High peripheral blood Th17 percent associated with poor lung function in cystic fibrosis

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Mulcahy, Emily M ^a   Hudson, Jo B ^a   Beggs, Sean A ^a,b   Reid, David W ^a,b,c   Roddam, Louise F ^a   Cooley, Margaret A ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b ROYAL HOBART HOSPITAL   (Australia)

^c THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ADULT; ARTICLE; BACTERIAL PNEUMONIA; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DISEASE EXACERBATION; FEMALE; FORCED EXPIRATORY VOLUME; GENDER; GENOTYPE; HUMAN; INFANT; LUNG FUNCTION; LYMPHOCYTE COUNT; MALE; NEWBORN; PERIPHERAL BLOOD MONONUCLEAR CELL; PSEUDOMONAS AERUGINOSA; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; COMPLICATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; LUNG; MICROBIOLOGY; MIDDLE AGED; MONONUCLEAR CELL; PRESCHOOL CHILD; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS; YOUNG ADULT;

PSEUDOMONAS AERUGINOSA;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; FEMALE; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; LUNG; MALE; MIDDLE AGED; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS; TH17 CELLS; YOUNG ADULT;

EID: 84925437095     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120912     Document Type: Article

References (35)

1. McDonald TV, Nghiem PT, Gardner P, Martens CL. Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current. J Biol Chem. 1992; 267: 3242-3248. PMID: 1371114
2. Skov M, Poulsen LK, Koch C. Increased antigen-specific Th-2 response in allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis. Pediatr Pulmonol. 1999; 27: 74-79. PMID: 10088929
3. Moser C, Kjaergaard S, Pressler T, Kharazmi A, Koch C, Hoiby N.The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type. Apmis. 2000; 108: 329-335. PMID: 10937769
4. Moss RB, Hsu YP, Olds L. Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes. Clin Exp Immunol. 2000; 120: 518-525. PMID: 10844532
5. Hausler M, Schweizer K, Biesterfel S, Opladen T, Heimann G. Peripheral decrease and pulmonary homing of CD4+CD45RO+ helper memory T cells in cystic fibrosis. Respir Med. 2002; 96: 87-94. PMID: 11860174
6. Brazova J, Sediva A, Pospisilova D, Vavrova V, Pohunek P, Macek M, et al. Differential cytokine profile in children with cystic fibrosis. Clin Immunol. 2005; 115: 210-215. PMID: 15885645
7. Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA. Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. J Immunol. 2006; 177: 5186-5194. PMID: 17015704
8. Hartl D, Griese M, Kappler M, Zissel G, Reinhardt D, Rebhan C, et al. Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J Allergy Clin Immunol. 2006; 117: 204-211. PMID: 16387607
9. Dubin P, McAllister F, Kolls J. Is cystic fibrosis a TH17 disease? Inflammation Research. 2007; 56: 221-227. PMID: 17607545
10. Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR. Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses. Am J Respir Cell Mol Biol. 2011; 44: 922-929. doi: 10.1165/rcmb.2010-0224OC PMID: 20724552
11. Tan HL, Regamey N, Brown S, Bush A, Lloyd CM, Davies JC. The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med. 2011; 184: 252-258. doi: 10.1164/rccm.201102-0236OC PMID: 21474644
12. Kushwah R, Gagnon S, Sweezey NB. Intrinsic predisposition of naive cystic fibrosis T cells to differentiate towards a Th17 phenotype. Respir Res. 2013; 14: 138. doi: 10.1186/1465-9921-14-138 PMID: 24344776
13. Chan YR, Chen K, Duncan SR, Lathrop KL, Latoche JD, Logar AJ, et al. Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes. J Allergy Clin Immunol. 2013; 131: 1117-1129, 1129 e1111-1115. doi: 10.1016/j.jaci.2012.05.036 PMID: 22795370
14. Tiringer K, Treis A, Fucik P, Gona M, Gruber S, Renner S, et al. A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med. 2013; 187: 621-629. doi: 10.1164/rccm.201206-1150OC PMID: 23306544
15. Knutsen AP, Slavin RG. Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin Dev Immunol. 2011: 843763. doi: 10.1155/2011/843763 PMID: 21603163
