메뉴 건너뛰기




Volumn 141, Issue 2, 2015, Pages 295-305

Bevacizumab-based combination therapy for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a systematic review of the literature

Author keywords

Bevacizumab; Chemotherapy; Combined treatment; Neuroendocrine neoplasms

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; MONOCLONAL ANTIBODY;

EID: 84925286683     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1757-5     Document Type: Review
Times cited : (33)

References (40)
  • 1
    • 0003514452 scopus 로고    scopus 로고
    • Oxford, International Agency for Research on Cancer. Pathology and genetics of tumours of the digestive system. IARC Press; Oxford University Press Distributor, Lyon:
    • Aaltonen L, Hamilton S (2000) World Health Organization. Oxford, International Agency for Research on Cancer. Pathology and genetics of tumours of the digestive system. IARC Press; Oxford University Press Distributor, Lyon
    • (2000) World Health Organization
    • Aaltonen, L.1    Hamilton, S.2
  • 2
    • 84901393568 scopus 로고    scopus 로고
    • Risk of mucocutaneous toxicities in patients with solid tumors treated with sorafenib; an updated systematic review and meta-analysis
    • Abdel-Rahman O, Fouad M (2014) Risk of mucocutaneous toxicities in patients with solid tumors treated with sorafenib; an updated systematic review and meta-analysis. Expert Rev Anticancer Ther [Epub ahead of print]
    • (2014) Expert Rev Anticancer Ther [Epub ahead of print]
    • Abdel-Rahman, O.1    Fouad, M.2
  • 3
    • 84879526437 scopus 로고    scopus 로고
    • Sorafenib versus capecitabine in the management of advanced hepatocellular carcinoma. Med Oncol (3):655. doi:10.1007/s12032-013-0655-z
    • Abdel-Rahman O, Abdelwahab M, Shaker M, AbdelWahab S, Elbassiony M, Ellithy M (2013) Sorafenib versus capecitabine in the management of advanced hepatocellular carcinoma. Med Oncol (3):655. doi:10.1007/s12032-013-0655-z. Epub 2013 Jul 4
    • (2013) Epub 2013 Jul 4
    • Abdel-Rahman, O.1    Abdelwahab, M.2    Shaker, M.3    AbdelWahab, S.4    Elbassiony, M.5    Ellithy, M.6
  • 4
    • 84899085315 scopus 로고    scopus 로고
    • Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the xelbevoct study
    • PID: 24628963
    • Berruti A, Fazio N, Ferrero A, Brizzi MP, Volante M, Nobili E et al (2014) Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the xelbevoct study. BMC Cancer 14(1):184. doi:10.1186/1471-2407-14-184
    • (2014) BMC Cancer , vol.14 , Issue.1 , pp. 184
    • Berruti, A.1    Fazio, N.2    Ferrero, A.3    Brizzi, M.P.4    Volante, M.5    Nobili, E.6
  • 5
    • 84868203410 scopus 로고    scopus 로고
    • World Health Organization, International Agency for Research on Cancer. WHO classification of tumours of the digestive system. (4th ed.)International Agency for Research on Cancer
    • Bosman F (2010), World Health Organization, International Agency for Research on Cancer. WHO classification of tumours of the digestive system. (4th ed.)International Agency for Research on Cancer, Lyon
    • (2010) Lyon
    • Bosman, F.1
  • 6
    • 70749123821 scopus 로고    scopus 로고
    • Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network
    • PID: 19886987
    • Brizzi MP, Berruti A, Ferrero A, Milanesi E, Volante M, Castiglione F (2009) Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte oncology network. BMC Cancer 9:388. doi:10.1186/1471-2407-9-388
    • (2009) BMC Cancer , vol.9 , pp. 388
    • Brizzi, M.P.1    Berruti, A.2    Ferrero, A.3    Milanesi, E.4    Volante, M.5    Castiglione, F.6
  • 7
    • 84888009143 scopus 로고    scopus 로고
    • Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumour: a phase II study of Spanish neuroendocrine tumour group (GETNE0801)
    • COI: 1:CAS:528:DC%2BC3sXhsVSkurbM, PID: 24012098, Epub 2013 Sep 5
