메뉴 건너뛰기




Volumn 131, Issue , 2015, Pages 207-214

Drugs, cancer and end-of-life care: A case study of pharmaceuticalization?

Author keywords

Clinical benefit; End of life cancer care; Expectations; Overtreatment; Patient preferences; Pharmaceuticalization; United Kingdom; United States

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 84925444094     PISSN: 02779536     EISSN: 18735347     Source Type: Journal    
DOI: 10.1016/j.socscimed.2014.12.007     Document Type: Article
Times cited : (54)

References (121)
  • 1
    • 73249142317 scopus 로고    scopus 로고
    • Partial progress: governing the pharmaceutical industry and the NHS, 1948-2008
    • Abraham J. Partial progress: governing the pharmaceutical industry and the NHS, 1948-2008. J. Health Polit. Policy Law 2009, 34(6):931-977.
    • (2009) J. Health Polit. Policy Law , vol.34 , Issue.6 , pp. 931-977
    • Abraham, J.1
  • 2
    • 77955412274 scopus 로고    scopus 로고
    • Pharmaceuticalisation of society in context: theoretical, empirical and health dimensions
    • Abraham J. Pharmaceuticalisation of society in context: theoretical, empirical and health dimensions. Sociology 2010, 4(4):603-622.
    • (2010) Sociology , vol.4 , Issue.4 , pp. 603-622
    • Abraham, J.1
  • 3
    • 84867051974 scopus 로고    scopus 로고
    • Discordance between conclusions stated in the abstract and conclusions in the article: analysis of published randomized controlled trials of systemic therapy in lung cancer
    • Altwairgi A.K., Booth C.M., Hopman W.M., Baetz T.D. Discordance between conclusions stated in the abstract and conclusions in the article: analysis of published randomized controlled trials of systemic therapy in lung cancer. J. Clin. Oncol. 2012, 30(28):3552-3557.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.28 , pp. 3552-3557
    • Altwairgi, A.K.1    Booth, C.M.2    Hopman, W.M.3    Baetz, T.D.4
  • 4
    • 84856229186 scopus 로고    scopus 로고
    • Poor correlation between progression-free and overall survival in modern clinical trials: are composite endpoints the answer?
    • Amir E., Seruga B., Kwong R., Tannock I.F., Ocana A. Poor correlation between progression-free and overall survival in modern clinical trials: are composite endpoints the answer?. Eur. J. Cancer 2012, 48:385-388.
    • (2012) Eur. J. Cancer , vol.48 , pp. 385-388
    • Amir, E.1    Seruga, B.2    Kwong, R.3    Tannock, I.F.4    Ocana, A.5
  • 6
    • 85031647287 scopus 로고    scopus 로고
    • Overoptimism about cancer
    • Anon Overoptimism about cancer. Lancet 2000, 355(9199):157.
    • (2000) Lancet , vol.355 , Issue.9199 , pp. 157
    • Anon1
  • 9
    • 79951821115 scopus 로고    scopus 로고
    • Raising the bar of efficacy for drug approval requires an understanding of patient diversity
    • Author reply e5
    • Berger M.L., Eck S., Ruberg S.J. Raising the bar of efficacy for drug approval requires an understanding of patient diversity. J. Clin. Oncol. 2010, 28:e343-e344. Author reply e5.
    • (2010) J. Clin. Oncol. , vol.28 , pp. e343-e344
    • Berger, M.L.1    Eck, S.2    Ruberg, S.J.3
  • 10
    • 84888780224 scopus 로고    scopus 로고
    • No improvement in median survival for patients with metastatic gastric cancer despite increased use of chemotherapy
    • Bernards N., Creemers G.J., Nieuwenhuijzen G.A.P., et al. No improvement in median survival for patients with metastatic gastric cancer despite increased use of chemotherapy. Ann. Oncol. 2013, 24(12):3056-3060.
    • (2013) Ann. Oncol. , vol.24 , Issue.12 , pp. 3056-3060
    • Bernards, N.1    Creemers, G.J.2    Nieuwenhuijzen, G.A.P.3
  • 11
    • 78650408868 scopus 로고    scopus 로고
    • Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past
    • Booth C. Evaluating patient-centered outcomes in the randomized controlled trial and beyond: informing the future with lessons from the past. Clin. Cancer Res. 2010, 16:5963-5971.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5963-5971
    • Booth, C.1
  • 12
    • 34547430159 scopus 로고    scopus 로고
    • External influences and priority-setting for anti-cancer agents: a case study of media coverage in adjuvant trastuzumab for breast Cancer
    • Booth C.M., Dranitsaris G., Gainford M.C., Berry S., Fralick M., Fralick J., Sue J., Clemons M. External influences and priority-setting for anti-cancer agents: a case study of media coverage in adjuvant trastuzumab for breast Cancer. BMC Cancer 2007, 7:110. 10.1186/1471-2407-7-110.
    • (2007) BMC Cancer , vol.7 , pp. 110
    • Booth, C.M.1    Dranitsaris, G.2    Gainford, M.C.3    Berry, S.4    Fralick, M.5    Fralick, J.6    Sue, J.7    Clemons, M.8
  • 13
    • 84860496547 scopus 로고    scopus 로고
    • Progression-free survival: meaningful or simply measurable?
