UV-emitting upconversion-based TiO2 photosensitizing nanoplatform: Near-infrared light mediated in vivo photodynamic therapy via mitochondria-involved apoptosis pathway

ACS Nano

Volumn 9, Issue 3, 2015, Pages 2584-2599

  Hou, Zhiyao ^a   Zhang, Yuanxin ^a   Deng, Kerong ^a,b   Chen, Yinyin ^a,b   Li, Xuejiao ^a   Deng, Xiaoran ^a,b   Cheng, Ziyong ^a   Lian, Hongzhou ^a   Li, Chunxia ^a   Lin, Jun ^a  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

core shell structure; mitochondria involved apoptosis; NIR light mediated; photodynamic therapy; titanium dioxide; upconversion nanoparticles

Indexed keywords

CELL DEATH; DISEASES; INFRARED DEVICES; IRRADIATION; MAMMALS; MITOCHONDRIA; NANOPARTICLES; OXIDE MINERALS; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; SODIUM COMPOUNDS; TIO2 NANOPARTICLES; TITANIUM DIOXIDE; TUMORS; YTTERBIUM COMPOUNDS;

CANCER CELL APOPTOSIS; CORE/SHELL STRUCTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEAR INFRARED LIGHT; NIR LIGHT MEDIATED; PHOTODYNAMIC THERAPY (PDT); TITANIUM DIOXIDES (TIO2); UPCONVERSION NANOPARTICLES;

YTTRIUM COMPOUNDS;

PHOTOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL; APOPTOSIS; CHEMISTRY; DRUG EFFECTS; FEMALE; HELA CELL LINE; HUMAN; INFRARED RADIATION; METABOLISM; MITOCHONDRION; MOUSE; NANOMEDICINE; NUDE MOUSE; PATHOLOGY; PHOTOCHEMOTHERAPY; PROCEDURES; RADIATION RESPONSE; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; FEMALE; HELA CELLS; HUMANS; INFRARED RAYS; MICE; MICE, NUDE; MITOCHONDRIA; NANOMEDICINE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; TITANIUM; ULTRAVIOLET RAYS;

EID: 84925652434     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn506107c     Document Type: Article

References (93)

