Intraoperative Surgical Margin Re-resection for Colorectal Liver Metastasis: Is It Worth the Effort?

Journal of Gastrointestinal Surgery

Volumn 19, Issue 4, 2015, Pages 699-707

  Margonis, Georgios A ^a   Spolverato, Gaya ^a   Kim, Yuhree ^a   Ejaz, Aslam ^a   Pawlik, Timothy M ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Colorectal liver metastasis; Intraoperative margin resection; Margin; Survival

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; COLORECTAL NEOPLASMS; FEMALE; HUMAN; LIVER NEOPLASMS; LIVER RESECTION; MALE; MIDDLE AGED; MORTALITY; PATHOLOGY; RETROSPECTIVE STUDY; SECONDARY; SURVIVAL RATE; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; COLORECTAL NEOPLASMS; FEMALE; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84925488769     PISSN: 1091255X     EISSN: 18734626     Source Type: Journal    
DOI: 10.1007/s11605-014-2710-2     Document Type: Article

References (38)

1. Adam R, De Gramont A, Figueras J, Guthrie A, Kokudo N, Kunstlinger F, Loyer E, Poston G, Rougier P, Rubbia-Brandt L et al: The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. The oncologist 2012, 17(10):1225-1239.
2. Wieser M, Sauerland S, Arnold D, Schmiegel W, Reinacher-Schick A: Peri-operative chemotherapy for the treatment of resectable liver metastases from colorectal cancer: A systematic review and meta-analysis of randomized trials. BMC cancer 2010, 10:309.
3. House MG, Ito H, Gonen M, Fong Y, Allen PJ, DeMatteo RP, Brennan MF, Blumgart LH, Jarnagin WR, D’Angelica MI: Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. Journal of the American College of Surgeons 2010, 210(5):752-755.
4. Vigano L, Russolillo N, Ferrero A, Langella S, Sperti E, Capussotti L: Evolution of long-term outcome of liver resection for colorectal metastases: analysis of actual 5-year survival rates over two decades. Annals of surgical oncology 2012, 19(6):2035-2044.
5. Spolverato G, Ejaz A, Azad N, Pawlik TM: Surgery for colorectal liver metastases: The evolution of determining prognosis. World journal of gastrointestinal oncology 2013, 5(12):207-221.
6. Mayo SC, Pawlik TM: Current management of colorectal hepatic metastasis. Expert review of gastroenterology & hepatology 2009, 3(2):131-144.
7. Pawlik TM, Choti MA: Surgical therapy for colorectal metastases to the liver. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 2007, 11(8):1057-1077.
8. Nathan H, de Jong MC, Pulitano C, Ribero D, Strub J, Mentha G, Gigot JF, Schulick RD, Choti MA, Aldrighetti L et al: Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients. Journal of the American College of Surgeons 2010, 210(5):755-764, 764-756.
9. Smith MD, McCall JL: Systematic review of tumour number and outcome after radical treatment of colorectal liver metastases. The British journal of surgery 2009, 96(10):1101-1113.
10. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH: Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Annals of surgery 1999, 230(3):309-318; discussion 318-321.
11. Rees M, Tekkis PP, Welsh FK, O’Rourke T, John TG: Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Annals of surgery 2008, 247(1):125-135.
12. Minagawa M, Makuuchi M, Torzilli G, Takayama T, Kawasaki S, Kosuge T, Yamamoto J, Imamura H: Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results. Annals of surgery 2000, 231(4):487-499.
13. Choti MA, Sitzmann JV, Tiburi MF, Sumetchotimetha W, Rangsin R, Schulick RD, Lillemoe KD, Yeo CJ, Cameron JL: Trends in long-term survival following liver resection for hepatic colorectal metastases. Annals of surgery 2002, 235(6):759-766.
14. John SK, Robinson SM, Rehman S, Harrison B, Vallance A, French JJ, Jaques BC, Charnley RM, Manas DM, White SA: Prognostic factors and survival after resection of colorectal liver metastasis in the era of preoperative chemotherapy: an 11-year single-centre study. Digestive surgery 2013, 30(4-6):293-301.
15. Elias D, Lasser P, Debaene B, Doidy L, Billard V, Spencer A, Leclercq B: Intermittent vascular exclusion of the liver (without vena cava clamping) during major hepatectomy. The British journal of surgery 1995, 82(11):1535-1539.
16. Ekberg H, Tranberg KG, Andersson R, Lundstedt C, Hagerstrand I, Ranstam J, Bengmark S: Determinants of survival in liver resection for colorectal secondaries. The British journal of surgery 1986, 73(9):727-731.
17. Shirabe K, Takenaka K, Gion T, Fujiwara Y, Shimada M, Yanaga K, Maeda T, Kajiyama K, Sugimachi K: Analysis of prognostic risk factors in hepatic resection for metastatic colorectal carcinoma with special reference to the surgical margin. The British journal of surgery 1997, 84(8):1077-1080.
