Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis

Nephrology

Volumn 19, Issue 12, 2014, Pages 802-813

  Conway, Bryan R ^a   Betz, Boris ^b   Sheldrake, Tara A ^b   Manning, Jonathan R ^a   Dunbar, Donald R ^a   Dobyns, Abigail ^c   Hughes, Jeremy ^b   Mullins, John J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c University of Illinois at Chicago   (United States)

Author keywords

diabetic nephropathy; fibrosis; hyperglycaemia; hypertension; regression

Indexed keywords

3 INDOLEMETHANOL; INSULIN; METALLOPROTEINASE; RENIN; SCLEROPROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; CYTOCHROME P450 1A1; GLUCOSE BLOOD LEVEL; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; REN2 PROTEIN, MOUSE; TISSUE INHIBITOR OF METALLOPROTEINASE-1 PROTEIN, RAT;

ADAPTIVE IMMUNITY; ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG IMPLANT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE CONTROL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERTENSION; INNATE IMMUNITY; KIDNEY FIBROSIS; KIDNEY HYPERTROPHY; LYSOSOME; MALE; MICROARRAY ANALYSIS; MYOFIBROBLAST; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; REMISSION; RODENT MODEL; SCAR; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TISSUE HOMOGENATE; TRANSGENE; UPREGULATION; ZYMOGRAPHY; ANIMAL; BLOOD; BLOOD PRESSURE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA MICROARRAY; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION PROFILING; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; PROMOTER REGION; TIME; TRANSGENIC RAT;

ALBUMINURIA; ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BLOOD PRESSURE; CYTOCHROME P-450 CYP1A1; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION PROFILING; HYPERTENSION; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; KIDNEY; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; RATS, TRANSGENIC; RENIN; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84925515919     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/nep.12335     Document Type: Article

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