-
1
-
-
84923005480
-
-
National Comprehensive Cancer Network Accessed 24 Nov 2014
-
®): non-Hodgkin's lymphoma (version 5.2014). 2014. http://www.nccn.org/. Accessed 24 Nov 2014.
-
(2014)
®): Non-Hodgkin's Lymphoma (Version 5.2014)
-
-
-
2
-
-
80052716066
-
Chronic lymphocytic leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
Eichhorst B, Dreyling M, Robak T, et al. Chronic lymphocytic leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2011;22(Suppl 6):vi50-4.
-
(2011)
Ann Oncol.
, vol.22
, pp. vi50-vi54
-
-
Eichhorst, B.1
Dreyling, M.2
Robak, T.3
-
3
-
-
84872875413
-
Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties
-
Klein C, Lammens A, Schäfer W, et al. Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties. mAbs. 2013;5(1):22-33.
-
(2013)
MAbs
, vol.5
, Issue.1
, pp. 22-33
-
-
Klein C, L.1
-
4
-
-
40449086383
-
Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: A study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients
-
Tam CS, Otero-Palacios J, Abruzzo LV, et al. Chronic lymphocytic leukaemia CD20 expression is dependent on the genetic subtype: a study of quantitative flow cytometry and fluorescent in-situ hybridization in 510 patients. Br J Haematol. 2008;141(1):36-40.
-
(2008)
Br J Haematol
, vol.141
, Issue.1
, pp. 36-40
-
-
Tam, C.S.1
Otero-Palacios, J.2
Abruzzo, L.V.3
-
7
-
-
84885671483
-
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
-
1:CAS:528:DC%2BC3sXhsFOhurrL 23873847
-
Herter S, Herting F, Mundigl O, et al. Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models. Mol Cancer Ther. 2013;12(10):2031-42.
-
(2013)
Mol Cancer Ther
, vol.12
, Issue.10
, pp. 2031-2042
-
-
Herter, S.1
Herting, F.2
Mundigl, O.3
-
8
-
-
84874835426
-
Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties
-
1:CAS:528:DC%2BC3sXjsFKjsrc%3D 23418626
-
Rafiq S, Butchar JP, Cheney C, et al. Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties. J Immunol. 2013;190(6):2702-11.
-
(2013)
J Immunol
, vol.190
, Issue.6
, pp. 2702-2711
-
-
Rafiq, S.1
Butchar, J.P.2
Cheney, C.3
-
9
-
-
84896499999
-
Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity
-
1:CAS:528:DC%2BC2cXivFOruro%3D 24489098
-
Herter S, Birk MC, Klein C, et al. Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity. J Immunol. 2014;192(5):2252-60.
-
(2014)
J Immunol
, vol.192
, Issue.5
, pp. 2252-2260
-
-
Herter, S.1
Birk, M.C.2
Klein, C.3
-
10
-
-
77951561987
-
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
-
Mössner E, Brünker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood. 2010;115(22):4393-402.
-
(2010)
Blood
, vol.115
, Issue.22
, pp. 4393-4402
-
-
Mössner, E.1
Brünker, P.2
Moser, S.3
-
11
-
-
85081868389
-
Obinutuzumab (GA101) 1,000 versus 2,000 mg in patients with chronic lymphocytic leukemia (CLL): Results of the phase II GAGE (GAO4768g) trial [abstract no. 7083]
-
Flynn JM, Byrd JC, Kipps TJ, et al. Obinutuzumab (GA101) 1,000 versus 2,000 mg in patients with chronic lymphocytic leukemia (CLL): results of the phase II GAGE (GAO4768g) trial [abstract no. 7083]. J Clin Oncol. 2014;32(15 Suppl. 1).
-
(2014)
J Clin Oncol
, vol.32
, Issue.15
-
-
Flynn, J.M.1
Byrd, J.C.2
Kipps, T.J.3
-
12
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
1:CAS:528:DC%2BC2cXlt1ems74%3D 24401022
-
Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014;370(12):1101-10.
-
(2014)
N Engl J Med
, vol.370
, Issue.12
, pp. 1101-1110
-
-
Goede, V.1
Fischer, K.2
Busch, R.3
-
13
-
-
84861835530
-
Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients
-
1:CAS:528:DC%2BC38XhtVWjsrfJ 22431570
-
Salles G, Morschhauser F, Lamy T, et al. Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients. Blood. 2012;119(22):5126-32.
