Tumor-infiltrating CD8+ lymphocytes effect on clinical outcome of muco-cutaneous melanoma

Indian Journal of Dermatology

Volumn 60, Issue 2, 2015, Pages 212-

  Rahbar, Mahtab ^a   Naraghi, Zahra Safaei ^b   Mardanpour, Marjan ^c   Mardanpour, Nyousha ^d  

^a KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

CD8+ T lymphocyte; clinical outcome; melanoma

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 2; IPILIMUMAB;

ADULT; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INFILTRATION; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS MELANOCYTIC CANCER; CUTANEOUS MELANOMA; CYTOTOXIC LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MALE; SEX RATIO; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR RECURRENCE; TUMOR VOLUME;

EID: 84925455483     PISSN: 00195154     EISSN: 19983611     Source Type: Journal    
DOI: 10.4103/0019-5154.152571     Document Type: Article

References (14)

1. Villunger A, Strasser A. The great escape: Is immune evasion required for tumor progression? Nat Med 1999;5:874-5.
2. Natali PG, Nicotra MR, Bigotti A, Venturo I, Marcenaro L, Giacomini P, et al. Selective changes in expression of HLA class I polymorphic determinants in human solid tumors. ProcNatlAcadSciU S A 1989;86:6719-23.
3. Barth RJ Jr, Camp BJ, Martuscello TA, Dain BJ, Memoli VA. The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival. Cancer 1996;78:1168-78.
4. Smyth MJ, Dunn GP, Schreiber RD. Cancer immunosurveillance and immunoediting: The roles of immunityin suppressing tumor development and shaping tumor immunogenicity. AdvImmunol 2006;90:1-50.
5. Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol 2004;22:329-60.
6. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, et al. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998;58:3491-4.
7. Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J ClinOncol 2011;29:610-8.
8. Angevin E, Kremer F, Gaudin C, Hercend T, Triebel F. Analysis of T-cell immune response in renal cell carcinoma: Polarization to type 1-like differentiation pattern, clonal T-cell expansion and tumor-specific cytotoxicity. Int J Cancer 1997;72:431-40.
9. th, VanHorn M, Hurwitz S, Zehngebot L, Goldman LI, et al . The role of lymph node dissection for clinical stage I malignant melanoma of intermediate thickness (1.51-3.99 mm).Cancer1985;56:413-8.
10. Mihm MC Jr, Clemente CG, Cascinelli N. Tumor infiltrating lymphocytes in lymph node melanoma metastases: A histopathologic prognostic indicator and an expression of local immune response. Lab Invest 1996;74:43-7.
11. Rosenberg SA, Dudley ME. Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes. Proc Natl Acad Sci USA 2004;101 (Suppl 2):14639-45.
12. Rosenberg SA, Yannelli JR, Yang JC, Topalian SL, Schwartzentruber DJ, Weber JS, et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J Natl Cancer Inst 1994;86:1159-66.
13. Stewart TH, Heppner GH. Immunological enhancement of breast cancer. Parasitology 1997;115 (Suppl):S141-53.
14. Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene2008;27:5904-12.