Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia

Neurobiology of Aging

Volumn 36, Issue 4, 2015, Pages 1751-1756

  Karlsson, Ida K ^a   Bennet, Anna M ^a   Ploner, Alexander ^a   Andersson, Therese M L ^a   Reynolds, Chandra A ^b   Gatz, Margaret ^a,c   Pedersen, Nancy L ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Alzheimer disease; Apolipoprotein e; Dementia; Depression

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; FEMALE; GENE INTERACTION; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; GENETIC ASSOCIATION STUDY; GENETICS; LONGITUDINAL STUDY; RISK FACTOR; TIME FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOLIPOPROTEIN E4; CASE-CONTROL STUDIES; DEMENTIA; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HETEROZYGOTE; HUMANS; LONGITUDINAL STUDIES; MALE; RISK FACTORS; TIME FACTORS;

EID: 84925297197     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.01.008     Document Type: Article

References (33)

1. Diagnostic and Statistical Manual of Mental Disorders: DSM-III-R 1987, American Psychiatric Association, American Psychiatric Association, Washington, DC.
2. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV 1994, American Psychiatric Association, American Psychiatric Association, Washington, DC.
3. Barnes D.E., Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011, 10:819-828.
4. Barnes D.E., Yaffe K., Byers A.L., McCormick M., Schaefer C., Whitmer R.A. Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch. Gen. Psychiatry 2012, 69:493-498.
5. Brommelhoff J.A., Gatz M., Johansson B., McArdle J.J., Fratiglioni L., Pedersen N.L. Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychol. Aging 2009, 24:373-384.
6. Byers A.L., Yaffe K. Depression and risk of developing dementia. Nat. Rev. Neurol. 2011, 7:323-331.
7. Eriksson U.K., Bennet A.M., Gatz M., Dickman P.W., Pedersen N.L. Nonstroke cardiovascular disease and risk of Alzheimer disease and dementia. Alzheimer Dis. Assoc. Disord. 2010, 24:213-219.
8. Ferri C.P., Prince M., Brayne C., Brodaty H., Fratiglioni L., Ganguli M., Hall K., Hasegawa K., Hendrie H., Huang Y., Jorm A., Mathers C., Menezes P.R., Rimmer E., Scazufca M. Global prevalence of dementia: a Delphi consensus study. Lancet 2005, 366:2112-2117.
9. Finkel D., Pedersen N. Processing speed and longitudinal trajectories of change for cognitive abilities: the Swedish Adoption/Twin study of aging. Neuropsychol. Dev. Cogn. B Aging Neuropsychol. Cogn. 2004, 11:325-345.
10. Fiske A., Wetherell J.L., Gatz M. Depression in older adults. Annu. Rev. Clin. Psychol. 2009, 5:363-389.
11. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J.Psychiatr. Res. 1975, 12:189-198.
12. Gatz M., Fratiglioni L., Johansson B., Berg S., Mortimer J.A., Reynolds C.A., Fiske A., Pedersen N.L. Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study. Neurobiol. Aging 2005, 26:439-447.
13. Gatz M., Pedersen N.L., Berg S., Johansson B., Johansson K., Mortimer J.A., Posner S.F., Viitanen M., Winblad B., Ahlbom A. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. J.Gerontol. A Biol. Sci. Med. Sci. 1997, 52:M117-M125.
14. Gatz M., Reynolds C.A., John R., Johansson B., Mortimer J.A., Pedersen N.L. Telephone screening to identify potential dementia cases in a population-based sample of older adults. Int. Psychogeriatr. 2002, 14:273-289.
15. Gold C.H., Malmberg B., McClearn G.E., Pedersen N.L., Berg S. Gender and health: a study of older unlike-sex twins. J.Gerontol. B Psychol. Sci. Soc. Sci. 2002, 57:S168-S176.
16. Greenland S., Thomas D.C. On the need for the rare disease assumption in case-control studies. Am. J. Epidemiol. 1982, 116:547-553.
17. Hansson G.K., Libby P. The immune response in atherosclerosis: a double-edged sword. Nat. Rev. Immunol. 2006, 6:508-519.
18. Himmelfarb S., Murrell S.A. Reliability and validity of five mental health scales in older persons. J.Gerontol. 1983, 38:333-339.
19. Huang Y. Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. Curr. Opin. Lipidol. 2010, 21:337-345.
20. Irie F., Masaki K.H., Petrovitch H., Abbott R.D., Ross G.W., Taaffe D.R., Launer L.J., White L.R. Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: the Honolulu-Asia Aging Study. Arch. Gen. Psychiatry 2008, 65:906-912.
21. Jorm A.F. History of depression as a risk factor for dementia: an updated review. Aust. N. Z. J. Psychiatry 2001, 35:776-781.
22. Kim J.M., Kim S.Y., Bae K.Y., Kim S.W., Shin I.S., Yang S.J., Song Y.H., Yoon J.S. Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older Korean population. Psychiatry Investig. 2010, 7:135-140.
23. Li G., Wang L.Y., Shofer J.B., Thompson M.L., Peskind E.R., McCormick W., Bowen J.D., Crane P.K., Larson E.B. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch. Gen. Psychiatry 2011, 68:970-977.
24. Magnusson P.K., Almqvist C., Rahman I., Ganna A., Viktorin A., Walum H., Halldner L., Lundstrom S., Ullen F., Langstrom N., Larsson H., Nyman A., Gumpert C.H., Rastam M., Anckarsater H., Cnattingius S., Johannesson M., Ingelsson E., Klareskog L., de Faire U., Pedersen N.L., Lichtenstein P. The swedish twin registry: establishment of a Biobank and other recent developments. Twin Res. Hum. Genet. 2012, 16:317-329.
25. McClearn G.E., Johansson B., Berg S., Pedersen N.L., Ahern F., Petrill S.A., Plomin R. Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science 1997, 276:1560-1563.
26. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
27. Meng X., D'Arcy C. Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors. Int. J. Geriatr. Psychiatry 2012, 28:1005-1014.
28. Radloff L.S. The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1977, 1:385-401.
29. Rodrigues L., Kirkwood B.R. Case-control designs in the study of common diseases: updaes on the demise of the rare disease assumption and the choice of sampling scheme for controls. Int. J. Epidemiol. 1990, 19:205-213.
30. Värdering Av Diagnoskvaliteten För Akut Hjärtinfarkt I Patientregistret 1987 och 1995 2000, Socialstyrelsen, Cited 2014 Aug 28. Avaliable at:, Accessed January 30, 2015. http://www.socialstyrelsen.se/publikationer2000/2000-0-100.
31. Steffens D.C., Plassman B.L., Helms M.J., Welsh-Bohmer K.A., Saunders A.M., Breitner J.C. Atwin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biol. Psychiatry 1997, 41:851-856.
32. Thronson L.R., Pagalilauan G.L. Psychopharmacology. Med. Clin. North Am. 2014, 98:927-958.
33. Vance J.E., Hayashi H. Formation and function of apolipoprotein E-containing lipoproteins in the nervous system. Biochim. Biophys. Acta 2010, 1801:806-818.