Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset

Rheumatology (United Kingdom)

Volumn 53, Issue 12, 2014, Pages 2204-2208

  Tansley, Sarah L ^a   Betteridge, Zoe E ^b   Shaddick, Gavin ^c   Gunawardena, Harsha ^d   Arnold, Katie ^e,f   Wedderburn, Lucy R ^e,f   McHugh, Neil J ^a  

^a ROYAL UNITED HOSPITALS BATH NHS FOUNDATION TRUST   (United Kingdom)

^b University of Bath   (United Kingdom)

^c University of Bath   (United Kingdom)

^d SOUTHMEAD HOSPITAL   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Age; Autoantibody; Calcinosis; Juvenile dermatomyositis

Indexed keywords

AUTOANTIBODY; NXP2 AUTOANTIBODY; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; BIOLOGICAL MARKER; DNA BINDING PROTEIN; MORC3 PROTEIN, HUMAN;

ADULT; ANTIBODY DETECTION; ARTICLE; CALCINOSIS; CHILDHOOD MYOSITIS ASSESSMENT SCORE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RISK PATIENT; HUMAN; IMMUNOPRECIPITATION; JUVENILE DERMATOMYOSITIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MUSCLE WEAKNESS; ONSET AGE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REMISSION; SCORING SYSTEM; BLOOD; CHILD; CLINICAL TRIAL; COMPLICATION; DERMATOMYOSITIS; IMMUNOLOGY; MULTICENTER STUDY; PRESCHOOL CHILD; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX;

ADENOSINE TRIPHOSPHATASES; AGE OF ONSET; AUTOANTIBODIES; BIOLOGICAL MARKERS; CALCINOSIS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DERMATOMYOSITIS; DNA-BINDING PROTEINS; FEMALE; HUMANS; MALE; MUSCLE WEAKNESS; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX;

EID: 84925222840     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu259     Document Type: Article

References (12)

1. Gunawardena H, Wedderburn LR, Chinoy H et al. Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. Arthritis Rheum 2009;60:1807-14.
2. Espada G, Maldonado Cocco J, Fertig N, Oddis CV. Clinical and serologic characterization of an Argentine pediatric myositis cohort: identification of a novel autoantibody (anti-MJ) to a 142-kDa protein. J Rheumatol 2009;36:2547-51.
3. Martin N, Krol P, Smith S et al. A comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study. Arthritis Care Res 2012;64: 1665-72.
4. Patwardhan A, Rennebohm R, Dvorchik I, Spencer CH. Is juvenile dermatomyositis a different disease in children up to three years of age at onset than in children above three years at onset? A retrospective review of 23 years of a single center's experience. Pediatr Rheumatol Online J 2012;10:34.
5. Martin N, Krol P, Smith S et al. A national registry for juvenile dermatomyositis and other paediatric idiopathic inflammatory myopathies: 10 years' experience; the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies. Rheumatology 2011;50: 137-45.
6. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med 1975;292:344-7.
7. Huber AM, Feldman BM, Rennebohm RM et al. Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies. Arthritis Rheum 2004;50:1595-603.
8. Lazarevic D, Pistorio A, Palmisani E et al. The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis. Ann Rheum Dis 2013;72: 686-93.
9. Sato S, Hoshino K, Satoh T et al. RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: association with rapidly progressive interstitial lung disease. Arthritis Rheum 2009;60: 2193-200.
10. R Core Team [online]. Vienna, Austria: R Foundation for Statistical Computing, 2012. http://www.R-project.org/ (3 June 2014, date last accessed).
11. Wood SN. Generalized additive models: an introduction with R. Boca Raton, FL, USA: Chapman & Hall/CRC, 2006.
12. Marhaug G, Shah V, Shroff R et al. Age-dependent inhibition of ectopic calcification: a possible role for fetuin-A and osteopontin in patients with juvenile dermatomyositis with calcinosis. Rheumatology 2008;47:1031-7.