    • Booth C.M., Eisenhauer E.A. Progression-free survival: meaningful or simply measurable?. J. Clin. Oncol. 2012, 30(10):1030-1033.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.10 , pp. 1030-1033
    • Booth, C.M.1    Eisenhauer, E.A.2
  • 14
    • 34648843239 scopus 로고    scopus 로고
    • The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis
    • Braga S., Miranda A., Fonsensca R., et al. The aggressiveness of cancer care in the last three months of life: a retrospective single centre analysis. Psychoonology 2007, 16:863-868.
    • (2007) Psychoonology , vol.16 , pp. 863-868
    • Braga, S.1    Miranda, A.2    Fonsensca, R.3
  • 15
    • 80155203588 scopus 로고    scopus 로고
    • Why do our patient get chemotherapy until the end of life?
    • Braga S. Why do our patient get chemotherapy until the end of life?. Ann. Oncol. 2011, 22:2345-2348.
    • (2011) Ann. Oncol. , vol.22 , pp. 2345-2348
    • Braga, S.1
  • 16
    • 77950366766 scopus 로고    scopus 로고
    • 'A pill for every ill': explaining the expansion in medical use
    • Busfield J. 'A pill for every ill': explaining the expansion in medical use. Soc. Sci. & Med. 2010, 70:934-941.
    • (2010) Soc. Sci. & Med. , vol.70 , pp. 934-941
    • Busfield, J.1
  • 17
    • 84905377379 scopus 로고    scopus 로고
    • Effect of integrated palliative care on the quality of end-of-life care: retrospective analysis of 521 cancer patients
    • Colombet I., Motheil V., Durand J.-P., et al. Effect of integrated palliative care on the quality of end-of-life care: retrospective analysis of 521 cancer patients. BMJ Support. Palliat. Care 2012, 2:239-247.
    • (2012) BMJ Support. Palliat. Care , vol.2 , pp. 239-247
    • Colombet, I.1    Motheil, V.2    Durand, J.-P.3
  • 18
    • 84925430157 scopus 로고    scopus 로고
    • Colon Cancer Alliance (undated) Two New Drugs Bring Hope for Stage IV Patients. Available at:. Accessed 5 September
    • Colon Cancer Alliance (undated) Two New Drugs Bring Hope for Stage IV Patients. Available at:. Accessed 5 September 2014. http://www.ccalliance.org/crc_news/articles/two_new_drugs.html.
    • (2014)
  • 19
    • 33947369143 scopus 로고    scopus 로고
    • The research priorities of patients attending UK cancer treatment centres: findings from a modified nominal group study
    • Corner J., Wright D., Hopkinson J., et al. The research priorities of patients attending UK cancer treatment centres: findings from a modified nominal group study. Br. J. Cancer 2007, 96:875-881.
    • (2007) Br. J. Cancer , vol.96 , pp. 875-881
    • Corner, J.1    Wright, D.2    Hopkinson, J.3
  • 20
    • 79960498401 scopus 로고    scopus 로고
    • Desperately seeking cancer drugs: explaining the emergence and outcomes of accelerated pharmaceutical regulation
    • Davis C., Abraham J. Desperately seeking cancer drugs: explaining the emergence and outcomes of accelerated pharmaceutical regulation. Sociol. Health Illn. 2011, 33(5):731-747.
    • (2011) Sociol. Health Illn. , vol.33 , Issue.5 , pp. 731-747
    • Davis, C.1    Abraham, J.2
  • 23
    • 0035281501 scopus 로고    scopus 로고
    • Does palliative chemotherapy palliate? evaluation of expectations, outcomes, and costs in women receiving chemotherapy for advanced ovarian cancer
    • Doyle C., Crump M., Pintilie M., Oza A.M. Does palliative chemotherapy palliate? evaluation of expectations, outcomes, and costs in women receiving chemotherapy for advanced ovarian cancer. J. Clin. Oncol. 2001, 19(5):1266-1274.
    • (2001) J. Clin. Oncol. , vol.19 , Issue.5 , pp. 1266-1274
    • Doyle, C.1    Crump, M.2    Pintilie, M.3    Oza, A.M.4
  • 24
    • 84856762181 scopus 로고    scopus 로고
    • It take a village
    • Earle C.C. It take a village. J. Clin. Oncol. 2011, 30(4):353-354.
    • (2011) J. Clin. Oncol. , vol.30 , Issue.4 , pp. 353-354
    • Earle, C.C.1
  • 25
    • 1342289771 scopus 로고    scopus 로고
    • Trends in the aggressiveness of cancer care near the end of life
    • Earle C.C., Neville B.A., Landrum M.B., et al. Trends in the aggressiveness of cancer care near the end of life. J. Clin. Oncol. 2004, 22(2):315-321.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.2 , pp. 315-321
    • Earle, C.C.1    Neville, B.A.2    Landrum, M.B.3
  • 26
    • 51349138014 scopus 로고    scopus 로고
    • Aggressiveness of cancer care near the end of Life: is it a quality-of-care issue?
    • Earle C.C., Landrum M.B., Souza J.M., et al. Aggressiveness of cancer care near the end of Life: is it a quality-of-care issue?. J. Clin. Oncol. 2008, 26(2300):3860-3866.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.2300 , pp. 3860-3866
    • Earle, C.C.1    Landrum, M.B.2    Souza, J.M.3
  • 27
    • 84899911233 scopus 로고    scopus 로고
    • American society of clinical oncology perspective: raising the bar for clinical trials by defining clinically meaningful outcomes
    • Ellis L.M., Bernstein D.S., Voest E.E., Berlin J.D., Sargent D., et al. American society of clinical oncology perspective: raising the bar for clinical trials by defining clinically meaningful outcomes. J. Clin. Oncol. 17 March 2014, 10.1200/JCO.2013.53.8009.
