Single-nucleotide polymorphisms of the PRKCG gene and osteosarcoma susceptibility

Tumor Biology

Volumn 35, Issue 12, 2014, Pages 12671-12677

  Zhang, Ying ^a   Hu, Xu ^a   Wang, Hong Kai ^a   Shen, Wei Wei ^a   Liao, Tong Quan ^a   Chen, Pei ^a   Chu, Tong Wei ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Disease susceptibility; Osteosarcoma; Polymorphism; Protein kinase C; Single nucleotide

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN KINASE C GAMMA; PROTEIN KINASE C;

ADULT; ARTICLE; CANCER RISK; CANCER STAGING; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; ONCOGENE; OSTEOSARCOMA; PATHOGENESIS; PRIORITY JOURNAL; PRKCG GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR LOCALIZATION; ADOLESCENT; ALLELE; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; MIDDLE AGED; RISK; YOUNG ADULT;

ADOLESCENT; ADULT; ALLELES; CASE-CONTROL STUDIES; CHILD; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; ODDS RATIO; OSTEOSARCOMA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN KINASE C; YOUNG ADULT;

EID: 84925282906     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2591-8     Document Type: Article

References (23)

1. Campanacci M. Bone and soft tissue tumors: clinical features, imaging, pathology and treatment. New York: Springer; 1999. p. 464–91.
2. Stiller CA, Bielack SS, Jundt G, et al. Bone tumours in European children and adolescents,1978–1997, report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42(2124).
3. Haddox CL, Han G, Anijar L, et al. Osteosarcoma in pediatric patients and young adults: a single institution retrospective review of presentation, therapy, and outcome. Sarcoma. 2014;2014:402509.
4. Wafa H, Grimer RJ. Surgical options and outcomes in bone sarcoma. Expert Rev Anticancer Ther. 2006;6:239–48.
5. Meyers PA, Schwartz CL, Krailo MD, et al. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival—a report from the Children's Oncology Group. J Clin Oncol. 2008;26:633–8.
6. Hawkins MM, Wilson LMK, Burton HS, et al. Radiotherapy, alkylating agents, and risk of bone cancer after childhood cancer. J Natl Cancer Inst. 1996;88:270–8.
7. Zhong GQ, Tu RH, Zeng ZY, et al. Novel functional role of heat shock protein 90 in protein kinase C-mediated ischemic postconditioning. J Surg Res. 2014;189:198–206.
8. Klebe S, Durr A, Rentschler A, et al. New mutations in protein kinase C gamma associated with spinocerebellar ataxia type 14. Ann Neurol. 2005;58:720–9.
9. Mochizuki H, Seki T, Adachi N, et al. R659S mutation of γPKC is susceptible to cell death: implication of this mutation/polymerp-hism in the pathogenesis of retinitis pigmentosa. Neurochem Int. 2006;49:669–75.
10. Parsons M, Adams JC. Rac regulates the interaction of fascin with protein kinase C in cell migration. J Cell Sci. 2008;121:2805–13.
11. Mazzoni E, Adam A, Bal de Kier Joffe E, et al. Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. Mol Cancer Res. 2003;1:776–87.
12. Xie X, Ma YT, Fu ZY, Yang YN, Ma X, Chen BD, et al. Haplotype analysis of the CYP8A1 gene associated with myocardial infarction. Clin Appl Thromb Hemost. 2009;15:574–80.
13. Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;15:97–8.
14. Li Z, Zhang Z, He Z, et al. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 2009;19:519–23.
15. Chen C, Kano M, Abeliovich A, et al. Impaired motor-coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell. 1995;83:1233–42.
16. Nolte D, Landendinger M, Schmitt E, et al. Spinocerebellar ataxia 14: novel mutation in exon 2 of PRKCG in a German family. Mov Disord. 2007;22:265–7.
17. Fahey MC, Knight MA, Shaw JH, et al. Spinocerebellar ataxia type 14: study of a family with an exon 5 mutation in the PRKCG gene. J Neurol Neurosurg Psychiatry. 2005;76:1720–2.
18. Hashimoto Y, Parsons M, Adams JC. Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis. Mol Biol Cell. 2007;18:4591–602.
19. Vignjevic D, Schoumacher M, Gavert N, et al. Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res. 2007;67:6844–53.
20. Li Y, Dang TA, Shen J, et al. Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics. 2006;6:3426–35.
21. Ren L, Hong SH, Cassavaugh J, et al. The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene. 2008;28:792–802.
22. Koivunen J, Aaltonen V, Koskela S, et al. Protein kinase C α/β inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer Res. 2004;64:5693–701.
23. Taylor J, Pampillo M, Bhattacharya M, Babwah AV. Kisspeptin/KISS1R signaling potentiates extravillous trophoblast adhesion to type-I collagen in a PKC- and ERK1/2-dependent manner. Mol Reprod Dev. 2014;81:42–54.