Differential immune cell densities in ductal carcinoma In-Situ and invasive breast cancer: Possible role of leukocytes in early stages of carcinogenesis

Pakistan Journal of Medical Sciences

Volumn 31, Issue 2, 2015, Pages 274-279

  Sikandar, Bushra ^a   Qureshi, Muhammad Asif ^a   Mirza, Talat ^a   Khan, Saeed ^a   Avesi, Lubna ^a  

^a DOW UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

Author keywords

Breast cancer; Immune cell densities; Immune infiltrates; Pre neoplasia

Indexed keywords

ARTICLE; BREAST CARCINOMA; CANCER CLASSIFICATION; CANCER PROGNOSIS; CELL DENSITY; CONTROLLED STUDY; CORRELATIONAL STUDY; IMMUNOCOMPETENT CELL; INTRADUCTAL CARCINOMA; LYMPHOCYTIC INFILTRATION; MYELOCYTE; SCORING SYSTEM;

EID: 84925302244     PISSN: 1682024X     EISSN: None     Source Type: Journal    
DOI: 10.12669/pjms.312.6481     Document Type: Article

References (20)

1. Ginsburg OM, Love RR. Breast cancer: a neglected disease for the majority of affected women worldwide. Breast J. 2011;17:289-295.
2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008. Int J Cancer. 2010;127:2893-2917.
3. Deya S, Solimana AS, Hablasb A, Seifeldeinc IA, Ismailb K, Ramadan M, et al. Urban-rural differences in breast cancer incidence in Egypt(1999-2006). Breast. 2010;19(5):417-423.
4. Kwong A, Mang OW, Wong CH, Chau WW. Breast Cancer in Hong Kong, Southern China: The First Population-Based Analysis of Epidemiological Characteristics, Stage-Specific, Cancer Specific, and Disease-Free Survival in Breast Cancer Patients: 1997-2001. Surg Oncol. 2011;18:3072-3078.
5. Bhurgri Y, Bhurgri A, Nishter S, Ahmed A, Usman A, Pervez S, et al. Pakistan-country profile of cancer and cancer control 1995-2004. J Pak Med Assoc. 2006;56:124-130.
6. Bhurgri Y, Bhurgri A, Hassan SH, Zaidi SM, Rahim A, Sankaranarayanan R, et al. Cancer incidence in Karachi, Pakistan: first results from Karachi Cancer Registry. J Cancer. 2000;85:325-329.
7. Collective Cancer Registry report [Internet] 2011 DEC 1 [Cites 2013 July 29] Available from: https://www. shaukatkhanum.org.pk/research/cancer-registry-andclinical-data-management.html.
8. Viale G. The current state of breast cancer classification. Ann Oncol. 2012;23:207-210.
9. Robbins SL, Cotran RS. Pathological Basis of Diseases. Philadelphia: The Thomson Press; 2004.
10. Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, et al. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010;12:20. doi: 10.1186/bcr2607
11. Rakha EA, Soria D, Green AR, Lemetre C, Powe DG, Nolan CC, et al. Nottingham prognostic index plus (npi+): a modern clinical decision making tool in breast cancer. Int J Cancer. 2014;110(7):1688-1697.
12. Galea MH, Blamey RW, Elston CE, Ellis IO. The Nottingham prognostic index in primary breast cancer. Breast Cancer Res Treat. 1992;22:207-209.
13. Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B, Senn HJ, et al. Strategies for subtypes: Dealing with the diversity of breast cancer—Highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22:1736-1747.
14. Hannigan A, Qureshi MA, Nixon C, Tsimbouri P, Jones S, Philbey A, et al. Lymphocyte deficiency limits Epstein- Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo. Molecular Cancer. 2011;10: doi: 10.1186/1476-4598-10-11.
15. Qureshi MA. Dissecting the role of LMP1CAO indcued chronic inflammation in EBV associated carcinogenesis [PhD thesis]. Glasgow: University of Glasgow; 2012.
16. Surgical Pathology Cancer Case Summary [Internet] 2012 JUNE. [Cited 2014 June 6; Available from: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2012/BreastInvasive_12protocol_3100.pdf
17. Hussein MR, Hassan HI. Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations. J Clin Pathol. 2006;59(9):972-977.
18. Kristensen VN, Vaske CH, Siegel JU, Loo PV, Nordgard SH, Sachidanandam R, et al. Integrated molecular profiles of invasive breast tumours and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling. Proc Natl Acad Sci USA. 2012;109:2802-2807. doi:10.1073/pnas.1108781108
19. Mouawad R, Spano JP, Khayat D. Lymphocyte infiltration in breast cancer: a key prognostic factor that should not be ignored. J Clin Onc. 2011;29(15):1935-1936. doi:10.1200/JCO.2011.35.4845.
20. Ruffell B, Au A, Rugo HS, Esserman LJ Hwang ES, Coussens LM. Leukocyte composition of human breast cancer. PNAS. 2012;109(8):2796-2801. doi:10.1073/pnas.1104303108.