    • Castellano D, Capdevila J, Sastre J, Alonso V, Llanos M, García-Carbonero R et al (2013) Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumour: a phase II study of Spanish neuroendocrine tumour group (GETNE0801). Eur J Cancer 49(18):3780–3787. doi:10.1016/j.ejca.2013.06.042 Epub 2013 Sep 5
    • (2013) Eur J Cancer , vol.49 , Issue.18 , pp. 3780-3787
    • Castellano, D.1    Capdevila, J.2    Sastre, J.3    Alonso, V.4    Llanos, M.5    García-Carbonero, R.6
  • 8
    • 84877921239 scopus 로고    scopus 로고
    • Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumours
    • COI: 1:CAS:528:DC%2BC3sXmvVemsLo%3D, PID: 23475104, Epub 2013 Mar 9
    • Chan JA, Mayer RJ, Jackson N et al (2013) Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumours. Cancer Chemother Pharmacol 71(5):1241–1246. doi:10.1007/s00280-013-2118-9 Epub 2013 Mar 9
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.5 , pp. 1241-1246
    • Chan, J.A.1    Mayer, R.J.2    Jackson, N.3
  • 9
    • 84865171421 scopus 로고    scopus 로고
    • Prospective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BC38XhsFert77N, PID: 22778320, Epub 2012 Jul 9
    • Chan JA, Stuart K, Earle CC, Clark JW, Bhargava P, Miksad R et al (2012) Prospective study of bevacizumab plus temozolomide in patients with advanced neuroendocrine tumors. J Clin Oncol 30(24):2963–2968. doi:10.1200/JCO.2011.40.3147 Epub 2012 Jul 9
    • (2012) J Clin Oncol , vol.30 , Issue.24 , pp. 2963-2968
    • Chan, J.A.1    Stuart, K.2    Earle, C.C.3    Clark, J.W.4    Bhargava, P.5    Miksad, R.6
  • 10
    • 84872220581 scopus 로고    scopus 로고
    • Bevacizumab, pertuzumab, and sandostatin for patients (pts) with advanced neuroendocrine cancers (NET)
    • Firdaus I, Shih K, Zakari A, Lang E, McCleod M, Alguire K et al. (2012) Bevacizumab, pertuzumab, and sandostatin for patients (pts) with advanced neuroendocrine cancers (NET). J Clin Oncol 30(suppl; abstr 4127)
    • (2012) J Clin Oncol , vol.30
    • Firdaus, I.1    Shih, K.2    Zakari, A.3    Lang, E.4    McCleod, M.5    Alguire, K.6
  • 11
    • 84939929788 scopus 로고    scopus 로고
    • Hobday T, Qin R, Reidy D, Moore M, Strosberg J, Kaubisch A et al. Multi-center Phase II Trial of Temsirolimus (TEM) and Bevacizumab (BEV) in Pancreatic Neuroendocrine Tumor (PNET): Results of a Planned interim analysis. Accessed 29 April 2014
    • Hobday T, Qin R, Reidy D, Moore M, Strosberg J, Kaubisch A et al. Multi-center Phase II Trial of Temsirolimus (TEM) and Bevacizumab (BEV) in Pancreatic Neuroendocrine Tumor (PNET): Results of a Planned interim analysis. http://www.nanets.net/nanets_cd/2012/pdfs/C19hobdayabstract.pdf. Accessed 29 April 2014
  • 12
    • 41349094931 scopus 로고    scopus 로고
    • MC044 h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study
    • Hobday T, Rubin J, Holen K et al. (2007) MC044 h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study. J Clin Oncol 25(18_suppl):4504
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 4504
    • Hobday, T.1    Rubin, J.2    Holen, K.3
  • 13
    • 84863047255 scopus 로고    scopus 로고
    • Combination therapy of gemcitabine or oral S-1 with the anti-VEGF monoclonal antibody bevacizumab for pancreatic neuroendocrine carcinoma
    • COI: 1:CAS:528:DC%2BC38XltFGlurY%3D, PID: 22969935, Epub 2012 Jan 18
    • Kasuya K, Nagakawa Y, Suzuki M, Suzuki Y, Kyo B, Suzuki S et al (2012) Combination therapy of gemcitabine or oral S-1 with the anti-VEGF monoclonal antibody bevacizumab for pancreatic neuroendocrine carcinoma. Exp Ther Med 3(4):599–602 Epub 2012 Jan 18
    • (2012) Exp Ther Med , vol.3 , Issue.4 , pp. 599-602
    • Kasuya, K.1    Nagakawa, Y.2    Suzuki, M.3    Suzuki, Y.4    Kyo, B.5    Suzuki, S.6
  • 14
    • 80054799278 scopus 로고    scopus 로고
    • Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms
    • PID: 22005112
