Effect of B vitamin (Folate, B6, and B12) supplementation on osteoporotic fracture and bone turnover markers: A meta-analysis

Medical Science Monitor

Volumn 21, Issue , 2015, Pages 875-881

  Ruan, Jianwei ^a   Gong, Xiaokang ^a   Kong, Jinsong ^a   Wang, Haibao ^a   Zheng, Xin ^a   Chen, Tao ^a  

^a TAIZHOU MUNICIPAL HOSPITAL   (China)

Author keywords

Bone; Fractures; Homocysteine; Meta analysis as topic; Vitamin B complex

Indexed keywords

ALKALINE PHOSPHATASE; CARBOXY TERMINAL TELOPEPTIDE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; OSTEOCALCIN; PLACEBO; PYRIDOXINE; BIOLOGICAL MARKER;

ARTICLE; BONE DENSITY; BONE TURNOVER; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONFIDENCE INTERVAL; DATA ANALYSIS; DIABETES MELLITUS; FRAGILITY FRACTURE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MANTEL HAENSZEL TEST; META ANALYSIS; POSTMENOPAUSE OSTEOPOROSIS; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCREENING; TRANSIENT ISCHEMIC ATTACK; VASCULAR DISEASE; VITAMIN SUPPLEMENTATION; BONE REMODELING; DIET SUPPLEMENTATION; FRACTURES, BONE; METABOLISM; OSTEOPOROTIC FRACTURES; PATHOPHYSIOLOGY; RISK FACTOR;

BIOMARKERS; BONE REMODELING; DIETARY SUPPLEMENTS; FOLIC ACID; FRACTURES, BONE; HUMANS; OSTEOPOROTIC FRACTURES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; VITAMIN B 12; VITAMIN B 6;

EID: 84925668480     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.893310     Document Type: Article

References (33)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis,and Therapy: Osteoporosis prevention, diagnosis, and therapy. JAMA, 2001; 285: 785–795
2. Melton LJ III: Adverse outcomes of osteoporotic fractures in the general population. J BoneMineral Res, 2003; 18: 1139–1141
3. Govindarajan P, Schlewitz G, Schliefke N et al: Implications of combined ovariectomy/multi-deficiency diet on rat bone with age-related variation in bone parameters and bone loss at multiple skeletal sites by DEXA. Med Sci Monit Basic Res, 2013; 19: 76–86
4. Kanis JA, McCloskey EV, Johansson H et al: European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int, 2013; 24: 23–57
5. Raisz LG: Homocysteine and osteoporotic fractures – culprit or bystander? N Engl J Med, 2004; 350: 2089–2090
6. Kim BJ, Koh JM, Ahn SH et al: High serum total homocysteine levels accelerate hip bone loss in healthy premenopausal women and men. Bone, 2013; 52: 56–62
7. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al: Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med, 2004; 350: 2033–2041
8. Yang J, Hu X, Zhang Q et al: Homocysteine level and risk of fracture: A meta- analysis and systematic review. Bone, 2012; 51: 376–382
9. Levasseur R: Bone tissue and hyperhomocysteinemia. Joint Bone Spine, 2009; 76: 234–240
10. McLean RR, Jacques PF, Selhub J et al: Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab, 2008; 93: 2206–2212
11. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists’ Collaboration. BMJ, 1998; 316: 894–898
12. Clarke M, Ward M, Strain JJ et al: B-vitamins and bone in health and disease: the current evidence. Proc Nutr Soc, 2014; 73: 330–339
13. Green TJ, McMahon JA, Skeaff CM et al: Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial. Am J Clin Nutr, 2007; 85: 460–464
14. Shahab-Ferdows S, Anaya-Loyola MA, Vergara-Castaneda H et al: VitaminB-12 supplementation of rural Mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker. J Nutr, 2012; 142: 1881–1887
15. Sato Y, Honda Y, Iwamoto J et al: Effect of folate and mecobalamin on hipfractures in patients with stroke: a randomized controlled trial. JAMA, 2005;293: 1082–1088
16. Sawka AM, Ray JG, Yi Q et al: Randomized clinical trial of homocysteine level lowering therapy and fractures. Arch Intern Med, 2007; 167: 2136–2139
17. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L, Clarke RJ et al: Effects of homocysteine-lowering with folic acid plus vitamin B12 vs. placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA, 2010; 303: 2486–2494
18. Gommans J, Yi Q, Eikelboom JW et al: The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial. BMC Geriatr, 2013; 13: 88
19. Keser I, Ilich JZ, Vrkic N et al: Folic acid and vitamin B(12) supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial. Nutr Res, 2013; 33: 211–219
20. Salari P, Abdollahi M, Heshmat R et al: Effect of folic acid on bone metabolism: a randomized double blind clinical trial in postmenopausal osteoporotic women. Daru, 2014; 22: 62
21. Morris MS, Jacques PF, Selhub J: Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone, 2005; 37: 234–242
22. Balogh E, Bereczky Z, Katona E et al: Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: a case-control study. Thromb Res, 2012; 129: 133–138
23. Lubec B, Fang-Kircher S, Lubec T et al: Evidence for McKusick’s hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta, 1996; 1315: 159–162
24. Perez-Castrillon JL, Arranz-Pena ML, Luis DD: Homocysteine as a predictive factor for hip fracture in older persons. New Engl J Med, 2004; 351: 1027–1030; author reply 1027–30
25. Saito M, Fujii K, Marumo K: Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int, 2006; 79: 160–168
26. Herrmann M, Widmann T, Herrmann W: Homocysteine – a newly recognised risk factor for osteoporosis. Clin Chem Lab Med, 2005; 43: 1111–1117
27. Kalani A, Kamat PK, Voor MJ et al: Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia. Mol Cell Biochem, 2014; 395: 89–98
28. Clarke R: Lowering blood homocysteine with folic acid-based supplements: meta-analysis of randomised trials. Indian Heart J, 2000; 52: 59–64
29. McKinley MC, McNulty H, McPartlin J et al: Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr, 2001; 73: 759–764
30. Herrmann M, Widmann T, Colaianni G et al: Increased osteoclast activity in the presence of increased homocysteine concentrations. Clin Chem, 2005; 51: 2348–2353
31. Kim DJ, Koh JM, Lee O et al: Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone, 2006; 39: 582–590
32. Herrmann M, Kraenzlin M, Pape G et al: Relation between homocysteine and biochemical bone turnover markers and bone mineral density in periand post-menopausal women. Clin Chem Lab Med, 2005; 43: 1118–1123
33. Zeng R, Xu CH, Xu YN et al: The effect of folate fortification on folic acidbased homocysteine-lowering intervention and stroke risk: a meta-analysis. Publ Health Nutr, 2014: 1–8 [Epub ahead of print]