Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: A chart-verified case-control analysis

Journal of the American Academy of Dermatology

Volumn 71, Issue 6, 2014, Pages 1144-1150

  Shlyankevich, Julia ^a,b   Chen, Allison J ^b   Kim, Grace E ^a,c   Kimball, Alexandra B ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

acne inversa; cardiovascular disease; comorbidities; hidradenitis; hidradenitis suppurativa; lymphoma; metabolic syndrome; obesity; prevalence

Indexed keywords

ADULT; AGE; ALCOHOLISM; ARTHROPATHY; ARTICLE; CASE CONTROL STUDY; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DEPENDENCE; DYSLIPIDEMIA; FEMALE; HUMAN; HYPERTENSION; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; OBESITY; OVARY POLYCYSTIC DISEASE; PREVALENCE; PRIORITY JOURNAL; RACE DIFFERENCE; RETROSPECTIVE STUDY; SEX DIFFERENCE; SMOKING; SQUAMOUS CELL CARCINOMA; SUPPURATIVE HIDRADENITIS; THYROID DISEASE; AGED; DYSLIPIDEMIAS; FACTUAL DATABASE; HIDRADENITIS SUPPURATIVA; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; SUBSTANCE-RELATED DISORDERS; THYROID DISEASES;

ADULT; AGED; ALCOHOLISM; CASE-CONTROL STUDIES; COMORBIDITY; DATABASES, FACTUAL; DIABETES MELLITUS; DYSLIPIDEMIAS; FEMALE; HIDRADENITIS SUPPURATIVA; HUMANS; HYPERTENSION; LYMPHOMA; MALE; MIDDLE AGED; OBESITY; PREVALENCE; RETROSPECTIVE STUDIES; SMOKING; SUBSTANCE-RELATED DISORDERS; THYROID DISEASES;

EID: 84925227341     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2014.09.012     Document Type: Article

References (46)

