Photosynthetic and extracellular production of glucosylglycerol by genetically engineered and gel-encapsulated cyanobacteria

Applied Microbiology and Biotechnology

Volumn 99, Issue 5, 2015, Pages 2147-2154

  Tan, Xiaoming ^a   Du, Wei ^a,b   Lu, Xuefeng ^a  

^a QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY   (China)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cyanobacteria; Gel encapsulation; Glucosylglycerol; Hypoosmotic shock; Metabolic engineering; Salt shock

Indexed keywords

CELL MEMBRANES; ENCODING (SYMBOLS); GENES; METABOLIC ENGINEERING; PHYSIOLOGY;

ANTIOXIDATIVE PROPERTY; CYANOBACTERIA; CYANOBACTERIUM SYNECHOCYSTIS; ENCAPSULATION METHODS; ENZYMATIC CATALYSIS; GENETICALLY MODIFIED; GLUCOSYLGLYCEROL; HYPOOSMOTIC SHOCK;

CYTOLOGY;

GLUCOSYLGLYCEROL; GLYCEROL DERIVATIVE; ION; UNCLASSIFIED DRUG; GLUCOSIDE; INORGANIC SALT;

ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIUM CULTURE; CELL GROWTH; CELL MEMBRANE; CONTROLLED STUDY; ENCAPSULATION; GEL; GENE DELETION; GENETIC ENGINEERING; HYPOOSMOTIC STRESS; NONHUMAN; PHOTOSYNTHESIS; REPRESSOR GENE; SYNECHOCYSTIS; DRUG EFFECTS; GENETICS; IMMOBILIZED CELL; METABOLIC ENGINEERING; METABOLISM; OSMOTIC PRESSURE;

CELLS, IMMOBILIZED; GENE DELETION; GLUCOSIDES; METABOLIC ENGINEERING; OSMOTIC PRESSURE; PHOTOSYNTHESIS; SALTS; SYNECHOCYSTIS;

EID: 84925533576     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-6273-7     Document Type: Article

References (28)

