A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer

International Journal of Colorectal Disease

Volumn 30, Issue 4, 2015, Pages 447-457

  Petrelli, Fausto ^a   Coinu, Andrea ^a   Lonati, Veronica ^a   Barni, Sandro ^a  

^a TREVIGLIO HOSPITAL   (Italy)

Author keywords

Adjuvant chemotherapy; Neoadjuvant chemoradiotherapy; Overall survival; Rectal cancer; Surgery

Indexed keywords

ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FOLLOW UP; HUMAN; META ANALYSIS; MULTIMODALITY CANCER THERAPY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECTUM CANCER; REVIEW; SENSITIVITY ANALYSIS; TREATMENT RESPONSE; ADJUVANT CHEMORADIOTHERAPY; ADJUVANT CHEMOTHERAPY; METASTASIS; MORTALITY; PATHOLOGY; PUBLISHING; RECTAL NEOPLASMS; SURVIVAL; TUMOR RECURRENCE;

CHEMORADIOTHERAPY, ADJUVANT; CHEMOTHERAPY, ADJUVANT; HUMANS; NEOADJUVANT THERAPY; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PUBLICATION BIAS; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 84925489925     PISSN: 01791958     EISSN: 14321262     Source Type: Journal    
DOI: 10.1007/s00384-014-2082-9     Document Type: Review

References (35)

1. Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C et al (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 30(16):1926–1933
2. Petersen SH, Harling H, Kirkeby LT, Wille-Jørgensen P, Mocellin S (2012) Postoperative adjuvant chemotherapy in rectal cancer operated for cure. Cochrane Database Syst Rev 3:CD004078
3. Bosset JF, Calais G, Mineur L, Maingon P, Stojanovic-Rundic S, Bensadoun RJ et al (2014) Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol 15(2):184–190
4. Glynne-Jones R, Counsell N, Quirke P, Mortensen N, Maraveyas A, Meadows HM et al (2014) Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (Xelox) versus control. Ann Oncol 25(7):1356–1362
5. Cionini L, Sainato A, De Paoli A (2010) Final results of randomized trial on adjuvant chemotherapy after preoperative chemoradiation in rectal cancer. Radiother Oncol 96(suppl 1):S113–S114
6. Breugom AJ, van den Broek CBM, van Gijn W (2013) The value of adjuvant chemotherapy in rectal cancer patients after preoperative radiotherapy or chemotherapy followed by TME-surgery: the PROCTOR/SCRIPT study. Eur J Cancer 49(suppl 3):S1
7. http://www.esmo.org/Guidelines-Practice/Clinical-Practice-Guidelines/Gastrointestinal-Cancers/Rectal-Cancer (last accessed 2014, May 1st)
8. http://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf (last accessed 2014, May 1st)
9. Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097
10. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283:2008–2012
11. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605
12. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Version 5.1.0. The Cochrane Collaboration; 2011 [updated March 2011].
13. You KY, Huang R, Ding PR, Qiu B, Zhou GQ, Chang H et al (2014) Selective use of adjuvant chemotherapy for rectal cancer patients with ypN0. Int J Color Dis 29(4):529–538
14. Tiselius C, Gunnarsson U, Smedh K, Glimelius B, Påhlman L (2013) Patients with rectal cancer receiving adjuvant chemotherapy have an increased survival: a population-based longitudinal study. Ann Oncol 24(1):160–165
15. Kiran RP, Kirat HT, Burgess AN, Nisar PJ, Kalady MF, Lavery IC (2012) Is adjuvant chemotherapy really needed after curative surgery for rectal cancer patients who are node-negative after neoadjuvant chemoradiotherapy? Ann Surg Oncol 19(4):1206–1212
16. Govindarajan A, Reidy D, Weiser MR, Paty PB, Temple LK, Guillem JG et al (2011) Recurrence rates and prognostic factors in ypN0 rectal cancer after neoadjuvant chemoradiation and total mesorectal excision. Ann Surg Oncol 18(13):3666–3672
17. Valentini V, van Stiphout RG, Lammering G, Gambacorta MA, Barba MC, Bebenek M et al (2011) Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials. J Clin Oncol 29(23):3163–3172
18. Du CZ, Chen YC, Cai Y, Xue WC, Gu J (2011) Oncologic outcomes of primary and post-irradiated early stage rectal cancer: a retrospective cohort study. World J Gastroenterol 17(27):3229–3234
19. Kusters M, Valentini V, Calvo FA, Krempien R, Nieuwenhuijzen GA, Martijn H et al (2010) Results of European pooled analysis of IORT-containing multimodality treatment for locally advanced rectal cancer: adjuvant chemotherapy prevents local recurrence rather than distant metastases. Ann Oncol 21(6):1279–1284
20. Huh JW, Kim HR (2009) Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0? J Surg Oncol 100(5):387–391
21. Valentini V, Coco C, Rizzo G, Manno A, Crucitti A, Mattana C et al (2009) Outcomes of clinical T4M0 extra-peritoneal rectal cancer treated with preoperative radiochemotherapy and surgery: a prospective evaluation of a single institutional experience. Surgery 145(5):486–494
22. Collette L, Bosset JF, den Dulk M, Nguyen F, Mineur L, Maingon P et al (2007) Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol 25(28):4379–4386
23. Hildebrandt B, Rau B, Löffel J, Wust P, Nicolaou A, Gellermann J et al (2006) Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection. Int J Color Dis 21(6):582–589
24. Chan AK, Wong A, Jenken D, Heine J, Buie D, Johnson D (2004) Is postoperative adjuvant chemotherapy necessary in locally advanced rectal cancers after preoperative chemoradiation. Int J Radiat Oncol Biol Phys 60(1 Suppl):S297
25. De Caluwé L, Van Nieuwenhove Y, Ceelen WP (2013) Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev 2:CD006041
26. An X, Lin X, Wang FH, Goodman K, Cai PQ, Kong LH et al (2013) Short term results of neoadjuvant chemoradiotherapy with fluoropyrimidine alone or in combination with oxaliplatin in locally advanced rectal cancer: a meta analysis. Eur J Cancer 49(4):843–851
27. Habr-Gama A, Gama-Rodrigues J, São Julião GP, Proscurshim I, Sabbagh C, Lynn PB et al (2014) Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control. Int J Radiat Oncol Biol Phys 88(4):822–828
28. Gunderson LL, Sargent DJ, Tepper JE, Wolmark N, O'Connell MJ, Begovic M et al (2004) Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis. J Clin Oncol 22(10):1785–1796
29. Sargent DJ, Wieand HS, Haller DG, Gray R, Benedetti JK, Buyse M et al (2005) Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 23(34):8664–8670
30. Uno H, Claggett B, Tian L, Inoue E, Gallo P, Miyata T et al (2014) Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol 32(22):2380–2385
31. André T, Quinaux E, Louvet C, Colin P, Gamelin E, Bouche O et al (2007) Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon cancer patients: final results of GERCOR C96.1. J Clin Oncol 25(24):3732–3738
32. Hofheinz RD, Wenz F, Post S, Matzdorff A, Laechelt S, Hartmann JT et al (2012) Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial. Lancet Oncol 13(6):579–588
33. Chua YJ, Barbachano Y, Cunningham D, Oates JR, Brown G, Wotherspoon A et al (2010) Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 11(3):241–248
34. Petrelli F, Sgroi G, Sarti E, Barni S (2013) Increasing the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer: a meta-analysis of published studies. Ann Surg. doi:10.1097/SLA.0000000000000368
35. Khrizman P, Niland JC, ter Veer A, Milne D, Bullard Dunn K, Carson WE 3rd et al (2013) Postoperative adjuvant chemotherapy use in patients with stage II/III rectal cancer treated with neoadjuvant therapy: a national comprehensive cancer network analysis. J Clin Oncol 31(1):30–38