1. Dougherty, T. J.; Kaufman, J. E.; Goldfarb, A.; Weishaupt, K. R.; Boyle, D.; Mittleman, A. Photoradiation Therapy for the Treatment of Malignant Tumors Cancer Res. 1978, 38, 2628-2635
2. Bonnett, R. Photosensitizers of the Porphyrin and Phthalocyanine Series for Photodynamic Therapy Chem. Soc. Rev. 1995, 24, 19-33
3. Dolmans, D. E. J. G. J.; Fukumura, D.; Jain, R. K. Photodynamic Therapy for Cancer Nat. Rev. Cancer 2003, 3, 380-387
4. Zhu, Z.; Tang, Z. W.; Phillips, J. A.; Yang, R. H.; Wang, H.; Tan, W. H. Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes J. Am. Chem. Soc. 2008, 130, 10856-10857
5. Celli, J. P.; Spring, B. Q.; Rizvi, I.; Evans, C. L.; Samkoe, K. S.; Verma, S.; Pogue, B. W.; Hasan, T. Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization Chem. Rev. 2010, 110, 2795-2838
6. Master, A.; Livingston, M.; Sen Gupta, A. Photodynamic Nanomedicine in the Treatment of Solid Tumors: Perspectives and Challenges J. Controlled Release 2013, 168, 88-102
7. 2 Particles Cancer Res. 1992, 52, 2346-2348
8. Rozhkova, E. A.; Ulasov, I.; Lai, B.; Dimitrijevic, N. M.; Lesniak, M. S.; Rajh, T. A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy Nano Lett. 2009, 9, 3337-3342
9. Kubota, Y.; Shuin, T.; Kawasaki, C.; Hosaka, M.; Kitamura, H.; Cai, R.; Sakai, H.; Hashimoto, K.; Fujishima, A. Photokilling of T-24 Human Bladder Cancer Cells with Titanium Dioxide Br. J. Cancer. 1994, 70, 1107-1111
10. Lagopati, N.; Kitsiou, P. V.; Kontos, A. I.; Venieratos, P.; Kotsopoulou, E.; Kontos, A. G.; Dionysiou, D. D.; Pispas, S.; Tsilibary, E. C.; Falaras, P. Photo-Induced Treatment of Breast Epithelial Cancer Cells Using Nanostructured Titanium Dioxide Solution J. Photochem. Photobiol., A 2010, 214, 215-223
11. 2 Can Prolong Survival in Glioma-Bearing Mice Mol. Biol. Rep. 2011, 38, 523-530
12. 2 Nanoparticles for Effective Photodynamic Therapy Colloids Surf., B 2013, 107, 220-226
13. 2 Nanocomposites for Magnetic Resonance Imaging and Potential Photodynamic Therapy Nanoscale 2013, 5, 2107-2113
14. 2/PEGDA Hybrid Hydrogel Prepared in Situ on Tumor Cells for Effective Photodynamic Therapy ACS Appl. Mater. Interfaces 2013, 5, 12317-12322
15. Oar, M. A.; Serin, J. M.; Dichtel, W. R.; Frechet, J. M. J.; Ohulchanskyy, T. Y.; Prasad, P. N. Photosensitization of Singlet Oxygen via Two-Photon-Excited Fluorescence Resonance Energy Transfer in a Water-Soluble Dendrimer Chem. Mater. 2005, 17, 2267-2275
16. Huang, Z.; Xu, H.; Meyers, A. D.; Musani, A. I.; Wang, L.; Tagg, R.; Barqawi, A. B.; Chen, Y. K. Photodynamic Therapy for Treatment of Solid Tumors-Potential and Technical Challenges Technol. Cancer Res. Treat. 2008, 7, 309-320
17. Wang, C.; Tao, H.; Cheng, L.; Liu, Z. Near-Infrared Light Induced in Vivo Photodynamic Therapy of Cancer Based on Upconversion Nanoparticles Biomaterials 2011, 32, 6145-6154
18. Shan, J. N.; Budijono, S. J.; Hu, G. H.; Yao, N.; Kang, Y. B.; Ju, Y. G.; Prudhomme, R. K. Pegylated Composite Nanoparticles Containing Upconverting Phosphors and meso-Tetraphenyl porphine (TPP) for Photodynamic Therapy Adv. Funct. Mater. 2011, 21, 2488-2495
19. Liu, K.; Liu, X.; Zeng, Q.; Zhang, Y.; Tu, L.; Liu, T.; Kong, X.; Wang, Y.; Cao, F.; Lambrechts, S. A. G.; Aalders, M. C. G.; Zhang, H. Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells ACS Nano 2012, 6, 4054-4062