    • (2014) J. Clin. Oncol.
    • Ellis, L.M.1    Bernstein, D.S.2    Voest, E.E.3    Berlin, J.D.4    Sargent, D.5
  • 28
    • 0038515640 scopus 로고    scopus 로고
    • Chemotherapy use among medicare beneficiaries at the end of life
    • Emanuel E.J., Young-Xu Y., Levinsky N.G., et al. Chemotherapy use among medicare beneficiaries at the end of life. Ann. Intern. Med. 2003, 138(8):639-643.
    • (2003) Ann. Intern. Med. , vol.138 , Issue.8 , pp. 639-643
    • Emanuel, E.J.1    Young-Xu, Y.2    Levinsky, N.G.3
  • 31
    • 84925441469 scopus 로고    scopus 로고
    • Available:, (accessed 05.09.14.)
    • Express Scripts Drug Trend Report. October 2013 2013, Available:, (accessed 05.09.14.). http://lab.express-scripts.com/%7E/media/previous%20reports%20pdfs/drug%20trend%20report%202012.ashx.
    • (2013) Drug Trend Report. October 2013
  • 32
    • 84925387441 scopus 로고    scopus 로고
    • Available:, (accessed 05.09.14.)
    • Express Scripts Drug Trend Report. April 2014 2014, Available:, (accessed 05.09.14.). http://lab.express-scripts.com/%7E/media/pdfs/drug%20trend%20report/express%20scripts%202013%20drug%20trend%20report.ashx.
    • (2014) Drug Trend Report. April 2014
  • 33
    • 84655160829 scopus 로고    scopus 로고
    • The value of progression-free survival to patients with advanced-stage cancer
    • Fallowfield L.J., Fleissig A. The value of progression-free survival to patients with advanced-stage cancer. Nat. Rev. Clin. Oncol. 2012, 9:41-47.
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 41-47
    • Fallowfield, L.J.1    Fleissig, A.2
  • 35
    • 2542641907 scopus 로고    scopus 로고
    • Food and Drug Administration, Available at:, (accessed 22.05.14.)
    • FDA Innovation or Stagnation: Challenge and Opportunity on the Critical Path to new Medical Products March 2004, Food and Drug Administration, Available at:, (accessed 22.05.14.). http://www.fda.gov/downloads/ScienceResearch/SpecialTopics/CriticalPathInitiative/CriticalPAthOpportunitiesReports/ucm113411.pdf.
    • (2004) Innovation or Stagnation: Challenge and Opportunity on the Critical Path to new Medical Products
  • 37
    • 77950982920 scopus 로고    scopus 로고
    • Cancer and the media. How does the news report on treatment and outcomes?
    • Fishman J., Ten Have T., Casarett D. Cancer and the media. How does the news report on treatment and outcomes?. Arch. Intern. Med. 2010, 170(6):515-518.
    • (2010) Arch. Intern. Med. , vol.170 , Issue.6 , pp. 515-518
    • Fishman, J.1    Ten Have, T.2    Casarett, D.3
  • 38
    • 68249134187 scopus 로고    scopus 로고
    • How much is life worth: Cetuximab, non-small cell lung cancer, and the $440 billion question
    • Fojo T., Grady C. How much is life worth: Cetuximab, non-small cell lung cancer, and the $440 billion question. J. Natl. Cancer Inst. 2009, 101:1044-1048.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1044-1048
    • Fojo, T.1    Grady, C.2
  • 39
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are We achieving too little by giving too Much?
    • Fojo T., Parkinon D.R. Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are We achieving too little by giving too Much?. Clin. Cancer Res. 2010, 16:5972-5980.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinon, D.R.2
  • 40
    • 84919725208 scopus 로고    scopus 로고
    • Unintended consequences of expensive cancer therapeutics: the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity
    • Published online July 28 2014
    • Fojo T., Mailankody S., Lo A. Unintended consequences of expensive cancer therapeutics: the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity. JAMA Otolaryngol. 2014, Published online July 28 2014. 10.1001/jamaoto.2014.1570.
    • (2014) JAMA Otolaryngol.
    • Fojo, T.1    Mailankody, S.2    Lo, A.3
  • 41
    • 84869503910 scopus 로고    scopus 로고
    • The debate about the funding of herceptin: a case study of 'countervailing powers'
    • Gabe J., Chamberlain K., Norris P., Dew K., Madden H., Hodgetts D. The debate about the funding of herceptin: a case study of 'countervailing powers'. Soc. Sci. & Med. 2012, 75:2353-2361.
    • (2012) Soc. Sci. & Med. , vol.75 , pp. 2353-2361
    • Gabe, J.1    Chamberlain, K.2    Norris, P.3    Dew, K.4    Madden, H.5    Hodgetts, D.6
  • 42
    • 0035832506 scopus 로고    scopus 로고
    • Lessons from the glitazones
    • Gale E.A.M. Lessons from the glitazones. Lancet 2001, 357:1870-1875.
    • (2001) Lancet , vol.357 , pp. 1870-1875
    • Gale, E.A.M.1
  • 43
    • 0037014947 scopus 로고    scopus 로고
    • Efficacy, safety and cost of new anticancer drugs
    • Garattini S., Bertele V. Efficacy, safety and cost of new anticancer drugs. BMJ 2002, 325:269-271.
