Ginkgo biloba extracts attenuate lipopolysaccharide-induced inflammatory responses in acute lung injury by inhibiting the COX-2 and NF-κB pathways

Chinese Journal of Natural Medicines

Volumn 13, Issue 1, 2015, Pages 52-58

  Yao, Xin ^a   Chen, Nan ^b   Ma, Chun Hua ^c   Tao, Jing ^a   Bao, Jian An ^a   Cheng, Zong Qi ^a   Chen, Zu Tao ^a   Miao, Li Yan ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cyclooxygenase; Ginkgo biloba extract; Lipopolysaccharide; Nuclear factor B

Indexed keywords

ANTIOXIDANT; CYCLOOXYGENASE 2; DEXAMETHASONE; GINKGO BILOBA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; PEROXIDASE; PLANT EXTRACT; PTGS2 PROTEIN, MOUSE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; INFLAMMATION; INFLAMMATORY CELL; LUNG EDEMA; LUNG HOMOGENATE; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL COUNT; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; GINKGO BILOBA; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; PHYTOTHERAPY;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CYCLOOXYGENASE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GINKGO BILOBA; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED BALB C; PEROXIDASE; PHYTOTHERAPY; PLANT EXTRACTS; PULMONARY EDEMA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84924980303     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(15)60006-1     Document Type: Article

References (29)

1. Chi G, Wei M, Xie X, et al. Suppression of MAPK and NF-κB pathways by limonene contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury [J]. Inflammation 2013, 36(2):501-511.
2. Sato K, Kadiiska MB, Ghio AJ, et al. In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS [J]. FASEB J 2002, 16(13):1713-1720.
3. Ma ZQ, Ji WW, Fu QF, et al. Formononetin inhibited the inflammation of PS-induced acute lung injury in mice associated with induction of PPAR gamma expression [J]. Inflammation 2013, 36(6):1560-1566.
4. Chen H, Bai C, Wang X The value of the lipopolysaccharide induced acute lung injury model in respiratory medicine [J]. Exp Rev Resp Med 2010, 4(6):773-783.
5. Pahl HL Activators and target genes of Rel/NF-kappaB transcription factors [J]. Oncogene 1999, 18(49):6853-6866.
6. Yang R, Yang L, Shen X, et al. Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide- induced acute lung injury in mice [J]. Eur J Pharmacol 2012, 674(2-3):391-396.
7. Di R, Huang MT, Ho CT Anti-inflammatory activities of mogrosides from Momordica grosvenorii in murine macrophages and a murine ear edema model [J]. J Agric Food Chem 2011, 59(13):7474-7481.
8. Fukunaga K, Kohli P, Bonnans C, et al. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury [J]. J Immunol 2005, 174(8):5033-5039.
9. Zhang LN, Zheng JJ, Zhang L, et al. Protective effects of asiaticoside on septic lung injury in mice [J]. Exptl Toxicol Pathol 2011, 63(6):519-625.
10. Jakubowski A, Maksimovich N, Olszanecki R, et al. S-Nitroso human serum albumin given after LPS challenge reduces acute lung injury and prolongs survival in a rat model of endotoxemia [J]. Naun Schmied Arch Pharmacol 2009, 379(3):281-290.
11. Sio SW, Ang SF, Lu J, et al. Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury [J]. J Immunol 2010, 185(10):6265-6276.
12. Huang CH, Yang ML, Tsai CH, et al. Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-κB- dependent matrix metalloproteinase-9 pathway [J]. Phytomedicine 2013, 20(3-4):303-309.
13. Major RT The ginkgo, the most ancient living tree. The resistance of Ginkgo biloba L. to pests accounts in part for the longevity of this species [J]. Science 1967, 157(3794):1270-1273.
14. Van-Beek TA, Montoro P Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals [J]. J Chromatogr A 2009, 1216(11):2002-2032.
15. Chan PC, Xia Q, Fu PP Ginkgo biloba leave extract: biological, medicinal, and toxicological effects [J]. J Environ Sci Hlth - Part C: Environ Carcinogen & Ecotoxicol Rev 2007, 25(3):211-244.
16. Diamond BJ, Shiflett SC, Feiwel N, et al. Ginkgo biloba extract: mechanisms and clinical indications [J]. Arch Phys Med Rehab 2000, 81(5):668-678.
17. Park YM, Won JH, Yun KJ, et al. Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells [J]. Biol Pharm Bull 2006, 29(5):985-990.
18. Lee YW, Lin JA, Chang CC, et al. Ginkgo biloba extract suppresses endotoxin-mediated monocyte activation by inhibiting nitric oxide- and tristetraprolin-mediated toll-like receptor 4 expression [J]. J Nutr Biochem 2011, 22(4):351-359.
19. Rubenfeld GD Epidemiology of acute lung injury [J]. Crit Care Med 2003, 31(4):276-284.
20. Knapp S, Florquin S, Golenbock DT, et al. Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS- induced lung inflammation in vivo [J]. J Immunol 2006, 176(5):3189-3195.
21. Chen Z, Zhang X, Chu X, et al. Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice [J]. Inflammation 2010, 33(5):306-314.
22. Cepkova M, Matthay MA Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome [J]. J Intens Care Med 2006, 21(3):119-143.
23. Teder P, Vandivier RW, Jiang D, et al. Resolution of lung inflammation by CD44 [J]. Science 2002, 296(1242):155-158.
24. Abraham E Neutrophils and acute lung injury [J]. Crit Care Med 2003, 31(5):195-199.
25. Bachofen M, Weibel ER Structural alterations of lung parenchyma in the adult respiratory distress syndrome [J]. Clin Chest Med 1982, 3(1):35-56.
26. Klebanoff SJ Myeloperoxidase: friend and foe [J]. J Leuk Biol 2005, 77:598-625.
27. Zhang X, Song K, Xiong H, et al. Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice [J]. Int Immunopharmacol 2009, 9(13-14):1525-1529.
28. Kang JL, Lee HW, Lee HS, et al. Time course for inhibition of lipopolysaccharide-induced lung injury by genistein: relationship to alteration in nuclear factor-kappaB activity and inflammatory agents [J]. Crit Care Med 2003, 31(2):517-524.
29. Cheng YW, Chang CY, Lin KL, et al. Shikonin derivatives inhibited LPS-induced NOS in raw 264.7 cells via downregulation of MAPK/NF-kappaB signaling [J]. J Ethnopharmacol 2008, 120(2):264-271.