20. Cui, S.; Yin, D.; Chen, Y.; Di, Y.; Chen, H.; Ma, Y.; Achilefu, S.; Gu, Y. In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct ACS Nano 2013, 7, 676-688
21. Boulnois, J. L. Photophysical Processes in Recent Medical Laser Developments: A Review Lasers Med. Sci. 1986, 1, 47-66
22. Frangioni, J. V. In Vivo near-Infrared Fluorescence Imaging Curr. Opin. Chem. Biol. 2003, 7, 626-634
23. Heer, S.; Kompe, K.; Gudel, H. U.; Hasse, M. Highly Efficient Multicolour Upconversion Emission in Transparent Colloids of Lanthanide-Doped NaYF4 Nanocrystals Adv. Mater. 2004, 16, 2102-2105
24. 3+ via Thermal Decomposition of Lanthanide Trifluoroacetate Precursors J. Am. Chem. Soc. 2006, 128, 7444-7445
25. 3+ Doped Fluoride Nanophosphors Nano Lett. 2008, 8, 3834-3838
26. Ye, X. C.; Collins, J. E.; Kang, Y. J.; Chen, J.; Chen, D. T. N.; Yodh, A. G.; Murray, C. B. Morphologically Controlled Synthesis of Colloidal Upconversion Nanophosphors and Their Shape-Directed Self-Assembly Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 22430-22435
27. Wang, H. Q.; Batentschuk, M.; Osvet, A.; Pinna, L.; Brabec, C. J. Rare-Earth Ion Doped Up-Conversion Materials for Photovoltaic Applications Adv. Mater. 2011, 23, 2675-2680
28. 2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging Adv. Funct. Mater. 2012, 22, 2713-2722
29. Gorris, H. H.; Wolfbeis, O. S. Photon-Upconverting Nanoparticles for Optical Encoding and Multiplexing of Cells, Biomolecules, and Microspheres Angew. Chem., Int. Ed. 2013, 52, 3584-3600
30. Mai, H. X.; Zhang, Y. W.; Si, R.; Yan, Z. G.; Sun, L. D.; You, L. P.; Yan, C. H. Glutathione- and Cysteine-Induced Transverse Overgrowth on Gold Nanorods J. Am. Chem. Soc. 2006, 128, 6402-6404
31. Chen, Z. G.; Chen, H. L.; Hu, H.; Yu, M. X.; Li, F. Y.; Zhang, Q.; Zhou, Z. G.; Yi, T.; Huang, C. H. Versatile Synthesis Strategy for Carboxylic Acid-Functionalized Upconverting Nanophosphors as Biological Labels J. Am. Chem. Soc. 2008, 130, 3023-3029
32. van der Ende, B. M.; Aarts, L.; Meijerink, A. Near-Infrared Quantum Cutting for Photovoltaics Adv. Mater. 2009, 21, 3073-3077
33. 3:Er Nanostructures for Bioimaging: Tuning of the Upconversion Fluorescence with Silver Nanoparticles J. Am. Chem. Soc. 2010, 132, 2850-2851
34. Wang, F.; Han, Y.; Lim, C. S.; Lu, Y. H.; Wang, J.; Xu, J.; Chen, H. Y.; Zhang, C.; Hong, M. H.; Liu, X. G. Simultaneous Phase and Size Control of Upconversion Nanocrystals through Lanthanide Doping Nature 2010, 463, 1061-1065
35. Wang, G. F.; Peng, Q.; Li, Y. D. Lanthanide-Doped Nanocrystals: Synthesis, Optical-Magnetic Properties, and Applications Acc. Chem. Res. 2011, 44, 322-332
36. Liu, Y. S.; Tu, D. T.; Zhu, H. M.; Chen, X. Y. Lanthanide-Doped Luminescent Nanoprobes: Controlled Synthesis, Optical Spectroscopy, and Bioapplications Chem. Soc. Rev. 2013, 42, 6924-6958
37. Zhang, P.; Steelant, W.; Kumar, M.; Scholfield, M. Versatile Photosensitizers for Photodynamic Therapy at Infrared Excitation J. Am. Chem. Soc. 2007, 129, 4526-4527
38. Idris, N. M.; Gnanasammandhan, M. K.; Zhang, J.; Ho, P. C.; Mahendran, R.; Zhang, Y. In Vivo Photodynamic Therapy Using Upconversion Nanoparticles as Remote-Controlled Nanotransducers Nat. Med. 2012, 18, 1580-1585
39. Yuan, Q.; Wu, Y.; Wang, J.; Lu, D. Q.; Zhao, Z. L.; Liu, T.; Zhang, X. B.; Tan, W. H. Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA Carrier and Near-Infrared Light Angew. Chem., Int. Ed. 2013, 52, 13965-13969
