Expression of CYP2R1 and VDR in human brain pericytes: The neurovascular vitamin D autocrine/paracrine model

NeuroReport

Volumn 26, Issue 5, 2015, Pages 245-248

  El Atifi, Michèle ^a   Dreyfus, Matthieu ^a   Berger, Franҫois ^a   Wion, Didier ^a  

^a UNIV GRENOBLE ALPES   (France)

Author keywords

CYP2R1; Neurodegenerative disease; Pericyte; Vitamin D; Vitamin D receptor

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCIFEDIOL; CALCITRIOL; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; GAMMA INTERFERON; NEUROSTEROID; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CHOLESTANETRIOL 26 MONOOXYGENASE; CYP2R1 PROTEIN, HUMAN; VDR PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOCRINE EFFECT; BONE TISSUE; BRAIN CELL; BRAIN PERICYTE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; PARACRINE SIGNALING; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; VITAMIN D METABOLISM; BRAIN; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PERICYTE;

AUTOCRINE COMMUNICATION; BRAIN; CELLS, CULTURED; CHOLESTANETRIOL 26-MONOOXYGENASE; HUMANS; INTERFERON-GAMMA; PARACRINE COMMUNICATION; PERICYTES; RECEPTORS, CALCITRIOL; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN D;

EID: 84925011013     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000328     Document Type: Article

References (25)

1. Nissou MF, Guttin A, Zenga C, Berger F, Issartel JP, Wion D. Additional clues for a protective role of vitamin D in neurodegenerative diseases: 1,25-dihydroxyvitamin D3 triggers an anti-inflammatory response in brain pericytes. J Alzheimers Dis 2014; 42:789-799.
2. Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 2002; 13:100-105.
3. Nissou MF, Brocard J, El Atifi M, Guttin A, Andrieux A, Berger F, et al. The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases. J Alzheimers Dis 2013; 35:553-564.
4. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266-281.
5. Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci USA 2004; 101:7711-7715.
6. Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 2001; 86:888-894.
7. Gyetko MR, Hsu CH, Wilkinson CC, Patel S, Young E. Monocyte 1 alpha-hydroxylase regulation: induction by inflammatory cytokines and suppression by dexamethasone and uremia toxin. J Leukoc Biol 1993; 54:17-22.
8. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29:21-30.
9. Stumpf WE, Sar M, Clark SA, DeLuca HF. Brain target sites for 1,25-dihydroxyvitamin D3. Science 1982; 215:1403-1405.
10. Cui X, Pelekanos M, Liu PY, Burne TH, McGrath JJ, Eyles DW. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience 2013; 236:77-87.
11. Eyles DW, Burne TH, McGrath JJ. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 2013; 34:47-64.
12. McGrath J, Feron F, Eyles D, Mackay-Sim A. Vitamin D: the neglected neurosteroid? Trends Neurosci 2001; 24:570-572.
13. Groves NJ, McGrath JJ, Burne TH. Vitamin D as a neurosteroid affecting the developing and adult brain. Annu Rev Nutr 2014; 34:117-141.
14. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3:301-313.
15. Appaix F, Nissou MF, van der Sanden B, Dreyfus M, Berger F, Issartel JP, Wion D. Brain mesenchymal stem cells: the other stem cells of the brain?World J Stem Cells 2014; 6:134-143.
16. Sá-Pereira I, Brites D, Brito MA. Neurovascular unit: a focus on pericytes. Mol Neurobiol 2012; 45:327-347.
17. Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 2011; 12:723-738.
18. Dalkara T, Gursoy-Ozdemir Y, Yemisci M. Brain microvascular pericytes in health and disease. Acta Neuropathol 2011; 122:1-9.
19. Fernandes de Abreu DA, Eyles D, Féron F. Vitamin D, a neuroimmunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 2009; 34 (Suppl 1):S265-S277.
20. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol 2014; 14:463-477.
21. Johansson P, Almqvist EG, Johansson JO, Mattsson N, Andreasson U, Hansson O, et al. Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease. PLoS One 2013; 8:e81989.
22. Baas D, Prüfer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarliève LL, Brachet P. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 2000; 31:59-68.
23. Furman I, Baudet C, Brachet P. Differential expression of M-CSF, LIF, and TNF-alpha genes in normal and malignant rat glial cells: regulation by lipopolysaccharide and vitamin D. J Neurosci Res 1996; 46:360-366.
24. Hewison M. Vitamin D and immune function: autocrine, paracrine or endocrine? Scand J Clin Lab Invest 2012; 243 (Suppl):92-102.
25. Baudet C, Chevalier G, Naveilhan P, Binderup L, Brachet P, Wion D. Cytotoxic effects of 1 alpha,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line. Cancer Lett 1996; 100 (1-2):3-10.