-
(2012)
Blood
, vol.119
, Issue.22
, pp. 5126-5132
-
-
Salles, G.1
Morschhauser, F.2
Lamy, T.3
-
14
-
-
76949107685
-
Phase i study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia [abstract no. 884]
-
Morschhauser F, Cartron G, Lamy T, et al. Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia [abstract no. 884]. Blood. 2009;114.
-
(2009)
Blood
, pp. 114
-
-
Morschhauser, F.1
Cartron, G.2
Lamy, T.3
-
15
-
-
84907698941
-
Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: Final data from the phase 1/2 GAUGUIN study
-
1:CAS:528:DC%2BC2cXhvVGrtr%2FN 25143487
-
Cartron G, de Guibert S, Dilhuydy M-S, et al. Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study. Blood. 2014;124(14):2196-202.
-
(2014)
Blood
, vol.124
, Issue.14
, pp. 2196-2202
-
-
Cartron, G.1
De Guibert, S.2
Dilhuydy, M.-S.3
-
16
-
-
84861830510
-
A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies
-
1:CAS:528:DC%2BC38XhtVWjsrfN 22438256
-
Sehn LH, Assouline SE, Stewart DA, et al. A phase 1 study of obinutuzumab induction followed by 2 years of maintenance in patients with relapsed CD20-positive B-cell malignancies. Blood. 2012;119(22):5118-25.
-
(2012)
Blood
, vol.119
, Issue.22
, pp. 5118-5125
-
-
Sehn, L.H.1
Assouline, S.E.2
Stewart, D.A.3
-
17
-
-
84925462844
-
Population pharmacokinetics of obinutuzumab (GA101) in chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma and exposure-response in CLL
-
1:CAS:528:DC%2BC2cXhvVemsrjM
-
Gibiansky E, Gibiansky L, Carlile DJ, et al. Population pharmacokinetics of obinutuzumab (GA101) in chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma and exposure-response in CLL. CPT Pharmacomet Syst Pharmacol. 2014;3:e144.
-
(2014)
CPT Pharmacomet Syst Pharmacol
, vol.3
, pp. 144
-
-
Gibiansky, E.1
Gibiansky, L.2
Carlile, D.J.3
-
18
-
-
85042290443
-
-
European Medicines Agency Accessed 24 Nov 2014
-
European Medicines Agency. Gazyvaro: CHMP assessment report. 2014. http://www.ema.europa.eu/ema/. Accessed 24 Nov 2014.
-
(2014)
Gazyvaro: CHMP Assessment Report
-
-
-
19
-
-
85081872205
-
-
US FDA Center for Drug Evaluation and Research Accessed 24 Nov 2014
-
US FDA Center for Drug Evaluation and Research. Medical review: GAZYA (obinutuzumab). 2013. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Accessed 24 Nov 2014.
-
(2013)
Medical Review: GAZYA (Obinutuzumab)
-
-
-
20
-
-
84932181406
-
Risk factors associated with the development of infusion-related reactions in patients with chronic lymphocytic leukaemia treated with anti-CD20 monoclonal antibodies: Analysis of the CLL11 study dataset [abstract no. 3339]
-
Freeman CL, Dixon M, Houghton R, et al. Risk factors associated with the development of infusion-related reactions in patients with chronic lymphocytic leukaemia treated with anti-CD20 monoclonal antibodies: analysis of the CLL11 study dataset [abstract no. 3339]. In: 56th American Society of Hematology Annual Meeting and Exposition; 2014.
-
(2014)
56th American Society of Hematology Annual Meeting and Exposition
-
-
Freeman, C.L.1
Dixon, M.2
Houghton, R.3
-
21
-
-
84857320492
-
Dose selection for phase III studies of the monoclonal anti-CD20 antibody obinutuzumab (GA101): A rational approach [abstract no. 0935]
-
Morschhauser A, Salles G, Cartron G, et al. Dose selection for phase III studies of the monoclonal anti-CD20 antibody obinutuzumab (GA101): a rational approach [abstract no. 0935]. Haematologica. 2011;96(Suppl 2):390.
-
(2011)
Haematologica
, vol.96
, pp. 390
-
-
Morschhauser, A.1
Salles, G.2
Cartron, G.3
-
22
-
-
84877878562
-
Monoclonal antibodies targeting CD20
-
Chang C-H, Rossi EA, Goldenberg DM. Monoclonal antibodies targeting CD20. mAbs. 2013;5(3):335-6.
-
(2013)
MAbs
, vol.5
, Issue.3
, pp. 335-336
-
-
Chang, C.-H.1
Rossi, E.A.2
Goldenberg, D.M.3
-
23
-
-
85081870397
-
FCR-3 as frontline therapy for patients with chronic lymphocytic leukemia [abstract no. 2117]
-
O'Brien S, Wierda WG, Faderl S, et al. FCR-3 as frontline therapy for patients with chronic lymphocytic leukemia [abstract no. 2117]. Blood. 2005;106.