40. Wang, C.; Cheng, L.; Liu, Y. M.; Wang, X. J.; Ma, X. X.; Deng, Z. Y.; Li, Y. G.; Liu, Z. Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light Adv. Funct. Mater. 2013, 23, 3077-3086
41. Idris, N. M.; Lucky, S. S.; Li, Z. Q.; Huang, K.; Zhang, Y. Photoactivation of Core-Shell Titania Coated Upconversion Nanoparticles and Its Effect on Cell Death J. Mater. Chem. B 2014, 2, 7017-7026
42. 2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy Chem.-Eur. J. 2014, 20, 14012-14017
43. Juzenas, P.; Chen, W.; Sun, Y. P.; Coelho, M. A. N.; Generalov, R.; Generalova, N.; Christensen, I. L. Quantum Dots and Nanoparticles for Photodynamic and Radiation Therapies of Cancer Adv. Drug Delivery Rev. 2008, 60, 1600-1614
44. Lim, M. E.; Lee, Y. L.; Zhang, Y.; Chu, J. J. H. Photodynamic Inactivation of Viruses Using Upconversion Nanoparticles Biomaterials 2012, 33, 1912-1920
45. Tian, G.; Ren, W. L.; Yan, L.; Jian, S.; Gu, Z. J.; Zhou, L. J.; Jin, S.; Yin, W. Y.; Li, S. J.; Zhao, Y. L. Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells under Near-Infrared Excitation Small 2013, 9, 1929-1938
46. Wang, M.; Chen, Z.; Zheng, W.; Zhu, H. M.; Lu, S.; Ma, E.; Tu, D. T.; Zhou, S. Y.; Huang, M. D.; Chen, X. Y. Lanthanide-Doped Upconversion Nanoparticles Electrostatically Coupled with Photosensitizers for Near-Infrared-Triggered Photodynamic Therapy Nanoscale 2014, 6, 8274-8282
47. Chen, Q.; C. Wang, C.; Cheng, L.; He, W. W.; Cheng, Z. P.; Liu, Z. Protein Modified Upconversion Nanoparticles for Imaging-Guided Combined Photothermal and Photodynamic Therapy Biomaterials 2014, 35, 2915-2923
48. 2 Core/Shell Nanoparticles Chem. Commun. 2010, 46, 2304-2306
49. 2 Shell under Mild Conditions and Their Upconversion-Based Photocatalysis Nanoscale 2014, 5, 8930-8933
50. 2 Coating Nanoscale 2013, 5, 3030-3036
51. 4:Yb,Tm Nanoplates and Regulate Their Photocatalytic Activities with the Core Size J. Mater. Chem. A 2014, 2, 13486-13491
52. n: A Macrobicyclic Bimetallic Chain Polymer Incorporating Deprotonated 2-Pyrrolodone Bridges Angew. Chem., Int. Ed. 1988, 100, 261-262
53. Li, Q.; Li, T.; Wu, J. G. Luminescence of Europium(III) and Terbium(III) Complexes Incorporated in Poly(vinyl pyrrolidone) Matrix J. Phys. Chem. B 2001, 105, 12293-12296
54. Meng, F. X.; Liu, S.; Wang, Y. F.; Tao, C.; Xu, P.; Guo, W. B.; Shen, L.; Zhang, X. D.; Ruan, S. P. Open-Circuit Voltage Enhancement of Inverted Polymer Bulk Heterojunction Solar Cells by Doping NaYF4 Nanoparticles/PVP Composites J. Mater. Chem. 2012, 22, 22382-22386
55. Yang, Y.; Li, J. R.; Mu, J. H.; Rong, L.; Jiang, L. A Gold Nanocomposite Made Soluble in Both Water and Oil by the Addition of a Second Adsorption Layer of Poly-N-vinyl-2-pyrrolidone on Gold Nanoparticles that Have Been Made Hydrophobic Nanotechnology 2006, 17, 461-465
56. 4 Nanocrystals with Multicolor Upconversion Fluorescence Emission Angew. Chem., Int. Ed. 2006, 45, 7732-7735
57. 2, Using Polyvinylpyrrolidone (PVP) as a Mediator J. Mater. Chem. 2010, 20, 5533-5537
58. 2 Hollow Colloids and Magnetic Multifunctional Particles Adv. Mater. 2008, 20, 1853-1858
59. 2 Core/Shell Nanoparticles Chem. Commun. 2010, 46, 2304-2306
60. 2 Core@Shell Microcrystals Appl. Catal. B: Environ. 2013, 142-143, 377-386
61. 2 Shell under Mild Conditions and Their Upconversion-Based Photocatalysis Nanoscale 2014, 5, 8930-8933
