SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes

Diabetologia

Volumn 58, Issue 3, 2015, Pages 543-548

  Germain, Marine ^a,b,c   Pezzolesi, Marcus G ^d   Sandholm, Niina ^e,f,g   McKnight, Amy J ^h   Susztak, Katalin ⁱ   Lajer, Maria ^j   Forsblom, Carol ^e,f   Marre, Michel ^k,l,m,n   Parving, Hans Henrik ^o,p   Rossing, Peter ^j,o,p   Toppila, Iiro ^e,f   Skupien, Jan ^d,q   Roussel, Ronan ^k,l,m,n   Ko, Yi An ⁱ   Ledo, Nora ⁱ   Folkersen, Lasse ^r,s   Civelek, Mete ^t   Maxwell, Alexander P ^h,u   Tregouet, David Alexandre ^a,b,c   Groop, Per Henrik ^e,f,v   Tarnow, Lise ^j,o,w   Hadjadj, Samy ^b,x,y   more..

^a SORBONNE UNIVERSITÉ   (France)

^b INSERM   (France)

^c Institute of Cardiometabolism and Nutrition (ICAN)   (France)

^d HARVARD MEDICAL SCHOOL   (United States)

^e FOLKHÄLSAN INSTITUTE OF GENETICS   (Finland)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^g AALTO UNIVERSITY   (Finland)

^h QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

^j STENO DIABETES CENTER   (Denmark)

^k UNIVERSITÉ PARIS DESCARTES   (France)

^l BICHAT HOSPITAL   (France)

^m Dé Partement Hospitalo Universitaire FIRE   (France)

ⁿ CENTRE DE RECHERCHE DES CORDELIERS   (France)

^o AARHUS UNIVERSITY   (Denmark)

^p UNIVERSITY OF COPENHAGEN   (Denmark)

^q JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^r NOVO NORDISK A S   (Denmark)

^s KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^t UNIVERSITY OF CALIFORNIA   (United States)

^u BELFAST CITY HOSPITAL   (United Kingdom)

^v BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^w HILLERØD HOSPITAL   (Denmark)

^x UNIVERSITÉ DE POITIERS   (France)

^y POITIERS UNIVERSITY HOSPITAL   (France)

more..

Author keywords

Diabetic nephropathy; GWAS; Kidney; Sorbin; Type 1 diabetes

Indexed keywords

PROTEIN; SORBIN AND SH3 DOMAIN CONTAINING PROTEIN 1; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; SORBS1 PROTEIN, HUMAN;

ALLELE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC PATIENT; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN GENOME; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; KIDNEY TUBULE; MAJOR CLINICAL STUDY; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; SINGLE NUCLEOTIDE POLYMORPHISM; SORBS1 GENE; CAUCASIAN; COMPLICATION; DIABETIC NEPHROPATHIES; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MALE; MIDDLE AGED; PROCEDURES;

DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84925519441     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3459-6     Document Type: Article

References (11)

1. Harjutsalo V, Katoh S, Sarti C, Tajima N, Tuomilehto J (2004) Population-based assessment of familial clustering of diabetic nephropathy in type 1 diabetes. Diabetes 53:2449–2454
2. Sandholm N, Salem RM, McKnight AJ et al (2012) New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 8:e1002921
3. Pezzolesi MG, Poznik GD, Mychaleckyj JC et al (2009) Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes 58:1403–1410
4. Tarnow L, Groop PH, Hadjadj S et al (2008) European rational approach for the genetics of diabetic complications–EURAGEDIC: patient populations and strategy. Nephrol Dial Transplant 23:161–168
5. Woroniecka KI, Park AS, Mohtat D, Thomas DB, Pullman JM, Susztak K (2011) Transcriptome analysis of human diabetic kidney disease. Diabetes 60:2354–2369
6. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904–909
7. Magi R, Morris AP (2010) GWAMA: software for genome-wide association meta-analysis. BMC Bioinforma 11:288
8. Folkersen L, van't Hooft F, Chernogubova E et al (2010) Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease. Circ Cardiovasc Genet 3:365–373
9. Erbilgin A, Civelek M, Romanoski CE et al (2013) Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res 54:1894–1905
10. Nakatani S, Kakehashi A, Ishimura E et al (2011) Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy. Exp Diabetes Res 2011:979354
11. Gilbert RE, Cooper ME (1999) The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 56:1627–1637