1. Aizawa Kyo S T, Kotani Yasuhiro, Iwata Koushi, Doi Kazuhisa (2013) Keratoconjunctival protecting agent, or keratoconjunctival disorder inhibiting agent. WO/2013/077433. WO/2013/077433
2. Dickson DJ, Page CJ, Ely RL (2009) Photobiological hydrogen production from Synechocystis sp. PCC 6803 encapsulated in silica sol–gel. Int J Hydrogen Energy 34:204–215
3. Du W, Liang F, Duan Y, Tan X, Lu X (2013) Exploring the photosynthetic production capacity of sucrose by cyanobacteria. Metab Eng 19:17–25
4. Ducat DC, Way JC, Silver PA (2011) Engineering cyanobacteria to generate high-value products. Trends Biotechnol 29:95–103
5. Elhai J, Wolk CP (1988) A versatile class of positive-selection vectors based on the nonviability of palindrome-containing plasmids that allows cloning into long polylinkers. Gene 68:119–138
6. Erdmann N, Zuther E, Abarzua S (1992) Comparative studies on the photoproduction of nonhydrogenous resources by cyanobacteria. Curr Microbiol 25:83–87
7. Goedl C, Sawangwan T, Mueller M, Schwarz A, Nidetzky B (2008) A high-yielding biocatalytic process for the production of 2-O-(α-D-glucopyranosyl)-sn-glycerol, a natural osmolyte and useful moisturizing ingredient. Angew Chem 47:10086–10089
8. Hagemann M (2011) Molecular biology of cyanobacterial salt acclimation. FEMS Microbiol Rev 35:87–123
9. Klähn S, Hagemann M (2011) Compatible solute biosynthesis in cyanobacteria. Environ Microbiol 13:551–562
10. Klahn S, Hohne A, Simon E, Hagemann M (2010) The gene ssl3076 encodes a protein mediating the salt-induced expression of ggpS for the biosynthesis of the compatible solute glucosylglycerol in Synechocystis sp. strain PCC 6803. J Bacteriol 192:4403–4412
11. Klein J, Stumm, Gerhard (2010) Use of glucosylglycerol. WO/2010/020424
12. Krutmann J, Lentzen, Georg, Schwarz, Thomas (2009) Osmolytes for the treatment of allergic or viral respiratory diseases. WO/2009/027069
13. Lu X (2010) A perspective: photosynthetic production of fatty acid-based biofuels in genetically engineered cyanobacteria. Biotechnol Adv 28:742–746
14. Machado IM, Atsumi S (2012) Cyanobacterial biofuel production. J Biotechnol 162:50–56
15. Marin K, Huckauf J, Fulda S, Hagemann M (2002) Salt-dependent expression of glucosylglycerol-phosphate synthase, involved in osmolyte synthesis in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol 184:2870–2877
16. Marin K, Zuther E, Kerstan T, Kunert A, Hagemann M (1998) The ggpS gene from Synechocystis sp. strain PCC 6803 encoding glucosyl-glycerol-phosphate synthase is involved in osmolyte synthesis. J Bacteriol 180:4843–4849
17. Mikkat S, Hagemann M (2000) Molecular analysis of the ggtBCD gene cluster of Synechocystis sp. strain PCC6803 encoding subunits of an ABC transporter for osmoprotective compounds. Arch Microbiol 174:273–282
18. Okumura Hidenobu U S (2012) Blood glucose level suppressant and food inhibiting sharp increase in blood glucose level. JP2003-129931
19. Pocard JA, Smith LT, Smith GM, Le Rudulier D (1994) A prominent role for glucosylglycerol in the adaptation of Pseudomonas mendocina SKB70 to osmotic stress. J Bacteriol 176:6877–6884
20. Quintana N, Van der Kooy F, Van de Rhee MD, Voshol GP, Verpoorte R (2011) Renewable energy from cyanobacteria: energy production optimization by metabolic pathway engineering. Appl Microbiol Biotechnol 91:471–490
21. Reed RH, Warr SRC, Kerby NW, Stewart WDP (1986) Osmotic shock-induced release of low-molecular-weight metabolites from free-living and immobilized cyanobacteria. Enzyme Microb Technol 8:101–104
22. Rippka R, Deruelles J, Waterbury JB, Herdman M, Stanier RY (1979) Generic assignments, strain histories and properties of pure cultures of cyanobacteria. J Gen Microbiol 111:1–61
23. Roder A, Hoffmann E, Hagemann M, Berg G (2005) Synthesis of the compatible solutes glucosylglycerol and trehalose by salt-stressed cells of Stenotrophomonas strains. FEMS Microbiol Lett 243:219–226
24. Sawangwan T, Goedl C, Nidetzky B (2010) Glucosylglycerol and glucosylglycerate as enzyme stabilizers. Biotechnol J 5:187–191
25. Stirnberg M, Fulda S, Huckauf J, Hagemann M, Krämer R, Marin K (2007) A membrane-bound FtsH protease is involved in osmoregulation in Synechocystis sp. PCC 6803: the compatible solute synthesizing enzyme GgpS is one of the targets for proteolysis. Mol Microbiol 63:86–102
26. Takenaka F, Uchiyama H, Imamura T (2000) Identification of alpha-D-glucosylglycerol in sake. Biosci, Biotechnol, Biochem 64:378–385
27. Tan X, Yao L, Gao Q, Wang W, Qi F, Lu X (2011) Photosynthesis driven conversion of carbon dioxide to fatty alcohols and hydrocarbons in cyanobacteria. Metab Eng 13:169–176
28. Xu Y, Tiago Guerra L, Li Z, Ludwig M, Charles Dismukes G, Bryant DA (2013) Altered carbohydrate metabolism in glycogen synthase mutants of Synechococcus sp. strain PCC 7002: cell factories for soluble sugars. Metab Eng 16:56–67