The worst of both worlds: Examining the hypervirulence of the shigatoxigenic/enteroaggregative Escherichia coli O104:H4

Journal of Infectious Diseases

Volumn 210, Issue 12, 2014, Pages 1860-1862

  Steiner, Theodore S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bacterial pathogenesis; Diarrheal infections; Hemorrhagic colitis

Indexed keywords

ACTIN FILAMENT; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM ISOLATE; BIOFILM; EPIDEMIC; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; ESCHERICHIA COLI O104 H4; HEMOLYTIC UREMIC SYNDROME; HOST PATHOGEN INTERACTION; HUMAN; MEMBRANE FORMATION; NONHUMAN; NOTE; PRIORITY JOURNAL; EPITHELIUM CELL; METABOLISM; PROTEIN TRANSPORT;

VEROTOXIN 2;

EPITHELIAL CELLS; ESCHERICHIA COLI; HUMANS; PROTEIN TRANSPORT; SHIGA TOXIN 2;

EID: 84925547235     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu400     Document Type: Note

References (18)

1. Frank C, Werber D, Cramer JP, etal. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 2011;365:1771-80.
2. Bielaszewska M, Mellmann A, Zhang W, et al. Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis 2011;11:671-6.
3. Rasko DA, Webster DR, Sahl JW, et al. Origins of the E.coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med 2011;365:709-17.
4. Nataro J, Kaper J, Robins Browne R, Prado V, Vial P, Levine M. Patterns of adherence of diarrheagenic Escherichia coli to HEp-2 cells. Pediatr Infect Dis J 1987;6:829-31.
5. Estrada-Garcia T, Navarro-Garcia F. Enteroaggregative Escherichia coli pathotype: a genetically heterogeneous emerging foodborne enteropathogen. FEMS Immunol Med Microbiol 2012;66:281-98.
6. Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL. Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide. J Med Microbiol 2013;62:896-905.
7. Zangari T, Melton-Celsa AR, Panda A, et al. Virulence of the Shiga toxin type 2-expressing Escherichia coli O104:H4 German outbreak isolate in two animal models. Infect Immun 2013;81:1562-74.
8. Harrington SM, Dudley EG, Nataro JP. Pathogenesis of enteroaggregative Escherichia coli infection. FEMS Microbiol Lett 2006;254:12-8.
9. Steiner TS, Nataro JP, Poteet-Smith CE, Smith JA, Guerrant RL. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J Clin Invest 2000;105:1769-7.
10. Harrington SM, Strauman MC, Abe CM, Nataro JP. Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli. Cell Microbiol 2005;7:1565-78.
11. Zhang W, Bielaszewska M, Kunsmann L, et al. Lability of the pAA Virulence Plasmid in O104:H4: Implications for Virulence in Humans. PLoS One 2013;8:e66717.
12. Wong CS, Jelacic S, Habeeb RL, Watkins SL, Tarr PI. The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections. N Engl J Med 2000;342:1930-6.
13. Safdar N, Said A, Gangnon RE, Maki DG. Risk of hemolytic uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 enteritis: a meta-analysis. JAMA 2002;288:996-1001.
14. Geerdes-Fenge HF, Lobermann M, Nurnberg M, et al. Ciprofloxacin reduces the risk of hemolytic uremic syndrome in patients with Escherichia coli O104:H4-associated diarrhea. Infection 2013;41:669-73.
15. Menne J, Nitschke M, Stingele R, et al. Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study. BMJ 2012;345:e4565.
16. Nitschke M, Sayk F, Hartel C, et al. Association between azithromycin therapy and duration of bacterial shedding among patients with Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. JAMA 2012;307:1046-52.
17. Corogeanu D, Willmes R, Wolke M, Plum G, Utermohlen O, Kronke M. Therapeutic concentrations of antibiotics inhibit Shiga toxin release from enterohemorrhagic E.coli O104:H4 from the 2011 German outbreak. BMC Microbiol 2012;12:160.
18. Bielaszewska M, Idelevich EA, Zhang W, et al. Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain. Antimicrob Agents Chemother 2012;56:3277-82.