Is Cognitive Impairment in Cirrhotic Patients Due to Increased Peroxynitrite and Oxidative Stress?

Antioxidants and Redox Signaling

Volumn 22, Issue 10, 2015, Pages 871-877

  Gimenez Garzó, Carla ^a   Urios, Amparo ^b   Agustí, Ana ^b   González López, Olga ^c   Escudero García, Desamparados ^d   Escudero Sanchis, Amparo ^c   Serra, Miguel Angel ^d   Giner Durán, Remedios ^c   Montoliu, Carmina ^b,e   Felipo, Vicente ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^c HOSPITAL ARNAU DE VILANOVA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CYCLIC GMP; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 18; INTERLEUKIN 6; MALONALDEHYDE; NITRIC OXIDE; NITRITE; PEROXYNITRITE; SUPEROXIDE DISMUTASE; PEROXYNITROUS ACID;

ADULT; AMMONIA BLOOD LEVEL; ANTIOXIDANT ACTIVITY; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MOTOR COORDINATION; NEUROPSYCHOLOGICAL TEST; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN CARBONYLATION; REVIEW; SELECTIVE ATTENTION; VISUOMOTOR COORDINATION; AGED; FIBROSIS; LIVER; METABOLISM; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT;

AGED; FEMALE; FIBROSIS; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; PEROXYNITROUS ACID;

EID: 84925134302     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.6240     Document Type: Review

References (9)

1. Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, and Brown RH Jr. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 42: 644-654, 1997.
2. Chabrier PE, Demerlé-Pallardy C, and Auguet M. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol Life Sci 55: 1029-1035, 1999.
3. Felipo V. Hepatic encephalopathy: effects of liver failure on brain function. Nat Rev Neurosci 14: 851-858, 2013.
4. Felipo V, Urios A, Montesinos E, Molina I, Garcia-Torres ML, Civera M, Olmo JA, Ortega J, Martinez-Valls J, Serra MA, Cassinello N, Wassel A, Jordá E, and Montoliu C. Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy. Metab Brain Dis 27: 51-58, 2012.
5. Kosenko E, Kaminsky Y, Kaminsky A, Valencia M, Lee L, Hermenegildo C, and Felipo V. Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic Res 27: 637-644, 1997.
6. Montoliu C, Cauli O, Urios A, El Mlili N, Serra MA, Giner-Duran R, González-Lopez O, Del Olmo JA, Wassel A, Rodrigo JM, and Felipo V. 3-nitro-tyrosine as a peripheral biomarker of the presence of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol 106: 1629-1637, 2011.
7. Montoliu C, Piedrafita B, Serra MA, del Olmo JA, Urios A, Rodrigo JM, and Felipo V. IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy. J Clin Gastroenterol 43: 272-279, 2009.
8. Pacher P, Beckman JS, and Liaudet L. Nitric oxide and peroxynitrite. Physiol Rev 87: 315-424, 2007.
9. Shawcross DL, Davies NA, Williams R, and Jalan R. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 40: 247-254, 2004.