-
(2005)
Blood
, pp. 106
-
-
O'Brien, S.1
Wierda, W.G.2
Faderl, S.3
-
24
-
-
0035871441
-
Rituximab dose-escalation trial in chronic lymphocytic leukemia
-
11304768
-
O'Brien SM, Kantarjian H, Thomas DA, et al. Rituximab dose-escalation trial in chronic lymphocytic leukemia. J Clin Oncol. 2001;19(8):2165-70.
-
(2001)
J Clin Oncol
, vol.19
, Issue.8
, pp. 2165-2170
-
-
O'Brien, S.M.1
Kantarjian, H.2
Thomas, D.A.3
-
25
-
-
85081870140
-
Obinutuzumab and chlorambucil versus chlorambucil monotherapy for treatment of previously untreated chronic lymphocytic leukemia where fludarabine-based chemotherapy is considered inappropriate: A Canadian cost-utility analysis [abstract no. 1288]
-
Cameron H, Thompson M, Marino J-P, et al. Obinutuzumab and chlorambucil versus chlorambucil monotherapy for treatment of previously untreated chronic lymphocytic leukemia where fludarabine-based chemotherapy is considered inappropriate: a Canadian cost-utility analysis [abstract no. 1288]. In: 56th American Society of Hematology Annual Meeting and Exposition; 2014.
-
(2014)
56th American Society of Hematology Annual Meeting and Exposition
-
-
Cameron, H.1
Thompson, M.2
Marino, J.-P.3
-
26
-
-
84925503668
-
The potential cost-effectiveness of obinutuzumab (GA101) in combination with chlorambucil in chronic lymphocytic leukemia [abstract no. PCN112]
-
Walzer S, Becker U, Samanta K, et al. The potential cost-effectiveness of obinutuzumab (GA101) in combination with chlorambucil in chronic lymphocytic leukemia [abstract no. PCN112]. Value Health. 2013;16(7):A412.
-
(2013)
Value Health
, vol.16
, Issue.7
, pp. 412
-
-
Walzer, S.1
Becker, U.2
Samanta, K.3
-
27
-
-
85081871112
-
Is obinutuzumab cost-effective in the first-line treatment of CLL? [abstract no. 7052]
-
Veenstra DL, Reyes CM, Ramsey SD. Is obinutuzumab cost-effective in the first-line treatment of CLL? [abstract no. 7052]. J Clin Oncol. 2014;32(15 Suppl. 1).
-
(2014)
J Clin Oncol.
, vol.32
, Issue.15
-
-
Veenstra, D.L.1
Reyes, C.M.2
Ramsey, S.D.3
-
28
-
-
84938262403
-
Cost-effectiveness analysis of obinutuzumab versus ofatumumab for previously untreated chronic lymphocytic leukemia (CLL) [abstract no. 1324]
-
Reyes C, Gazauskas G, Becker U, et al. Cost-effectiveness analysis of obinutuzumab versus ofatumumab for previously untreated chronic lymphocytic leukemia (CLL) [abstract no. 1324]. In: 56th American Society of Hematology Annual Meeting and Exposition; 2014.
-
(2014)
56th American Society of Hematology Annual Meeting and Exposition
-
-
Reyes, C.1
Gazauskas, G.2
Becker, U.3
-
29
-
-
85081866218
-
-
National Institute for Health and Care Excellence Accessed 3 Dec 2014
-
National Institute for Health and Care Excellence. NICE set to recommend another leukaemia drug. 2014. https://www.nice.org.uk/. Accessed 3 Dec 2014.
-
(2014)
NICE Set to Recommend Another Leukaemia Drug
-
-
-
31
-
-
85081872307
-
Indirect treatment comparisons of obinutuzumab (GA101) plus chlorambucil (Clb) versus bendamustine and versus ofatumumab plus Clb in patients with chronic lymphocytic Leukemia [abstract no. PSY9]
-
Waterboer T, Moreno SG, Shang A, et al. Indirect treatment comparisons of obinutuzumab (GA101) plus chlorambucil (Clb) versus bendamustine and versus ofatumumab plus Clb in patients with chronic lymphocytic Leukemia [abstract no. PSY9]. Value Health. 2014;17(3):A225.
-
(2014)
Value Health
, vol.17
, Issue.3
, pp. 225
-
-
Waterboer, T.1
Moreno, S.G.2
Shang, A.3
|