    • Kloppel G (2011) Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer 18(Suppl. 1):S1–S16
    • (2011) Endocr Relat Cancer , vol.18 , pp. S1-S16
    • Kloppel, G.1
  • 15
    • 84860338333 scopus 로고    scopus 로고
    • Combination treatment with metronomic temozolomide, bevacizumab and long-acting octreotide for malignant neuroendocrine tumours. Endocr Relat Cancer 19(1):L1–4. doi:10.1530/ERC-11-0287
    • Koumarianou A, Antoniou S, Kanakis G, Economopoulos N, Rontogianni D, Ntavatzikos A et al. (2012), Combination treatment with metronomic temozolomide, bevacizumab and long-acting octreotide for malignant neuroendocrine tumours. Endocr Relat Cancer 19(1):L1–4. doi:10.1530/ERC-11-0287. Print 2012 Feb
    • (2012) Print 2012 Feb
    • Koumarianou, A.1    Antoniou, S.2    Kanakis, G.3    Economopoulos, N.4    Rontogianni, D.5    Ntavatzikos, A.6
  • 16
    • 79955618719 scopus 로고    scopus 로고
    • Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors
    • PID: 21245995
    • Kuiper P, Hawinkels LJ, de Jonge-Muller ES, Biemond I, Lamers CB, Verspaget HW (2011) Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors. World J Gastroenterol 17(2):219–225. doi:10.3748/wjg.v17.i2.219
    • (2011) World J Gastroenterol , vol.17 , Issue.2 , pp. 219-225
    • Kuiper, P.1    Hawinkels, L.J.2    de Jonge-Muller, E.S.3    Biemond, I.4    Lamers, C.B.5    Verspaget, H.W.6
  • 17
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BD28XhsFSku70%3D, PID: 16421420
    • Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A et al (2006a) Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24(3):401–406
    • (2006) J Clin Oncol , vol.24 , Issue.3 , pp. 401-406
    • Kulke, M.H.1    Stuart, K.2    Enzinger, P.C.3    Ryan, D.P.4    Clark, J.W.5    Muzikansky, A.6
  • 18
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BD28XhsFSku70%3D, PID: 16421420
    • Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A et al (2006b) Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24(3):401–406
    • (2006) J Clin Oncol , vol.24 , Issue.3 , pp. 401-406
    • Kulke, M.H.1    Stuart, K.2    Enzinger, P.C.3    Ryan, D.P.4    Clark, J.W.5    Muzikansky, A.6
  • 19
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • COI: 1:CAS:528:DC%2BC3cXnsFOntr8%3D, PID: 20368568, Epub 2010 Apr 5
    • Lam ET, Ringel MD, Kloos RT et al (2010) Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 28(14):2323–2330. doi:10.1200/JCO.2009.25.0068 Epub 2010 Apr 5
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 20
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • COI: 1:CAS:528:DyaK3cXls1GltLo%3D, PID: 2479986
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246:1306–1309
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 21
    • 84872584434 scopus 로고    scopus 로고
    • Tomas D Immunohistochemical expression and prognostic significance of HIF-1α and VEGF-C in neuroendocrine breast cancer
    • PID: 23225420
    • Marton I, Knezevic F, Ramic S, Milosevic M (2012) Tomas D Immunohistochemical expression and prognostic significance of HIF-1α and VEGF-C in neuroendocrine breast cancer. Anticancer Res 32(12):5227–5232
    • (2012) Anticancer Res , vol.32 , Issue.12 , pp. 5227-5232
    • Marton, I.1    Knezevic, F.2    Ramic, S.3    Milosevic, M.4
  • 22
    • 52449104598 scopus 로고    scopus 로고
    • Priorities for improving the management of gastroenteropancreatic neuroendocrine tumours
    • PID: 18780869
    • Modlin I, Moss S, Chung D et al (2008a) Priorities for improving the management of gastroenteropancreatic neuroendocrine tumours. J Natl Cancer Inst 100:1282–1289
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1282-1289
    • Modlin, I.1    Moss, S.2    Chung, D.3
  • 23
    • 37449029464 scopus 로고    scopus 로고
    • Gastroenteropancreatic neuroendocrine tumours