    • (2002) BMJ , vol.325 , pp. 269-271
    • Garattini, S.1    Bertele, V.2
  • 45
    • 84856723931 scopus 로고    scopus 로고
    • Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer
    • Greer J.A., Pirl W.F., Jackson V.A., Muzikansky A., et al. Effect of early palliative care on chemotherapy use and end-of-life care in patients with metastatic non-small-cell lung cancer. J. Clin. Oncol. 2011, 30(4):394-400.
    • (2011) J. Clin. Oncol. , vol.30 , Issue.4 , pp. 394-400
    • Greer, J.A.1    Pirl, W.F.2    Jackson, V.A.3    Muzikansky, A.4
  • 47
    • 84898641943 scopus 로고    scopus 로고
    • New York Magazine, October 20. Available at:, (accessed 14.11.13.)
    • Hall S.S. The Cost of Living 2013, New York Magazine, October 20. Available at:, (accessed 14.11.13.). http://nymag.com/news/features/cancer-drugs-2013-10/.
    • (2013) The Cost of Living
    • Hall, S.S.1
  • 48
    • 84925430152 scopus 로고    scopus 로고
    • Forbes, Available at:, (accessed 14.11.13.)
    • Harper M. The FDA's Cancer Czar Says He Can't Approve New Drugs Fast Enough 23 June 2013, Forbes, Available at:, (accessed 14.11.13.). http://www.forbes.com/sites/matthewherper/2013/06/23/the-fdas-cancer-czar-says-he-cant-approve-new-drugs-fast-enough/.
    • (2013) The FDA's Cancer Czar Says He Can't Approve New Drugs Fast Enough
    • Harper, M.1
  • 49
    • 44949115223 scopus 로고    scopus 로고
    • The role of chemotherapy at the end of life: when is enough, enough?
    • Harrington S.E., Smith T.J. The role of chemotherapy at the end of life: when is enough, enough?. JAMA 2008, 299(22):2667-2678.
    • (2008) JAMA , vol.299 , Issue.22 , pp. 2667-2678
    • Harrington, S.E.1    Smith, T.J.2
  • 50
    • 49849101435 scopus 로고    scopus 로고
    • The ADVANTAGE seeding trial: a review of internal documents
    • Hill K.P., Ross J.S., Egilman D.S., Krumholz H.M. The ADVANTAGE seeding trial: a review of internal documents. Ann. Intern. Med. 2008, 149(4):251-258.
    • (2008) Ann. Intern. Med. , vol.149 , Issue.4 , pp. 251-258
    • Hill, K.P.1    Ross, J.S.2    Egilman, D.S.3    Krumholz, H.M.4
  • 51
    • 79951748712 scopus 로고    scopus 로고
    • Demands for 'off-licence' access to trastuzumab (Herceptin): content analysis of UK newspaper articles
    • Hind D., Wailoo A.J., Sutcliffe P. Demands for 'off-licence' access to trastuzumab (Herceptin): content analysis of UK newspaper articles. Health Expect. 2011, 14:38-47.
    • (2011) Health Expect. , vol.14 , pp. 38-47
    • Hind, D.1    Wailoo, A.J.2    Sutcliffe, P.3
  • 52
    • 79954996499 scopus 로고    scopus 로고
    • Trends in the aggressiveness of end-of-life Cancer care in the universal health care system of Ontario, Canada
    • Ho T.H., Barbera L., Saskin R., et al. Trends in the aggressiveness of end-of-life Cancer care in the universal health care system of Ontario, Canada. J. Clin. Oncol. 2011, 29(12):1587-1591.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.12 , pp. 1587-1591
    • Ho, T.H.1    Barbera, L.2    Saskin, R.3
  • 53
    • 84925452155 scopus 로고    scopus 로고
    • Mail Online, 4 March 2013. Available at:, (accessed 14.11.13.)
    • Hope J. New Drug for Advanced Bowel cancer can Increase Patients' Lives by Six Weeks 2013, Mail Online, 4 March 2013. Available at:, (accessed 14.11.13.). http://www.dailymail.co.uk/health/article-2287613/New-drug-advanced-bowel-cancer-increase-patients-lives-weeks.html.
    • (2013) New Drug for Advanced Bowel cancer can Increase Patients' Lives by Six Weeks
    • Hope, J.1
  • 55
    • 84902782651 scopus 로고    scopus 로고
    • Setting the bar for therapeutic trials in non-small-cell lung Cancer: how low can we go?
    • Johnson D.H. Setting the bar for therapeutic trials in non-small-cell lung Cancer: how low can we go?. J. Clin. Oncol. 2014, 32(14):1389-1391.
    • (2014) J. Clin. Oncol. , vol.32 , Issue.14 , pp. 1389-1391
    • Johnson, D.H.1
  • 56
    • 35948937686 scopus 로고    scopus 로고
    • Aglobal comparison regarding patient access to cancer drugs
    • Jonsson B., Wilking N. Aglobal comparison regarding patient access to cancer drugs. Ann. Oncol. 2007, 18(Suppl.3).
    • (2007) Ann. Oncol. , vol.18
    • Jonsson, B.1    Wilking, N.2
  • 57
  • 58
    • 84886719809 scopus 로고    scopus 로고
    • Cancer drugs in the United States: Justum Pretium - the just price
    • Published online May 6, 2013
    • Kantarjian H.M., Fojo T., Mathsien M., Zwelling L.A. Cancer drugs in the United States: Justum Pretium - the just price. J. Clin. Oncol. 2013, Published online May 6, 2013. 10.1200/JCO.2013.49.1845.
