syst Rev 2010;12: CD008121.
9. Gardner D. Effect size illustrator. 2009. http://esi.medicine.dal.ca.
10. Bauer M, El-Khalili N, Datto C, Szamosi J, Eriksson H. A pooled analysis of two randomised, placebo-controlled studies of extended release quetiapine fumarate adjunctive to antidepressant therapy in patients with major depressive disorder. J Affect Disord 2010;127:19-30.
11. Bauer M, Dell'Osso L, Kasper S, Pitchot W, Dencker Vansvik E, Kohler J, et al. Extended-release quetiapine fumarate (quetiapine XR) monotherapy and quetiapine XR or lithum as add-on to antidepressants in patients with treatment-resistant major depressive disorder. J Affect Disord 2013;151:209-19.
12. McIntyre A, Gendron A, McIntyre A. Quetiapine adjunct to selective serotonin reuptake inhibitors or venlafaxine in patients with major depression, comorbid anxiety, and residual depressive symptoms: a randomized, placebo-controlled pilot study. Depress Anxiety 2007;24:487-94.
13. Liebowitz M, Lam RW, Lepola U, Datto C, Sweitzer D, Eriksson H. Efficacy and tolerabiity of extended release quetiapine fumarate monotherapy as maintenance treatment of major depressive disorder: a randomized placebo-controlled trial. Depress Anxiety 2010;27:964-76.
14. Pratt LA, Brody DJ. Depression and obesity in the U. S. adult household population, 2005-2010. 2014. www.cdc.gov/nchs/data/databriefs/db167.htm.
15. Fiedorowicz JG. Depression and cardiovascular disease: an update on how course of illness may influence risk. Curr Psychiatry Rep 2014;16:492.
16. General practice research database Seroquel XR safety study. 2014. clinicaltrials.gov/ct2/show/NCT01447082.
17. EMR data to assess monitoring of patients treated with quetiapine. 2014. clinicaltrials. gov/ct2/show/NCT01793324.
18. Efficacy of extended release quetiapine (Seroquel XR) as adjunctive therapy to cognitive behavioural therapy in the treatment of patients with comorbid major depression and generalized anxiety disorder. 2013. clinicaltrials.gov/ct2/show/NCT01971203.
19. National Institute for Health and Clinical Excellence. Depression in adults. NICE, 2009 (clinical guideline 90).
20. Connolly KR, Thase ME. If at first you don't succeed: a review of the evidence for antidepressant augmentation, combination and switching strategies. Drugs 2011;71:43-64.
21. Papakostas GI, Fava M, Thase ME. Treatment of SSRI-resistant depression: a meta-analysis comparing within-versus across-class switches. Biol Psychiatry 2008;63:699-704.
22. Aronson R, Offman HJ, Joffe RT. Triiodothyronine augmentation in the treatment of refractory depression: a meta-analysis. Arch Gen Psychiatry 1996;53:842-8.
23. Crossley NA, Bauer M. Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials. J Clin Psychiatry 2007;68:935-40.
24. Cuijpers P, Dekker J, Hollon SD, Andersson G. Adding psychotherapy to pharmacotherapy in the treatment of depressive disorders in adults: a meta-analysis. J Clin Psychiatry 2009;70:1219-29.
25. Gardner DM, Teehan MD. Antipsychotics and their side effects. Cambridge University Press, 2010.