62. 2 and ZnO Nanoparticles as Photosensitizers in Photodynamic Therapy for Cancer J. Biomed. Nanotechnol. 2014, 10, 1450-1457
63. Han, L.; Du, L. B.; Kumar, A.; Jia, H. Y.; Liang, X. J.; Tian, Q.; Nie, G. J. Inhibitory Effects of Trolox-Encapsulated Chitosan Nanoparticles on Tert-Butylhydroperoxide Induced RAW264.7 Apoptosis Biomaterials 2012, 33, 8517-8528
64. Wang, L.; Lu, K. Y.; Hao, H. H.; Li, X. Y.; Wang, J.; Wang, K.; Wang, J.; Yan, Z.; Zhang, S. L.; Du, Y. H.; Liu, H. R. Decreased Autophagy in Rat Heart Induced by Anti-beta 1-Adrenergic Receptor Autoantibodies Contributes to the Decline in Mitochondrial Membrane Potential PLoS One 2013, 8, e81296
65. Cavalieri, E.; Rigo, A.; Bonifacio, M.; De Prati, A. C.; Guardalben, E.; Bergamini, C.; Fato, R.; Pizzolo, G.; Suzuki, H.; Vinante, F. Pro-Apoptotic Activity of Alpha-Bisabolol in Preclinical Models of Primary Human Acute Leukemia Cells J. Transl. Med. 2011, 9, 45
66. Shin, Y. S.; Shin, H. A.; Kang, S. U.; Kim, J. H.; Oh, Y. T.; Park, K. H.; Kim, C. H. Effect of Epicatechin against Radiation-Induced Oral Mucositis: in Vitro and in Vivo Study PLoS One 2013, 8, e69151
67. Daniel, P. T.; Schulze-Osthoff, K.; Belka, C.; Guner, D. Guardians of Cell Death: the Bcl-2 Family Proteins Essays Biochem. 2003, 39, 73-88
68. Reed, J. C. Bcl-2 Family Proteins: Regulators of Apoptosis and Chemoresistance in Hematologic Malignancies Semin. Hematol. 1997, 34, 9-19
69. Kirkin, V.; Joos, S.; Zornig, M. The Role of Bcl-2 Family Members in Tumorigenesis Biochim. Biophys. Acta 2004, 1644, 229-249
70. Hsiao, C. J.; Hsiao, G.; Chen, W. L.; Wang, S. W.; Chiang, C. P.; Liu, L. Y.; Guh, J. W.; Lee, T. H.; Chung, C. L. Cephalochromin Induces G0/G1 Cell Cycle Arrest and Apoptosis in A549 Human Non-Small-Cell Lung Cancer Cells by Inflicting Mitochondrial Disruption J. Nat. Prod. 2014, 77, 758-765
71. Griffiths, G. J.; Dubrez, L.; Morgan, C. P.; Jones, N. A.; Whitehouse, J.; Corfe, B. M.; Dive, C.; Hickman, J. A. Cell Damage Induced Conformational Changes of the Pro-Apoptotic Protein Bak in Vivo Precede the Onset of Apoptosis J. Cell Biol. 1999, 144, 903-914
72. Wei, M. C.; Lindsten, T.; Mootha, V. K.; Weiler, S.; Gross, A.; Ashiya, M.; Thompson, C. B.; Korsmeyer, S. J. tBID, a Membrane-Targeted Death Ligand, Oligomerizes BAK to Release Cytochrome C Genes Dev. 2000, 14, 2060-2071
73. Wei, M. C.; Zong, W. X.; Cheng, E. H.; Lindsten, T.; Panoutsakopoulou, V.; Ross, A. J.; Roth, K. A.; MacCregor, G. R.; Thompson, C. B.; Korsmeyer, S. J. Proapoptotic BAX and BAK: a Requisite Gateway to Mitochondrial Dysfunction and Death Science 2001, 292, 727-730
74. Yu, C. H.; Chen, H. M.; Lin, H. P.; Chiang, C. P. Expression of Bak and Bak/Mcl-1 Ratio Can Predict Photodynamic Therapy Outcome for Oral Verrucous Hyperplasia and Leukoplakia J. Oral. Pathol. Med. 2013, 42, 257-262
75. Chen, H. M.; Yu, C. H.; Lin, H. P.; Cheng, S. J.; Chiang, C. P. 5-Aminolevulinic Acid-Mediated Photodynamic Therapy for Oral Cancers and Precancers J. Dent. Sci. 2012, 7, 307-315
76. Frank, J. C.; Plötz, M.; Prokop, A.; Geilen, C. C.; Schmalz, H. G.; Eberle, J. New Caspase-Independent but ROS-Dependent Apoptosis Pathways Are Targeted in Melanoma Cells by an Iron-Containing Cytosine Analogue Biochem. Pharmacol. 2010, 79, 575-586
77. Chen, C.; Hu, S. Y.; Luo, D. Q.; Zhu, S. Y.; Zhou, C. Q. Potential Antitumor Agent from the Endophytic Fungus Pestalotiopsis Photiniae Induces Apoptosis via the Mitochondrial Pathway in HeLa Cells Oncol. Rep. 2013, 30, 1773-1781
