Cell therapy for macular degeneration—first phase I/II pluripotent stem cell-based clinical trial shows promise

Science China Life Sciences

Volumn 58, Issue 1, 2015, Pages 119-120

  Chen, ZhiGuo ^a,b   Zhang, Y Alex ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; EMBRYONIC STEM CELL; FEMALE; HUMAN; MALE; PIGMENT EPITHELIUM; TRANSPLANTATION;

EMBRYONIC STEM CELLS; FEMALE; HUMANS; MALE; RETINAL PIGMENT EPITHELIUM;

EID: 84925521415     PISSN: 16747305     EISSN: 18691889     Source Type: Journal    
DOI: 10.1007/s11427-014-4791-2     Document Type: Article

References (4)

1. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature, 1981, 292: 154–156
2. Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet advance online publication 15 October 2014; doi:10.1016/S0140-6736 (14)61376-3
3. Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, Mickunas E, Gay R, Klimanskaya I, Lanza R. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet, 2012, 379: 713–720
4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006, 126: 663–676