Effect of hyaluronan-enriched embryo transfer medium on IVF outcome: a prospective randomized clinical trial

Archives of Gynecology and Obstetrics

Volumn 291, Issue 5, 2015, Pages 1173-1179

  Fancsovits, Peter ^a   Lehner, Adam ^a   Murber, Akos ^a   Kaszas, Zita ^a   Rigo, Janos ^a   Urbancsek, Janos ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Birthweight; Embryo transfer; Hyaluronan; Implantation rate; IVF; Pregnancy rate

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; FOLLITROPIN; HUMAN MENOPAUSAL GONADOTROPIN; HYALURONIC ACID; PROGESTERONE; TRIPTORELIN;

ADULT; ARTICLE; BIRTH WEIGHT; CELL COUNT; CONTROLLED STUDY; CULTURE MEDIUM; DELIVERY; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MATERNAL AGE; NEWBORN; NIDATION; OOCYTE; OUTCOME ASSESSMENT; PREGNANCY RATE; PROSPECTIVE STUDY; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EMBRYO CULTURE; MIDDLE AGED; PHYSIOLOGY; PREGNANCY; PROCEDURES;

ADULT; BIRTH WEIGHT; DOUBLE-BLIND METHOD; EMBRYO CULTURE TECHNIQUES; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMANS; HYALURONIC ACID; MATERNAL AGE; MIDDLE AGED; OOCYTES; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES;

EID: 84925541827     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-014-3541-9     Document Type: Article

References (45)

