Clinical outcomes and microbiological characteristics of severe pneumonia in cancer patients: A prospective cohort study

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Rabello, Ligia S C F ^a   Silva, Jose R L ^a   Azevedo, Luciano C P ^b   Souza, Ivens ^b   Torres, Viviane B L ^a   Rosolem, Maíra M ^c   Lisboa, Thiago ^d   Soares, Marcio ^a,e,f   Salluh, Jorge I F ^a,e,f  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL SÍRIO LIBANÊS   (Brazil)

^c Intensive Care Unit Hospital Barra Dor   (Brazil)

^d Intensive Care Unit   (Brazil)

^e D OR INSTITUTE FOR RESEARCH AND EDUCATION IDOR   (Brazil)

^f INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CANCER PATIENT; CLINICAL FEATURE; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; FUNCTIONAL STATUS ASSESSMENT; GRAM NEGATIVE INFECTION; HEALTHCARE ASSOCIATED INFECTION; HEMATOLOGIC MALIGNANCY; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; MORTALITY; OUTCOME ASSESSMENT; PNEUMONIA; PRESCRIPTION; PROGNOSIS; PROSPECTIVE STUDY; SEPTIC SHOCK; SOLID TUMOR; STREPTOCOCCUS PNEUMONIAE; COMPLICATION; CRITICAL ILLNESS; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOSPITAL MORTALITY; ISOLATION AND PURIFICATION; LENGTH OF STAY; MICROBIOLOGY; MIDDLE AGED; NEOPLASM; PSEUDOMONAS AERUGINOSA; SHOCK, SEPTIC; STAPHYLOCOCCUS AUREUS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

NEGIBACTERIA; STAPHYLOCOCCUS AUREUS;

ANTIINFECTIVE AGENT;

AGED; ANTI-BACTERIAL AGENTS; CRITICAL ILLNESS; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MIDDLE AGED; MORTALITY; NEOPLASMS; PNEUMONIA; PROSPECTIVE STUDIES; PSEUDOMONAS AERUGINOSA; RESPIRATION, ARTIFICIAL; SHOCK, SEPTIC; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84925715640     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120544     Document Type: Article

References (38)

1. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/ SIS International Sepsis Definitions Conference. 2003. pp. 1250-6.
2. de Montmollin E, Tandjaoui-Lambiotte Y, Legrand M, Lambert J, Mokart D, Kouatchet A, et al. Outcomes in critically ill cancer patients with septic shock of pulmonary origin. Shock. 2013 Mar; 39 (3):250-4. doi: 10.1097/SHK.0b013e3182866d32 PMID: 23364436
3. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993 Dec; 270(24):2957-63. PMID: 8254858
4. Welte T, Köhnlein T. Global and local epidemiology of community-acquired pneumonia: the experience of the CAPNETZ Network. Semin Respir Crit Care Med. 2009 Apr; 30(2):127-35. doi: 10.1055/s-0029-1202941 PMID: 19296412
5. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. 1996. pp. 707-10.
6. Mandell LA. Epidemiology and etiology of community-acquired pneumonia. Infect Dis Clin North Am.Dec; 18(4):761-76-vii. PMID: 15555823
7. Soares M, Salluh JIF, Ferreira CG, Luiz RR, Spector N, Rocco JR. Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patients. Intensive Care Med. 2005; 31 (3):408-15. PMID: 15678310
8. Rello J. Demographics, guidelines, and clinical experience in severe community-acquired pneumonia. Crit Care. 2008; 12 Suppl 6:S2. doi: 10.1186/cc7025 PMID: 19105795
9. Benoit DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA. Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a lifethreatening complication. Critical care medicine. 2003 Jan; 31(1):104-12. PMID: 12545002
10. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. American journal of respiratory and critical care medicine. 2005. pp. 388-416.
11. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987; 40(5):373-83. PMID: 3558716
12. Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest. 2005 Dec; 128(6):3854-62. PMID: 16354854
13. Shindo Y, Sato S, Maruyama E, Ohashi T, Ogawa M, Hashimoto N, et al. Health-care-associated pneumonia among hospitalized patients in a Japanese community hospital. Chest. 2009 Mar; 135(3):633-40. doi: 10.1378/chest.08-1357 PMID: 19017892
14. Park HK, Song J-U, Um S-W, Koh W-J, Suh GY, Chung MP, et al. Clinical characteristics of health care-associated pneumonia in a Korean teaching hospital. Respir Med. 2010 Nov; 104(11):1729-35. doi: 10.1016/j.rmed.2010.06.009 PMID: 20605087
15. Carratalà J, Mykietiuk A, Fernández-Sabé N, Suárez C, Dorca J, Verdaguer R, et al. Health care-associated pneumonia requiring hospital admission: epidemiology, antibiotic therapy, and clinical outcomes. Arch Intern Med. 2007 Jul 9; 167(13):1393-9. PMID: 17620533
16. Venditti M, Falcone M, Corrao S, Licata G, Serra P, Study Group of the Italian Society of Internal Medicine. Outcomes of patients hospitalized with community-acquired, health care-associated, and hospi-tal-acquired pneumonia. Ann Intern Med. 2009 Jan 6; 150(1):19-26. PMID: 19124816
17. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of communi-ty-acquired pneumonia in adults. 2007. pp. S27-72.
18. Cockerill FR. Performance Standards for Antimicrobial Susceptibility Testing. Clinical & Laboratory Standards Institute; 2010. 1 p.
19. Micek ST, Kollef KE, Reichley RM, Roubinian N, Kollef MH. Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother. 2007 Oct; 51(10):3568-73. PMID: 17682100
20. Ewig S, Torres A. Healthcare-associated pneumonia: meeting the yeti. Eur Respir J. 2011 Oct; 38 (4):755-7. doi: 10.1183/09031936.00070011 PMID: 21965499
21. Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. 2012. pp. 268-81.
22. Niederman MS, Bass JB, Campbell GD, Fein AM, Grossman RF, Mandell LA, et al. Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. American Thoracic Society. Medical Section of the American Lung Association. The American review of respiratory disease. 1993. pp. 1418-26.
23. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982 Apr; 143(1):29-36. PMID: 7063747
24. Azoulay E, Soares M, Darmon M, Benoit D, Pastores S, Afessa B. Intensive care of the cancer patient: recent achievements and remaining challenges. Annals of intensive care. 2011; 1(1):5. doi: 10.1186/ 2110-5820-1-5 PMID: 21906331
25. Polverino E, Torres A, Menendez R, Cilloniz C, Valles JM, Capelastegui A, et al. Microbial aetiology of healthcare associated pneumonia in Spain: a prospective, multicentre, case-control study. Thorax.Nov; 68(11):1007-14. doi: 10.1136/thoraxjnl-2013-203828 PMID: 24130227
26. Jung JY, Park MS, Kim YS, Park BH, Kim SK, Chang J, et al. Healthcare-associated pneumonia among hospitalized patients in a Korean tertiary hospital. BMC Infect Dis. 2011; 11:61. doi: 10.1186/ 1471-2334-11-61 PMID: 21396096
27. Chalmers JD, Taylor JK, Singanayagam A, Fleming GB, Akram AR, Mandal P, et al. Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: a UK cohort study. Clin Infect Dis. 2011 Jul 15; 53(2):107-13. doi: 10.1093/cid/cir274 PMID: 21690616
28. Shorr AF, Zilberberg MD, Reichley R, Kan J, Hoban A, Hoffman J, et al. Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis. 2012 Jan 15; 54(2):193-8. doi: 10.1093/cid/cir813 PMID: 22109951
29. Aliberti S, Di Pasquale M, Zanaboni AM, Cosentini R, Brambilla AM, Seghezzi S, et al. Stratifying risk factors for multidrug-resistant pathogens in hospitalized patients coming from the community with pneumonia. Clin Infect Dis. 2012 Feb 15; 54(4):470-8. doi: 10.1093/cid/cir840 PMID: 22109954
30. Adrie C, Schwebel C, Garrouste-Orgeas M, Vignoud L, Planquette B, Azoulay E, et al. Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance. Crit Care. 2013 Nov 7; 17(6):R265. doi: 10.1186/cc13095 PMID: 24200097
31. Rosolem MM, Rabello LSCF, Lisboa T, Caruso P, Costa RT, Leal JVR, et al. Critically ill patients with cancer and sepsis: clinical course and prognostic factors. J Crit Care. 2012 Jun; 27(3):301-7. doi: 10. 1016/j.jcrc.2011.06.014 PMID: 21855281
32. Rello J, Luján M, Gallego M, Vallés J, Belmonte Y, Fontanals D, et al. Why mortality is increased in health-care-associated pneumonia: lessons from pneumococcal bacteremic pneumonia. Chest. 2010 May; 137(5):1138-44. doi: 10.1378/chest.09-2175 PMID: 19952058
33. Garcia-Vidal C, Viasus D, Roset A, Adamuz J, Verdaguer R, Dorca J, et al. Low incidence of multidrugresistant organisms in patients with healthcare-associated pneumonia requiring hospitalization. Clin Microbiol Infect. 2011 Nov; 17(11):1659-65. doi: 10.1111/j.1469-0691.2011.03484.x PMID: 21463391
34. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. 2013. pp. 580- 637.
35. Taccone FS, Artigas AA, Sprung CL, Moreno R, Sakr Y, Vincent J-L. Characteristics and outcomes of cancer patients in European ICUs. Crit Care. 2009; 13(1):R15. doi: 10.1186/cc7713 PMID: 19200368
36. Soares M, Caruso P, Silva E, Teles JMM, Lobo SMA, Friedman G, et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Critical care medicine. 2010; 38(1):9-15. doi: 10.1097/CCM.0b013e3181c0349e PMID: 19829101
37. Vandijck DM, Benoit DD, Depuydt PO, Offner FC, Blot SI, Van Tilborgh AK, et al. Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies. Intensive Care Med. 2008 May; 34(5):847-55. doi: 10.1007/s00134-008-1002-2 PMID: 18214437
38. Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, et al. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. The Lancet infectious diseases. 2012 Dec; 12(12):919-24. doi: 10.1016/S1473-3099(12)70239-6 PMID: 23103175