Myocardial adaptations to recreational marathon training among middle-aged men

Circulation: Cardiovascular Imaging

Volumn 8, Issue 2, 2015, Pages

  Zilinski, Jodi L ^a   Contursi, Miranda E ^a   Isaacs, Stephanie K ^a   Deluca, James R ^a   Lewis, Gregory D ^a   Weiner, Rory B ^a   Hutter, Adolph M ^a   D'Hemecourt, Pierre A ^b,c   Troyanos, Christopher ^c   Dyer, K Sophia ^c,d   Baggish, Aaron L ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Boston Athletic Association   (United States)

^d BOSTON MEDICAL CENTER   (United States)

Author keywords

Echocardiography; Exercise; Risk factors

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; BIOLOGICAL MARKER; LIPID;

ADULT; ARTICLE; BODY MASS; CARDIOPULMONARY EXERCISE TEST; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; ECHOCARDIOGRAPHY; EXERCISE PHYSIOLOGY; HEART FUNCTION; HEART LEFT ATRIUM END DIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART VOLUME; HUMAN; LONGITUDINAL STUDY; MALE; MARATHON RUNNER; MIDDLE AGED; MYOCARDIAL ADAPTATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; STUDY DESIGN; TRAINING; ADAPTATION; AGE; BLOOD; DOPPLER ECHOCARDIOGRAPHY; ENDURANCE; EXERCISE INDUCED CARDIOMEGALY; EXERCISE TEST; HEART; HEART ATRIUM FUNCTION; HEART ATRIUM REMODELING; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; PHYSIOLOGY; RUNNING; SEX DIFFERENCE; TIME;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGE FACTORS; ATRIAL FUNCTION, LEFT; ATRIAL REMODELING; BIOLOGICAL MARKERS; CARDIOMEGALY, EXERCISE-INDUCED; ECHOCARDIOGRAPHY, DOPPLER; EXERCISE TEST; HEART; HUMANS; LIPIDS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PROSPECTIVE STUDIES; RUNNING; SEX FACTORS; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84925024387     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.114.002487     Document Type: Article

References (38)