    • COI: 1:CAS:528:DC%2BD1cXivVOltQ%3D%3D, PID: 18177818
    • Modlin I, Oberg K, Chung D et al (2008b) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9:61–72
    • (2008) Lancet Oncol , vol.9 , pp. 61-72
    • Modlin, I.1    Oberg, K.2    Chung, D.3
  • 24
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • PID: 19631508
    • Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62(10):1006–1012
    • (2009) J Clin Epidemiol , vol.62 , Issue.10 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3
  • 25
    • 66549116148 scopus 로고    scopus 로고
    • Neuroendocrine gastroenteropancreatic tumours: ESMO clinical recommendation for diagnosis, treatment and follow-up
    • PID: 19454440
    • Oberg K, Jelic S (2009) Neuroendocrine gastroenteropancreatic tumours: ESMO clinical recommendation for diagnosis, treatment and follow-up. Ann Oncol 20(Suppl. 4):150–153
    • (2009) Ann Oncol , vol.20 , pp. 150-153
    • Oberg, K.1    Jelic, S.2
  • 26
    • 9444236228 scopus 로고    scopus 로고
    • Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part II-specific NE tumour types
    • PID: 15545183
    • Oberg K, Astrup L, Eriksson B et al (2004a) Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part II-specific NE tumour types. Acta Oncol 43:626–636
    • (2004) Acta Oncol , vol.43 , pp. 626-636
    • Oberg, K.1    Astrup, L.2    Eriksson, B.3
  • 27
    • 9444233954 scopus 로고    scopus 로고
    • Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I-general overview
    • PID: 15545182
    • Oberg K, Astrup L, Eriksson B et al (2004b) Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms). Part I-general overview. Acta Oncol 43:617–625
    • (2004) Acta Oncol , vol.43 , pp. 617-625
    • Oberg, K.1    Astrup, L.2    Eriksson, B.3
  • 28
    • 17044402977 scopus 로고    scopus 로고
    • Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas
    • COI: 1:CAS:528:DC%2BD2MXktVOlu7g%3D
    • Pavel ME, Hassler G, Baum U, Hahn EG, Lohmann T, Schuppan D (2005) Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in neuroendocrine carcinomas. Clin Endocrinol (Oxf) 62(4):434–443
    • (2005) Clin Endocrinol (Oxf) , vol.62 , Issue.4 , pp. 434-443
    • Pavel, M.E.1    Hassler, G.2    Baum, U.3    Hahn, E.G.4    Lohmann, T.5    Schuppan, D.6
  • 29
    • 83255167036 scopus 로고    scopus 로고
    • Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study
    • COI: 1:CAS:528:DC%2BC3MXhsF2rt7rM, PID: 22119496, Epub 2011 Nov 25
    • Pavel ME, Hainsworth JD, Baudin E, Peeters M, Hörsch D, Winkler RE et al (2011) Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 378(9808):2005–2012. doi:10.1016/S0140-6736(11)61742-X Epub 2011 Nov 25
    • (2011) Lancet , vol.378 , Issue.9808 , pp. 2005-2012
    • Pavel, M.E.1    Hainsworth, J.D.2    Baudin, E.3    Peeters, M.4    Hörsch, D.5    Winkler, R.E.6
  • 30
    • 84891846992 scopus 로고    scopus 로고
    • An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes
    • COI: 1:CAS:528:DC%2BC3sXhslyrsbzJ, PID: 24231952, Epub 2013 Nov 14
    • Pinato DJ, Tan TM, Toussi ST, Ramachandran R, Martin N, Meeran K et al (2014) An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes. Br J Cancer 110(1):115–122. doi:10.1038/bjc.2013.682 Epub 2013 Nov 14
    • (2014) Br J Cancer , vol.110 , Issue.1 , pp. 115-122
    • Pinato, D.J.1    Tan, T.M.2    Toussi, S.T.3    Ramachandran, R.4    Martin, N.5    Meeran, K.6
  • 31
    • 20544477435 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS)
    • COI: 1:STN:280:DC%2BD2M3nt1Chtw%3D%3D, PID: 15838182
    • Plockinger U, Rindi G, Arnold R et al (2004) Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology 80:394–424
    • (2004) Neuroendocrinology , vol.80 , pp. 394-424
    • Plockinger, U.1    Rindi, G.2    Arnold, R.3
  • 32
    • 21044444847 scopus 로고    scopus 로고
    • Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut 54(Suppl. 4), pp
    • Ramage J, Davies A, Ardill J et al. (2005) Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours. Gut 54(Suppl. 4), pp. iv1–16
    • (2005) iv1–16
    • Ramage, J.1    Davies, A.2    Ardill, J.3
  • 33
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BC3MXhvVyisrY%3D, PID: 21306237
    • Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C et al (2011) Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364(6):501–513. doi:10.1056/NEJMoa1003825
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.L.3    Bang, Y.J.4    Borbath, I.5    Lombard-Bohas, C.6
  • 34
    • 70350442637 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group
    • COI: 1:CAS:528:DC%2BD1MXhtlGgtbnJ, PID: 19704057
    • Rinke A, Muller HH, Schade-Brittinger C et al (2009) Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27:4656–4663
    • (2009) J Clin Oncol , vol.27 , pp. 4656-4663
    • Rinke, A.1    Muller, H.H.2    Schade-Brittinger, C.3
  • 35
    • 0024791032 scopus 로고
    • Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family
    • COI: 1:CAS:528:DyaK3cXksFegtLs%3D, PID: 2610687
    • Tischer E et al (1989) Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family. Biochem Biophys Res Commun 165:1198–1206
    • (1989) Biochem Biophys Res Commun , vol.165 , pp. 1198-1206
    • Tischer, E.1
  • 36
    • 38049008967 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors
    • COI: 1:CAS:528:DC%2BD1cXjsFWlug%3D%3D, PID: 17589846, Epub 2007 Jun 23
    • Varker KA, Campbell J, Shah MH (2008) Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors. Cancer Chemother Pharmacol 61(4):661–668 Epub 2007 Jun 23
    • (2008) Cancer Chemother Pharmacol , vol.61 , Issue.4 , pp. 661-668
    • Varker, K.A.1    Campbell, J.2    Shah, M.H.3
  • 37
    • 79956216573 scopus 로고    scopus 로고
    • The pathological diagnosis of neuroendocrine tumours: common questions and tentative answers
    • COI: 1:CAS:528:DC%2BC3MXjsFyltLo%3D, PID: 21344263
    • Volante M, Righi L, Berruti A et al (2011) The pathological diagnosis of neuroendocrine tumours: common questions and tentative answers. Virchows Arch 458:393–402
    • (2011) Virchows Arch , vol.458 , pp. 393-402
    • Volante, M.1    Righi, L.2    Berruti, A.3
  • 38
    • 84939929791 scopus 로고    scopus 로고
    • Yao J, Phan A, Hess K, Fogelman D, Jacobs C, Dagohoy C et al. Randomized run-in study of Bevacizumab and Everolimus in low- to intermediate- grade neuroendocrine tumor (LGNETs) using perfusion CT (pCT) as functional biomarker. Accessed 29 April 2014
    • Yao J, Phan A, Hess K, Fogelman D, Jacobs C, Dagohoy C et al. Randomized run-in study of Bevacizumab and Everolimus in low- to intermediate- grade neuroendocrine tumor (LGNETs) using perfusion CT (pCT) as functional biomarker. http://www.nanets.net/nanets_cd/2010/pdfs/C36.pdf. Accessed 29 April 2014
  • 39
    • 41649114168 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b
    • COI: 1:CAS:528:DC%2BD1cXksVehu7k%3D, PID: 18323556
    • Yao JC, Phan A, Hoff PM, Chen HX, Charnsangavej C, Yeung SC et al (2008) Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 26(8):1316–1323. doi:10.1200/JCO.2007.13.6374
    • (2008) J Clin Oncol , vol.26 , Issue.8 , pp. 1316-1323
    • Yao, J.C.1    Phan, A.2    Hoff, P.M.3    Chen, H.X.4    Charnsangavej, C.5    Yeung, S.C.6
  • 40
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BC3MXhvVyiu7s%3D, PID: 21306238
    • Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E et al (2011) Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364(6):514–523. doi:10.1056/NEJMoa1009290
    • (2011) N Engl J Med , vol.364 , Issue.6 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3    Bohas, C.L.4    Wolin, E.M.5    Van Cutsem, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.