PEDF improves mitochondrial function in RPE cells during oxidative stress

Investigative ophthalmology & visual science

Volumn 55, Issue 10, 2014, Pages 6742-6755

  He, Yuan ^a   Leung, Kar W ah ^a   Ren, Yuan ^a   Pei, Jinzhi ^a   Ge, Jian ^a   Tombran Tink, Joyce ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

aging; apoptosis; ATP; caspase 3; cyclophilin D; MAPK; mitochondria; mitochondria structure; mitochondrial membrane potential; oxidative stress; PEDF; PI3K Akt; ROS; RPE; UCP2

Indexed keywords

EYE PROTEIN; ION CHANNEL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; NERVE GROWTH FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

AGED; AGING; APOPTOSIS; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; PIGMENT EPITHELIUM; REAL TIME POLYMERASE CHAIN REACTION; RETINA DISEASE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGED; AGING; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; EYE PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ION CHANNELS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NERVE GROWTH FACTORS; OXIDATIVE STRESS; PROTEASE INHIBITORS; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; SERPINS; SIGNAL TRANSDUCTION;

EID: 84925283258     PISSN: None     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-14696     Document Type: Article

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