    • (2013) J. Clin. Oncol.
    • Kantarjian, H.M.1    Fojo, T.2    Mathsien, M.3    Zwelling, L.A.4
  • 59
    • 77955410161 scopus 로고    scopus 로고
    • End-of-life care for Older Cancer patients in the veterans health adminsitration versus the private sector
    • Keating N.L., Landrum M.B., Lamont E.B., et al. End-of-life care for Older Cancer patients in the veterans health adminsitration versus the private sector. Cancer August 2010, 1:3732-3739.
    • (2010) Cancer , vol.1 , pp. 3732-3739
    • Keating, N.L.1    Landrum, M.B.2    Lamont, E.B.3
  • 60
    • 0842287228 scopus 로고    scopus 로고
    • Palliative chemotherapy or best supportive care? A prospective study explaining patients' treatment preference and choice
    • Koedoot C.G., de Haan R.J., Stiggelbour A.M., et al. Palliative chemotherapy or best supportive care? A prospective study explaining patients' treatment preference and choice. Br. J. Cancer 2003, 89:2219-2226.
    • (2003) Br. J. Cancer , vol.89 , pp. 2219-2226
    • Koedoot, C.G.1    de Haan, R.J.2    Stiggelbour, A.M.3
  • 61
    • 49549097349 scopus 로고    scopus 로고
    • How do the media report cancer research? A study of the UK's BBC website
    • Lewison G., Tootell S., Roe P., Sullivan R. How do the media report cancer research? A study of the UK's BBC website. Br. J. Cancer 2008, 99:569-576.
    • (2008) Br. J. Cancer , vol.99 , pp. 569-576
    • Lewison, G.1    Tootell, S.2    Roe, P.3    Sullivan, R.4
  • 62
    • 83655214959 scopus 로고    scopus 로고
    • Bearing the risks of Prescription drugs
    • Columbia University Press, New York, D.W. Light (Ed.)
    • Light D.W. Bearing the risks of Prescription drugs. The Risks of Prescription Drugs 2010, Columbia University Press, New York. D.W. Light (Ed.).
    • (2010) The Risks of Prescription Drugs
    • Light, D.W.1
  • 63
    • 77949902396 scopus 로고    scopus 로고
    • End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences
    • Mack J.W., Weeks J.C., Wright A.A., Block S.D., Prigerson H.G. End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J. Clin. Oncol. 2010, 28(7):1203-1208.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.7 , pp. 1203-1208
    • Mack, J.W.1    Weeks, J.C.2    Wright, A.A.3    Block, S.D.4    Prigerson, H.G.5
  • 64
    • 84864544224 scopus 로고    scopus 로고
    • Reasons why physicians do not have discussions about poor prognosis, why its matters, and what can Be improved
    • Mack J.W., Smith T.J. Reasons why physicians do not have discussions about poor prognosis, why its matters, and what can Be improved. J. Clin. Oncol. 2012, 30(22):2715-2717.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.22 , pp. 2715-2717
    • Mack, J.W.1    Smith, T.J.2
  • 65
    • 36749083959 scopus 로고    scopus 로고
    • Cancer chemotherapy near the end of life: the Time has come to set guidelines for its appropriate use
    • Martoni A.A., Taneberger S., Mutri V. Cancer chemotherapy near the end of life: the Time has come to set guidelines for its appropriate use. Tumori 2007, 93:417-422.
    • (2007) Tumori , vol.93 , pp. 417-422
    • Martoni, A.A.1    Taneberger, S.2    Mutri, V.3
  • 66
    • 33746795538 scopus 로고    scopus 로고
    • Why do patients choose chemotherapy near the end of life? a review of the perspective of those facing death from cancer
    • Matsuyama R., Reddy S., Smith T.J. Why do patients choose chemotherapy near the end of life? a review of the perspective of those facing death from cancer. J. Clin. Oncol. 2006, 24(21):3490-3496.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.21 , pp. 3490-3496
    • Matsuyama, R.1    Reddy, S.2    Smith, T.J.3
  • 67
    • 0142119266 scopus 로고    scopus 로고
    • From access to evidence: an Advocate's journey
    • Mayer M. From access to evidence: an Advocate's journey. J. Clin. Oncol. 2003, 21(2):3881-3884.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.2 , pp. 3881-3884
    • Mayer, M.1
  • 69
    • 0035458696 scopus 로고    scopus 로고
    • The controvery over high-Dose chemotherapy with autologous bone marrow transplant for breast cancer
    • Mello M.M., Brennan T.A. The controvery over high-Dose chemotherapy with autologous bone marrow transplant for breast cancer. Health Aff. 2001, 20(5):101-117.
    • (2001) Health Aff. , vol.20 , Issue.5 , pp. 101-117
    • Mello, M.M.1    Brennan, T.A.2
  • 70
    • 84873372840 scopus 로고    scopus 로고
    • Patients' perspective on palliative chemotherapy of colorectal and non-colorectal cancer: a prospective study in chemotherapy-exposed population
    • Mende M., Trautmann K., Rentsch, et al. Patients' perspective on palliative chemotherapy of colorectal and non-colorectal cancer: a prospective study in chemotherapy-exposed population. BMC Cancer 2013, 13:66.