16. Way EE, Chen K, Kolls JK. Dysregulation in lung immunity-The protective and pathologic Th17 response in infection. Eur J Immunol. 2013; 43: 3116-3124. doi: 10.1002/eji.201343713 PMID: 24130019
17. Tang XX, Fok KL, Chen H, Chan KS, Tsang LL, Rowlands DK, et al. Lymphocyte CFTR promotes epithelial bicarbonate secretion for bacterial killing. J Cell Physiol. 2012; 227: 3887-3894. doi: 10.1002/jcp.24101 PMID: 22552906
18. Anil N, Singh M. CD4(+)CD25(high) FOXP3(+) regulatory T cells correlate with FEV1 in North Indian children with cystic fibrosis. Immunol Invest. 2014; 43: 535-543. doi: 10.3109/08820139.2014.888447 PMID: 24661230
19. Bernardi DM, Ribeiro AF, Mazzola TN, Vilela MM, Sgarbieri VC. The impact of cystic fibrosis on the immunologic profile of pediatric patients. J Pediatr (Rio J). 2013; 89: 40-47. doi: 10.1016/j.jped.2013.02.007 PMID: 23544809
20. Smith DJ, Hill GR, Bell SC, Reid DW. Reduced mucosal associated invariant T-cells are associated with increased disease severity and Pseudomonas aeruginosa infection in cystic fibrosis. PLoS One. 2014; 9: e109891. doi: 10.1371/journal.pone.0109891 PMID: 25296025
21. Rosenfeld M, Emerson J, Williams-Warren J, Pepe M, Smith A, Montgomery AB, et al. Defining a pulmonary exacerbation in cystic fibrosis. J Pediatrics. 2001; 139: 359-365. PMID: 11562614
22. Australian Cystic Fibrosis Data Registry. Cystic Fibrosis in Australia 2012. http://www.cysticfibrosis.org.au/media/wysiwyg/CF-Australia/medical-documents/ACFDR-2012/ACFDR-Annual-Report-2012r.pdf
23. Brett MM, Simmonds EJ, Ghoneim AT, Littlewood JM. The value of serum IgG titres against Pseudomonas aeruginosa in the management of early pseudomonal infection in cystic fibrosis. Arch Dis Child. 1992; 67: 1086-1088. PMID: 1417051
24. Vargas-Rojas MI, Ramirez-Venegas A, Limon-Camacho L, Ochoa L, Hernandez-Zenteno R, Sansores RH. Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease. Respir Med. 2011; 105: 1648-1654. doi: 10.1016/j.rmed.2011.05.017 PMID: 21763119
25. Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev. 2014; 13: 668-677. doi: 10.1016/j.autrev.2013.12.004 PMID: 24418308
26. Hovhannisyan Z, Treatman J, Littman DR, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011; 140: 957-965. doi: 10.1053/j.gastro.2010.12.002 PMID: 21147109
27. Lee RJ, Foskett JK. Ca(2)(+) signaling and fluid secretion by secretory cells of the airway epithelium. Cell Calcium. 2014; 55: 325-336. doi: 10.1016/j.ceca.2014.02.001 PMID: 24703093
28. McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzoava M, et al. Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort. Clin Exp Allergy. 2012; 42: 392-404. doi: 10.1111/j.1365-2222.2011.03882.x PMID: 22092655
29. Holt PG. Infection and the development of allergic disease. Allergy. 2011; 66 Suppl 95: 13-15. doi: 10.1111/j.1398-9995.2011.02623.x PMID: 21668843
30. Dosanjh AK, David E, Robbins RC. The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10. J Interfer Cytok Res. 1998; 18: 851-854.
31. Walter GJ, Evans HG, Menon B, Gullick NJ, Kirkham BW, Cope AP, et al. Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells. Arthritis Rheum. 2013; 65: 627-638. doi: 10.1002/art.37832 PMID: 23280063
32. Schadenberg AW, Vastert SJ, Evens FC, Kuis W, van Vught AJ, Jansen NJ, et al. FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human. Eur J Immunol. 2011; 41: 1132-1142. doi: 10.1002/eji.201040363 PMID: 21381018
33. Fazekas de St Groth B, Zhu E, Asad S, Lee L. Flow cytometric detection of human regulatory T cells. Methods Mol Biol. 2011; 707: 263-279. doi: 10.1007/978-1-61737-979-6-17 PMID: 21287341
34. Gratz IK, Truong HA, Yang SH, Maurano MM, Lee K, Abbas AK, et al. Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol. 2013; 190: 4483-4487. doi: 10.4049/jimmunol.1300212 PMID: 23543753
35. Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol. 2013; 190: 2001-2008. doi: 10.4049/jimmunol.1201379 PMID: 23359504