1. Grünig E, Henn P, D'Andrea A, Claussen M, Ehlken N, Maier F, Naeije R, Nagel C, Prange F, Weidenhammer J, Fischer C, Bossone E. Reference values for and determinants of right atrial area in healthy adults by 2-dimensional echocardiography. Circ Cardiovasc Imaging. 2013;6:117-124. doi: 10.1161/CIRCIMAGING.112.978031
2. Oxborough D, Sharma S, Shave R, Whyte G, Birch K, Artis N, Batterham AM, George K. The right ventricle of the endurance athlete: the relationship between morphology and deformation. J Am Soc Echocardiogr. 2012;25:263-271. doi: 10.1016/j.echo.2011.11.017
3. Pelliccia A, Culasso F, Di Paolo FM, Maron BJ. Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med. 1999;130:23-31
4. Pelliccia A, Maron BJ, Di Paolo FM, Biffi A, Quattrini FM, Pisicchio C, Roselli A, Caselli S, Culasso F. Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol. 2005;46:690-696. doi: 10.1016/j.jacc.2005.04.052
5. Pelliccia A, Maron BJ, Spataro A, Proschan MA, Spirito P. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Med. 1991;324:295-301. doi: 10.1056/NEJM199101313240504
6. Rodriguez Reguero JJ, Iglesias Cubero G, Lòpez de la Iglesia J, Terrados N, Gonzalez V, Cortina R, Cortina A. Prevalence and upper limit of cardiac hypertrophy in professional cyclists. Eur J Appl Physiol Occup Physiol. 1995;70:375-378
7. Baggish AL, Wang F, Weiner RB, Elinoff JM, Tournoux F, Boland A, Picard MH, Hutter AM Jr, Wood MJ. Training-specific changes in cardiac structure and function: a prospective and longitudinal assessment of competitive athletes. J Appl Physiol (1985). 2008;104:1121-1128. doi: 10.1152/japplphysiol.01170.2007
8. Baggish AL, Yared K, Wang F, Weiner RB, Hutter AM Jr, Picard MH, Wood MJ. The impact of endurance exercise training on left ventricular systolic mechanics. Am J Physiol Heart Circ Physiol. 2008;295:H1109-H1116. doi: 10.1152/ajpheart.00395.2008
9. Iwasaki K, Zhang R, Zuckerman JH, Levine BD. Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit? J Appl Physiol (1985). 2003;95:1575-1583. doi: 10.1152/japplphysiol.00482.2003
10. Burfoot A. The history of the marathon: 1976-present. Sports Med. 2007;37:284-287
11. Lamppa R. Running USA's Annual Marathon Report. 2013
12. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A; American College of Sports Medicine; American Heart Association. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1081-1093. doi: 10.1161/CIRCULATIONAHA.107.185649
13. Gaudreault V, Tizon-Marcos H, Poirier P, Pibarot P, Gilbert P, Amyot M, Rodés-Cabau J, Després JP, Bertrand O, Larose E. Transient myocardial tissue and function changes during a marathon in less fit marathon runners. Can J Cardiol. 2013;29:1269-1276. doi: 10.1016/j.cjca.2013.04.022
14. Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu TT, Yoerger DM, Jassal DS, Lewandrowski KB, Siegel AJ, Marshall JE, Douglas PS, Lawlor D, Picard MH, Wood MJ. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation. 2006;114:2325-2333. doi: 10.1161/CIRCULATIONAHA.106.647461
15. Shave R, Baggish A, George K, Wood M, Scharhag J, Whyte G, Gaze D, Thompson PD. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. J Am Coll Cardiol. 2010;56:169-176. doi: 10.1016/j.jacc.2010.03.037
16. Jones NL, Robertson DG, Kane JW. Difference between end-tidal and arterial PCO2 in exercise. J Appl Physiol Respir Environ Exerc Physiol. 1979;47:954-960
17. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985). 1986;60:2020-2027
18. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-1463
19. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009;22:107-133. doi: 10.1016/j.echo.2008.11.023
20. Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987;317:1098. doi: 10.1056/NEJM198710223171717
21. Oxborough D, Sharma S, Shave R, Whyte G, Birch K, Artis N, Batterham AM, George K. The right ventricle of the endurance athlete: the relationship between morphology and deformation. J Am Soc Echocardiogr. 2012;25:263-271. doi: 10.1016/j.echo.2011.11.017
22. Weiner RB, Hutter AM Jr, Wang F, Kim J, Weyman AE, Wood MJ, Picard MH, Baggish AL. The impact of endurance exercise training on left ventricular torsion. JACC Cardiovasc Imaging. 2010;3:1001-1009. doi: 10.1016/j.jcmg.2010.08.003
23. Baggish AL, Wood MJ. Athlete's heart and cardiovascular care of the athlete: scientific and clinical update. Circulation. 2011;123:2723-2735. doi: 10.1161/CIRCULATIONAHA.110.981571
24. La Gerche A, Burns AT, D'Hooge J, Macisaac AI, Heidbüchel H, Prior DL. Exercise strain rate imaging demonstrates normal right ventricular contractile reserve and clarifies ambiguous resting measures in endurance athletes. J Am Soc Echocardiogr. 2012;25:253-262.e1. doi: 10.1016/j. echo.2011.11.023
25. Helliker K. Marathon runners stop aging out of the race. Wall Street Journal. October 29, 2012
26. Shave R, Baggish A, George K, Wood M, Scharhag J, Whyte G, Gaze D, Thompson PD. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. J Am Coll Cardiol. 2010;56:169-176. doi: 10.1016/j.jacc.2010.03.037
27. Helliker K. One running shoe in the grave. Wall Street Journal. November 27, 2012
28. Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D, Levine BD. Effect of aging and physical activity on left ventricular compliance. Circulation. 2004;110:1799-1805. doi: 10.1161/01. CIR.0000142863.71285.74
29. Fontaine KR, Redden DT, Wang C, Westfall AO, Allison DB. Years of life lost due to obesity. JAMA. 2003;289:187-193
30. Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L; NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003;138:24-32
31. Blair SN, Kohl HW III, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA. 1995;273:1093-1098
32. Lee IM, Hsieh CC, Paffenbarger RS Jr. Exercise intensity and longevity in men. The Harvard Alumni Health Study. JAMA. 1995;273:1179-1184
33. Hunninghake DB, Stein EA, Dujovne CA, Harris WS, Feldman EB, Miller VT, Tobert JA, Laskarzewski PM, Quiter E, Held J. The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia. N Engl J Med. 1993;328:1213-1219. doi: 10.1056/NEJM199304293281701
34. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 2003;326:1423. doi: 10.1136/bmj.326.7404.1423
35. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R; Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005;366:1267-1278. doi: 10.1016/S0140-6736(05)67394-1
36. Mohlenkamp S, Lehmann N, Breuckmann F, Brocker-Preuss M, Nassenstein K, Halle M, Budde T, Mann K, Barkhausen J, Heusch G, Jockel KH, Erbel R, Marathon Study I and Heinz Nixdorf Recall Study I. Running: the risk of coronary events: Prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J. 2008;29:1903-10
37. Schnohr P, Marott JL, Lange P, Jensen GB. Longevity in male and female joggers: the Copenhagen City Heart Study. Am J Epidemiol. 2013;177:683-689. doi: 10.1093/aje/kws301
38. Kim JH, Malhotra R, Chiampas G, d'Hemecourt P, Troyanos C, Cianca J, Smith RN, Wang TJ, Roberts WO, Thompson PD, Baggish AL; Race Associated Cardiac Arrest Event Registry (RACER) Study Group. Cardiac arrest during long-distance running races. N Engl J Med. 2012;366:130-140. doi: 10.1056/NEJMoa1106468.