    • (2013) BMC Cancer , vol.13 , pp. 66
    • Mende, M.1    Trautmann, K.2    Rentsch3
  • 71
    • 6944239864 scopus 로고    scopus 로고
    • Communication about the ending of anticancer treatment and transition to palliative care
    • Morita T., Akechi T., Ikenaga M., et al. Communication about the ending of anticancer treatment and transition to palliative care. Ann. Oncol. 2004, 15:1551-1557.
    • (2004) Ann. Oncol. , vol.15 , pp. 1551-1557
    • Morita, T.1    Akechi, T.2    Ikenaga, M.3
  • 73
    • 33751204741 scopus 로고    scopus 로고
    • Chemotherapy given near the end of life by community oncologists for advanced non-small cell lung cancer
    • Murillo J.R., Koeller J. Chemotherapy given near the end of life by community oncologists for advanced non-small cell lung cancer. Oncol. 2006, 11:1095-1099.
    • (2006) Oncol. , vol.11 , pp. 1095-1099
    • Murillo, J.R.1    Koeller, J.2
  • 74
  • 75
    • 84925441172 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network Guidelines
    • NCCN Palliative Care Version 2.2013 2013, National Comprehensive Cancer Network Guidelines.
    • (2013) Palliative Care Version 2.2013
  • 76
    • 84865165918 scopus 로고    scopus 로고
    • The price we pay for progress: a meta-analysis of the harms of newly approved anticancer drugs
    • Niraula S., Seruga B., Ocana A., et al. The price we pay for progress: a meta-analysis of the harms of newly approved anticancer drugs. J. Clin. Oncol. 2012, 20(24):3012-3019.
    • (2012) J. Clin. Oncol. , vol.20 , Issue.24 , pp. 3012-3019
    • Niraula, S.1    Seruga, B.2    Ocana, A.3
  • 78
    • 78651320045 scopus 로고    scopus 로고
    • When are 'Positive' clinical trials in oncology Truly positive?
    • Ocana A., Tannock I.F. When are 'Positive' clinical trials in oncology Truly positive?. J. Natl. Cancer Inst. 2011, 103(1):16-20.
    • (2011) J. Natl. Cancer Inst. , vol.103 , Issue.1 , pp. 16-20
    • Ocana, A.1    Tannock, I.F.2
  • 79
    • 47749118439 scopus 로고    scopus 로고
    • Endpoints for assessing drug activity in clinical trials
    • Pazdur R. Endpoints for assessing drug activity in clinical trials. Oncologist 2008, 13(Suppl.2):19-21.
    • (2008) Oncologist , vol.13 , pp. 19-21
    • Pazdur, R.1
  • 80
    • 75649140509 scopus 로고    scopus 로고
    • Association of trial registration with the results and conclusions of published trials of new oncology drugs
    • Rasmussen N., Lee K., Bero L. Association of trial registration with the results and conclusions of published trials of new oncology drugs. Trials 2009, 10:116. 10.1186/1745-6215-10-116.
    • (2009) Trials , vol.10 , pp. 116
    • Rasmussen, N.1    Lee, K.2    Bero, L.3
  • 81
    • 79959338988 scopus 로고    scopus 로고
    • Survival for metastatic colorectal cancer in the Bevacizumab ear: a population-based analysis
    • Renouf D.J., Lim H.J., Speers C., et al. Survival for metastatic colorectal cancer in the Bevacizumab ear: a population-based analysis. Clin. Colorectal Cancer 2011, 10(2):97-101.
    • (2011) Clin. Colorectal Cancer , vol.10 , Issue.2 , pp. 97-101
    • Renouf, D.J.1    Lim, H.J.2    Speers, C.3
  • 83
    • 84873406382 scopus 로고    scopus 로고
    • Palliative care reduces morbidity and mortality in cancer
    • Rocque G.B., Cleary J.F. Palliative care reduces morbidity and mortality in cancer. Nat. Rev. Clin. Oncol. 2013, 10:80-89.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 80-89
    • Rocque, G.B.1    Cleary, J.F.2
  • 84
    • 84902829674 scopus 로고    scopus 로고
    • Shifting patterns in the interpretation of phase III clinical trial outcomes in advanced non-small-cell lung cancer: the bar is dropping
    • Sacher A.G., Le L.W., Leighl N.B. Shifting patterns in the interpretation of phase III clinical trial outcomes in advanced non-small-cell lung cancer: the bar is dropping. J. Clin. Oncol. 2014, 32(14):1407-1411.
    • (2014) J. Clin. Oncol. , vol.32 , Issue.14 , pp. 1407-1411
    • Sacher, A.G.1    Le, L.W.2    Leighl, N.B.3
  • 86
    • 55549108067 scopus 로고    scopus 로고
    • Progress in cancer care: the hope, the hype, and the gap between reality and perception
    • Salz L. Progress in cancer care: the hope, the hype, and the gap between reality and perception. J. Clin. Oncol. 2009, 26(31):5020-5021.
    • (2009) J. Clin. Oncol. , vol.26 , Issue.31 , pp. 5020-5021
    • Salz, L.1
  • 87
    • 77951778977 scopus 로고    scopus 로고
    • Personalized medicine in oncology: the future is now
    • Schilsky R.L. Personalized medicine in oncology: the future is now. Nat. Rev. Drug Discov. 2010, 9:363366.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 363366
    • Schilsky, R.L.1
  • 88
    • 84863195517 scopus 로고    scopus 로고
    • American Society of clinical oncology identifies five key opportunities to improve care and reduce costs: the top five list for oncology
    • Schnipper L.E., Smith T.J., Raghavan D., Blayney D.W., Ganz P.A., Mulvey T.M., et al. American Society of clinical oncology identifies five key opportunities to improve care and reduce costs: the top five list for oncology. J. Clin. Oncol. 2012, 30:1715-1724.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1715-1724
    • Schnipper, L.E.1    Smith, T.J.2    Raghavan, D.3    Blayney, D.W.4    Ganz, P.A.5    Mulvey, T.M.6
  • 89
    • 3242686833 scopus 로고    scopus 로고
    • The price tag on progress - chemotherapy for colorectal cancer
    • Schrag D. The price tag on progress - chemotherapy for colorectal cancer. N. Engl. J. Med. 2004, 351(4):317-319.
