The Mitochondria in Heart Failure: A Target for Coenzyme Q10 Therapy?

Clinical Pharmacology and Therapeutics

Volumn 96, Issue 6, 2014, Pages 645-647

  Mortensen, S A ^a   Mortensen, A L ^b  

^a Mental Health Center Glostrup   (Denmark)

^b Pcovery   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; UBIDECARENONE; UBIQUINONE;

ADJUVANT THERAPY; CARDIOGENIC SHOCK; DRUG BLOOD LEVEL; GASTROINTESTINAL SYMPTOM; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; INOTROPISM; KIDNEY DYSFUNCTION; MITOCHONDRION; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SURVIVAL RATE; ANALOGS AND DERIVATIVES; BLOOD; DIET SUPPLEMENTATION; DRUG EFFECTS; HEART MITOCHONDRION; METABOLISM;

DIETARY SUPPLEMENTS; HEART FAILURE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MITOCHONDRIA, HEART; PRACTICE GUIDELINES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; UBIQUINONE;

EID: 84925551223     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.175     Document Type: Review

References (13)

1. Opie, L.H. The metabolic vicious cycle in heart failure. Lancet 364, 1733-1734 (2004
2. Folkers, K., Vadhanavikit, S. & Mortensen, S. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc. Natl. Acad. Sci. USA 82, 901-904 (1985
3. Mortensen, S. Overview on coenzyme Q10 as adjunctive therapy in chronic heart failure. Rationale, design and end-points of "Q-symbio"-multinational trial. Biofactors 18, 79-89 (2003
4. Morisco, C., Trimarco, B. & Condorelli, M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: A long-term multicenter randomized study. Clin. Invest. 71 (suppl.), S134-S136 (1993
5. Mortensen, S.A. et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. Eur. J. Heart Fail. Suppl. 12 (suppl.), S21 (2013
6. Soja, A. & Mortensen, S.A. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol. Aspects Med. 18 (suppl.), S159-S168 (1997
7. Sander, S., Coleman, C.I., Patel, A.A., Kluger, J. & White, C.M. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J. Card. Fail. 12, 464-472 (2006
8. Fotino, A., Thompson-Paul, A. & Bazzano, L. Effect of coenzyme Q10 supplementation on heart failure: A meta-analysis. Am. J. Clin. Nutr. 97, 268-275 (2013
9. Madmani, M.E. et al. Coenzyme Q10 for heart failure. Cochrane Database Syst. Rev. 9, CD008684 (2013
10. Rosenfeldt, F., Hilton, D., Pepe, S. & Krum, H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors 18, 91-100 (2003).
11. Stone, N.J. et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circ., published online 12 November 2013. doi: 10/1161/01. cir.0000437738.53.7a
12. Marcoff, L. & Thompson, P.D. The role of coenzyme Q10 in statin-associated myopathy: A systematic review. J. Am. Coll. Cardiol. 49, 2231-2237 (2007
13. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N. Engl. J. Med. 316, 1429-1435 (1987).