Platelet-mediated changes to neuronal glutamate receptor expression at sites of microthrombosis following experimental subarachnoid hemorrhage: Laboratory investigation

Journal of Neurosurgery

Volumn 121, Issue 6, 2014, Pages 1424-1431

  Bell, Joshua D ^a,b   Thomas, Theresa Currier ^c,d,e   Lass, Elliot ^b   Ai, Jinglu ^b   Wan, Hoyee ^b   Lifshitz, Jonathan ^c,d,e,f   Baker, Andrew J ^a,b   MacDonald, R Loch ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c PHOENIX CHILDREN'S HOSPITAL   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^e Department of Endocrinology Phoenix VA Health Care System Mail Code 111E   (United States)

^f ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Glutamate receptor expression; Microthrombi; Platelet; Subarachnoid hemorrhage; Traumatic brain injury; Vascular disorders

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; FIBRINOGEN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROPIDIUM IODIDE; THROMBIN; GLUTAMIC ACID; HEMOSTATIC AGENT; NEUROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN DYSFUNCTION; BRAIN INJURY; CELL SURVIVAL; CELL VIABILITY; CLINICAL EVALUATION; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MALE; MICROTHROMBUS; NERVE CELL; NERVE CELL CULTURE; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PHENOTYPIC VARIATION; PLATELET-RICH PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STAINING; SUBARACHNOID HEMORRHAGE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; ANIMAL; CELL COMMUNICATION; CYTOLOGY; DRUG EFFECTS; METABOLISM; MICROELECTRODE; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE; SPRAGUE DAWLEY RAT; THROMBOCYTE; THROMBOSIS; WISTAR RAT;

ANIMALS; BLOOD PLATELETS; CELL COMMUNICATION; GLUTAMIC ACID; HEMOSTATICS; MALE; MICROELECTRODES; NEURONS; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; PLATELET ACTIVATION; PLATELET-RICH PLASMA; PRIMARY CELL CULTURE; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GLUTAMATE; SUBARACHNOID HEMORRHAGE; THROMBIN; THROMBOSIS;

EID: 84925223326     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2014.3.JNS132130     Document Type: Conference Paper

References (26)

1. Al-Khindi T, Macdonald RL, Schweizer TA: Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke 41:e519-e536, 2010
2. Bell JD, Ai J, Chen Y, Baker AJ: Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain 130:2528-2542, 2007
3. Bell JD, Park E, Ai J, Baker AJ: PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma. Cell Death Differ 16:1665-1680, 2009
4. Burmeister JJ, Pomerleau F, Palmer M, Day BK, Huettl P, Gerhardt GA: Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS. J Neurosci Methods 119:163-171, 2002
5. Cooke SF, Bliss TV: Plasticity in the human central nervous system. Brain 129:1659-1673, 2006
6. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R: Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 10:63-74, 2011
7. Friedrich V, Flores R, Muller A, Sehba FA: Escape of intraluminal platelets into brain parenchyma after subarachnoid hemorrhage. Neuroscience 165:968-975, 2010
8. Friedrich V, Flores R, Muller A, Sehba FA: Luminal platelet aggregates in functional deficits in parenchymal vessels after subarachnoid hemorrhage. Brain Res 1354:179-187, 2010
9. Germanó A, d'Avella D, Cicciarello R, Hayes RL, Tomasello F Blood-brain barrier permeability changes after experimental subarachnoid hemorrhage. Neurosurgery 30:882-886, 1992
10. Hanley JG, Henley JM: PICK1 is a calcium-sensor for NMDA-induced AMPA receptor trafficking. EMBO J 24:3266-3278, 2005
11. Hinzman JM, Thomas TC, Burmeister JJ, Quintero JE, Huettl P, Pomerleau F, et al: Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study. J Neurotrauma 27:889-899, 2010
12. Hinzman JM, Thomas TC, Quintero JE, Gerhardt GA, Lifshitz J: Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury. J Neurotrauma 29:1197-1208, 2012
13. Jeon H, Ai J, Sabri M, Tariq A, Macdonald RL: Learning deficits after experimental subarachnoid hemorrhage in rats. Neuroscience 169:1805-1814, 2010
14. Jeon H, Ai J, Sabri M, Tariq A, Shang X, Chen G, et al: Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage. BMC Neurosci 10:103 2009
15. LeRoux PD, Elliott JP, Grady MS, Newell DW, Mayberg MR, Winn HR: Anterior circulation aneurysms: improvement in outcome in good-grade patients 1983-1993. Clin Neurosurg 41:325-333, 1994
16. Lovelock CE, Rinkel GJ, Rothwell PM: Time trends in outcome of subarachnoid hemorrhage: population-based study and systematic review. Neurology 74:1494-1501, 2010
17. Malenka RC, Bear MF LTP and LTD: an embarrassment of riches. Neuron 44:5-21, 2004
18. McKenna P, Willison JR, Phil B, Lowe D, Neil-Dwyer G: Cognitive outcome and quality of life one year after subarachnoid haemorrhage. Neurosurgery 24:361-367, 1989
19. Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, et al: Glutamate mediates platelet activation through the AMPA receptor. J Exp Med 205:575-584, 2008
20. Nickell J, Pomerleau F, Allen J, Gerhardt GA: Age-related changes in the dynamics of potassium-evoked L-glutamate release in the striatum of Fischer 344 rats. J Neural Transm 112:87-96, 2005
21. Prunell GF, Mathiesen T, Svendgaard NA: A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage. Neuroreport 13:2553-2556, 2002
22. Sattler R, Tymianski M: Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med (Berl) 78:3-13, 2000
23. Tariq A, Ai J, Chen G, Sabri M, Jeon H, Shang X, et al: Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats. Neuroscience 165:418-426, 2010
24. Terashima A, Pelkey KA, Rah JC, Suh YH, Roche KW, Collingridge GL, et al: An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity. Neuron 57:872-882, 2008
25. Thomas TC, Grandy DK, Gerhardt GA, Glaser PE: Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum. Neuropsy-chopharmacology 34:436-445, 2009
26. Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB: Microthrombosis after aneurysmal subarachnoid hemorrhage: an additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab 28:1761-1770, 2008