    • (2004) N. Engl. J. Med. , vol.351 , Issue.4 , pp. 317-319
    • Schrag, D.1
  • 90
    • 77954254832 scopus 로고    scopus 로고
    • Absolute benefits of medical therapies in phase III clinical trials for breast and colorectal cancer
    • Seruga B., Hertz P.C., Wang L., et al. Absolute benefits of medical therapies in phase III clinical trials for breast and colorectal cancer. Ann. Oncol. 2010, 21:1411-1418.
    • (2010) Ann. Oncol. , vol.21 , pp. 1411-1418
    • Seruga, B.1    Hertz, P.C.2    Wang, L.3
  • 91
    • 84893593815 scopus 로고    scopus 로고
    • Survival trends among patients with advanced renal cell carcinoma (RCC) in the United States
    • Abstract 422
    • Shah B.K., Ghimire K.B. Survival trends among patients with advanced renal cell carcinoma (RCC) in the United States. J. Clin. Oncol. 2013, 31(Suppl.6). Abstract 422.
    • (2013) J. Clin. Oncol. , vol.31
    • Shah, B.K.1    Ghimire, K.B.2
  • 92
    • 84887412695 scopus 로고    scopus 로고
    • Exediting drug development - the FDA's new "Breakthrough Therapy" designation
    • Sherman R.E., Li J., Shapley S., Robb M., Woodcock J. Exediting drug development - the FDA's new "Breakthrough Therapy" designation. N. Engl. J. Med. 2013, 369(20):1877-1880.
    • (2013) N. Engl. J. Med. , vol.369 , Issue.20 , pp. 1877-1880
    • Sherman, R.E.1    Li, J.2    Shapley, S.3    Robb, M.4    Woodcock, J.5
  • 93
    • 0032547529 scopus 로고    scopus 로고
    • Preferences for chemotherapy in patients with advanced non-small cell lung cancer: descriptive study based on scripted interviews
    • Silverstri G., Pritchard R., Welch H.G. Preferences for chemotherapy in patients with advanced non-small cell lung cancer: descriptive study based on scripted interviews. Br. Med. J. 1998, 317:771-775.
    • (1998) Br. Med. J. , vol.317 , pp. 771-775
    • Silverstri, G.1    Pritchard, R.2    Welch, H.G.3
  • 94
    • 73349122015 scopus 로고    scopus 로고
    • Incremental advance or seismic shift? the need to raise the bar of efficacy for drug approval
    • Sobrero A., Bruzzi P. Incremental advance or seismic shift? the need to raise the bar of efficacy for drug approval. J. Clin. Oncol. 2009, 27(35):5868-5873.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.35 , pp. 5868-5873
    • Sobrero, A.1    Bruzzi, P.2
  • 96
    • 77958145439 scopus 로고    scopus 로고
    • Palliative chemotherapy. When is it Worth it and when is it not?
    • Swetz K.M., Smith T.J. Palliative chemotherapy. When is it Worth it and when is it not?. Cancer J. 2010, 16(5):467-472.
    • (2010) Cancer J. , vol.16 , Issue.5 , pp. 467-472
    • Swetz, K.M.1    Smith, T.J.2
  • 97
    • 50249147933 scopus 로고    scopus 로고
    • Aggressiveness of care in a prospective cohort of patients with advanced NSCLC
    • Temel J.S., McCannon J., Greer J.A., et al. Aggressiveness of care in a prospective cohort of patients with advanced NSCLC. Cancer 2008, 113(4):826-833.
    • (2008) Cancer , vol.113 , Issue.4 , pp. 826-833
    • Temel, J.S.1    McCannon, J.2    Greer, J.A.3
  • 98
    • 77955877759 scopus 로고    scopus 로고
    • Early palliative care for patients with metastatic non-small-cell lung cancer
    • Temel J.S., Greer J.A., Muzikansky A., et al. Early palliative care for patients with metastatic non-small-cell lung cancer. NEJM 2010, 363(8):733-742.
    • (2010) NEJM , vol.363 , Issue.8 , pp. 733-742
    • Temel, J.S.1    Greer, J.A.2    Muzikansky, A.3
  • 99
    • 79959304656 scopus 로고    scopus 로고
    • Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer
    • Temel J.S., Greer J.A., Admane S., Gallagher E., Jackson V.A., et al. Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer. J. Oncol. 2011, 29(17):2319-2326.
    • (2011) J. Oncol. , vol.29 , Issue.17 , pp. 2319-2326
    • Temel, J.S.1    Greer, J.A.2    Admane, S.3    Gallagher, E.4    Jackson, V.A.5
  • 100
    • 47349119330 scopus 로고    scopus 로고
    • Towards a sociology of disease
    • Timmermans S., Haas S. Towards a sociology of disease. Sociol. Health Illn. 2008, 30(5):659-676.
