The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis

Thrombosis Research

Volumn 135, Issue 3, 2015, Pages 537-543

  Schouten, Marcel ^a   Van 'T Veer, Cornelis ^a   Poulussen, Nadia ^a   Meijers, Joost C M ^a   Levi, Marcel ^a   Esmon, Charles T ^b   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

coagulation; inflammation; pneumonia; protein C; S. pneumoniae; sepsis

Indexed keywords

ACTIVATED PROTEIN C; CYTOKINE; D DIMER; INTERLEUKIN 6; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1591; MONOCLONAL ANTIBODY 1609; MONOCLONAL ANTIBODY 1716; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROCOAGULANT; THROMBIN ANTITHROMBIN COMPLEX; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; CRYOPROTECTIVE AGENT; PROTEIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BACTERIAL STRAIN; BLOOD CLOTTING; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; FIBRINOLYSIS; IN VITRO STUDY; IN VIVO STUDY; LUNG; MALE; MOUSE; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK REDUCTION; SEPSIS; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; ANIMAL; BLOOD; C57BL MOUSE; COMPLICATION; ENZYME ACTIVATION; ISOLATION AND PURIFICATION; METABOLISM; PNEUMONIA, PNEUMOCOCCAL;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CRYOPROTECTIVE AGENTS; ENZYME ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PNEUMONIA, PNEUMOCOCCAL; PROTEIN C; SEPSIS; STREPTOCOCCUS PNEUMONIAE;

EID: 84925723873     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.12.020     Document Type: Article

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