Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing

European Journal of Clinical Pharmacology

Volumn 71, Issue 4, 2015, Pages 441-447

  Fanta, Samuel ^a,b   Kinnunen, Mari ^a   Backman, Janne T ^a   Kalso, Eija ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

CYP2B6; CYP3A4; First pass effect; Ketamine; Norketamine; Population pharmacokinetics; S ketamine; Well stirred model

Indexed keywords

ANALGESIC AGENT; DRUG METABOLITE; ESKETAMINE; NORKETAMINE; PLACEBO; UNCLASSIFIED DRUG; KETAMINE;

ABSORPTION RATE CONSTANT; ADULT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION AT STEADY-STATE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIMULATION; STEADY STATE; VOLUME OF DISTRIBUTION; YOUNG ADULT; ANALOGS AND DERIVATIVES; CHRONIC PAIN; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PROCEDURES;

ADMINISTRATION, ORAL; ADULT; ANALGESICS; CHRONIC PAIN; HEALTHY VOLUNTEERS; HUMANS; INFUSIONS, INTRAVENOUS; KETAMINE; YOUNG ADULT;

EID: 84925485665     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-015-1826-y     Document Type: Article

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