Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons

Neural Development

Volumn 10, Issue 1, 2015, Pages

  Dupin, Isabelle ^a,b   Lokmane, Ludmilla ^c   Dahan, Maxime ^d   Garel, Sonia ^c   Studer, Vincent ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b University of Bordeaux   (France)

^c PSL RESEARCH UNIVERSITY   (France)

^d INSTITUT CURIE   (France)

Author keywords

Axon guidance; Hippocampal neurons; Microfluidic; Netrin 1; Slit1; Thalamic neurons

Indexed keywords

LAMININ; NETRIN 1; SLIT 1 PROTEIN; SLIT PROTEIN; UNCLASSIFIED DRUG; NERVE GROWTH FACTOR; NERVE PROTEIN; NETRIN-1; RECOMBINANT PROTEIN; SLIT1 PROTEIN, HUMAN; SLIT1 PROTEIN, MOUSE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CELL CULTURE; CELLS BY BODY ANATOMY; CONTROLLED STUDY; DENSITY GRADIENT; FLUORESCENCE MICROSCOPY; GENERAL DEVICE; HIPPOCAMPAL NERVE CELL; IMAGE ANALYSIS; MICROFLUIDIC DEVICE; MICROTECHNOLOGY; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; ROSTRAL THALAMIC NERVE FIBER; SIMULATION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; TREATMENT RESPONSE; VALIDATION PROCESS; ANIMAL; ANTIBODY SPECIFICITY; AXON; CELL CULTURE TECHNIQUE; CHEMOTAXIS; CLASSIFICATION; CYTOLOGY; DEVICES; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; HIPPOCAMPUS; HUMAN; LAB ON A CHIP; MICROFLUIDIC ANALYSIS; PHYSIOLOGY; SPRAGUE DAWLEY RAT; THALAMUS;

ANIMALS; AXONS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HIPPOCAMPUS; HUMANS; LAB-ON-A-CHIP DEVICES; LAMININ; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; THALAMUS; TUMOR SUPPRESSOR PROTEINS;

EID: 84925368816     PISSN: None     EISSN: 17498104     Source Type: Journal    
DOI: 10.1186/s13064-015-0036-8     Document Type: Article

References (18)

1. Round J, Stein E. Netrin signaling leading to directed growth cone steering. Curr Opin Neurobiol. 2007;17:15-21.
2. Bonnin A, Torii M, Wang L, Rakic P, Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci. 2007;10:588-97.
3. Hopker VH, Shewan D, Tessier-Lavigne M, Poo M, Holt C. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature. 1999;401:69-73.
4. Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science. 2001;291:1928-38.
5. Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, et al. Presenilin-dependent receptor processing is required for axon guidance. Cell. 2011;144:106-18.
6. Kim M, Farmer WT, Bjorke B, McMahon SA, Fabre PJ, Charron F, et al. Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion. Neural Dev. 2014;9:17.
7. Bielle F, Marcos-Mondejar P, Leyva-Diaz E, Lokmane L, Mire E, Mailhes C, et al. Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography. Curr Biol. 2011;21:1748-55.
8. Dupin I, Dahan M, Studer V. Investigating axonal guidance with microdevice-based approaches. J Neurosci. 2013;33:17647-17655.
9. Morel M, Shynkar V, Galas JC, Dupin I, Bouzigues C, Studer V, et al. Amplification and temporal filtering during gradient sensing by nerve growth cones probed with a microfluidic assay. Biophys J. 2012;103:1648-56.
10. Morel M, Galas JC, Dahan M, Studer V. Concentration landscape generators for shear free dynamic chemical stimulation. Lab Chip. 2012;12:1340-6.
11. Joanne Wang C, Li X, Lin B, Shim S, Ming GL, Levchenko A. A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip. 2008;8:227-37.
12. Yam PT, Langlois SD, Morin S, Charron F. Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron. 2009;62:349-62.
13. Rosoff WJ, Urbach JS, Esrick MA, McAllister RG, Richards LJ, Goodhill GJ. A new chemotaxis assay shows the extreme sensitivity of axons to molecular gradients. Nat Neurosci. 2004;7:678-82.
14. Leyva-Diaz E, Del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, et al. FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014;24:494-508.
15. Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 1999;96:795-806.
16. Bartoe JL, McKenna WL, Quan TK, Stafford BK, Moore JA, Xia J, et al. Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J Neurosci. 2006;26:3192-205.
17. Pinato G, Cojoc D, Lien LT, Ansuini A, Ban J, D'Este E, et al. Less than 5 Netrin-1 molecules initiate attraction but 200 Sema3A molecules are necessary for repulsion. Sci Rep. 2012;2:675.
18. Lopez-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garratt AN, et al. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006;125:127-42.