    • (2008) Sociol. Health Illn. , vol.30 , Issue.5 , pp. 659-676
    • Timmermans, S.1    Haas, S.2
  • 101
    • 76649131423 scopus 로고    scopus 로고
    • The FDA's deadly track record
    • Available at:, (accessed 14.11.13.)
    • Trowbridge R.L., Walker S. The FDA's deadly track record. Wall Str. J. August 14, 2007, Available at:, (accessed 14.11.13.). http://abigail-alliance.org/WSJ%20OP-ED%20FDA%27s_Deadly_Track_Rec%2008-14-07.pdf.
    • (2007) Wall Str. J.
    • Trowbridge, R.L.1    Walker, S.2
  • 105
    • 84898744858 scopus 로고    scopus 로고
    • Comparison of survival outcomes of patients treated in and out of clinical trials
    • First published online: March 13, 2014
    • Unger J., Barlow W., Martin D.P., Ramsey S., LeBlanc M., Hershman D.L. Comparison of survival outcomes of patients treated in and out of clinical trials. J. Natl. Cancer Inst. 2014, First published online: March 13, 2014. 10.1093/jnci/dju002.
    • (2014) J. Natl. Cancer Inst.
    • Unger, J.1    Barlow, W.2    Martin, D.P.3    Ramsey, S.4    LeBlanc, M.5    Hershman, D.L.6
  • 112
    • 84875139810 scopus 로고    scopus 로고
    • Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer
    • Vera-Badillo F.E., Shapiro R., Ocana A., et al. Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer. Ann. Oncol. 2013, 24:1238-1244.
    • (2013) Ann. Oncol. , vol.24 , pp. 1238-1244
    • Vera-Badillo, F.E.1    Shapiro, R.2    Ocana, A.3
  • 113
    • 18144406881 scopus 로고    scopus 로고
    • Futility: clinical decisions at the end-of-life in women with ovarian cancer
    • von Gruenigen V.E., Daly B.J. Futility: clinical decisions at the end-of-life in women with ovarian cancer. Gynecol. Oncol. 2005, 97:638-644.
    • (2005) Gynecol. Oncol. , vol.97 , pp. 638-644
    • von Gruenigen, V.E.1    Daly, B.J.2
  • 114
    • 43049138365 scopus 로고    scopus 로고
    • Indicators of survival duration in ovarian cancer and implications for aggressiveness of care
    • von Gruenigen V., Daly B., Gibbons H., Hutchins J., Green A. Indicators of survival duration in ovarian cancer and implications for aggressiveness of care. Cancer 2008, 112(10):2221-2227.
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2221-2227
    • von Gruenigen, V.1    Daly, B.2    Gibbons, H.3    Hutchins, J.4    Green, A.5
  • 115
    • 84867828250 scopus 로고    scopus 로고
    • Patients' expectations about effects of chemotherapy for advanced cancer
    • Weeks J.C., Catalano P., Cronin A. Patients' expectations about effects of chemotherapy for advanced cancer. New Engl. J. Med. 2012, 367(17):1616-1625.
    • (2012) New Engl. J. Med. , vol.367 , Issue.17 , pp. 1616-1625
    • Weeks, J.C.1    Catalano, P.2    Cronin, A.3
  • 117
    • 34548421624 scopus 로고    scopus 로고
    • The characteristics of unsolicited clinical oncology literature provided by pharmaceutical industry
    • Wick C., Egger M., Trelle S., Juni P., Fey M.F. The characteristics of unsolicited clinical oncology literature provided by pharmaceutical industry. Ann. Oncol. 2007, 18(9):1580-1582.
    • (2007) Ann. Oncol. , vol.18 , Issue.9 , pp. 1580-1582
    • Wick, C.1    Egger, M.2    Trelle, S.3    Juni, P.4    Fey, M.F.5
  • 118
    • 79960497480 scopus 로고    scopus 로고
    • The pharmaceuticalisation of society? A framework for analysis
    • Williams S.J., Martin P., Gabe J. The pharmaceuticalisation of society? A framework for analysis. Sociol. Health Illn. 2011, 33(5):710-725.
    • (2011) Sociol. Health Illn. , vol.33 , Issue.5 , pp. 710-725
    • Williams, S.J.1    Martin, P.2    Gabe, J.3
  • 120
    • 84896528620 scopus 로고    scopus 로고
    • Associations between palliative chemotherapy and adult cancer patients' end of life care and place of death: prospective cohort study
    • Published 4 March 2014
    • Wright A.A., Zhang B., Keating N.L., Weeks J.C., Prigerson H.G. Associations between palliative chemotherapy and adult cancer patients' end of life care and place of death: prospective cohort study. BMJ 2014, Published 4 March 2014. 10.1136/bmj.g1219.
    • (2014) BMJ
    • Wright, A.A.1    Zhang, B.2    Keating, N.L.3    Weeks, J.C.4    Prigerson, H.G.5
  • 121
    • 84874631714 scopus 로고    scopus 로고
    • The financial toxicity of cancer treatments: a pilot study assessing out-of-pocket expenses and the insured cancer patient's experience
    • Zafar S.Y., Peppercorn J.M., Schrag D., et al. The financial toxicity of cancer treatments: a pilot study assessing out-of-pocket expenses and the insured cancer patient's experience. Oncologist 2013, 18:381-390.
    • (2013) Oncologist , vol.18 , pp. 381-390
    • Zafar, S.Y.1    Peppercorn, J.M.2    Schrag, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.