78. Zhang, Y. Q.; Xiao, C. X.; Lin, B. Y.; Shi, Y.; Liu, Y. P.; Liu, J. J.; Guleng, B.; Ren, J. L. Silencing of Pokemon Enhances Caspase-Dependent Apoptosis via Fas- and Mitochondria-Mediated Pathways in Hepatocellular Carcinoma Cells PLoS One 2013, 8, e68981
79. Agostinis, P.; Buytaert, E.; Breyssens, H.; Hendrickx, N. Regulatory Pathways in Photodynamic Therapy Induced Apoptosis Photochem. Photobiol. Sci. 2004, 3, 721-729
80. Zhang, Y. X.; Li, Q. S.; Ge, Y. K.; Chen, Y. P.; Chen, J.; Dong, Y.; Shi, W. Silibinin Triggers Apoptosis and Cell-Cycle Arrest of SGC7901 Cells Phytother. Res. 2013, 27, 397-403
81. Oleinick, N. L.; Morris, R. L.; Belichenko, I. The Role of Apoptosis in Response to Photodynamic Therapy: What, Where, Why, and How Photochem. Photobiol. Sci. 2002, 1, 1-21
82. Castano, A. P.; Demidova, T. N.; Hamblin, M. R. Mechanisms in Photodynamic Therapy: Part Two-Cellular Signaling, Cell Metabolism and Modes of Cell Death Photodiagn. Photodyn. Ther. 2005, 2, 1-23
83. Zhao, H. Y.; Yin, R.; Chen, D. Y.; Ren, J.; Wang, Y. C.; Zhang, J. Y.; Deng, H.; Wang, Y.; Qiu, H. X.; Huang, N. Y.; Zou, Q. L.; Zhao, J. Q.; Gu, Y. In Vitro and in Vivo Antitumor Activity of a Novel Hypocrellin B Derivative for Photodynamic Therapy Photodiagn. Photodyn. Ther. 2014, 11, 204-212
84. Almeida, R. D.; Manadas, B. J.; Casvalho, A. P.; Duarte, C. B. Intracellular Signaling Mechanisms in Photodynamic Therapy Biochim. Biophys. Acta 2004, 1704, 59-86
85. Buytaert, E.; Devaele, M.; Agostinis, P. Molecular Effectors of Multiple Cell Death Pathways Initiated by Photodynamic Therapy Biochim. Biophys. Acta 2007, 1776, 86-107
86. Agrawal, S. S.; Saraswati, S.; Mathur, R.; Pandey, M. Cytotoxic and Antitumor Effects of Brucine on Ehrlich Ascites Tumor and Human Cancer Cell Line Life Sci. 2011, 89, 147-158
87. Xue, M. L.; Ge, Y. L.; Zhang, J. Y.; Wang, Q.; Hou, L.; Liu, Y. C.; Sun, L. L.; Li, Q. Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer in Vitro and in Vivo PLoS One 2012, 7, e43483
88. Maheshwari, A.; Misro, M. M.; Aggarwal, A.; Sharma, R. K. N-Acetyl-L-cysteine Modulates Multiple Signaling Pathways to Rescue Male Germ Cells from Apoptosis Induced by Chronic hCG Administration to Rats Apoptosis 2012, 17, 551-565
89. Yu, W.; Zha, W. L.; Guo, S.; Cheng, H. K.; Wu, J. L.; Liu, C. Flos Puerariae Extract Prevents Myocardial Apoptosis via Attenuation Oxidative Stress in Streptozotocin-Induced Diabetic Mice PLoS One 2014, 9, e98044
90. Park, Y. I.; Kim, H. M.; Kim, J. H.; Moon, K. C.; Yoo, B.; Lee, K. T.; Lee, N.; Choi, Y.; Park, W.; Ling, D.; Na, K.; Moon, W. K.; Choi, S. H.; Park, H. S.; Yoon, S.-Y.; Suh, Y. D.; Lee, S. H.; Hyeon, T. Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous in Vivo Dual-Modal Imaging and Photodynamic Therapy Adv. Mater. 2012, 24, 5755-5761
91. 3+@Silica Fiber Nanocomposite Adv. Funct. Mater. 2011, 21, 2356-2365
92. Wang, G. F.; Peng, Q.; Li, Y. D. Lanthanide-Doped Nanocrystals: Synthesis, Optical-Magnetic Properties, and Applications Acc. Chem. Res. 2011, 44, 322-332
93. Li, C. X.; Yang, D. M.; Ma, P. A.; Chen, Y. Y.; Wu, Y.; Hou, Z. Y.; Dai, Y. L.; Zhao, J. H.; Sui, C. P.; Lin, J. Multifunctional Upconversion Mesoporous Silica Nanostructures for Dual Modal Imaging and in Vivo Drug Delivery Small 2013, 9, 4150-4159