18. Fuhrman GM, Curley SA, Hohn DC, Roh MS: Improved survival after resection of colorectal liver metastases. Annals of surgical oncology 1995, 2(6):537-541.
19. Steele G, Jr., Bleday R, Mayer RJ, Lindblad A, Petrelli N, Weaver D: A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 1991, 9(7):1105-1112.
20. Pawlik TM, Scoggins CR, Zorzi D, Abdalla EK, Andres A, Eng C, Curley SA, Loyer EM, Muratore A, Mentha G et al: Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Annals of surgery 2005, 241(5):715-722, discussion 722-714.
21. Kokudo N, Miki Y, Sugai S, Yanagisawa A, Kato Y, Sakamoto Y, Yamamoto J, Yamaguchi T, Muto T, Makuuchi M: Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Archives of surgery 2002, 137(7):833-840.
22. Muratore A, Ribero D, Zimmitti G, Mellano A, Langella S, Capussotti L: Resection margin and recurrence-free survival after liver resection of colorectal metastases. Annals of surgical oncology 2010, 17(5):1324-1329.
23. Nuzzo G, Giuliante F, Ardito F, Vellone M, Giovannini I, Federico B, Vecchio FM: Influence of surgical margin on type of recurrence after liver resection for colorectal metastases: a single-center experience. Surgery 2008, 143(3):384-393.
24. Figueras J, Burdio F, Ramos E, Torras J, Llado L, Lopez-Ben S, Codina-Barreras A, Mojal S: Effect of subcentimeter nonpositive resection margin on hepatic recurrence in patients undergoing hepatectomy for colorectal liver metastases. Evidences from 663 liver resections. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO 2007, 18(7):1190-1195.
25. Angelsen JH, Horn A, Eide GE, Viste A: Surgery for colorectal liver metastases: the impact of resection margins on recurrence and overall survival. World journal of surgical oncology 2014, 12:127.
26. Andreou A, Aloia TA, Brouquet A, Dickson PV, Zimmitti G, Maru DM, Kopetz S, Loyer EM, Curley SA, Abdalla EK et al: Margin status remains an important determinant of survival after surgical resection of colorectal liver metastases in the era of modern chemotherapy. Ann Surg 2013, 257(6):1079-1088.
27. Bodingbauer M, Tamandl D, Schmid K, Plank C, Schima W, Gruenberger T: Size of surgical margin does not influence recurrence rates after curative liver resection for colorectal cancer liver metastases. The British journal of surgery 2007, 94(9):1133-1138.
28. Inoue Y, Hayashi M, Komeda K, Masubuchi S, Yamamoto M, Yamana H, Kayano H, Shimizu T, Asakuma M, Hirokawa F et al: Resection margin with anatomic or nonanatomic hepatectomy for liver metastasis from colorectal cancer. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 2012, 16(6):1171-1180.
29. Ayez N, Lalmahomed ZS, Eggermont AM, Ijzermans JN, de Jonge J, van Montfort K, Verhoef C: Outcome of microscopic incomplete resection (R1) of colorectal liver metastases in the era of neoadjuvant chemotherapy. Ann Surg Oncol 2012, 19(5):1618-1627.
30. de Haas RJ, Wicherts DA, Flores E, Azoulay D, Castaing D, Adam R: R1 resection by necessity for colorectal liver metastases: is it still a contraindication to surgery? Annals of surgery 2008, 248(4):626-637.
31. Khan SA, Matthews JB: Intraoperative margin re-resection for colorectal cancer liver metastases. Hepatobiliary surgery and nutrition 2013, 2(2):108-112.
32. Edge SB BD, Compton CC, Fritz AG, Greene FL, Trotti A.: AJCC Cancer Staging Manual (7th edn). 2010.
33. Couinaud C: Liver anatomy: portal (and suprahepatic) or biliary segmentation. Digestive surgery 1999, 16(6):459-467.
34. Spolverato G, Pawlik TM: Liver-directed therapies: surgical approaches, alone and in combination with other interventions. American Society of Clinical Oncology educational book / ASCO American Society of Clinical Oncology Meeting 2014:101-110.
35. Dindo D, Demartines N, Clavien PA: Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of surgery 2004, 240(2):205-213.
36. Cady B, Jenkins RL, Steele GD, Jr., Lewis WD, Stone MD, McDermott WV, Jessup JM, Bothe A, Lalor P, Lovett EJ et al: Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Annals of surgery 1998, 227(4):566-571.
37. Wray CJ, Lowy AM, Matthews JB, James LE, Mammen JM, Choe KA, Hanto DW, Ahmad SA: Intraoperative margin re-resection for colorectal liver metastases. Journal of surgical education 2007, 64(3):150-157.
38. Mavros MN, de Jong M, Dogeas E, Hyder O, Pawlik TM: Impact of complications on long-term survival after resection of colorectal liver metastases. The British journal of surgery 2013, 100(5):711-718.