Serum level of testosterone, dihydrotestosterone and IGF-1 during an Acute exacerbation of COPD and their relationships with inflammatory and prognostic indices: A pilot study

Minerva Medica

Volumn 105, Issue 4, 2014, Pages 289-294

  Corbo, G M ^a   Di Marco Berardino, A ^a   Mancini, A ^a   Inchingolo, R ^a   Smargiassi, A ^a   Raimondo, S ^a   Valente, S ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Chronic obstructive; Dihydrotestosterone; Inflammation; Pulmonary disease; Testosterone

Indexed keywords

ANABOLIC AGENT; ANDROSTANOLONE; CORTICOSTEROID; DOBUTAMINE; DOPAMINE; SERUM AMYLOID A; SOMATOMEDIN C; TESTOSTERONE; BIOLOGICAL MARKER;

ACUTE EXACERBATION CHRONIC OBSTRUCTIVE LUNG DISEASE; ADULT; AGED; APACHE; ARTICLE; BLOOD SAMPLING; CALCULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CORTICOSTEROID THERAPY; DESCRIPTIVE RESEARCH; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; HORMONE BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPOGONADISM; INFLAMMATION; MALE; MIDDLE AGED; MULTICENTER STUDY; PILOT STUDY; PREDICTIVE VALUE; PROGNOSIS; SERUM; TESTOSTERONE BLOOD LEVEL; VERY ELDERLY; BLOOD; COMPLICATION; DISEASE COURSE; METABOLISM; REFERENCE VALUE;

AGED; APACHE; BIOLOGICAL MARKERS; DIHYDROTESTOSTERONE; DISEASE PROGRESSION; FEMALE; HUMANS; HYPOGONADISM; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; MALE; PILOT PROJECTS; PROGNOSIS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REFERENCE VALUES; SERUM AMYLOID A PROTEIN; TESTOSTERONE;

EID: 84925228423     PISSN: 00264806     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Laghi F, Adiguzel N, Tobin MJ. Endocrinological derangements in COPD. Eur Resp J 2009;34:975-96.
2. Spruit MA, Gosselink R, Troosters T, Kasran A, Gayan-Ramirez G, Bogaerts P et al. Muscle force during an acute exarcebation in hospitalised patients with COPD and its relationship with CXCL8 and IGF-1. Thorax 2003;58:752-6.
3. Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987;106:196-204.
4. Soler-Cataluna JJ, Martinez-Garcia MA, Roman Sanchez P, Salcedon E, Navarro M, Ochando R. Severe acute exacerbation and mortality in patients with Chronic obstructive pulmonary disease. Thorax 2005;60:925-31.
5. Van Vliet M, Spruit MA, Verleden G, Kasran A, Van Herck E, Pitta F et al. Hypogonadism, quadriceps weakness and exercise intolerance in Chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;172:1105-11.
6. Laghi F, Langbein WE, Antonescu-Turcu A, Jubran A, Bammert C, Tobin MJ. Respiratory and skeletal muscle in hypogonodal men with Chronic Obstructive pulmonary disease. Am J Respir Crit Care Med 2005;197:598-605.
7. Snyder PJ. Hypogonadism in elderly men - what to do until the evidence comes. N Engl J Med 2004;350:440-2.
8. Ferguson GT. Effects of cortisone and testosterone on diaphragmatic function and biochemistry in the rabbit. J Appl Physiol 1995;78:1459-68.
9. Scalvini SI, Volterrani M, Vitacca M, Clark AL, Solfrini R, Panzali AM et al. Plasma hormone levels and haemodynamics in patients with chronic obstructive lung disease. Monaldi Arch Chest Dis 1996;51:380-6.
10. Itoh T, Nagaya N, Yoshikawa M, Fukuoka A, Takenaka H, Shimizu Y et al. Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2004;170:879-82.
11. Debigaré R, Marquis K, Côté CH, Tremblay RR, Michaud A, LeBlanc P et al. Catabolic/anabolic balance and muscle wasting in patients with COPD. Chest 2003;124:83-9.
12. Frutos MG, Cacicedo L, Fernández C, Vicent D, Velasco B, Zapatero H et al. Insights into the role of GH secretagogues in reversing the age decline in the GH/IGF1 axis. Am J Physiol Endocrinol Metab 2007;293:E1140-52.
13. Laghi F, Tobin MJ. Disorders of the respiratory muscles. Am J Respir Crit Care Med 2003;168:10-48.
14. Karadag F, Ozcan H, Karul AB, Yilmaz M, Cildag O. Sex hormone alterations and systemic inflammation in Chronic obstructive pulmonary disease. Int J Clin Pract 2009;63:275-81.
15. Akbaç T, Karakurt S, Unliigiizel G, Celikel T, Akalin S. The endocrinologie changes in critically ill chronic obstructive pulmonary disease patients. COPD 2010;7:240-7.
16. Schuetz PI, Christ-Crain M, Schild U, Süess E, Facompre M, Baty F et al. Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitaryadrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease. BMC Pulm Med 2008;8:1-8.
17. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29.
18. Bozinovski S, Hutchinson A, Thompson M, Macgregor L, Black J, Giannakis E et al. Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Critic Care Med 2008;177:269-78.
19. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) [Internet]. Available from www.goldcopd.org [cited 2014, Jul. 14].
20. Ly PL, Handelsman D. Empirical stimation of free testosterone from testosterone and sex hormone binding globulin immunoassays. EurJ Endo 2005;152:471-8.
21. Miravitlles M, Guerrero T, Mayordomo C, Sanchezagudo L, Nicolai F, Segu JL. Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO study group. Respiration 2000;67:495-501.
22. Semple PD, Beastall GH, Watson WS, Hume R. Serum testosterone depression associated with hypoxia in respiratory failure. Clin Sei 1980;58:105-6.
23. Jagoe RT, Engelen MP. Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease. Eur Respir J (Suppl.) 2003;46:52s-63s.
24. Vaitkus M, Lavinskiene S, Barkauskiene D, Bieksiene K, Jeroch J, Sakalauskas R. Reactive oxygen species in peripheral blood and sputum neutrophils during bacterial and non bacterial acute exacerbation of chronic obstructive pulmonary disease. Inflammation 2013;36:1485-93.
25. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-26.
26. Vitale G, Salvioli S., Franceschi C. Oxidative stress and the ageing endocrine system. Nat Rev Endocrinol 2013;9:228-40.
27. Imrie H, Abbas A, Viswambharan H, Rajwani A, Cubbon RM, Gage M et al. Vascular insuline like growth factor 1 resistance and diet-induced obesity. Endocrinology 2009;150:4575-82.
28. Doucet M, Russell AP, Léger B, Debigaré R, Joanisse DR, Caron MA et al. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. Am J Crit Care Med 2007;176:261-9.