1. Meintjes M (2012) Media composition: macromolecules and embryo growth. Methods Mol Biol 912:107–127
2. Bungum M, Humaidan P, Bungum L (2002) Recombinant human albumin as protein source in culture media used for IVF: a prospective randomized study. Reprod Biomed Online 4:233–236
3. Simon A, Safran A, Revel A, Aizenman E, Reubinoff B, Porat-Katz A, Lewin A, Laufer N (2003) Hyaluronic acid can successful replace albumin as the sole macromolecule in a human embryo transfer medium. Fertil Steril 79:1434–1438
4. Van Os HC, Drogendijk AC, Fetter WP, Heijtink RA, Zeilmaker GH (1991) The influence of contamination of culture medium with hepatitis B virus on the outcome of in vitro fertilization pregnancies. Am J Obstet Gynecol 165:152–159
5. Gardner DK, Rodriegez-Martinez H, Lane M (1999) Fetal development after transfer is increased by replacing protein with the glycosaminoglycan hyaluronan for mouse embryo culture and transfer. Hum Reprod 1991(14):2575–2580
6. Stojkovic M, Kölle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, Wenigerkind H, Reichenbach HD, Sinowatz F, Wolf E (2002) Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction 124:141–153
7. Girish KS, Kemparaju K (2007) The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci 80:1921–1943
8. Eppig JJ (1979) FSH stimulates hyaluronic acid synthesis by oocyte-cumulus cell complexes from mouse preovulatory follicles. Nature 281:483–484
9. Suchanek E, Simunic V, Juretic D, Grizelj V (1994) Follicular fluid contents of hyaluronic acid, follicle-stimulating hormone and steroids relative to the success of in vitro fertilization of human oocytes. Fertil Steril 62:347–352
10. Saito H, Kaneko T, Takahashi T, Kawachiya S, Saito T, Hiroi M (2000) Hyaluronan in follicular fluids and fertilization of oocytes. Fertil Steril 74:1148–1152
11. Meizel S (1985) Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anat 174:285–302
12. Kornovski BS, McCoshen J, Kredentser J, Turley E (1994) The regulation of sperm motility by a novel hyaluronan receptor. Fertil Steril 61:935–940
13. Campbell S, Swann HR, Aplin JD, Seif MW, Kimber SJ, Elstein M (1995) CD44 is expressed throughout pre-implantation human embryo development. Hum Reprod 10:425–430
14. Yaegashi N, Fujita N, Yajima A, Nakamura M (1995) Menstrual cycle dependent expression of CD44 in normal human endometrium. Hum Pathol 26:862–865
15. Furnus CC, Valcarcel A, Dulout FN, Errecalde AL (2003) The hyaluronic acid receptor (CD44) is expressed in bovine oocytes and early stage embryos. Theriogenology 60:1633–1644
16. Scott JE (1992) Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues. FASEB J 6:2639–2645
17. Carson DD, Dutt A, Tang JP (1987) Glycoconjugate synthesis during early pregnancy: hyaluronate synthesis and function. Dev Biol 120:228–235
18. Brown JJ, Pappaioannou VE (1992) Distribution of hyaluronan in the mouse endometrium during the periimplantation period of pregnancy. Differentiation 52:61–68
19. Miyano T, Hiro-Oka RE, Kano K, Miyake M, Kusunoki H, Kato S (1994) Effects of hyaluronic acid on the development of 1- and 2-cell porcine embryos to the blastocyst stage in vitro. Theriogenology 41:1299–1305
20. Kano K, Miyano T, Kato S (1998) Effects of glycosaminoglycans on the development of in vitro-matured and -fertilized porcine oocytes to the blastocyst stage in vitro. Biol Reprod 58:1226–1232
21. Stojkovic M, Thompson JG, Tervit HR (1999) Effects of hyaluronic acid supplementation on in vitro development of bovine embryos in a two-step culture system. Theriogenology 51:254
22. Friedler S, Schachter M, Strassburger D, Esther K, Ron El R, Raziel A (2007) A randomized clinical trial comparing recombinant hyaluronan/recombinant albumin versus human tubal fluid for cleavage stage embryo transfer in patients with multiple IVF-embryo transfer failure. Hum Reprod 22:2444–2448
23. Loutradi KE, Prassas I, Bili E, Sanopoulou T, Bontis I, Tarlatzis BC (2007) Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization. Fertil Steril 87:48–52
24. Korosec S, Virant-Klun I, Tomazevic T, Zech NH, Meden-Vrtovec H (2007) Single fresh and frozen-thawed blastocyst transfer using hyaluronan-rich transfer medium. Reprod Biomed Online 15:701–707
25. Urman B, Yakin K, Ata B, Isiklar A, Balaban B (2008) Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfers: a prospective randomized study. Fertil Steril 90:604–612
26. Sifer C, Mour P, Tranchant S, Visentin E, Hafhouf E, Sermondade N, Martin-Pont B, Benzacken B, Lévy R (2009) Is there an interest in the addition of hyaluronan to human embryo culture in IVF/ICSI attempts? Gynecol Obstet Fertil 37:884–889
27. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group Embryology (2011) Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod Biomed Online 22:632–646
28. Schoolcraft W, Lane M, Stevens J, Gardner D (2002) Increased hyaluronan concentration in the embryo transfer medium results in a significant increase in human embryo implantation rate [Abstract]. Fertil Steril 78:S5
29. Gardner DK, Lane M (2003) Blastocyst transfer. Clin Obstet Gynecol 46:231–238
30. West DC, Hampson IN, Arnold F, Kumar S (1985) Angiogenesis induced by degradation products of hyaluronic acid. Science 228:1324–1326
31. Sato E, Tanaka T, Takeya T, Miyamoto H, Koide SS (1991) Ovarian glycosaminoglycans potentiate angiogenic activity of epidermal growth factor in mice. Endocrinology 128:2402–2406
32. Turley E, Moore DC (1984) Hyaluronate binding proteins also bind to fibronectin, laminin and collagen. Biochem Biophys Res Commun 121:808–814
33. Behzad F, Seif MW, Campbell S, Aplin JD (1994) Expression of two isoforms of CD44 in human endometrium. Biol Reprod 51:739–747
34. Hambiliki F, Ljunger E, Kalström PO, Stavreus-Evers A (2010) Hyaluronan-enriched transfer medium in cleavage-stage frozen-thawed embryo transfers increases implantation rate without improvement of delivery rate. Fertil Steril 94:1669–1673
35. Nakagawa K, Takahashi C, Nishi Y, Jyuen H, Sugiyama R, Kuribayashi Y, Sugiyama R (2012) Hyalurinan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures. J Assist Reprod Genet 29:679–685
36. Valojerdi MR, Karimian L, Yazdi PE, Sadighi Gilani MA, Madani T, Baghestani AR (2006) Efficacy of human embryo transfer medium: a prospective, randomized clinical trial study. J Assist Reprod Genet 23:207–212
37. Hazlett WD, Meyer LR, Nasta TE, Mangan PA, Karande VC (2008) Impact of EmbryoGlue as the embryo transfer medium. Fertil Steril 90:214–216
38. Bontekoe S, Blake D, Heineman HJ, Williams EC, Johnson N (2010) Adherence compounds in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst Rev 7:CD007421
39. Bontekoe S, Heineman MJ, Johnson N, Blake D (2014) Adherence compounds in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst Rev 2:CD007421
40. Nelissen ECM, Van Montfoort APA, Smits LJM, Menheere PPCA, Evers JLH, Coonen E, Derhaag JG, Peeters LL, Coumans AB, Dumoulin JCM (2013) IVF culture medium affects human intrauterine growth as early as the second trimester of pregnancy. Hum Reprod 28:2067–2074
41. Hassani F, Eftekhari-Yazdi P, Karimian L, Rezazadeh Valojerdi M, Movaghar B, Fazel M, Fouladi HR, Shabani F, Johansson L (2013) The Effects of ISM1 Medium on Embryo Quality and Outcomes of IVF/ICSI Cycles. Int J Fertil Steril 7:108–115
42. Eskild A, Monkerud L, Tanbo T (2013) Birthweight and placental weight; do changes in culture media used for IVF matter? Comparisons with spontaneous pregnancies in the corresponding time periods. Hum Reprod 28:3207–3214
43. Carrasco B, Boada M, Rodríguez I, Coroleu B, Barri PN, Veiga A (2013) Does culture medium influence offspring birth weight? Fertil Steril 100:1283–1288
44. Ho Y, Wigglesworth K, Eppig JJ, Schultz RM (1995) Preimplantation development of mouse embryos in KSOM: augmentation by amino acids and analysis of gene expression. Mol Reprod Dev 41:232–238
45. Mann MR, Lee SS, Doherty AS, Verona RI, Nolen LD, Schultz RM, Bartolomei MS (2004) Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131:3727–3735