Should HLA mismatch acceptability for sensitized transplant candidates be determined at the high-resolution rather than the antigen level?

American Journal of Transplantation

Volumn 15, Issue 4, 2015, Pages 923-930

  Duquesnoy, R J ^a   Kamoun, M ^b   Baxter Lowe, L A ^c   Woodle, E S ^d   Bray, R A ^e   Claas, F H J ^f   Eckels, D D ^g   Friedewald, J J ^h   Fuggle, S V ⁱ   Gebel, H M ^e   Gerlach, J A ^j   Fung, J J ^k   Middleton, D ^l   Nickerson, P ^m   Shapiro, R ^a   Tambur, A R ^h   Taylor, C J ⁿ   Tinckam, K ^o   Zeevi, A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

^e EMORY UNIVERSITY HOSPITAL   (United States)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^g MLC Group LLC   (United States)

^h NORTHWESTERN UNIVERSITY   (United States)

ⁱ OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^j MICHIGAN STATE UNIVERSITY   (United States)

^k LERNER RESEARCH INSTITUTE   (United States)

^l ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^m UNIVERSITY OF MANITOBA   (Canada)

ⁿ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^o TORONTO GENERAL HOSPITAL   (Canada)

more..

Author keywords

Alloantibody; immunogenetics; major histocompatibility complex (MHC); panel reactive antibody (PRA); sensitization

Indexed keywords

EPITOPE; HLA ANTIBODY; HLA ANTIGEN; AUTOANTIBODY;

ALLELE; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGENICITY; BONE MARROW TRANSPLANTATION; DONOR SELECTION; GENE EXPRESSION; GRAFT RECIPIENT; GRAFT SURVIVAL; HAPLOTYPE; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY TEST; HLA MATCHING; HLA MISMATCH; HLA TYPING; HOSPITAL ADMISSION; IMMUNE RESPONSE; KIDNEY TRANSPLANTATION; LABORATORY TEST; ORGAN DONOR; PREDICTION; PRIORITY JOURNAL; REVIEW; SENSITIZATION; SEROLOGY; DONOR; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY;

ALLELES; AUTOANTIBODIES; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; TISSUE DONORS; TRANSPLANTATION IMMUNOLOGY;

EID: 84925271973     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13167     Document Type: Review

References (23)

1. Delmonico FL, Fuller A, Cosimi AB, et al. New approaches to donor crossmatching and successful transplantation of highly sensitized patients. Transplantation 1983; 36: 629-633.
2. Oldfather JW, Anderson CB, Phelan DL, Cross DE, Luger AM, Rodey GE,. Prediction of crossmatch outcome in highly sensitized dialysis patients based on the identification of serum HLA antibodies. Transplantation 1986; 42: 267-270.
3. Rodey GE, Neylan JF, Whelchel JD, Revels KW, Bray RA,. Epitope specificity of HLA class I alloantibodies. I. Frequency analysis of antibodies to private versus public specificities in potential transplant recipients. Hum Immunol 1994; 39: 272-280.
4. Fuller AA, Rodey GE, Parham P, Fuller TC,. Epitope map of the HLA-B7 CREG using affinity-purified human alloantibody probes. Hum Immunol 1990; 28: 306-325.
5. Fuller AA, Trevithick JE, Rodey GE, Parham P, Fuller TC,. Topographic map of the HLA-A2 CREG epitopes using human alloantibody probes. Hum Immunol 1990; 28: 284-305.
6. Barbetti AA, Park MS, Terasaki PI, Clark B, Fan JL,. HLA serologic epitopes. Clin Transplant 1989; 477-498.
7. Terasaki PI, Park MS, Takemoto S, et al. Overview and epitope matching. Clin Transplant 1989; 499-516.
8. Terasaki PI, Takemoto S, Park MS, Clark B,. Landsteiner Award. HLA epitope matching. [see comment]. Transfusion 1992; 32: 775-786.
9. Duquesnoy RJ,. A structurally based approach to determine HLA compatibility at the humoral immune level. Hum Immunol 2006; 67: 847-862.
10. Duquesnoy RJ, Marrari M, Mulder A, et al. First report on the antibody verification of HLA-ABC epitopes recorded in the HLA epitope registry. Tissue Antigens 2014; 83 391-400.
11. Lomago J, Jelenik L, Zern D, et al. How did a patient who types for HLA-B 4403 develop antibodies that react with HLA-B 4402? Hum Immunol 2010; 71: 176-178.
12. Marrari M, Conca R, Praticò-Barbato L, Amoroso A, Duquesnoy R, Brief Report: Why did two patients who type for HLA-B13 have antibodies that react with all Bw4 antigens except HLA-B13. Transplant Immunol 2011; 25: 217-220.
13. Lutz CT, Al-Attar A, May JR, Jennings CD,. Alloantibody to a Bw4 Epitope in a Bw4+ B 27:05 Patient. Transplantation 2014; 98: 853-856.
14. Middleton D, Menchaca L, Rood H, Komerofsky R. New allele frequency database: http://www.allelefrequencies.net Tissue Antigens 2003; 403-407.
15. Duquesnoy RJ, Awadalla Y, Lomago J, et al. Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes. Transpl Immunol 2008; 18: 352-360.
16. Wiebe C, Pochinco D, Blydt-Hansen TD,. al. e. Class II HLA epitope matching-A strategy to minimize de novo donor-specific antibody development and improve outcomes. Am J Transplant 2013; 13: 3114-3122.
17. Tambur A, Rosati J, Roitberg R, Glotz D, Friedewald JJ, Leventhal JR,. Epitope analysis of HLA-DQ antigens: What does the antibody see. Transplantation 2014; 98: 157-166.
18. Tambur AR, Buckingham M, McDonald L, Luo X,. Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: The role of epitope sharing and epitope matching. Clin Transplant 2006; 399-404.
19. Thaunat O, Hanf W, Dubois V, et al. Chronic humoral rejection mediated by anti-HLA-DP alloantibodies: Insights into the role of epitope sharing in donor-specific and non-donor specific alloantibodies generation. Transpl Immunol 2009; 20: 209-211.
20. Billen EVA, Christiaans MHL, Doxiadis IIN, Voorter CEM, van den Berg-Loonen EM,. HLA-DP antibodies before and after renal transplantation. Tissue Antigens 2010; 75: 278-285.
21. Heinold A, Opelz G, Dohler B, et al. Deleterious impact of HLA-DRB1 allele mismatch in sensitized recipients of kidney retransplants. Transplantation 2013; 95: 137-141.
22. Madbouly A, Gragert L, Freeman J, et al. Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments. Tissue Antigens 2014; 84: 285-229.
23. Mack SJ, Cano P, Hollenbach JA, et al. Common and well-documented HLA alleles: 2012 Uupdate to the CWD catalogue. Tissue Antigens 2013; 81: 194-203.