1. F.W. Danby, and L.J. Margesson Hidradenitis suppurativa Dermatol Clin 28 2010 779 793
2. R.L. Attanoos, M.A. Appleton, and A.G. Douglas-Jones The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands Br J Dermatol 133 1995 254 258
3. I. Cosmatos, A. Matcho, R. Weinstein, M.O. Montgomery, and P. Stang Analysis of patient claims data to determine the prevalence of hidradenitis suppurativa in the United States J Am Acad Dermatol 68 2013 412 419
4. G.B. Jemec, M. Heidenheim, and N.H. Nielsen The prevalence of hidradenitis suppurativa and its potential precursor lesions J Am Acad Dermatol 35 1996 191 194
5. L. Naldi Epidemiology G. Jemec, J. Revuz, J. Leyden, Hidradenitis suppurativa Vol 1 2006 Springer Berlin (Germany) 58 59 64
6. J.E. Revuz, F. Canoui-Poitrine, P. Wolkenstein, C. Viallette, G. Gabison, and F. Pouget Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies J Am Acad Dermatol 59 2008 596 601
7. K. Sartorius, L. Emtestam, G.B. Jemec, and J. Lapins Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity Br J Dermatol 161 2009 831 839
8. R. Sabat, A. Chanwangpong, S. Schneider-Burrus, D. Metternich, G. Kokolakis, and A. Kurek Increased prevalence of metabolic syndrome in patients with acne inversa PLoS One 7 2012 e31810
9. D.A. Gold, V.J. Reeder, M.G. Mahan, and I.H. Hamzavi The prevalence of metabolic syndrome in patients with hidradenitis suppurativa J Am Acad Dermatol 70 2014 699 703
10. I.K. Altunay, G. Gokdemir, A. Kurt, and S. Kayaoglu Hidradenitis suppurativa and squamous cell carcinoma Dermatol Surg 28 2002 88 90
11. H.H. van der Zee, K. de Winter, C.J. van der Woude, and E.P. Prens The prevalence of hidradenitis suppurativa in 1093 patients with inflammatory bowel disease Br J Dermatol 171 2014 673 675
12. J.N. Kraft, and G.E. Searles Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy J Cutan Med Surg 11 2007 125 131
13. Kromann CB, Deckers IE, Esmann S, Boer J, Prens EP, Jemec GB. Risk-factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study. Br J Dermatol doi:10.1111/bjd.13090. Published online May 7, 2014.
14. G.E. Kim, J. Shlyankevich, and A.B. Kimball The validity of the diagnostic code for hidradenitis suppurativa in an electronic database Br J Dermatol 171 2014 338 342
15. F. Canoui-Poitrine, J.E. Revuz, P. Wolkenstein, C. Viallete, G. Gabison, and F. Pouget Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity J Am Acad Dermatol 61 2009 51 57
16. G.B. Jemec Clinical practice: hidradenitis suppurativa N Engl J Med 366 2012 158 164
17. A.B. Kimball, F. Kerdel, D. Adams, U. Mrowietz, J.M. Gelfand, and R. Gniadecki Adalimumab for the treatment of moderate to severe hidradenitis suppurativa: a parallel randomized trial Ann Intern Med 157 2012 846 855
18. L.H. Chen, V. Quinn, L. Xu, M.K. Gould, S.J. Jacobsen, and C. Koebnick The accuracy and trends of smoking history documentation in electronic medical records in a large managed care organization Subst Use Misuse 48 2013 731 742
19. M.B. Stephens Coding and obesity: room to grow J Am Board Fam Med 24 2011 329 330
20. A. Alikhan, P.J. Lynch, and D.B. Eisen Hidradenitis suppurativa: a comprehensive review J Am Acad Dermatol 60 2009 539 561 quiz 562-3
21. P.S. Mortimer, R.P. Dawber, M.A. Gales, and R.A. Moore Mediation of hidradenitis suppurativa by androgens Br Med J (Clin Res Ed) 292 1986 245 248
22. B.J. Harrison, G.F. Read, and L.E. Hughes Endocrine basis for the clinical presentation of hidradenitis suppurativa Br J Surg 75 1988 972 975
23. J.H. Barth, A.M. Layton, and W.J. Cunliffe Endocrine factors in pre- and postmenopausal women with hidradenitis suppurativa Br J Dermatol 134 1996 1057 1059
24. B.C. Melnik, and G. Plewig Impaired notch signaling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa) Br J Dermatol 168 2013 876 878
25. R. Verdolini, N. Clayton, A. Smith, N. Alwash, and B. Mannello Metformin for the treatment of hidradenitis suppurativa: a little help along the way J Eur Acad Dermatol Venereol 27 2013 1101 1108
26. P. Ettehadi, M.W. Greaves, D. Wallach, D. Aderka, and R.D. Camp Elevated tumor necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions Clin Exp Immunol 96 1994 146 151
27. C. Bonifati, M. Carducci, P. Cordiali Fei, E. Trento, G. Sacerdoti, and M. Fazio Correlated increases of tumor necrosis factor-alpha, interleukin-6 and granulocyte monocyte-colony stimulating factor levels in suction blister fluids and sera of psoriatic patients-relationships with disease severity Clin Exp Dermatol 19 1994 383 387
28. T. Henseler, and E. Christophers Disease concomitance in psoriasis J Am Acad Dermatol 32 1995 982 986
29. A. Mussi, C. Bonifati, M. Carducci, G. D'Agosto, F. Pimpinelli, and D. D'Urso Serum TNF-alpha levels correlate with disease severity and are reduced by effective therapy in plaque-type psoriasis J Biol Regul Homeost Agents 11 1997 115 118
30. D.M. Sommer, S. Jenisch, M. Suchan, E. Christophers, and M. Weichenthal Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis Arch Dermatol Res 298 2006 321 328
31. L. Matusiak, A. Bieniek, and J.C. Szepietowski Increased serum tumor necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumor necrosis factor-alpha agents? Acta Derm Venereol 89 2009 601 603
32. C. Schlapbach, T. Hanni, N. Yawalkar, and R.E. Hunger Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa J Am Acad Dermatol 65 2011 790 798
33. A. Grant, T. Gonzalez, M.O. Montgomery, V. Cardenas, and F.A. Kerdel Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial J Am Acad Dermatol 62 2010 205 217
34. E. Zintzaras, M. Voulgarelis, and H.M. Moutsopoulos The risk of lymphoma development in autoimmune diseases: a meta-analysis Arch Intern Med 165 2005 2337 2344
35. A. Hansen, P.E. Lipsky, and T. Dorner B-cell lymphoproliferation in chronic inflammatory rheumatic diseases Nat Clin Pract Rheumatol 3 2007 561 569
36. C. Pouplard, E. Brenaut, C. Horreau, T. Barnetche, L. Misery, and M.A. Richard Risk of cancer in psoriasis: a systematic review and meta-analysis of epidemiological studies J Eur Acad Dermatol Venereol 27 Suppl 2013 36 46
37. J.M. Gelfand, J. Berlin, A. Van Voorhees, and D.J. Margolis Lymphoma rates are low but increased in patients with psoriasis: results from a population-based cohort study in the United Kingdom Arch Dermatol 139 2003 1425 1429
38. J.M. Gelfand, D.B. Shin, A.L. Neimann, X. Wang, D.J. Margolis, and A.B. Troxel The risk of lymphoma in patients with psoriasis J Invest Dermatol 126 2006 2194 2201
39. S.T. Williams, R.C. Busby, R.J. DeMuth, and H. Nelson Perineal hidradenitis suppurativa: presentation of two unusual complications and a review Ann Plast Surg 26 1991 456 462
40. G.M. Maclean, and D.J. Coleman Three fatal cases of squamous cell carcinoma arising in chronic perineal hidradenitis suppurativa Ann R Coll Surg Engl 89 2007 709 712
41. C. Lavogiez, E. Delaporte, S. Darras-Vercambre, E. Martin De Lassalle, C. Castillo, and X. Mirabel Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa Dermatology 220 2010 147 153
42. P. Wolkenstein, A. Loundou, K. Barrau, P. Auquier, and J. Revuz Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases J Am Acad Dermatol 56 2007 621 623
43. J.M. von der Werth, and G.B. Jemec Morbidity in patients with hidradenitis suppurativa Br J Dermatol 144 2001 809 813
44. A. Kurek, E.M. Peters, A. Chanwangpong, R. Sabat, W. Sterry, and S. Schneider-Burrus Profound disturbances of sexual health in patients with acne inversa J Am Acad Dermatol 67 2012 422 428 428.e1
45. S. Esmann, and G.B. Jemec Psychosocial impact of hidradenitis suppurativa: a qualitative study Acta Derm Venereol 91 2011 328 332
46. A. Kurek, E.M. Johanne Peters, R. Sabat, W. Sterry, and S. Schneider-Burrus Depression is a frequent co-morbidity in patients with acne inversa J Dtsch Dermatol Ges 11 2013 743 750